"Bryostatins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
| Descriptor ID |
D054713
|
| MeSH Number(s) |
D02.540.576.500.937
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Bryostatins".
Below are MeSH descriptors whose meaning is more specific than "Bryostatins".
This graph shows the total number of publications written about "Bryostatins" by people in this website by year, and whether "Bryostatins" was a major or minor topic of these publications.
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Below are the most recent publications written about "Bryostatins" by people in Profiles.
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Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. 2019 07 09; 58(27):3016-3030.
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A Phase II trial of bryostatin-1 for patients with metastatic renal cell carcinoma. Cancer. 2000 Aug 01; 89(3):615-8.
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Tumor promotion by depleting cells of protein kinase C delta. Mol Cell Biol. 1997 Jun; 17(6):3418-28.
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Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death. J Clin Invest. 1995 Oct; 96(4):1874-86.