"Werner Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease.
| Descriptor ID |
D014898
|
| MeSH Number(s) |
C16.320.925 C18.452.284.960
|
| Concept/Terms |
Werner Syndrome- Werner Syndrome
- Syndrome, Werner
- Adult Progeria
- Werner's Syndrome
- Syndrome, Werner's
- Werners Syndrome
- Syndrome, Werners
- Adult Premature Aging Syndrome
- Progeria, Adult
|
Below are MeSH descriptors whose meaning is more general than "Werner Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Werner Syndrome".
This graph shows the total number of publications written about "Werner Syndrome" by people in this website by year, and whether "Werner Syndrome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
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Below are the most recent publications written about "Werner Syndrome" by people in Profiles.
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Werner syndrome through the lens of tissue and tumour genomics. Sci Rep. 2016 08 25; 6:32038.
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The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle. 2011 Jun 15; 10(12):1998-2007.
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The Werner's Syndrome RecQ helicase/exonuclease at the nexus of cancer and aging. Hawaii Med J. 2011 Mar; 70(3):52-5.
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Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy. Cancer Biol Ther. 2010 Sep 01; 10(5):430-7.
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WRN at telomeres: implications for aging and cancer. J Cell Sci. 2007 Mar 01; 120(Pt 5):713-21.
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Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 2005 Nov 01; 19(21):2560-70.
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Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol. 2004 Oct; 24(19):8437-46.
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Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet. 2004 Aug; 36(8):877-82.
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An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum Genet. 1997 Dec; 101(2):121-5.
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Werner's syndrome. Dermatol Clin. 1995 Jan; 13(1):163-8.