BENJAMIN DENEEN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurosurgery
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


    Collapse Research 
    Collapse research activities and funding
    R01AG071687     (DENEEN, BENJAMIN)Apr 15, 2021 - Feb 28, 2026
    NIH
    Defining Roles for Astrocyte Subpopulations in the Aging Brain
    Role: Principal Investigator

    R01CA217105     (BONDY, MELISSA L.)May 8, 2018 - Apr 30, 2024
    NIH
    Discovery, Biology and Risk of Inherited Variants in Glioma
    Role: Co-Principal Investigator

    R01CA223388     (NOEBELS, JEFFREY)Dec 15, 2017 - Nov 30, 2022
    NIH
    MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMA
    Role: Co-Principal Investigator

    U01CA217842     (MILLS, GORDON B.)Sep 6, 2017 - Jul 31, 2022
    NIH
    Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancer
    Role: Co-Principal Investigator

    R01NS096096     (DENEEN, BENJAMIN)Feb 1, 2017 - Jan 31, 2022
    NIH
    MOLECULAR AND CELLULAR CONTROL OF INJURY-INDUCED ASTROGENESIS
    Role: Co-Principal Investigator

    RF1AG054111     (ZHENG, HUI)Aug 15, 2016 - Mar 31, 2021
    NIH
    Decoding the role of diverse astrocyte populations in aging and AD
    Role: Co-Principal Investigator

    R21NS093145     (DENEEN, BENJAMIN)Jul 15, 2016 - Jun 30, 2018
    NIH
    Developing Novel Therapeutic Approaches for White Matter Injury in the Neonatal Brain
    Role: Principal Investigator

    R21NS089366     (DENEEN, BENJAMIN)Feb 1, 2015 - Jan 31, 2017
    NIH
    The nature of astrocyte heterogeneity in RTT
    Role: Principal Investigator

    R01NS071153     (DENEEN, BENJAMIN)Sep 1, 2010 - Jun 30, 2024
    NIH
    Transcriptional Control of Gliogenesis in the CNS
    Role: Principal Investigator

    F32NS048666     (DENEEN, BENJAMIN)Apr 1, 2006 - Mar 31, 2007
    NIH
    The role of NFI genes in glial cell fate determination
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deneen B. Heartbeat of brain tumours targeted. Nature. 2023 01; 613(7942):29-30. PMID: 36517681.
      Citations:    
    2. Goethe EA, Deneen B, Noebels J, Rao G. The Role of Hyperexcitability in Gliomagenesis. Int J Mol Sci. 2023 Jan 01; 24(1). PMID: 36614191; PMCID: PMC9820922.
      Citations:    
    3. Khan AB, Lee S, Harmanci AS, Patel R, Latha K, Yang Y, Marisetty A, Lee HK, Heimberger AB, Fuller GN, Deneen B, Rao G. CXCR4 expression is associated with proneural-to-mesenchymal transition in glioblastoma. Int J Cancer. 2023 02 15; 152(4):713-724. PMID: 36250346.
      Citations:    
    4. Yu K, Kong K, Lozzi B, Luna-Figueroa E, Cervantes A, Curry R, Mohila CA, Rao G, Jalali A, Mills GB, Scott KL, Deneen B. In Vivo Functional Characterization of EGFR Variants Identifies Novel Drivers of Glioblastoma. Neuro Oncol. 2022 Aug 31. PMID: 36044040.
      Citations:    
    5. Sardar D, Chen HC, Reyes A, Varadharajan S, Jain A, Mohila C, Curry R, Lozzi B, Rajendran K, Cervantes A, Yu K, Jalali A, Rao G, Mack SC, Deneen B, Sardar D, Chen HC, Reyes A, Varadharajan S, Jain A, Mohila C, Curry R, Lozzi B, Rajendran K, Cervantes A, Yu K, Jalali A, Rao G, Mack SC, Deneen B. Sox9 directs divergent epigenomic states in brain tumor subtypes. Proc Natl Acad Sci U S A. 2022 07 19; 119(29):e2202015119. PMID: 35858326; PMCID: PMC9303974.
      Citations:    Fields:    Translation:Animals
    6. Gu T, Hao D, Woo J, Huang TW, Guo L, Lin X, Guzman AG, Tovy A, Rosas C, Jeong M, Zhou Y, Deneen B, Huang Y, Li W, Goodell MA, Gu T, Hao D, Woo J, Huang TW, Guo L, Lin X, Guzman AG, Tovy A, Rosas C, Jeong M, Zhou Y, Deneen B, Huang Y, Li W, Goodell MA. The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development. Nat Genet. 2022 05; 54(5):625-636. PMID: 35534561; PMCID: PMC9295050.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Cheng YT, Woo J, Deneen B, Cheng YT, Woo J, Deneen B. Sculpting Astrocyte Diversity through Circuits and Transcription. Neuroscientist. 2022 Apr 02; 10738584221082620. PMID: 35373633; PMCID: PMC9526762.
      Citations:    Fields:    
    8. Cvetkovic C, Patel R, Shetty A, Hogan MK, Anderson M, Basu N, Aghlara-Fotovat S, Ramesh S, Sardar D, Veiseh O, Ward ME, Deneen B, Horner PJ, Krencik R, Cvetkovic C, Patel R, Shetty A, Hogan MK, Anderson M, Basu N, Aghlara-Fotovat S, Ramesh S, Sardar D, Veiseh O, Ward ME, Deneen B, Horner PJ, Krencik R. Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids. J Cell Biol. 2022 02 09; 221(4). PMID: 35139144; PMCID: PMC8842185.
      Citations: 1     Fields:    Translation:HumansCells
    9. Krawczyk MC, Haney JR, Pan L, Caneda C, Khankan RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong W, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, Zhang Y, Krawczyk MC, Haney JR, Pan L, Caneda C, Khankan RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong W, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, Zhang Y. Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures. J Neurosci. 2022 02 23; 42(8):1587-1603. PMID: 34987109; PMCID: PMC8883850.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT, Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. Author Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2022 Jan 05; 13(1):190. PMID: 34987156; PMCID: PMC8733027.
      Citations:    Fields:    
    11. David-Bercholz J, Kuo CT, Deneen B, David-Bercholz J, Kuo CT, Deneen B. Astrocyte and Oligodendrocyte Responses From the Subventricular Zone After Injury. Front Cell Neurosci. 2021; 15:797553. PMID: 35002630; PMCID: PMC8740317.
      Citations:    
    12. Akdemir ES, Woo J, Bosquez Huerta NA, Lozzi B, Groves AK, Harmanci AS, Deneen B, Akdemir ES, Woo J, Bosquez Huerta NA, Lozzi B, Groves AK, Harmanci AS, Deneen B. Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing. J Neurosci. 2022 01 26; 42(4):567-580. PMID: 34872929; PMCID: PMC8805626.
      Citations:    Fields:    Translation:AnimalsCells
    13. Sardar D, Deneen B, Sardar D, Deneen B. Rnf43 is "lord of the ring" finger proteins in remyelination. Neuron. 2021 10 06; 109(19):3069-3071. PMID: 34619086.
      Citations:    Fields:    Translation:Cells
    14. Lee S, Deneen B, Rao G, Lee S, Deneen B, Rao G. CX3CR1 and malignant progression of glioma. Aging (Albany NY). 2021 09 12; 13(17):20856-20857. PMID: 34516407; PMCID: PMC8457602.
      Citations:    Fields:    Translation:Humans
    15. Ung K, Huang TW, Lozzi B, Woo J, Hanson E, Pekarek B, Tepe B, Sardar D, Cheng YT, Liu G, Deneen B, Arenkiel BR, Ung K, Huang TW, Lozzi B, Woo J, Hanson E, Pekarek B, Tepe B, Sardar D, Cheng YT, Liu G, Deneen B, Arenkiel BR. Olfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain. Nat Commun. 2021 09 01; 12(1):5230. PMID: 34471129; PMCID: PMC8410770.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Huang TW, Iyer AA, Manalo JM, Woo J, Bosquez Huerta NA, McGovern MM, Schrewe H, Pereira FA, Groves AK, Ohlemiller KK, Deneen B, Huang TW, Iyer AA, Manalo JM, Woo J, Bosquez Huerta NA, McGovern MM, Schrewe H, Pereira FA, Groves AK, Ohlemiller KK, Deneen B. Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis. J Neurosci. 2021 08 25; 41(34):7171-7181. PMID: 34253626; PMCID: PMC8387121.
      Citations:    Fields:    Translation:AnimalsCells
    17. Carlson JC, Cantu Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen B, Carlson JC, Cantu Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen B. Identification of diverse tumor endothelial cell populations in malignant glioma. Neuro Oncol. 2021 06 01; 23(6):932-944. PMID: 33367832; PMCID: PMC8168823.
      Citations: 11     Fields:    Translation:HumansCells
    18. Sardar D, Lozzi B, Woo J, Huang TW, Cvetkovic C, Creighton CJ, Krencik R, Deneen B, Sardar D, Lozzi B, Woo J, Huang TW, Cvetkovic C, Creighton CJ, Krencik R, Deneen B. Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds. Int J Mol Sci. 2021 Apr 12; 22(8). PMID: 33921461; PMCID: PMC8069033.
      Citations: 1     Fields:    Translation:AnimalsCells
    19. Jalali A, Yu K, Beechar V, Bosquez Huerta NA, Grichuk A, Mehra D, Lozzi B, Kong K, Scott KL, Rao G, Bainbridge MN, Bondy ML, Deneen B, Jalali A, Yu K, Beechar V, Bosquez Huerta NA, Grichuk A, Mehra D, Lozzi B, Kong K, Scott KL, Rao G, Bainbridge MN, Bondy ML, Deneen B. POT1 Regulates Proliferation and Confers Sexual Dimorphism in Glioma. Cancer Res. 2021 05 15; 81(10):2703-2713. PMID: 33782098; PMCID: PMC8243722.
      Citations:    Fields:    Translation:AnimalsCells
    20. Arabzade A, Zhao Y, Varadharajan S, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, De León LA, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC, Arabzade A, Zhao Y, Varadharajan S, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, De León LA, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC, De Le?n LA. ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma. Cancer Discov. 2021 09; 11(9):2200-2215. PMID: 33741710; PMCID: PMC8418998.
      Citations: 18     Fields:    Translation:Animals
    21. Kupp R, Ruff L, Terranova S, Nathan E, Ballereau S, Stark R, Sekhar Reddy Chilamakuri C, Hoffmann N, Wickham-Rahrmann K, Widdess M, Arabzade A, Zhao Y, Varadharajan S, Zheng T, Murugesan M, Pfister SM, Kawauchi D, Pajtler KW, Deneen B, Mack SC, Masih KE, Gryder BE, Khan J, Gilbertson RJ, Kupp R, Ruff L, Terranova S, Nathan E, Ballereau S, Stark R, Sekhar Reddy Chilamakuri C, Hoffmann N, Wickham-Rahrmann K, Widdess M, Arabzade A, Zhao Y, Varadharajan S, Zheng T, Murugesan M, Pfister SM, Kawauchi D, Pajtler KW, Deneen B, Mack SC, Masih KE, Gryder BE, Khan J, Gilbertson RJ. ZFTA Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors. Cancer Discov. 2021 09; 11(9):2216-2229. PMID: 33741711; PMCID: PMC8918067.
      Citations: 11     Fields:    Translation:Animals
    22. Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A, Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A, Escartin C, Galea E, Lakatos A, Steinh?user C, Bonvento G, Cohen-Salmon M, D?az-Castro B, G?tz M, Guti?rrez A, Kettenmann H, Oliet SHR, Oliveira JF, Panatier A, Pellerin L, P?rez-Nievas BG, Pfrieger FW, Riquelme-Perez M, Rose CR, Rouach N, Vitorica J. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325. PMID: 33589835; PMCID: PMC8007081.
      Citations: 249     Fields:    Translation:HumansAnimalsCells
    23. Wei H, Wu X, You Y, Duran RC, Zheng Y, Narayanan KL, Hai B, Li X, Tallapragada N, Prajapati TJ, Kim DH, Deneen B, Cao QL, Wu JQ, Wei H, Wu X, You Y, Duran RC, Zheng Y, Narayanan KL, Hai B, Li X, Tallapragada N, Prajapati TJ, Kim DH, Deneen B, Cao QL, Wu JQ. Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis. Cell Rep. 2021 02 02; 34(5):108721. PMID: 33535036; PMCID: PMC7920574.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    24. Ung K, Tepe B, Pekarek B, Arenkiel BR, Deneen B, Ung K, Tepe B, Pekarek B, Arenkiel BR, Deneen B. Parallel astrocyte calcium signaling modulates olfactory bulb responses. J Neurosci Res. 2020 08; 98(8):1605-1618. PMID: 32426930; PMCID: PMC8147697.
      Citations: 10     Fields:    Translation:AnimalsCells
    25. Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JL, Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JL. Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model. J Clin Invest. 2020 05 01; 130(5):2286-2300. PMID: 32250339; PMCID: PMC7190940.
      Citations: 18     Fields:    Translation:AnimalsCells
    26. Huang AY, Woo J, Sardar D, Lozzi B, Bosquez Huerta NA, Lin CJ, Felice D, Jain A, Paulucci-Holthauzen A, Deneen B, Huang AY, Woo J, Sardar D, Lozzi B, Bosquez Huerta NA, Lin CJ, Felice D, Jain A, Paulucci-Holthauzen A, Deneen B. Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities. Neuron. 2020 06 17; 106(6):992-1008.e9. PMID: 32320644; PMCID: PMC7879989.
      Citations: 31     Fields:    Translation:AnimalsCells
    27. Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Magnon C, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler F, Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Magnon C, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler F, Magnon C. Roadmap for the Emerging Field of Cancer Neuroscience. Cell. 2020 04 16; 181(2):219-222. PMID: 32302564; PMCID: PMC7286095.
      Citations: 54     Fields:    Translation:Humans
    28. Akdemir ES, Huang AY, Deneen B, Akdemir ES, Huang AY, Deneen B. Astrocytogenesis: where, when, and how. F1000Res. 2020; 9. PMID: 32269761; PMCID: PMC7122459.
      Citations: 16     Fields:    Translation:HumansCells
    29. Lozzi B, Huang TW, Sardar D, Huang AY, Deneen B, Lozzi B, Huang TW, Sardar D, Huang AY, Deneen B. Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain. Front Neurosci. 2020; 14:61. PMID: 32153350; PMCID: PMC7046629.
      Citations: 16     
    30. Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen B, Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen B. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020 02; 578(7793):166-171. PMID: 31996845; PMCID: PMC7577741.
      Citations: 38     Fields:    Translation:Animals
    31. Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B, Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B. Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury. J Clin Invest. 2019 10 01; 129(10):4408-4418. PMID: 31498149; PMCID: PMC6763246.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    32. Khakh BS, Deneen B, Khakh BS, Deneen B. The Emerging Nature of Astrocyte Diversity. Annu Rev Neurosci. 2019 07 08; 42:187-207. PMID: 31283899.
      Citations: 110     Fields:    Translation:AnimalsCells
    33. Wang CY, Deneen B, Tzeng SF, Wang CY, Deneen B, Tzeng SF. BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination. Glia. 2019 09; 67(9):1775-1792. PMID: 31184779.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    34. Cuevas-Diaz Duran R, Wang CY, Zheng H, Deneen B, Wu JQ, Cuevas-Diaz Duran R, Wang CY, Zheng H, Deneen B, Wu JQ. Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases. eNeuro. 2019 Mar-Apr; 6(2). PMID: 30957015; PMCID: PMC6449165.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    35. Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M, Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep. 2018 12 26; 25(13):3811-3827.e7. PMID: 30590051.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    36. Laug D, Glasgow SM, Deneen B, Laug D, Glasgow SM, Deneen B. A glial blueprint for gliomagenesis. Nat Rev Neurosci. 2018 07; 19(7):393-403. PMID: 29777182; PMCID: PMC6536307.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    37. Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT, Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2018 03 13; 9(1):1057. PMID: 29535300; PMCID: PMC5849741.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    38. Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JB, Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JB. Cooperative p16 and p21 action protects female astrocytes from transformation. Acta Neuropathol Commun. 2018 02 20; 6(1):12. PMID: 29458417; PMCID: PMC5819173.
      Citations: 22     Fields:    Translation:AnimalsCells
    39. Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJ, Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJ. Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases. Clin Cancer Res. 2018 05 01; 24(9):2182-2193. PMID: 29440175; PMCID: PMC5932236.
      Citations: 34     Fields:    Translation:HumansCells
    40. Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Wels WS, Koch J, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed N, Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Wels WS, Koch J, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed N, Wels WS, Koch J. TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res. 2018 01 15; 78(2):489-500. PMID: 29183891; PMCID: PMC5771806.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    41. Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B, Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B. Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 10 20; 6. PMID: 29053101; PMCID: PMC5650470.
      Citations: 10     Fields:    Translation:HumansCells
    42. Wang CY, Deneen B, Tzeng SF, Wang CY, Deneen B, Tzeng SF. MicroRNA-212 inhibits oligodendrocytes during maturation by down-regulation of differentiation-associated gene expression. J Neurochem. 2017 10; 143(1):112-125. PMID: 28771716.
      Citations: 10     Fields:    Translation:AnimalsCells
    43. Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis YM, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee SK, Mohila CA, Deneen B, Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis YM, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee SK, Mohila CA, Deneen B, Clovis YM, Lee SK. Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017 Nov; 20(11):1520-1528. PMID: 28892058; PMCID: PMC5919190.
      Citations: 18     Fields:    Translation:AnimalsCells
    44. John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B, John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405. PMID: 28166219; PMCID: PMC5824716.
      Citations: 209     Fields:    Translation:HumansAnimalsCells
    45. Glasgow SM, Deneen B, Glasgow SM, Deneen B. lnc'edin to Myelin. Neuron. 2017 Jan 18; 93(2):252-254. PMID: 28103473.
      Citations:    Fields:    Translation:Cells
    46. Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen B, Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen B. Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 11 23; 36(47):11904-11917. PMID: 27881777; PMCID: PMC5125245.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    47. Molofsky AV, Deneen B, Molofsky AV, Deneen B. Astrocyte development: A Guide for the Perplexed. Glia. 2015 Aug; 63(8):1320-9. PMID: 25963996.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    48. Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B, Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 Oct; 63(10):1840-9. PMID: 25946682; PMCID: PMC4534334.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    49. Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B, Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B. Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18; 85(6):1227-43. PMID: 25754822; PMCID: PMC4402944.
      Citations: 40     Fields:    Translation:AnimalsCells
    50. Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BR, Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BR. Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb. Brain Struct Funct. 2016 Jan; 221(1):1-20. PMID: 25224546; PMCID: PMC4362939.
      Citations: 9     Fields:    Translation:AnimalsCells
    51. Glasgow SM, Zhu W, Stolt CC, Huang TW, Chen F, LoTurco JJ, Neul JL, Wegner M, Mohila C, Deneen B, Glasgow SM, Zhu W, Stolt CC, Huang TW, Chen F, LoTurco JJ, Neul JL, Wegner M, Mohila C, Deneen B, Stolt CC, Wegner M. Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci. 2014 Oct; 17(10):1322-9. PMID: 25151262; PMCID: PMC4313923.
      Citations: 56     Fields:    Translation:AnimalsCells
    52. Gallo V, Deneen B, Gallo V, Deneen B. Glial development: the crossroads of regeneration and repair in the CNS. Neuron. 2014 Jul 16; 83(2):283-308. PMID: 25033178; PMCID: PMC4114724.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    53. Lee JS, Xiao J, Patel P, Schade J, Wang J, Deneen B, Erdreich-Epstein A, Song HR, Lee JS, Xiao J, Patel P, Schade J, Wang J, Deneen B, Erdreich-Epstein A, Song HR. A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. Neuro Oncol. 2014 Jan; 16(2):191-203. PMID: 24305710; PMCID: PMC3895381.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    54. Chaboub LS, Deneen B, Chaboub LS, Deneen B. Astrocyte form and function in the developing central nervous system. Semin Pediatr Neurol. 2013 Dec; 20(4):230-5. PMID: 24365570; PMCID: PMC3874818.
      Citations: 20     Fields:    Translation:HumansCells
    55. John Lin CC, Deneen B, John Lin CC, Deneen B. Astrocytes: the missing link in neurologic disease? Semin Pediatr Neurol. 2013 Dec; 20(4):236-41. PMID: 24365571; PMCID: PMC3874830.
      Citations: 8     Fields:    Translation:HumansCells
    56. Glasgow SM, Laug D, Brawley VS, Zhang Z, Corder A, Yin Z, Wong ST, Li XN, Foster AE, Ahmed N, Deneen B, Glasgow SM, Laug D, Brawley VS, Zhang Z, Corder A, Yin Z, Wong ST, Li XN, Foster AE, Ahmed N, Deneen B. The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS. J Neurosci. 2013 Aug 14; 33(33):13560-8. PMID: 23946414; PMCID: PMC3742938.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    57. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC, Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32. PMID: 23840004; PMCID: PMC3909648.
      Citations: 28     Fields:    Translation:AnimalsCells
    58. Chaboub LS, Deneen B, Chaboub LS, Deneen B. Developmental origins of astrocyte heterogeneity: the final frontier of CNS development. Dev Neurosci. 2012; 34(5):379-88. PMID: 23147551; PMCID: PMC3576470.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    59. Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B, Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B. Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol. 2012 Aug; 72(2):224-33. PMID: 22807310; PMCID: PMC3429638.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    60. Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH, Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 01; 26(9):891-907. PMID: 22549954; PMCID: PMC3347787.
      Citations: 314     Fields:    Translation:HumansCells
    61. Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B, Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12; 74(1):79-94. PMID: 22500632; PMCID: PMC3543821.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    62. Lee HK, Deneen B, Lee HK, Deneen B. Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Dev Cell. 2012 Jan 17; 22(1):183-96. PMID: 22227309; PMCID: PMC3264735.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    63. Song HR, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Gilles FH, Deneen B, Erdreich-Epstein A, Song HR, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Gilles FH, Deneen B, Erdreich-Epstein A. Nuclear factor IA is expressed in astrocytomas and is associated with improved survival. Neuro Oncol. 2010 Feb; 12(2):122-32. PMID: 20150379; PMCID: PMC2940580.
      Citations: 21     Fields:    Translation:Humans
    64. Namihira M, Kohyama J, Semi K, Sanosaka T, Deneen B, Taga T, Nakashima K, Namihira M, Kohyama J, Semi K, Sanosaka T, Deneen B, Taga T, Nakashima K. Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009 Feb; 16(2):245-55. PMID: 19217426.
      Citations: 134     Fields:    Translation:AnimalsCells
    65. Hochstim C, Deneen B, Lukaszewicz A, Zhou Q, Anderson DJ, Hochstim C, Deneen B, Lukaszewicz A, Zhou Q, Anderson DJ, Lukaszewicz A. Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell. 2008 May 02; 133(3):510-22. PMID: 18455991; PMCID: PMC2394859.
      Citations: 150     Fields:    Translation:AnimalsCells
    66. Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ, Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006 Dec 21; 52(6):953-68. PMID: 17178400.
      Citations: 212     Fields:    Translation:AnimalsCells
    67. Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ, Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ, Lukaszewicz A. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1551-6. PMID: 16432183; PMCID: PMC1345718.
      Citations: 32     Fields:    Translation:AnimalsCells
    68. Deneen B, Hamidi H, Denny CT, Deneen B, Hamidi H, Denny CT. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15; 63(14):4268-74. PMID: 12874036.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    69. Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT, Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun; 23(11):3897-908. PMID: 12748291; PMCID: PMC155223.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    70. Deneen B, Denny CT, Deneen B, Denny CT. Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene. 2001 Oct 11; 20(46):6731-41. PMID: 11709708.
      Citations: 46     Fields:    Translation:AnimalsCells
    71. Welford SM, Hebert SP, Deneen B, Arvand A, Denny CT, Welford SM, Hebert SP, Deneen B, Arvand A, Denny CT. DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis. J Biol Chem. 2001 Nov 09; 276(45):41977-84. PMID: 11553628.
      Citations: 19     Fields:    Translation:AnimalsCells
    72. Page SL, McKim KS, Deneen B, Van Hook TL, Hawley RS, Page SL, McKim KS, Deneen B, Van Hook TL, Hawley RS. Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila. Genetics. 2000 Aug; 155(4):1757-72. PMID: 10924472; PMCID: PMC1461182.
      Citations: 36     Fields:    Translation:AnimalsCells
    73. Sekelsky JJ, McKim KS, Messina L, French RL, Hurley WD, Arbel T, Chin GM, Deneen B, Force SJ, Hari KL, Jang JK, Laurençon AC, Madden LD, Matthies HJ, Milliken DB, Page SL, Ring AD, Wayson SM, Zimmerman CC, Hawley RS, Sekelsky JJ, McKim KS, Messina L, French RL, Hurley WD, Arbel T, Chin GM, Deneen B, Force SJ, Hari KL, Jang JK, Laurençon AC, Madden LD, Matthies HJ, Milliken DB, Page SL, Ring AD, Wayson SM, Zimmerman CC, Hawley RS, Lauren?on AC. Identification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics. 1999 Jun; 152(2):529-42. PMID: 10353897; PMCID: PMC1460643.
      Citations: 46     Fields:    Translation:AnimalsCells
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