 Islets of Langerhans
"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
| Descriptor ID |
D007515
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| MeSH Number(s) |
A03.734.414 A06.407.414
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| Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
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Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1990 | 1 | 2 | 3 | | 1991 | 1 | 1 | 2 | | 1992 | 5 | 1 | 6 | | 1994 | 1 | 1 | 2 | | 1995 | 6 | 3 | 9 | | 1996 | 3 | 2 | 5 | | 1997 | 3 | 5 | 8 | | 1998 | 2 | 2 | 4 | | 1999 | 4 | 2 | 6 | | 2000 | 3 | 2 | 5 | | 2001 | 5 | 1 | 6 | | 2002 | 6 | 3 | 9 | | 2003 | 3 | 6 | 9 | | 2004 | 7 | 8 | 15 | | 2005 | 8 | 1 | 9 | | 2006 | 7 | 1 | 8 | | 2007 | 5 | 4 | 9 | | 2008 | 8 | 5 | 13 | | 2009 | 3 | 6 | 9 | | 2010 | 2 | 2 | 4 | | 2011 | 3 | 3 | 6 | | 2012 | 4 | 0 | 4 | | 2013 | 1 | 2 | 3 | | 2014 | 2 | 5 | 7 | | 2015 | 3 | 3 | 6 | | 2016 | 3 | 1 | 4 | | 2017 | 2 | 4 | 6 | | 2018 | 1 | 3 | 4 | | 2019 | 2 | 2 | 4 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Vehik K, Lynch KF, Wong MC, Tian X, Ross MC, Gibbs RA, Ajami NJ, Petrosino JF, Rewers M, Toppari J, Ziegler AG, She JX, Lernmark A, Akolkar B, Hagopian WA, Schatz DA, Krischer JP, Hyöty H, Lloyd RE. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes. Nat Med. 2019 12; 25(12):1865-1872.
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Redondo MJ, Evans-Molina C, Steck AK, Atkinson MA, Sosenko J. The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes. Diabetes Care. 2019 08; 42(8):1357-1364.
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Elsakr JM, Dunn JC, Tennant K, Zhao SK, Kroeten K, Pasek RC, Takahashi DL, Dean TA, Velez Edwards DR, McCurdy CE, Aagaard KM, Powers AC, Friedman JE, Kievit P, Gannon M. Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition. Mol Metab. 2019 07; 25:73-82.
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Pilla SJ, Balasubramanyam A, Knowler WC, Lazo M, Nathan DM, Pi-Sunyer X, Clark JM, Maruthur NM. Islet autoantibody positivity in overweight and obese adults with type 2 diabetes. Autoimmunity. 2018 12; 51(8):408-416.
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Lam CJ, Chatterjee A, Shen E, Cox AR, Kushner JA. Low-Level Insulin Content Within Abundant Non-ß Islet Endocrine Cells in Long-standing Type 1 Diabetes. Diabetes. 2019 03; 68(3):598-608.
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Vatanen T, Franzosa EA, Schwager R, Tripathi S, Arthur TD, Vehik K, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Stewart CJ, Ajami NJ, Petrosino JF, Gevers D, Lähdesmäki H, Vlamakis H, Huttenhower C, Xavier RJ. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature. 2018 10; 562(7728):589-594.
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Lai BK, Chae H, Gómez-Ruiz A, Cheng P, Gallo P, Antoine N, Beauloye C, Jonas JC, Seghers V, Seino S, Gilon P. Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers. Diabetes. 2018 11; 67(11):2239-2253.
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Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, Antinozzi P, Sosenko J, Atkinson M, Pugliese A, Oram RA. A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk. Diabetes Care. 2018 09; 41(9):1887-1894.
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Farina M, Chua CYX, Ballerini A, Thekkedath U, Alexander JF, Rhudy JR, Torchio G, Fraga D, Pathak RR, Villanueva M, Shin CS, Niles JA, Sesana R, Demarchi D, Sikora AG, Acharya GS, Gaber AO, Nichols JE, Grattoni A. Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells. Biomaterials. 2018 09; 177:125-138.
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Sprouse ML, Scavuzzo MA, Blum S, Shevchenko I, Lee T, Makedonas G, Borowiak M, Bettini ML, Bettini M. High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity. JCI Insight. 2018 01 25; 3(2).
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