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BENJAMIN DENEEN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
DivisionNeuroscience
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neurosurgery
    DivisionNeurosurgery


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    F32NS048666     (DENEEN, BENJAMIN)Apr 1, 2006 - Mar 31, 2007
    NIH/NINDS
    The role of NFI genes in glial cell fate determination
    Role: Principal Investigator

    R01NS071153     (DENEEN, BENJAMIN)Sep 1, 2010 - Jun 30, 2019
    NIH/NINDS
    Transcriptional regulation of gliogenesis in the CNS
    Role: Principal Investigator

    R21NS089366     (DENEEN, BENJAMIN)Feb 1, 2015 - Jan 31, 2017
    NIH/NINDS
    The nature of astrocyte heterogeneity in RTT
    Role: Principal Investigator

    R21NS093145     (DENEEN, BENJAMIN)Jul 15, 2016 - Jun 30, 2018
    NIH/NINDS
    Developing Novel Therapeutic Approaches for White Matter Injury in the Neonatal Brain
    Role: Principal Investigator

    RF1AG054111     (ZHENG, HUI)Aug 15, 2016 - Jun 30, 2021
    NIH/NIA
    Decoding the role of diverse astrocyte populations in aging and AD
    Role: Co-Principal Investigator

    R01NS096096     (KUO, CHAY TITUS)Feb 1, 2017 - Jan 31, 2022
    NIH/NINDS
    Molecular and cellular control of injury-induced astrogenesis
    Role: Co-Principal Investigator

    U01CA217842     (MILLS, GORDON B.)Sep 6, 2017 - Jul 31, 2022
    NIH/NCI
    Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancer
    Role: Co-Principal Investigator

    R01CA223388     (NOEBELS, JEFFREY)Dec 15, 2017 - Nov 30, 2022
    NIH/NCI
    MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMA
    Role: Co-Principal Investigator

    R01CA217105     (BONDY, MELISSA L.)May 8, 2018 - Apr 30, 2023
    NIH/NCI
    Discovery, Biology and Risk of Inherited Variants in Glioma
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang CY, Deneen B, Tzeng SF. BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination. Glia. 2019 Jun 11. PMID: 31184779.
      View in: PubMed
    2. Cuevas-Diaz Duran R, Wang CY, Zheng H, Deneen B, Wu JQ. Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases. eNeuro. 2019 Mar-Apr; 6(2). PMID: 30957015.
      View in: PubMed
    3. Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep. 2018 Dec 26; 25(13):3811-3827.e7. PMID: 30590051.
      View in: PubMed
    4. Laug D, Glasgow SM, Deneen B. A glial blueprint for gliomagenesis. Nat Rev Neurosci. 2018 Jul; 19(7):393-403. PMID: 29777182.
      View in: PubMed
    5. Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang F, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2018 03 13; 9(1):1057. PMID: 29535300.
      View in: PubMed
    6. Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JB. Cooperative p16 and p21 action protects female astrocytes from transformation. Acta Neuropathol Commun. 2018 02 20; 6(1):12. PMID: 29458417.
      View in: PubMed
    7. Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJ. Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases. Clin Cancer Res. 2018 May 01; 24(9):2182-2193. PMID: 29440175.
      View in: PubMed
    8. Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Wels WS, Koch J, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed N. TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res. 2018 01 15; 78(2):489-500. PMID: 29183891.
      View in: PubMed
    9. Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B. Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 10 20; 6. PMID: 29053101.
      View in: PubMed
    10. Wang CY, Deneen B, Tzeng SF. MicroRNA-212 inhibits oligodendrocytes during maturation by down-regulation of differentiation-associated gene expression. J Neurochem. 2017 10; 143(1):112-125. PMID: 28771716.
      View in: PubMed
    11. Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis YM, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee SK, Mohila CA, Deneen B. Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017 Nov; 20(11):1520-1528. PMID: 28892058.
      View in: PubMed
    12. John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405. PMID: 28166219.
      View in: PubMed
    13. Glasgow SM, Deneen B. lnc'edin to Myelin. Neuron. 2017 Jan 18; 93(2):252-254. PMID: 28103473.
      View in: PubMed
    14. Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen B. Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 11 23; 36(47):11904-11917. PMID: 27881777.
      View in: PubMed
    15. Molofsky AV, Deneen B. Astrocyte development: A Guide for the Perplexed. Glia. 2015 Aug; 63(8):1320-9. PMID: 25963996.
      View in: PubMed
    16. Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 Oct; 63(10):1840-9. PMID: 25946682.
      View in: PubMed
    17. Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B. Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18; 85(6):1227-43. PMID: 25754822.
      View in: PubMed
    18. Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BR. Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb. Brain Struct Funct. 2016 Jan; 221(1):1-20. PMID: 25224546.
      View in: PubMed
    19. Glasgow SM, Zhu W, Stolt CC, Huang TW, Chen F, LoTurco JJ, Neul JL, Wegner M, Mohila C, Deneen B. Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci. 2014 Oct; 17(10):1322-9. PMID: 25151262.
      View in: PubMed
    20. Gallo V, Deneen B. Glial development: the crossroads of regeneration and repair in the CNS. Neuron. 2014 Jul 16; 83(2):283-308. PMID: 25033178.
      View in: PubMed
    21. Lee JS, Xiao J, Patel P, Schade J, Wang J, Deneen B, Erdreich-Epstein A, Song HR. A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. Neuro Oncol. 2014 Jan; 16(2):191-203. PMID: 24305710.
      View in: PubMed
    22. Chaboub LS, Deneen B. Astrocyte form and function in the developing central nervous system. Semin Pediatr Neurol. 2013 Dec; 20(4):230-5. PMID: 24365570.
      View in: PubMed
    23. John Lin CC, Deneen B. Astrocytes: the missing link in neurologic disease? Semin Pediatr Neurol. 2013 Dec; 20(4):236-41. PMID: 24365571.
      View in: PubMed
    24. Glasgow SM, Laug D, Brawley VS, Zhang Z, Corder A, Yin Z, Wong ST, Li XN, Foster AE, Ahmed N, Deneen B. The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS. J Neurosci. 2013 Aug 14; 33(33):13560-8. PMID: 23946414.
      View in: PubMed
    25. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32. PMID: 23840004.
      View in: PubMed
    26. Chaboub LS, Deneen B. Developmental origins of astrocyte heterogeneity: the final frontier of CNS development. Dev Neurosci. 2012; 34(5):379-88. PMID: 23147551.
      View in: PubMed
    27. Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B. Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol. 2012 Aug; 72(2):224-33. PMID: 22807310.
      View in: PubMed
    28. Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 01; 26(9):891-907. PMID: 22549954.
      View in: PubMed
    29. Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12; 74(1):79-94. PMID: 22500632.
      View in: PubMed
    30. Lee HK, Deneen B. Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Dev Cell. 2012 Jan 17; 22(1):183-96. PMID: 22227309.
      View in: PubMed
    31. Song HR, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Gilles FH, Deneen B, Erdreich-Epstein A. Nuclear factor IA is expressed in astrocytomas and is associated with improved survival. Neuro Oncol. 2010 Feb; 12(2):122-32. PMID: 20150379.
      View in: PubMed
    32. Namihira M, Kohyama J, Semi K, Sanosaka T, Deneen B, Taga T, Nakashima K. Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009 Feb; 16(2):245-55. PMID: 19217426.
      View in: PubMed
    33. Hochstim C, Deneen B, Lukaszewicz A, Zhou Q, Anderson DJ. Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell. 2008 May 02; 133(3):510-22. PMID: 18455991.
      View in: PubMed
    34. Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006 Dec 21; 52(6):953-68. PMID: 17178400.
      View in: PubMed
    35. Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1551-6. PMID: 16432183.
      View in: PubMed
    36. Deneen B, Hamidi H, Denny CT. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15; 63(14):4268-74. PMID: 12874036.
      View in: PubMed
    37. Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun; 23(11):3897-908. PMID: 12748291.
      View in: PubMed
    38. Deneen B, Denny CT. Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene. 2001 Oct 11; 20(46):6731-41. PMID: 11709708.
      View in: PubMed
    39. Welford SM, Hebert SP, Deneen B, Arvand A, Denny CT. DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis. J Biol Chem. 2001 Nov 09; 276(45):41977-84. PMID: 11553628.
      View in: PubMed
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