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SHAILAJA K MANI

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Psychiatry & Behavioral Sciences
DivisionPsychiatry & Behavioral Sciences
AddressMOLECULAR & CELLULAR BIOLOGY DEPARTMENT
ONE BAYLOR PLAZA
HOUSTON TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


    Collapse Research 
    Collapse research activities and funding
    R29MH057442     (MANI, SHAILAJA K)Apr 1, 1998 - Mar 31, 2004
    NIH/NIMH
    HORMONES, NEURONAL PHOSPHOPROTEINS AND BEHAVIOR
    Role: Principal Investigator

    R01MH057442     (MANI, SHAILAJA K)Apr 1, 1998 - May 31, 2010
    NIH/NIMH
    Hormones, Neuronal Phosphoproteins and Behavior
    Role: Principal Investigator

    R01MH063954     (MANI, SHAILAJA K)Jul 1, 2002 - Apr 30, 2008
    NIH/NIMH
    Steroid Hormones Regulatory Mechanisms and Behavior
    Role: Principal Investigator

    R01HD062512     (MANI, SHAILAJA K)Aug 23, 2010 - Jun 30, 2015
    NIH/NICHD
    Non-Classical Cellular Pathways for Progesterone Regulation of Behavior
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mani SK. Neuroendocrine regulation of reproduction, stress, inflammation and energy homeostasis. J Neuroendocrinol. 2018 Oct; 30(10):e12648. PMID: 30256474.
      View in: PubMed
    2. Larco DO, Bauman BM, Cho-Clark M, Mani SK, Wu TJ. GnRH-(1-5) Inhibits TGF-ß Signaling to Regulate the Migration of Immortalized Gonadotropin-Releasing Hormone Neurons. Front Endocrinol (Lausanne). 2018; 9:45. PMID: 29515521.
      View in: PubMed
    3. Portillo W, González-Flores O, Camacho FJ, Mani SK, Paredes RG. Participation of progesterone receptors in facilitation and sequential inhibition of lordosis response induced by ring A-reduced progesterone metabolites in female mice. Behav Neurosci. 2016 12; 130(6):624-34. PMID: 27786501.
      View in: PubMed
    4. Mani SK. Introduction. J Neuroendocrinol. 2016 07; 28(7). PMID: 27340765.
      View in: PubMed
    5. Liu Z, Oyola MG, Zhou S, Chen X, Liao L, Tien JC, Mani SK, Xu J. Knockout of the Histone Demethylase Kdm3b Decreases Spermatogenesis and Impairs Male Sexual Behaviors. Int J Biol Sci. 2015; 11(12):1447-57. PMID: 26681924; PMCID: PMC4672002.
    6. Acevedo-Rodriguez A, Mani SK, Handa RJ. Oxytocin and Estrogen Receptor ß in the Brain: An Overview. Front Endocrinol (Lausanne). 2015; 6:160. PMID: 26528239; PMCID: PMC4606117.
    7. Acharya KD, Finkelstein SD, Bless EP, Nettles SA, Mulac-Jericevic B, Conneely OM, Mani SK, Tetel MJ. Estradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus eNeuro. 2015 Jul-Aug; 2(4). PMID: 26465008; PMCID: PMC4596027.
    8. Cho-Clark M, Larco DO, Zahn BR, Mani SK, Wu TJ. GnRH-(1-5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion. Mol Cell Endocrinol. 2015 Nov 05; 415:114-25. PMID: 26277400.
      View in: PubMed
    9. Oyola MG, Zuloaga DG, Carbone D, Malysz AM, Acevedo-Rodriguez A, Handa RJ, Mani SK. CYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male Mice. Endocrinology. 2015 Jun; 156(6):2150-61. PMID: 25849728.
      View in: PubMed
    10. Mani SK, Anselmo-Franci J, Lara H, Suchecki D, Poletini MO, Handa RJ, Wu TY. Neuroendocrine regulation and homeostasis. J Neuroendocrinol. 2014 Sep; 26(9):555-6. PMID: 25059493.
      View in: PubMed
    11. Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F, Wang C, Yang Y, Hinton A, Yan C, Ding H, Zhu L, Yu L, Yang B, Feng Y, Clegg DJ, Khan S, DiMarchi R, Mani SK, Tong Q, Xu Y. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. J Clin Invest. 2014 Oct; 124(10):4351-62. PMID: 25157819; PMCID: PMC4191033.
    12. Larco DO, Semsarzadeh NN, Cho-Clark M, Mani SK, Wu TJ. ß-Arrestin 2 is a mediator of GnRH-(1-5) signaling in immortalized GnRH neurons. Endocrinology. 2013 Dec; 154(12):4726-36. PMID: 24140715.
      View in: PubMed
    13. Stashi E, Wang L, Mani SK, York B, O'Malley BW. Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences. Mol Endocrinol. 2013 Oct; 27(10):1776-87. PMID: 23927929; PMCID: PMC3787127.
    14. Larco DO, Semsarzadeh NN, Cho-Clark M, Mani SK, Wu TJ. The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor. Front Endocrinol (Lausanne). 2013; 4:83. PMID: 23847594; PMCID: PMC3703583.
    15. Larco DO, Cho-Clark M, Mani SK, Wu TJ. The metabolite GnRH-(1-5) inhibits the migration of immortalized GnRH neurons. Endocrinology. 2013 Feb; 154(2):783-95. PMID: 23321696.
      View in: PubMed
    16. Cho-Clark M, Larco DO, Semsarzadeh NN, Vasta F, Mani SK, Wu TJ. GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor. Mol Endocrinol. 2014 Jan; 28(1):80-98. PMID: 24264576.
      View in: PubMed
    17. Mani SK, Blaustein JD. Neural progestin receptors and female sexual behavior. Neuroendocrinology. 2012; 96(2):152-61. PMID: 22538437; PMCID: PMC3498483.
    18. Handa RJ, Mani SK, Uht RM. Estrogen receptors and the regulation of neural stress responses. Neuroendocrinology. 2012; 96(2):111-8. PMID: 22538291; PMCID: PMC3526110.
    19. Zuloaga DG, Yahn SL, Pang Y, Quihuis AM, Oyola MG, Reyna A, Thomas P, Handa RJ, Mani SK. Distribution and estrogen regulation of membrane progesterone receptor-ß in the female rat brain. Endocrinology. 2012 Sep; 153(9):4432-43. PMID: 22778216; PMCID: PMC3423618.
    20. Mani SK, Oyola MG. Progesterone signaling mechanisms in brain and behavior. Front Endocrinol (Lausanne). 2012; 3:7. PMID: 22649404; PMCID: PMC3355960.
    21. Oyola MG, Portillo W, Reyna A, Foradori CD, Kudwa A, Hinds L, Handa RJ, Mani SK. Anxiolytic effects and neuroanatomical targets of estrogen receptor-ß (ERß) activation by a selective ERß agonist in female mice. Endocrinology. 2012 Feb; 153(2):837-46. PMID: 22186418; PMCID: PMC3275390.
    22. Mani S, Portillo W. Activation of progestin receptors in female reproductive behavior: Interactions with neurotransmitters. Front Neuroendocrinol. 2010 Apr; 31(2):157-71. PMID: 20116396; PMCID: PMC2849835.
    23. Balasubramanian B, Portillo W, Reyna A, Chen JZ, Moore AN, Dash PK, Mani SK. Nonclassical mechanisms of progesterone action in the brain: I. Protein kinase C activation in the hypothalamus of female rats. Endocrinology. 2008 Nov; 149(11):5509-17. PMID: 18617608; PMCID: PMC2584599.
    24. Balasubramanian B, Portillo W, Reyna A, Chen JZ, Moore AN, Dash PK, Mani SK. Nonclassical mechanisms of progesterone action in the brain: II. Role of calmodulin-dependent protein kinase II in progesterone-mediated signaling in the hypothalamus of female rats. Endocrinology. 2008 Nov; 149(11):5518-26. PMID: 18617607; PMCID: PMC2584600.
    25. Gill JC, Wadas B, Chen P, Portillo W, Reyna A, Jorgensen E, Mani S, Schwarting GA, Moenter SM, Tobet S, Kaiser UB. The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice. Endocrinology. 2008 Sep; 149(9):4596-604. PMID: 18499748.
      View in: PubMed
    26. Mani S. Progestin receptor subtypes in the brain: the known and the unknown. Endocrinology. 2008 Jun; 149(6):2750-6. PMID: 18308838; PMCID: PMC2408817.
    27. Roberts JL, Mani SK, Woller MJ, Glucksman MJ, Wu TJ. LHRH-(1-5): a bioactive peptide regulating reproduction. Trends Endocrinol Metab. 2007 Dec; 18(10):386-92. PMID: 17997103.
      View in: PubMed
    28. Markaverich BM, Alejandro M, Thompson T, Mani S, Reyna A, Portillo W, Sharp J, Turk J, Crowley JR. Tetrahydrofurandiols (THF-diols), leukotoxindiols (LTX-diols), and endocrine disruption in rats. Environ Health Perspect. 2007 May; 115(5):702-8. PMID: 17520056; PMCID: PMC1868002.
    29. Wu TJ, Glucksman MJ, Roberts JL, Mani SK. Facilitation of lordosis in rats by a metabolite of luteinizing hormone releasing hormone. Endocrinology. 2006 May; 147(5):2544-9. PMID: 16497796.
      View in: PubMed
    30. Mani SK, Reyna AM, Chen JZ, Mulac-Jericevic B, Conneely OM. Differential response of progesterone receptor isoforms in hormone-dependent and -independent facilitation of female sexual receptivity. Mol Endocrinol. 2006 Jun; 20(6):1322-32. PMID: 16484336.
      View in: PubMed
    31. Markaverich BM, Crowley JR, Alejandro MA, Shoulars K, Casajuna N, Mani S, Reyna A, Sharp J. Leukotoxin diols from ground corncob bedding disrupt estrous cyclicity in rats and stimulate MCF-7 breast cancer cell proliferation. Environ Health Perspect. 2005 Dec; 113(12):1698-704. PMID: 16330350.
      View in: PubMed
    32. Mani SK, Reyna AM, Alejandro MA, Crowley J, Markaverich BM. Disruption of male sexual behavior in rats by tetrahydrofurandiols (THF-diols). Steroids. 2005 Oct; 70(11):750-4. PMID: 15927221.
      View in: PubMed
    33. Ma X, Reyna A, Mani SK, Matzuk MM, Kumar TR. Impaired male sexual behavior in activin receptor type II knockout mice. Biol Reprod. 2005 Dec; 73(6):1182-90. PMID: 16093358.
      View in: PubMed
    34. Wu TJ, Mani SK, Glucksman MJ, Roberts JL. Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5). Endocrinology. 2005 Jan; 146(1):280-6. PMID: 15486221.
      View in: PubMed
    35. Mani S. Emerging concepts in the regulation of female sexual behavior. Scand J Psychol. 2003 Jul; 44(3):231-9. PMID: 12914586.
      View in: PubMed
    36. Markaverich B, Mani S, Alejandro MA, Mitchell A, Markaverich D, Brown T, Velez-Trippe C, Murchison C, O'Malley B, Faith R. A novel endocrine-disrupting agent in corn with mitogenic activity in human breast and prostatic cancer cells. Environ Health Perspect. 2002 Feb; 110(2):169-77. PMID: 11836146.
      View in: PubMed
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