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Jason T. Yustein

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Oncology
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Patil SL, Palat A, Pan Y, Rajapakshe K, Mirchandani R, Bondesson M, Yustein JT, Coarfa C, Gunaratne PH. MicroRNA-509-3p inhibits cellular migration, invasion, and proliferation, and sensitizes osteosarcoma to cisplatin. Sci Rep. 2019 Dec 13; 9(1):19089. PMID: 31836741.
      View in: PubMed
    2. Nomura M, Rainusso N, Lee YC, Dawson B, Coarfa C, Han R, Larson JL, Shuck R, Kurenbekova L, Yustein JT. Tegavivint and the ß-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma. J Natl Cancer Inst. 2019 Nov 01; 111(11):1216-1227. PMID: 30793158.
      View in: PubMed
    3. Nan X, Wang J, Cheng H, Yin Z, Sheng J, Qiu B, Lau CC, Yustein JT, Zhao H, Wong STC. Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways. Cancer Lett. 2020 Jan 28; 469:195-206. PMID: 31672491.
      View in: PubMed
    4. Garcia D, Nasarre P, Bonilla IV, Hilliard E, Peterson YK, Spruill L, Broome AM, Hill EG, Yustein JT, Mehrotra S, Klauber-DeMore N. Development of a Novel Humanized Monoclonal Antibody to Secreted Frizzled-Related Protein-2 That Inhibits Triple-Negative Breast Cancer and Angiosarcoma Growth In Vivo. Ann Surg Oncol. 2019 Dec; 26(13):4782-4790. PMID: 31515721.
      View in: PubMed
    5. Bailey K, Cost C, Davis I, Glade-Bender J, Grohar P, Houghton P, Isakoff M, Stewart E, Laack N, Yustein J, Reed D, Janeway K, Gorlick R, Lessnick S, DuBois S, Hingorani P. Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force. F1000Res. 2019; 8. PMID: 31031965.
      View in: PubMed
    6. Rainusso N, Cleveland H, Hernandez JA, Quintanilla NM, Hicks J, Vasudevan S, Marco RAW, Allen-Rhoades W, Wang LL, Yustein JT. Generation of patient-derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas. Pediatr Blood Cancer. 2019 04; 66(4):e27579. PMID: 30548185.
      View in: PubMed
    7. Fuja DG, Rainusso NC, Shuck RL, Kurenbekova L, Donehower LA, Yustein JT. Transglutaminase-2 promotes metastatic and stem-like phenotypes in osteosarcoma. Am J Cancer Res. 2018; 8(9):1752-1763. PMID: 30323968.
      View in: PubMed
    8. Shapiro MC, Tang T, Dasgupta A, Kurenbekova L, Shuck R, Gaber MW, Yustein JT. In Vitro and In Vivo Characterization of a Preclinical Irradiation-Adapted Model for Ewing Sarcoma. Int J Radiat Oncol Biol Phys. 2018 05 01; 101(1):118-127. PMID: 29534895.
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    9. Allen-Rhoades W, Yustein JT. Detection of Plasma MicroRNA Signature in Osteosarcoma Patients. Methods Mol Biol. 2018; 1699:113-118. PMID: 29086373.
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    10. Basal LA, Bailey MD, Romero J, Ali MM, Kurenbekova L, Yustein J, Pautler RG, Allen MJ. Fluorinated EuII-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging. Chem Sci. 2017 Dec 01; 8(12):8345-8350. PMID: 29780447.
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    11. Dasgupta A, Trucco M, Rainusso N, Bernardi RJ, Shuck R, Kurenbekova L, Loeb DM, Yustein JT. Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties. Oncotarget. 2017 Sep 29; 8(44):77292-77308. PMID: 29100387.
      View in: PubMed
    12. Satterfield L, Shuck R, Kurenbekova L, Allen-Rhoades W, Edwards D, Huang S, Rajapakshe K, Coarfa C, Donehower LA, Yustein JT. miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma. Int J Cancer. 2017 11 15; 141(10):2062-2075. PMID: 28748534.
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    13. Nakka M, Allen-Rhoades W, Li Y, Kelly AJ, Shen J, Taylor AM, Barkauskas DA, Yustein JT, Andrulis IL, Wunder JS, Gorlick R, Meltzer PS, Lau CC, Man TK. Biomarker significance of plasma and tumor miR-21, miR-221, and miR-106a in osteosarcoma. Oncotarget. 2017 Nov 14; 8(57):96738-96752. PMID: 29228567.
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    14. Dasgupta A, Nomura M, Shuck R, Yustein J. Cancer's Achilles' Heel: Apoptosis and Necroptosis to the Rescue. Int J Mol Sci. 2016 Dec 23; 18(1). PMID: 28025559.
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    15. Techavichit P, Gao Y, Kurenbekova L, Shuck R, Donehower LA, Yustein JT. Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential. BMC Cancer. 2016 11 08; 16(1):869. PMID: 27821163.
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    16. Xu Yang, Arindam Chaudhury, Ming Zhang, Barbara Savoldo, Leonid Metelitsa, John Rodgers, Jason T. Yustein, Joel Neilson, Gianpietro Dotti. T effector-memory cells are adapted to hypoxia through HIF1a and glycolytic metabolism. Journal Clinical Investigation. 2016; 7(126):2678-88.
    17. Xu Y, Chaudhury A, Zhang M, Savoldo B, Metelitsa LS, Rodgers J, Yustein JT, Neilson JR, Dotti G. Glycolysis determines dichotomous regulation of T cell subsets in hypoxia. J Clin Invest. 2016 07 01; 126(7):2678-88. PMID: 27294526.
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    18. Roos A, Satterfield L, Zhao S, Fuja D, Shuck R, Hicks MJ, Donehower LA, Yustein JT. Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis. Br J Cancer. 2015 Nov 03; 113(9):1289-97. PMID: 26528706.
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    19. Rao PH, Zhao S, Zhao YJ, Yu A, Rainusso N, Trucco M, Allen-Rhoades W, Satterfield L, Fuja D, Borra VJ, Man TK, Donehower LA, Yustein JT. Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma. Genes Chromosomes Cancer. 2015 Dec; 54(12):796-808. PMID: 26355645.
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    20. Gargi Ghosal and Jason T. Yustein. Journal of Cancer Biology & Research. EWS-FLI1 Regulates Genotoxic Stress Response in Ewing Sarcoma. 2015; 2(3):1-8.
    21. Allen-Rhoades W, Kurenbekova L, Satterfield L, Parikh N, Fuja D, Shuck RL, Rainusso N, Trucco M, Barkauskas DA, Jo E, Ahern C, Hilsenbeck S, Donehower LA, Yustein JT. Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma. Cancer Med. 2015 Jul; 4(7):977-88. PMID: 25784290.
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    22. Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JT. NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 2015 Sep 24; 34(39):5069-79. PMID: 25579177.
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    23. Allen-Rhoades, W., L. Kurenbekova, L. Satterfield, N. Parikh, D. Fuja, R. Shuck, S. Hillsenbeck, L.A. Donehower, J.T. Yustein. Cross-species validation of circulating microRNA signature for detection and therapeutic monitoring of osteosarcoma. Cancer Medicine. 2015.
    24. Rainusso N, Wang LL, Yustein JT. The adolescent and young adult with cancer: state of the art -- bone tumors. Curr Oncol Rep. 2013 Aug; 15(4):296-307. PMID: 23690089.
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    25. Ruan MZ, Erez A, Guse K, Dawson B, Bertin T, Chen Y, Jiang MM, Yustein J, Gannon F, Lee BH. Proteoglycan 4 expression protects against the development of osteoarthritis. Sci Transl Med. 2013 Mar 13; 5(176):176ra34. PMID: 23486780.
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    26. Ke S, Wang W, Qiu X, Zhang F, Yustein JT, Cameron AG, Zhang S, Yu D, Zou C, Gao X, Lin J, Yallampalli S, Li M. Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice. Curr Mol Med. 2013 Mar; 13(3):446-58. PMID: 23331017.
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    27. Wu G, Yustein JT, McCall MN, Zilliox M, Irizarry RA, Zeller K, Dang CV, Ji H. ChIP-PED enhances the analysis of ChIP-seq and ChIP-chip data. Bioinformatics. 2013 May 01; 29(9):1182-9. PMID: 23457041.
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    28. Awad O, Yustein JT, Shah P, Gul N, Katuri V, O'Neill A, Kong Y, Brown ML, Toretsky JA, Loeb DM. High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. PLoS One. 2010 Nov 11; 5(11):e13943. PMID: 21085683.
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    29. Yustein JT, Rednam S, Bertuch AA, Goss JA, Brandt ML, Eldin K, Lu X, Hicks J. Abdominal undifferentiated small round cell tumor with unique translocation (X;19)(q13;q13.3). Pediatr Blood Cancer. 2010 Jul 01; 54(7):1041-4. PMID: 20162687.
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    30. Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, Chng WJ, Eberhart CG, Bergsagel PL, Dang CV. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3534-9. PMID: 20133585.
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    31. Dang CV, Kim JW, Gao P, Yustein J. The interplay between MYC and HIF in cancer. Nat Rev Cancer. 2008 01; 8(1):51-6. PMID: 18046334.
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    32. Yustein JT, Dang CV. Biology and treatment of Burkitt's lymphoma. Curr Opin Hematol. 2007 Jul; 14(4):375-81. PMID: 17534164.
      View in: PubMed
    33. Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT, Ooi HS, Orlov YL, Shahab A, Yong HC, Fu Y, Weng Z, Kuznetsov VA, Sung WK, Ruan Y, Dang CV, Wei CL. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17834-9. PMID: 17093053.
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    34. Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, Kim JW, Yustein JT, Lee LA, Dang CV. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol. 2005 Jul; 25(14):6225-34. PMID: 15988031.
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    35. Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Mol Cell Biol. 2003 Nov; 23(22):8282-94. PMID: 14585985.
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    36. Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. Oncogene. 2003 Sep 18; 22(40):6129-41. PMID: 13679851.
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    37. Yustein JT, Li D, Robinson D, Kung HJ. KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway. Oncogene. 2000 Feb 03; 19(5):710-8. PMID: 10698516.
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    38. Robinson D, Chen HC, Li D, Yustein JT, He F, Lin WC, Hayman MJ, Kung HJ. Tyrosine kinase expression profiles of chicken erythro-progenitor cells and oncogene-transformed erythroblasts. J Biomed Sci. 1998; 5(2):93-100. PMID: 9662068.
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    39. Andrews, L., G.P. Kushto, and J.T. Yustein. The Journal of Physical Chemistry. Reactions of pulsed-laser-evaporated thallium atoms with O2. Matrix infrared spectra of new TlO2 species. Trends in Group 13 dioxides and dioxide anions. 1997; (101):9077-9084.
    40. Chertihin, G.V., W. Saffel, and J.T. Yustein. Reactions of laser-ablated iron atoms oxygen molecules in condensing argon. Infrared spectra and density functional calculations of iron oxide product molecules. The Journal of Physical Chemistry. 1996; 100:5261-5273.
    41. Andrews, L, C.A. Thompson, and J.T. Yustein. Reactions of pulsed-laser evaporated Ca, Sr, and Ba atoms with O2. Infrared spectra of the metal oxides, oxide dimers, dioxides, and peroxides in solid argon. The Journal of Physical Chemistry. 1994; 98:6514-6521.
    42. Andrews, L., and J.T. Yustein. Reaction of pulsed laser evaporated magnesium atoms with oxygen. Infrared spectra of linear OmgO and MgOMg in solid argon. The Journal of Physical Chemistry. 1993; 97:12700-4.
    43. Andrews, L., T.R. Burkholder, and J.T. Yustein. Reactions of pulsed-laser evaporated aluminum atoms with oxygen. Infrared spectra of the reaction products in solid argon. The Journal of Physical Chemistry. 1992; 96:10182-9.
    44. Burkholder, T.R., L. Andrews, and J.T. Yustein . Reactions of pulsed laser evaporated Ga and In atoms with molecular oxygen. Matrix infrared spectra of new GaO2 and InO2 species. The Journal of Physical Chemistry. 1992; 96:10189-95.
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