Multiple Endocrine Neoplasia Type 2b
"Multiple Endocrine Neoplasia Type 2b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
| Descriptor ID |
D018814
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| MeSH Number(s) |
C04.588.322.400.510 C04.651.600.510 C04.700.630.510 C16.320.700.630.510 C19.344.400.510
|
| Concept/Terms |
Multiple Endocrine Neoplasia Type 2b- Multiple Endocrine Neoplasia Type 2b
- MEN2b
- Multiple Endocrine Neoplasms Type 2b
- Neoplasia, Multiple Endocrine Type 2b
- Neoplasms, Multiple Endocrine Type 2b
- Neuromata, Mucosal, With Endocrine Tumors
- Wagenmann-Froboese Syndrome
- Syndrome, Wagenmann-Froboese
- Wagenmann Froboese Syndrome
- Multiple Endocrine Neoplasia, Type IIb
- MEA 2b
- MEA IIb
- MEN 2b
- MEN 3
- MEN IIb
- MEN III
- Mucosal Neuroma Syndrome
- Mucosal Neuroma Syndromes
- Neuroma Syndrome, Mucosal
- Multiple Endocrine Neoplasia, Type 2b
|
Below are MeSH descriptors whose meaning is more general than "Multiple Endocrine Neoplasia Type 2b".
Below are MeSH descriptors whose meaning is more specific than "Multiple Endocrine Neoplasia Type 2b".
This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 2b" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 2b" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 2b" by people in Profiles.
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Genetic characterization of medullary thyroid cancer in childhood survivors of the Chernobyl accident. Surgery. 2019 01; 165(1):58-63.
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Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood. Clin Cancer Res. 2017 07 01; 23(13):e123-e132.
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Vandetanib successfully controls medullary thyroid cancer-related Cushing syndrome in an adolescent patient. J Clin Endocrinol Metab. 2014 Sep; 99(9):3055-9.
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Failure to recognize multiple endocrine neoplasia 2B: more common than we think? Ann Surg Oncol. 2008 Jan; 15(1):293-301.
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Genetic testing in endocrinology: lessons learned from experience with multiple endocrine neoplasia type 2 (MEN2). Growth Horm IGF Res. 2004 Jun; 14 Suppl A:S150-7.
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Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship. Arch Surg. 2003 Apr; 138(4):409-16; discussion 416.
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The surgical treatment of medullary thyroid carcinoma. Semin Surg Oncol. 1999 Jan-Feb; 16(1):50-63.
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Multiple endocrine neoplasia type II and familial medullary thyroid carcinoma. Impact of genetic screening on management. Cancer Treat Res. 1997; 89:421-41.
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RET protooncogene mutational analysis in multiple endocrine neoplasia syndrome type 2B: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Sep; 82(3):288-94.
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ret protooncogene mutations and endocrine neoplasia--a story intertwined with neural crest differentiation. Endocrinology. 1996 May; 137(5):1509-11.