YI-CHEN LAI

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6621 FANNIN
Houston, TX 77030
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    R21NS119929     (LAI, YI-CHEN)Jul 1, 2021 - Dec 31, 2022
    NIH
    Assessing determinants of electrocardiographic alterations and identifying exacerbating factors in pediatric epilepsy
    Role: Principal Investigator

    K08NS063117     (LAI, YI-CHEN)May 15, 2009 - Apr 30, 2014
    NIH
    PARP-1 activation in seizures and status epilepticus
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vasquez A, Farias-Moeller R, Sánchez-Fernández I, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman K, Clark J, Gaillard WD, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sands TT, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Super-Refractory Status Epilepticus in Children: A Retrospective Cohort Study. Pediatr Crit Care Med. 2021 12 01; 22(12):e613-e625. PMID: 34120133.
      Citations:    Fields:    Translation:Humans
    2. Sheehan T, Amengual-Gual M, Vasquez A, Abend NS, Anderson A, Appavu B, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Jackson M, Kapur K, Kahoud R, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sands TT, Sannagowdara K, Shellhaas R, Smith G, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T. Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus. Epilepsia. 2021 11; 62(11):2766-2777. PMID: 34418087.
      Citations: 1     Fields:    Translation:Humans
    3. Martinez LA, Lai YC, Holder JL, Anderson AE. Genetics in Epilepsy. Neurol Clin. 2021 08; 39(3):743-777. PMID: 34215385.
      Citations: 2     Fields:    Translation:Humans
    4. Chan SW, Dervan LA, Watson RS, Anderson AE, Lai YC. Epilepsy duration is an independent factor for electrocardiographic changes in pediatric epilepsy. Epilepsia Open. 2021 09; 6(3):588-596. PMID: 34235879.
      Citations: 1     Fields:    Translation:Humans
    5. Gaínza-Lein M, Barcia Aguilar C, Piantino J, Chapman KE, Sánchez Fernández I, Amengual-Gual M, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Huh L, Kahoud R, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Nayak A, Novotny E, Ostendorf AP, Payne ET, Peariso K, Reece L, Riviello J, Sannagowdara K, Sands TT, Sheehan T, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T. Factors associated with long-term outcomes in pediatric refractory status epilepticus. Epilepsia. 2021 09; 62(9):2190-2204. PMID: 34251039.
      Citations: 1     Fields:    Translation:Humans
    6. Sculier C, Barcia Aguilar C, Gaspard N, Gaínza-Lein M, Sánchez Fernández I, Amengual-Gual M, Anderson A, Arya R, Burrows BT, Brenton JN, Carpenter JL, Chapman KE, Clark J, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Gorman M, Lai YC, McDonough TL, Mikati MA, Nayak A, Peariso K, Riviello J, Rusie A, Sperberg K, Stredny CM, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T. Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort). Epilepsia. 2021 07; 62(7):1629-1642. PMID: 34091885.
      Citations: 4     Fields:    Translation:Humans
    7. Koh S, Wirrell E, Vezzani A, Nabbout R, Muscal E, Kaliakatsos M, Wickström R, Riviello JJ, Brunklaus A, Payne E, Valentin A, Wells E, Carpenter JL, Lee K, Lai YC, Eschbach K, Press CA, Gorman M, Stredny CM, Roche W, Mangum T. Proposal to optimize evaluation and treatment of Febrile infection-related epilepsy syndrome (FIRES): A Report from FIRES workshop. Epilepsia Open. 2021 03; 6(1):62-72. PMID: 33681649.
      Citations: 6     Fields:    Translation:Humans
    8. Lai YC, Muscal E, Wells E, Shukla N, Eschbach K, Hyeong Lee K, Kaliakatsos M, Desai N, Wickström R, Viri M, Freri E, Granata T, Nangia S, Dilena R, Brunklaus A, Wainwright MS, Gorman MP, Stredny CM, Asiri A, Hundallah K, Doja A, Payne E, Wirrell E, Koh S, Carpenter JL, Riviello J. Anakinra usage in febrile infection related epilepsy syndrome: an international cohort. Ann Clin Transl Neurol. 2020 12; 7(12):2467-2474. PMID: 33506622.
      Citations: 11     Fields:    Translation:Humans
    9. Vasquez A, Gaínza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman K, Clark J, Farias-Moeller R, Gaillard WD, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. First-line medication dosing in pediatric refractory status epilepticus. Neurology. 2020 11 10; 95(19):e2683-e2696. PMID: 32913024.
      Citations: 3     Fields:    Translation:Humans
    10. Sánchez Fernández I, Abend NS, Amengual-Gual M, Anderson A, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser T, Goldstein J, Goodkin HP, Guerriero RM, Lai YC, McDonough T, Mikati MA, Morgan LA, Novotny E, Payne E, Peariso K, Piantino J, Ostendorf A, Sands TT, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Association of guideline publication and delays to treatment in pediatric status epilepticus. Neurology. 2020 09 01; 95(9):e1222-e1235. PMID: 32611646.
      Citations: 2     Fields:    Translation:Humans
    11. Levine AT, Born HA, Landstrom AP, Larson S, Lee WL, Dao AT, Wehrens XH, Lai YC, Anderson AE. Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep. 2020 03 04; 10(1):4043. PMID: 32132552.
      Citations: 1     Fields:    Translation:Animals
    12. Ansorge R, Romano S, Sayavedra L, Porras MÁG, Kupczok A, Tegetmeyer HE, Dubilier N, Petersen J. Functional diversity enables multiple symbiont strains to coexist in deep-sea mussels. Nat Microbiol. 2019 12; 4(12):2487-2497. PMID: 31611646.
      Citations: 26     Fields:    Translation:AnimalsCells
    13. Sansevere AJ, Arya R, Sánchez Fernández I, Gaillard WD, Tasker RC, Lai YC, Anderson AE, Tchapyjnikov D, Chapman KE, Brenton JN, Carpenter JL, Gaínza-Lein M, Goldstein JL, Goodkin HP, Jackson MC, Kapur K, Mikati MA, Peariso K, Glauser TA, Topjian AA, Wainwright M, Wilfong AA, Williams KL, Loddenkemper T, Abend NS. Electroencephalographic Reporting for Refractory Status Epilepticus. J Clin Neurophysiol. 2019 Sep; 36(5):365-370. PMID: 31166226.
      Citations:    Fields:    Translation:Humans
    14. Sánchez Fernández I, Gaínza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Davis Gaillard W, Glauser TA, Goldstein J, Goodkin HP, Guerriero RM, Hecox K, Jackson M, Kapur K, Kelley SA, Kossoff EHW, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sannagowdara K, Stafstrom CE, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. The onset of pediatric refractory status epilepticus is not distributed uniformly during the day. Seizure. 2019 Aug; 70:90-96. PMID: 31323566.
      Citations: 2     Fields:    Translation:Humans
    15. Egbenya DL, Hussain S, Lai YC, Xia J, Anderson AE, Davanger S. Changes in synaptic AMPA receptor concentration and composition in chronic temporal lobe epilepsy. Mol Cell Neurosci. 2018 10; 92:93-103. PMID: 30064010.
      Citations: 16     Fields:    Translation:AnimalsCells
    16. Vasquez A, Gaínza-Lein M, Sánchez Fernández I, Abend NS, Anderson A, Brenton JN, Carpenter JL, Chapman K, Clark J, Gaillard WD, Glauser T, Goldstein J, Goodkin HP, Lai YC, Loddenkemper T, McDonough TL, Mikati MA, Nayak A, Payne E, Riviello J, Tchapyjnikov D, Topjian AA, Wainwright MS, Tasker RC. Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers. Pediatr Neurol. 2018 09; 86:33-41. PMID: 30075875.
      Citations: 2     Fields:    Translation:Humans
    17. Arya R, Peariso K, Gaínza-Lein M, Harvey J, Bergin A, Brenton JN, Burrows BT, Glauser T, Goodkin HP, Lai YC, Mikati MA, Fernández IS, Tchapyjnikov D, Wilfong AA, Williams K, Loddenkemper T. Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus. Epilepsy Res. 2018 08; 144:1-6. PMID: 29727818.
      Citations: 16     Fields:    Translation:Humans
    18. Sánchez Fernández I, Gaínza-Lein M, Abend NS, Anderson AE, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Helseth AR, Jackson MC, Kapur K, Lai YC, McDonough TL, Mikati MA, Nayak A, Peariso K, Riviello JJ, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Factors associated with treatment delays in pediatric refractory convulsive status epilepticus. Neurology. 2018 05 08; 90(19):e1692-e1701. PMID: 29643084.
      Citations: 6     Fields:    Translation:Humans
    19. Lai YC, Li N, Lawrence W, Wang S, Levine A, Burchhardt DM, Pautler RG, Valderrábano M, Wehrens XH, Anderson AE. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. Epilepsia Open. 2018 Jun; 3(2):213-223. PMID: 29881800.
      Citations: 3     Fields:    
    20. Ali W, Bubolz BA, Nguyen L, Castro D, Coss-Bu J, Quach MM, Kennedy CE, Anderson AE, Lai YC. Epilepsy is associated with ventricular alterations following convulsive status epilepticus in children. Epilepsia Open. 2017 Dec; 2(4):432-440. PMID: 29430560.
      Citations: 3     Fields:    
    21. Hussain S, Egbenya DL, Lai YC, Dosa ZJ, Sørensen JB, Anderson AE, Davanger S. The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines. Hippocampus. 2017 11; 27(11):1168-1177. PMID: 28686803.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Lai YC, Baker JS, Donti T, Graham BH, Craigen WJ, Anderson AE. Mitochondrial Dysfunction Mediated by Poly(ADP-Ribose) Polymerase-1 Activation Contributes to Hippocampal Neuronal Damage Following Status Epilepticus. Int J Mol Sci. 2017 Jul 12; 18(7). PMID: 28704930.
      Citations: 7     Fields:    Translation:AnimalsCells
    23. Lai YC, Aneja RK, Satchell MA, Clark RSB. Detecting and Quantifying pADPr In Vivo. Methods Mol Biol. 2017; 1608:27-43. PMID: 28695501.
      Citations:    Fields:    Translation:HumansAnimalsCells
    24. Brewster AL, Marzec K, Hairston A, Ho M, Anderson AE, Lai YC. Early cardiac electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy. Epilepsia. 2016 11; 57(11):1907-1915. PMID: 27555091.
      Citations: 9     Fields:    Translation:AnimalsCells
    25. Lai YC. Seizure Detection in the PICU: Can We "See" Seizures Better in Color? Pediatr Crit Care Med. 2015 Jun; 16(5):486-7. PMID: 26039430.
      Citations: 1     Fields:    Translation:Humans
    26. Valentine G, Thomas TA, Nguyen T, Lai YC. Chronic granulomatous disease presenting as hemophagocytic lymphohistiocytosis: a case report. Pediatrics. 2014 Dec; 134(6):e1727-30. PMID: 25422023.
      Citations: 14     Fields:    Translation:HumansCells
    27. Lai YC, Aneja RK, Satchell MA, Clark RS. Detecting and quantifying pADPr in vivo. Methods Mol Biol. 2011; 780:117-34. PMID: 21870258.
      Citations: 2     Fields:    Translation:HumansAnimals
    28. Bayir H, Adelson PD, Wisniewski SR, Shore P, Lai Y, Brown D, Janesko-Feldman KL, Kagan VE, Kochanek PM. Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med. 2009 Feb; 37(2):689-95. PMID: 19114918.
      Citations: 40     Fields:    Translation:Humans
    29. Fink EL, Lai Y, Zhang X, Janesko-Feldman K, Adelson PD, Szabó C, Berger RP, Sarnaik AA, Kochanek PM, Clark RS. Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injury. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1523-9. PMID: 18506195.
      Citations: 12     Fields:    Translation:HumansCells
    30. Lai Y, Chen Y, Watkins SC, Nathaniel PD, Guo F, Kochanek PM, Jenkins LW, Szabó C, Clark RS. Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury. J Neurochem. 2008 Mar; 104(6):1700-11. PMID: 17996029.
      Citations: 52     Fields:    Translation:AnimalsCells
    31. Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab. 2008 Mar; 28(3):540-50. PMID: 17786151.
      Citations: 68     Fields:    Translation:AnimalsCells
    32. Shore PM, Berger RP, Varma S, Janesko KL, Wisniewski SR, Clark RS, Adelson PD, Thomas NJ, Lai YC, Bayir H, Kochanek PM. Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury. J Neurotrauma. 2007 Jan; 24(1):75-86. PMID: 17263671.
      Citations: 19     Fields:    Translation:Humans
    33. Di Filippo S, Lai Y, Manrique A, Pigula F, Muñoz R. Intensive care course after stage 1 Norwood procedure: are there early predictors of failure? Intensive Care Med. 2007 Jan; 33(1):111-9. PMID: 17115134.
      Citations: 1     Fields:    Translation:Humans
    34. Kochanek AR, Kline AE, Gao WM, Chadha M, Lai Y, Clark RS, Dixon CE, Jenkins LW. Gel-based hippocampal proteomic analysis 2 weeks following traumatic brain injury to immature rats using controlled cortical impact. Dev Neurosci. 2006; 28(4-5):410-9. PMID: 16943664.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    35. Cousar JL, Lai Y, Marco CD, Bayir H, Adelson PD, Janesko-Feldman KL, Kochanek PM, Clark RS. Heme oxygenase 1 in cerebrospinal fluid from infants and children after severe traumatic brain injury. Dev Neurosci. 2006; 28(4-5):342-7. PMID: 16943657.
      Citations: 15     Fields:    Translation:HumansCells
    36. Lai Y, Stange C, Wisniewski SR, Adelson PD, Janesko-Feldman KL, Brown DS, Kochanek PM, Clark RS. Mitochondrial heat shock protein 60 is increased in cerebrospinal fluid following pediatric traumatic brain injury. Dev Neurosci. 2006; 28(4-5):336-41. PMID: 16943656.
      Citations: 12     Fields:    Translation:HumansCells
    37. Lai Y, Du L, Dunsmore KE, Jenkins LW, Wong HR, Clark RS. Selectively increasing inducible heat shock protein 70 via TAT-protein transduction protects neurons from nitrosative stress and excitotoxicity. J Neurochem. 2005 Jul; 94(2):360-6. PMID: 15998287.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    38. Satchell MA, Lai Y, Kochanek PM, Wisniewski SR, Fink EL, Siedberg NA, Berger RP, DeKosky ST, Adelson PD, Clark RS. Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuse. J Cereb Blood Flow Metab. 2005 Jul; 25(7):919-27. PMID: 15744250.
      Citations: 37     Fields:    Translation:Humans
    39. Du L, Bayir H, Lai Y, Zhang X, Kochanek PM, Watkins SC, Graham SH, Clark RS. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem. 2004 Sep 10; 279(37):38563-70. PMID: 15234982.
      Citations: 155     Fields:    Translation:AnimalsCells
    40. Fink EL, Alexander H, Marco CD, Dixon CE, Kochanek PM, Jenkins LW, Lai Y, Donovan HA, Hickey RW, Clark RS. Experimental model of pediatric asphyxial cardiopulmonary arrest in rats. Pediatr Crit Care Med. 2004 Mar; 5(2):139-44. PMID: 14987343.
      Citations: 40     Fields:    Translation:Animals
    41. Lai Y, Kochanek PM, Adelson PD, Janesko K, Ruppel RA, Clark RS. Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children. J Neurotrauma. 2004 Mar; 21(3):229-37. PMID: 15115598.
      Citations: 12     Fields:    Translation:Humans
    42. Seidberg NA, Clark RS, Zhang X, Lai Y, Chen M, Graham SH, Kochanek PM, Watkins SC, Marion DW. Alterations in inducible 72-kDa heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury. J Neurochem. 2003 Feb; 84(3):514-21. PMID: 12558971.
      Citations: 11     Fields:    Translation:Humans
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