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BENJAMIN DENEEN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurosurgery
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


    Collapse Research 
    Collapse research activities and funding
    U01CA281902     (MILLS, GORDON B.)Sep 19, 2023 - Aug 31, 2028
    NIH
    Systematic Characterization and Targeting of Neomorphic Drivers in Cancer
    Role: Co-Principal Investigator
    R01CA284455     (MACK, STEPHEN C)Aug 1, 2023 - Jul 31, 2028
    NIH
    Transcriptional Regulation in ZFTA-RELA Ependymoma
    Role: Co-Principal Investigator
    R21MH134002     (DENEEN, BENJAMIN)Aug 1, 2023 - Jul 31, 2025
    NIH
    Defining Astrocyte Engram Ensembles During Memory Formation
    Role: Principal Investigator
    R35NS132230     (DENEEN, BENJAMIN)May 15, 2023 - Apr 30, 2031
    NIH
    Astrocyte Transcriptional Dependencies in Brain Circuits
    Role: Principal Investigator
    R01AG071687     (DENEEN, BENJAMIN)Apr 15, 2021 - Feb 28, 2026
    NIH
    Defining Roles for Astrocyte Subpopulations in the Aging Brain
    Role: Principal Investigator
    R01CA217105     (BONDY, MELISSA L.)May 8, 2018 - Apr 30, 2024
    NIH
    Discovery, Biology and Risk of Inherited Variants in Glioma
    Role: Co-Principal Investigator
    R01CA223388     (DENEEN, BENJAMIN ;NOEBELS, JEFFREY)Dec 15, 2017 - Nov 30, 2023
    NIH
    MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMA
    Role: Co-Principal Investigator
    U01CA217842     (MILLS, GORDON B.)Sep 6, 2017 - Jul 31, 2022
    NIH
    Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancer
    Role: Co-Principal Investigator
    R01NS096096     (DENEEN, BENJAMIN)Feb 1, 2017 - Jan 31, 2022
    NIH
    MOLECULAR AND CELLULAR CONTROL OF INJURY-INDUCED ASTROGENESIS
    Role: Co-Principal Investigator
    RF1AG054111     (ZHENG, HUI)Aug 15, 2016 - Mar 31, 2021
    NIH
    Decoding the role of diverse astrocyte populations in aging and AD
    Role: Co-Principal Investigator
    R21NS093145     (DENEEN, BENJAMIN)Jul 15, 2016 - Jun 30, 2018
    NIH
    Developing Novel Therapeutic Approaches for White Matter Injury in the Neonatal Brain
    Role: Principal Investigator
    R21NS089366     (DENEEN, BENJAMIN)Feb 1, 2015 - Jan 31, 2017
    NIH
    The nature of astrocyte heterogeneity in RTT
    Role: Principal Investigator
    R01NS071153     (DENEEN, BENJAMIN)Sep 1, 2010 - Jun 30, 2024
    NIH
    Transcriptional Control of Gliogenesis in the CNS
    Role: Principal Investigator
    F32NS048666     (DENEEN, BENJAMIN)Apr 1, 2006 - Mar 31, 2007
    NIH
    The role of NFI genes in glial cell fate determination
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Amit M, Anastasaki C, Dantzer R, Demir IE, Deneen B, Dixon KO, Egeblad M, Gibson EM, Hervey-Jumper SL, Hondermarck H, Magnon C, Monje M, Na'ara S, Pan Y, Repasky EA, Scheff NN, Sloan EK, Talbot S, Tracey KJ, Trotman LC, Valiente M, Van Aelst L, Venkataramani V, Venkatesh HS, Vermeer PD, Winkler F, Wong RJ, Gutmann DH, Borniger JC. Next Directions in the Neuroscience of Cancers Arising outside the CNS. Cancer Discov. 2024 Apr 04; 14(4):669-673. PMID: 38571430.
      Citations:    Fields:    
    2. Curry RN, Ma Q, McDonald MF, Ko Y, Srivastava S, Chin PS, He P, Lozzi B, Aiba I, Meyer J, Jing J, Wang S, Harmanci AO, Athukuri P, Noebels J, Arenkiel B, Jiang X, Deneen B, Rao G, Harmanci AS, Serin Harmanci A, Curry RN, Ma Q, McDonald MF, Ko Y, Srivastava S, Chin PS, He P, Lozzi B, Jing J, Athukuri P, Wang S, Harmanci AO, Arenkiel B, Jiang X, Deneen B, Rao G, Harmanci AS. Spiking GABAergic OPC tumor cells prolong survival in IDH1 mutant glioma. bioRxiv. 2024 Mar 19. PMID: 38496434; PMCID: PMC10942290.
      Citations:    
    3. Kwon W, Choi DJ, Yu K, Williamson MR, Murali S, Ko Y, Woo J, Deneen B. Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions. Int J Mol Sci. 2024 Jan 13; 25(2). PMID: 38256095; PMCID: PMC10816327.
      Citations:    Fields:    Translation:HumansCells
    4. Tripathi S, Nathan CL, Tate MC, Horbinski CM, Templer JW, Rosenow JM, Sita TL, James CD, Deneen B, Miller SD, Heimberger AB. The immune system and metabolic products in epilepsy and glioma-associated epilepsy: emerging therapeutic directions. JCI Insight. 2024 Jan 09; 9(1). PMID: 38193532; PMCID: PMC10906461.
      Citations:    Fields:    Translation:HumansAnimals
    5. Fuchs E, Sahai E, Weeraratna AT, Deneen B, Chak-Lui Wong C, Simon A. Understanding the microenvironment and how this controls cell fate. Dev Cell. 2023 Dec 18; 58(24):2819-2821. PMID: 38113847.
      Citations:    Fields:    Translation:Humans
    6. Williamson MR, Le SP, Franzen RL, Donlan NA, Rosow JL, Nicot-Cartsonis MS, Cervantes A, Deneen B, Dunn AK, Jones TA, Drew MR. Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke. Nat Commun. 2023 10 10; 14(1):6341. PMID: 37816732; PMCID: PMC10564905.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson MR, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Remote neuronal activity drives glioma progression through SEMA4F. Nature. 2023 Jul; 619(7971):844-850. PMID: 37380778; PMCID: PMC10840127.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    8. McDonald MF, Prather LL, Helfer CR, Ludmir EB, Echeverria AE, Yust-Katz S, Patel AJ, Deneen B, Rao G, Jalali A, Dhar SU, Amos CI, Mandel JJ. Prevalence of pathogenic germline variants in adult-type diffuse glioma. Neurooncol Pract. 2023 Oct; 10(5):482-490. PMID: 37720399; PMCID: PMC10502787.
      Citations:    
    9. Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel BR, Maze I, Deneen B. Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. Science. 2023 06 16; 380(6650):eade0027. PMID: 37319217; PMCID: PMC10874521.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Belykh E, Bardonova L, Abramov I, Byvaltsev VA, Kerymbayev T, Yu K, Healey DR, Luna-Melendez E, Deneen B, Mehta S, Liu JK, Preul MC. 5-aminolevulinic acid, fluorescein sodium, and indocyanine green for glioma margin detection: analysis of operating wide-field and confocal microscopy in glioma models of various grades. Front Oncol. 2023; 13:1156812. PMID: 37287908; PMCID: PMC10242067.
      Citations:    
    11. Choi DJ, Armstrong G, Lozzi B, Vijayaraghavan P, Plon SE, Wong TC, Boerwinkle E, Muzny DM, Chen HC, Gibbs RA, Ostrom QT, Melin B, Deneen B, Bondy ML, Gliogene Consortium, Genomics England Research Consortium, Bainbridge MN, Amos CI, Barnholtz-Sloan JS, Bernstein JL, Claus EB, Houlston RS, Il'yasova D, Jenkins RB, Johansen C, Lachance D, Lai R, Melin BS, Merrell RT, Olson SH, Sadetzki S, Schildkraut J, Shete S, Ambrose JC, Arumugam P, Bevers R, Bleda M, Boardman-Pretty F, Boustred CR, Brittain H, Brown MA, Caulfield MJ, Chan GC, Giess A, Griffin JN, Hamblin A, Henderson S, Hubbard TJP, Jackson R, Jones LJ, Kasperaviciute D, Kayikci M, Kousathanas A, Lahnstein L, Lakey A, Leigh SEA, Leong IUS, Lopez FJ, Maleady-Crowe F, McEntagart M, Minneci F, Mitchell J, Moutsianas L, Mueller M, Murugaesu N, Need AC, O'Donovan P, Odhams CA, Patch C, Perez-Gil D, Pereira MB, Pullinger J, Rahim T, Rendon A, Rogers T, Savage K, Sawant K, Scott RH, Siddiq A, Sieghart A, Smith SC, Sosinsky A, Stuckey A, Tanguy M, Taylor Tavares AL, Thomas ERA, Thompson SR, Tucci A, Welland MJ, Williams E, Witkowska K, Wood SM, Zarowiecki M. The genomic landscape of familial glioma. Sci Adv. 2023 04 28; 9(17):eade2675. PMID: 37115922; PMCID: PMC10146888.
      Citations: 2     Fields:    Translation:Humans
    12. Cheng YT, Luna-Figueroa E, Woo J, Chen HC, Lee ZF, Harmanci AS, Deneen B. Inhibitory input directs astrocyte morphogenesis through glial GABABR. Nature. 2023 May; 617(7960):369-376. PMID: 37100909; PMCID: PMC10733939.
      Citations:    Fields:    Translation:Cells
    13. Winkler F, Venkatesh HS, Amit M, Batchelor T, Demir IE, Deneen B, Gutmann DH, Hervey-Jumper S, Kuner T, Mabbott D, Platten M, Rolls A, Sloan EK, Wang TC, Wick W, Venkataramani V, Monje M. Cancer neuroscience: State of the field, emerging directions. Cell. 2023 04 13; 186(8):1689-1707. PMID: 37059069; PMCID: PMC10107403.
      Citations: 7     Fields:    Translation:HumansCells
    14. Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson M, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Remote neuronal activity drives glioma infiltration via Sema4f. bioRxiv. 2023 Mar 16. PMID: 36993539; PMCID: PMC10055154.
      Citations:    
    15. Cheng YT, Luna-Figueroa E, Woo J, Chen HC, Lee ZF, Harmanci AS, Deneen B. Inhibitory input directs astrocyte morphogenesis through glial GABA B R. bioRxiv. 2023 Mar 15. PMID: 36993256; PMCID: PMC10054985.
      Citations:    
    16. Yu K, Kong K, Lozzi B, Luna-Figueroa E, Cervantes A, Curry R, Mohila CA, Rao G, Jalali A, Mills GB, Scott KL, Deneen B. In vivo functional characterization of EGFR variants identifies novel drivers of glioblastoma. Neuro Oncol. 2023 03 14; 25(3):471-481. PMID: 36044040; PMCID: PMC10013639.
      Citations:    
    17. Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel B, Maze I, Deneen B. Activity-dependent induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. bioRxiv. 2023 Feb 27. PMID: 36909526; PMCID: PMC10002681.
      Citations:    
    18. Curry RN, Aiba I, Meyer J, Lozzi B, Ko Y, McDonald MF, Rosenbaum A, Cervantes A, Huang-Hobbs E, Cocito C, Greenfield JP, Jalali A, Gavvala J, Mohila C, Serin Harmanci A, Noebels J, Rao G, Deneen B. Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation. Neuron. 2023 03 01; 111(5):682-695.e9. PMID: 36787748; PMCID: PMC9991983.
      Citations: 4     Fields:    Translation:HumansAnimals
    19. Cheng YT, Woo J, Luna-Figueroa E, Maleki E, Harmanci AS, Deneen B. Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits. Neuron. 2023 04 19; 111(8):1301-1315.e5. PMID: 36787749; PMCID: PMC10121837.
      Citations: 1     Fields:    Translation:AnimalsCells
    20. Goethe EA, Deneen B, Noebels J, Rao G. The Role of Hyperexcitability in Gliomagenesis. Int J Mol Sci. 2023 Jan 01; 24(1). PMID: 36614191.
      Citations:    Fields:    
    21. Deneen B. Heartbeat of brain tumours targeted. Nature. 2022 Dec 14. PMID: 36517681.
      Citations: 1     Fields:    
    22. Khan AB, Lee S, Harmanci AS, Patel R, Latha K, Yang Y, Marisetty A, Lee HK, Heimberger AB, Fuller GN, Deneen B, Rao G. CXCR4 expression is associated with proneural-to-mesenchymal transition in glioblastoma. Int J Cancer. 2023 02 15; 152(4):713-724. PMID: 36250346; PMCID: PMC10071545.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    23. Sardar D, Chen HC, Reyes A, Varadharajan S, Jain A, Mohila C, Curry R, Lozzi B, Rajendran K, Cervantes A, Yu K, Jalali A, Rao G, Mack SC, Deneen B. Sox9 directs divergent epigenomic states in brain tumor subtypes. Proc Natl Acad Sci U S A. 2022 07 19; 119(29):e2202015119. PMID: 35858326; PMCID: PMC9303974.
      Citations:    Fields:    Translation:Animals
    24. Gu T, Hao D, Woo J, Huang TW, Guo L, Lin X, Guzman AG, Tovy A, Rosas C, Jeong M, Zhou Y, Deneen B, Huang Y, Li W, Goodell MA. The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development. Nat Genet. 2022 05; 54(5):625-636. PMID: 35534561; PMCID: PMC9295050.
      Citations: 1     Fields:    Translation:AnimalsCells
    25. Cheng YT, Woo J, Deneen B. Sculpting Astrocyte Diversity through Circuits and Transcription. Neuroscientist. 2023 08; 29(4):445-460. PMID: 35373633; PMCID: PMC9526762.
      Citations:    Fields:    
    26. Cvetkovic C, Patel R, Shetty A, Hogan MK, Anderson M, Basu N, Aghlara-Fotovat S, Ramesh S, Sardar D, Veiseh O, Ward ME, Deneen B, Horner PJ, Krencik R. Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids. J Cell Biol. 2022 02 09; 221(4). PMID: 35139144; PMCID: PMC8842185.
      Citations: 1     Fields:    Translation:HumansCells
    27. Krawczyk MC, Haney JR, Pan L, Caneda C, Khankan RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong W, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, Zhang Y. Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures. J Neurosci. 2022 02 23; 42(8):1587-1603. PMID: 34987109; PMCID: PMC8883850.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    28. Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. Author Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2022 Jan 05; 13(1):190. PMID: 34987156; PMCID: PMC8733027.
      Citations:    Fields:    
    29. David-Bercholz J, Kuo CT, Deneen B. Astrocyte and Oligodendrocyte Responses From the Subventricular Zone After Injury. Front Cell Neurosci. 2021; 15:797553. PMID: 35002630; PMCID: PMC8740317.
      Citations:    
    30. Akdemir ES, Woo J, Bosquez Huerta NA, Lozzi B, Groves AK, Harmanci AS, Deneen B. Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing. J Neurosci. 2022 01 26; 42(4):567-580. PMID: 34872929; PMCID: PMC8805626.
      Citations:    Fields:    Translation:AnimalsCells
    31. Sardar D, Deneen B. Rnf43 is "lord of the ring" finger proteins in remyelination. Neuron. 2021 10 06; 109(19):3069-3071. PMID: 34619086.
      Citations:    Fields:    Translation:Cells
    32. Lee S, Deneen B, Rao G. CX3CR1 and malignant progression of glioma. Aging (Albany NY). 2021 09 12; 13(17):20856-20857. PMID: 34516407; PMCID: PMC8457602.
      Citations:    Fields:    Translation:Humans
    33. Ung K, Huang TW, Lozzi B, Woo J, Hanson E, Pekarek B, Tepe B, Sardar D, Cheng YT, Liu G, Deneen B, Arenkiel BR. Olfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain. Nat Commun. 2021 09 01; 12(1):5230. PMID: 34471129; PMCID: PMC8410770.
      Citations: 4     Fields:    Translation:AnimalsCells
    34. Huang TW, Iyer AA, Manalo JM, Woo J, Bosquez Huerta NA, McGovern MM, Schrewe H, Pereira FA, Groves AK, Ohlemiller KK, Deneen B. Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis. J Neurosci. 2021 08 25; 41(34):7171-7181. PMID: 34253626; PMCID: PMC8387121.
      Citations:    Fields:    Translation:AnimalsCells
    35. Carlson JC, Cantu Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen B. Identification of diverse tumor endothelial cell populations in malignant glioma. Neuro Oncol. 2021 06 01; 23(6):932-944. PMID: 33367832; PMCID: PMC8168823.
      Citations: 11     Fields:    Translation:HumansCells
    36. Sardar D, Lozzi B, Woo J, Huang TW, Cvetkovic C, Creighton CJ, Krencik R, Deneen B. Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds. Int J Mol Sci. 2021 Apr 12; 22(8). PMID: 33921461; PMCID: PMC8069033.
      Citations: 1     Fields:    Translation:AnimalsCells
    37. Jalali A, Yu K, Beechar V, Bosquez Huerta NA, Grichuk A, Mehra D, Lozzi B, Kong K, Scott KL, Rao G, Bainbridge MN, Bondy ML, Deneen B. POT1 Regulates Proliferation and Confers Sexual Dimorphism in Glioma. Cancer Res. 2021 05 15; 81(10):2703-2713. PMID: 33782098; PMCID: PMC8243722.
      Citations:    Fields:    Translation:AnimalsCells
    38. Arabzade A, Zhao Y, Varadharajan S, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC, De Le?n LA. ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma. Cancer Discov. 2021 09; 11(9):2200-2215. PMID: 33741710; PMCID: PMC8418998.
      Citations: 18     Fields:    Translation:Animals
    39. Kupp R, Ruff L, Terranova S, Nathan E, Ballereau S, Stark R, Sekhar Reddy Chilamakuri C, Hoffmann N, Wickham-Rahrmann K, Widdess M, Arabzade A, Zhao Y, Varadharajan S, Zheng T, Murugesan M, Pfister SM, Kawauchi D, Pajtler KW, Deneen B, Mack SC, Masih KE, Gryder BE, Khan J, Gilbertson RJ. ZFTA Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors. Cancer Discov. 2021 09; 11(9):2216-2229. PMID: 33741711; PMCID: PMC8918067.
      Citations: 11     Fields:    Translation:Animals
    40. O'Callaghan JP, Petzold GC, Serrano-Pozo A, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Butt AM, Chen WT, Cunningham C, Deneen B, De Strooper B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Parpura V, Pekna M, Pekny M, Perea G, Poskanzer KE, Quintana FJ, Ransohoff RM, Robel S, Rothstein JD, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A, Escartin C, Galea E, Lakatos A, Steinh?user C, Bonvento G, Cohen-Salmon M, D?az-Castro B, G?tz M, Guti?rrez A, Kettenmann H, Oliet SHR, Oliveira JF, Panatier A, Pellerin L, P?rez-Nievas BG, Pfrieger FW, Riquelme-Perez M, Rose CR, Rouach N, Vitorica J. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325. PMID: 33589835; PMCID: PMC8007081.
      Citations: 249     Fields:    Translation:HumansAnimalsCells
    41. Wei H, Wu X, You Y, Duran RC, Zheng Y, Narayanan KL, Hai B, Li X, Tallapragada N, Prajapati TJ, Kim DH, Deneen B, Cao QL, Wu JQ. Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis. Cell Rep. 2021 02 02; 34(5):108721. PMID: 33535036; PMCID: PMC7920574.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    42. Ung K, Tepe B, Pekarek B, Arenkiel BR, Deneen B. Parallel astrocyte calcium signaling modulates olfactory bulb responses. J Neurosci Res. 2020 08; 98(8):1605-1618. PMID: 32426930; PMCID: PMC8147697.
      Citations: 10     Fields:    Translation:AnimalsCells
    43. Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JL. Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model. J Clin Invest. 2020 05 01; 130(5):2286-2300. PMID: 32250339; PMCID: PMC7190940.
      Citations: 18     Fields:    Translation:AnimalsCells
    44. Huang AY, Woo J, Sardar D, Lozzi B, Bosquez Huerta NA, Lin CJ, Felice D, Jain A, Paulucci-Holthauzen A, Deneen B. Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities. Neuron. 2020 06 17; 106(6):992-1008.e9. PMID: 32320644; PMCID: PMC7879989.
      Citations: 31     Fields:    Translation:AnimalsCells
    45. Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler F, Magnon C. Roadmap for the Emerging Field of Cancer Neuroscience. Cell. 2020 04 16; 181(2):219-222. PMID: 32302564; PMCID: PMC7286095.
      Citations: 54     Fields:    Translation:Humans
    46. Akdemir ES, Huang AY, Deneen B. Astrocytogenesis: where, when, and how. F1000Res. 2020; 9. PMID: 32269761; PMCID: PMC7122459.
      Citations: 16     Fields:    Translation:HumansCells
    47. Lozzi B, Huang TW, Sardar D, Huang AY, Deneen B. Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain. Front Neurosci. 2020; 14:61. PMID: 32153350; PMCID: PMC7046629.
      Citations: 16     
    48. Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen B. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020 02; 578(7793):166-171. PMID: 31996845; PMCID: PMC7577741.
      Citations: 38     Fields:    Translation:Animals
    49. Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B. Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury. J Clin Invest. 2019 10 01; 129(10):4408-4418. PMID: 31498149; PMCID: PMC6763246.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    50. Khakh BS, Deneen B. The Emerging Nature of Astrocyte Diversity. Annu Rev Neurosci. 2019 07 08; 42:187-207. PMID: 31283899.
      Citations: 110     Fields:    Translation:AnimalsCells
    51. Wang CY, Deneen B, Tzeng SF. BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination. Glia. 2019 09; 67(9):1775-1792. PMID: 31184779.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    52. Cuevas-Diaz Duran R, Wang CY, Zheng H, Deneen B, Wu JQ. Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases. eNeuro. 2019 Mar-Apr; 6(2). PMID: 30957015; PMCID: PMC6449165.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    53. Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep. 2018 12 26; 25(13):3811-3827.e7. PMID: 30590051.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    54. Laug D, Glasgow SM, Deneen B. A glial blueprint for gliomagenesis. Nat Rev Neurosci. 2018 07; 19(7):393-403. PMID: 29777182; PMCID: PMC6536307.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    55. Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2018 03 13; 9(1):1057. PMID: 29535300; PMCID: PMC5849741.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    56. Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JB. Cooperative p16 and p21 action protects female astrocytes from transformation. Acta Neuropathol Commun. 2018 02 20; 6(1):12. PMID: 29458417; PMCID: PMC5819173.
      Citations: 22     Fields:    Translation:AnimalsCells
    57. Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJ. Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases. Clin Cancer Res. 2018 05 01; 24(9):2182-2193. PMID: 29440175; PMCID: PMC5932236.
      Citations: 34     Fields:    Translation:HumansCells
    58. Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed N, Wels WS, Koch J. TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res. 2018 01 15; 78(2):489-500. PMID: 29183891; PMCID: PMC5771806.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    59. Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B. Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 10 20; 6. PMID: 29053101; PMCID: PMC5650470.
      Citations: 10     Fields:    Translation:HumansCells
    60. Wang CY, Deneen B, Tzeng SF. MicroRNA-212 inhibits oligodendrocytes during maturation by down-regulation of differentiation-associated gene expression. J Neurochem. 2017 10; 143(1):112-125. PMID: 28771716.
      Citations: 10     Fields:    Translation:AnimalsCells
    61. Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Mohila CA, Deneen B, Clovis YM, Lee SK. Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017 Nov; 20(11):1520-1528. PMID: 28892058; PMCID: PMC5919190.
      Citations: 18     Fields:    Translation:AnimalsCells
    62. John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405. PMID: 28166219; PMCID: PMC5824716.
      Citations: 209     Fields:    Translation:HumansAnimalsCells
    63. Glasgow SM, Deneen B. lnc'edin to Myelin. Neuron. 2017 Jan 18; 93(2):252-254. PMID: 28103473.
      Citations:    Fields:    Translation:Cells
    64. Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen B. Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 11 23; 36(47):11904-11917. PMID: 27881777; PMCID: PMC5125245.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    65. Molofsky AV, Deneen B. Astrocyte development: A Guide for the Perplexed. Glia. 2015 Aug; 63(8):1320-9. PMID: 25963996.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    66. Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 Oct; 63(10):1840-9. PMID: 25946682; PMCID: PMC4534334.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    67. Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B. Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18; 85(6):1227-43. PMID: 25754822; PMCID: PMC4402944.
      Citations: 40     Fields:    Translation:AnimalsCells
    68. Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BR. Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb. Brain Struct Funct. 2016 Jan; 221(1):1-20. PMID: 25224546; PMCID: PMC4362939.
      Citations: 9     Fields:    Translation:AnimalsCells
    69. Glasgow SM, Zhu W, Huang TW, Chen F, LoTurco JJ, Neul JL, Mohila C, Deneen B, Stolt CC, Wegner M. Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci. 2014 Oct; 17(10):1322-9. PMID: 25151262; PMCID: PMC4313923.
      Citations: 56     Fields:    Translation:AnimalsCells
    70. Gallo V, Deneen B. Glial development: the crossroads of regeneration and repair in the CNS. Neuron. 2014 Jul 16; 83(2):283-308. PMID: 25033178; PMCID: PMC4114724.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    71. Lee JS, Xiao J, Patel P, Schade J, Wang J, Deneen B, Erdreich-Epstein A, Song HR. A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. Neuro Oncol. 2014 Jan; 16(2):191-203. PMID: 24305710; PMCID: PMC3895381.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    72. Chaboub LS, Deneen B. Astrocyte form and function in the developing central nervous system. Semin Pediatr Neurol. 2013 Dec; 20(4):230-5. PMID: 24365570; PMCID: PMC3874818.
      Citations: 20     Fields:    Translation:HumansCells
    73. John Lin CC, Deneen B. Astrocytes: the missing link in neurologic disease? Semin Pediatr Neurol. 2013 Dec; 20(4):236-41. PMID: 24365571; PMCID: PMC3874830.
      Citations: 8     Fields:    Translation:HumansCells
    74. Glasgow SM, Laug D, Brawley VS, Zhang Z, Corder A, Yin Z, Wong ST, Li XN, Foster AE, Ahmed N, Deneen B. The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS. J Neurosci. 2013 Aug 14; 33(33):13560-8. PMID: 23946414; PMCID: PMC3742938.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    75. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32. PMID: 23840004; PMCID: PMC3909648.
      Citations: 28     Fields:    Translation:AnimalsCells
    76. Chaboub LS, Deneen B. Developmental origins of astrocyte heterogeneity: the final frontier of CNS development. Dev Neurosci. 2012; 34(5):379-88. PMID: 23147551; PMCID: PMC3576470.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    77. Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B. Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol. 2012 Aug; 72(2):224-33. PMID: 22807310; PMCID: PMC3429638.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    78. Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 01; 26(9):891-907. PMID: 22549954; PMCID: PMC3347787.
      Citations: 314     Fields:    Translation:HumansCells
    79. Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12; 74(1):79-94. PMID: 22500632; PMCID: PMC3543821.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    80. Lee HK, Deneen B. Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Dev Cell. 2012 Jan 17; 22(1):183-96. PMID: 22227309; PMCID: PMC3264735.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    81. Song HR, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Gilles FH, Deneen B, Erdreich-Epstein A. Nuclear factor IA is expressed in astrocytomas and is associated with improved survival. Neuro Oncol. 2010 Feb; 12(2):122-32. PMID: 20150379; PMCID: PMC2940580.
      Citations: 21     Fields:    Translation:Humans
    82. Namihira M, Kohyama J, Semi K, Sanosaka T, Deneen B, Taga T, Nakashima K. Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009 Feb; 16(2):245-55. PMID: 19217426.
      Citations: 134     Fields:    Translation:AnimalsCells
    83. Hochstim C, Deneen B, Zhou Q, Anderson DJ, Lukaszewicz A. Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell. 2008 May 02; 133(3):510-22. PMID: 18455991; PMCID: PMC2394859.
      Citations: 150     Fields:    Translation:AnimalsCells
    84. Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006 Dec 21; 52(6):953-68. PMID: 17178400.
      Citations: 212     Fields:    Translation:AnimalsCells
    85. Mukouyama YS, Deneen B, Novitch BG, Wichterle H, Jessell TM, Anderson DJ, Lukaszewicz A. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1551-6. PMID: 16432183; PMCID: PMC1345718.
      Citations: 32     Fields:    Translation:AnimalsCells
    86. Deneen B, Hamidi H, Denny CT. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15; 63(14):4268-74. PMID: 12874036.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    87. Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun; 23(11):3897-908. PMID: 12748291; PMCID: PMC155223.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    88. Deneen B, Denny CT. Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene. 2001 Oct 11; 20(46):6731-41. PMID: 11709708.
      Citations: 48     Fields:    Translation:AnimalsCells
    89. Welford SM, Hebert SP, Deneen B, Arvand A, Denny CT. DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis. J Biol Chem. 2001 Nov 09; 276(45):41977-84. PMID: 11553628.
      Citations: 20     Fields:    Translation:AnimalsCells
    90. Page SL, McKim KS, Deneen B, Van Hook TL, Hawley RS. Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila. Genetics. 2000 Aug; 155(4):1757-72. PMID: 10924472; PMCID: PMC1461182.
      Citations: 39     Fields:    Translation:AnimalsCells
    91. Sekelsky JJ, McKim KS, Messina L, French RL, Hurley WD, Arbel T, Chin GM, Deneen B, Force SJ, Hari KL, Jang JK, Madden LD, Matthies HJ, Milliken DB, Page SL, Ring AD, Wayson SM, Zimmerman CC, Hawley RS, Lauren?on AC. Identification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics. 1999 Jun; 152(2):529-42. PMID: 10353897; PMCID: PMC1460643.
      Citations: 49     Fields:    Translation:AnimalsCells
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