Islets of Langerhans

"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Descriptor ID	D007515
MeSH Number(s)	A03.734.414 A06.407.414
Concept/Terms	Islets of Langerhans Islets of Langerhans Langerhans Islets Pancreatic Islets Islet, Pancreatic Islets, Pancreatic Pancreatic Islet Nesidioblasts Nesidioblast Pancreas, Endocrine Endocrine Pancreas Islands of Langerhans Langerhans Islands Islet Cells Cell, Islet Cells, Islet Islet Cell

Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".

Anatomy [A]
Digestive System [A03]
Pancreas [A03.734]
Islets of Langerhans [A03.734.414]
Endocrine System [A06]
Endocrine Glands [A06.407]
Islets of Langerhans [A06.407.414]

Below are MeSH descriptors whose meaning is related to "Islets of Langerhans".

Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.

Bar chart showing 186 publications over 30 distinct years, with a maximum of 15 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1992	5	1	6
1994	1	1	2
1995	5	3	8
1996	3	2	5
1997	3	5	8
1998	2	2	4
1999	4	2	6
2000	3	3	6
2001	5	1	6
2002	6	3	9
2003	3	6	9
2004	7	8	15
2005	9	0	9
2006	7	1	8
2007	5	4	9
2008	9	4	13
2009	3	5	8
2010	2	2	4
2011	3	3	6
2012	5	0	5
2013	1	2	3
2014	2	4	6
2015	3	3	6
2016	2	1	3
2017	1	4	5
2018	1	3	4
2019	2	2	4
2020	3	0	3
2021	2	3	5
2022	1	0	1

Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.

Pradhan G, Lee JH, Wu CS, Wang H, Lin L, Donti T, Graham BH, Rajan AS, Balasubramanyam A, Samson SL, Guo S, Sun Y. Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets. Biomolecules. 2022 03 06; 12(3).

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Astudillo M, Tosur M, Castillo B, Rafaey A, Siller AF, Nieto J, Sisley S, McKay S, Nella AA, Balasubramanyam A, Bacha F, Redondo MJ. Type 2 diabetes in prepubertal children. Pediatr Diabetes. 2021 11; 22(7):946-950.

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Tosur M, Soler-Alfonso C, Chan KM, Khayat MM, Jhangiani SN, Meng Q, Refaey A, Muzny D, Gibbs RA, Murdock DR, Posey JE, Balasubramanyam A, Redondo MJ, Sabo A. Exome sequencing in children with clinically suspected maturity-onset diabetes of the young. Pediatr Diabetes. 2021 11; 22(7):960-968.

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Nieto J, Castillo B, Astudillo M, Tosur M, Balasubramanyam A, Pietropaolo M, Redondo MJ. Islet autoantibody types mark differential clinical characteristics at diagnosis of pediatric type 1 diabetes. Pediatr Diabetes. 2021 09; 22(6):882-888.

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Wang MY, Dean ED, Quittner-Strom E, Zhu Y, Chowdhury KH, Zhang Z, Zhao S, Li N, Ye R, Lee Y, Zhang Y, Chen S, Yu X, Leonard DC, Poffenberger G, Von Deylen A, McCorkle SK, Schlegel A, Sloop KW, Efanov AM, Gimeno RE, Scherer PE, Powers AC, Unger RH, Holland WL. Glucagon blockade restores functional ß-cell mass in type 1 diabetic mice and enhances function of human islets. Proc Natl Acad Sci U S A. 2021 03 02; 118(9).

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Redondo MJ, Nathan BM, Jacobsen LM, Sims E, Bocchino LE, Pugliese A, Schatz DA, Atkinson MA, Skyler J, Palmer J, Geyer S, Sosenko JM. Index60 as an additional diagnostic criterion for type 1 diabetes. Diabetologia. 2021 04; 64(4):836-844.

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Redondo MJ, Sosenko J, Libman I, McVean JJF, Tosur M, Atkinson MA, Becker D, Geyer S. Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance. J Clin Endocrinol Metab. 2020 05 01; 105(5).

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Hartig SM, Cox AR. Paracrine signaling in islet function and survival. J Mol Med (Berl). 2020 04; 98(4):451-467.

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Ferrara-Cook C, Geyer SM, Evans-Molina C, Libman IM, Becker DJ, Gitelman SE, Redondo MJ. Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents. Diabetes Care. 2020 03; 43(3):580-587.

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Vehik K, Lynch KF, Wong MC, Tian X, Ross MC, Gibbs RA, Ajami NJ, Petrosino JF, Rewers M, Toppari J, Ziegler AG, She JX, Lernmark A, Akolkar B, Hagopian WA, Schatz DA, Krischer JP, Hyöty H, Lloyd RE. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes. Nat Med. 2019 12; 25(12):1865-1872.

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