alpha 1-Antitrypsin Deficiency
"alpha 1-Antitrypsin Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.
| Descriptor ID |
D019896
|
| MeSH Number(s) |
C06.552.074 C08.381.112 C16.320.060 C23.550.325.500.500
|
| Concept/Terms |
alpha 1-Antitrypsin Deficiency- alpha 1-Antitrypsin Deficiency
- Deficiencies, alpha 1-Antitrypsin
- Deficiency, alpha 1-Antitrypsin
- alpha 1 Antitrypsin Deficiency
- alpha 1-Antitrypsin Deficiencies
|
Below are MeSH descriptors whose meaning is more general than "alpha 1-Antitrypsin Deficiency".
Below are MeSH descriptors whose meaning is more specific than "alpha 1-Antitrypsin Deficiency".
This graph shows the total number of publications written about "alpha 1-Antitrypsin Deficiency" by people in this website by year, and whether "alpha 1-Antitrypsin Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 1998 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 2 | 3 |
| 2014 | 2 | 1 | 3 |
| 2015 | 3 | 1 | 4 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha 1-Antitrypsin Deficiency" by people in Profiles.
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Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance. Hepatol Commun. 2023 Dec 01; 7(12).
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Regulation of PGC1a Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant a1-Antitrypsin Deficiency Variant Z. Gastroenterology. 2022 07; 163(1):270-284.
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An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)-A systems biology approach. Adv Protein Chem Struct Biol. 2021; 127:315-342.
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Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin Deficiency. Am J Respir Crit Care Med. 2020 07 01; 202(1):73-82.
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An analog of glibenclamide selectively enhances autophagic degradation of misfolded a1-antitrypsin Z. PLoS One. 2019; 14(1):e0209748.
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An RNA structure-mediated, posttranscriptional model of human a-1-antitrypsin expression. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):E10244-E10253.
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A Rare Phenotype of Alpha-1-Antitrypsin Deficiency Owing to PI*IS in a Newborn With Liver Disease. J Pediatr Gastroenterol Nutr. 2017 11; 65(5):e112-e113.
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A Library of Rare a1-Antitrypsin (AAT) Variant Phenotypes to Aid in the Diagnosis of AAT Deficiency. Am J Clin Pathol. 2016 Sep; 146(3):289-93.
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Is severe progressive liver disease caused by alpha-1-antitrypsin deficiency more common in children or adults? Liver Transpl. 2016 07; 22(7):886-94.
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Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem. 2015 Dec 11; 290(50):29742-57.