Multiple Endocrine Neoplasia Type 2b
"Multiple Endocrine Neoplasia Type 2b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
| Descriptor ID |
D018814
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| MeSH Number(s) |
C04.588.322.400.510 C04.651.600.510 C04.700.630.510 C16.320.700.630.510 C19.344.400.510
|
| Concept/Terms |
Multiple Endocrine Neoplasia Type 2b- Multiple Endocrine Neoplasia Type 2b
- MEN2b
- Multiple Endocrine Neoplasms Type 2b
- Neoplasia, Multiple Endocrine Type 2b
- Neoplasms, Multiple Endocrine Type 2b
- Neuromata, Mucosal, With Endocrine Tumors
- Wagenmann-Froboese Syndrome
- Syndrome, Wagenmann-Froboese
- Wagenmann Froboese Syndrome
- Multiple Endocrine Neoplasia, Type IIb
- MEA 2b
- MEA IIb
- MEN 2b
- MEN 3
- MEN IIb
- MEN III
- Mucosal Neuroma Syndrome
- Mucosal Neuroma Syndromes
- Neuroma Syndrome, Mucosal
- Multiple Endocrine Neoplasia, Type 2b
|
Below are MeSH descriptors whose meaning is more general than "Multiple Endocrine Neoplasia Type 2b".
Below are MeSH descriptors whose meaning is more specific than "Multiple Endocrine Neoplasia Type 2b".
This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 2b" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 2b" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 2b" by people in Profiles.
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Efficacy and Safety of Selective RET Inhibitors in Patients with Advanced Hereditary Medullary Thyroid Carcinoma. Thyroid. 2025 Jan; 35(1):6-17.
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Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study. Lancet Diabetes Endocrinol. 2019 03; 7(3):213-220.
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Genetic characterization of medullary thyroid cancer in childhood survivors of the Chernobyl accident. Surgery. 2019 01; 165(1):58-63.
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A comprehensive review on MEN2B. Endocr Relat Cancer. 2018 02; 25(2):T29-T39.
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Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood. Clin Cancer Res. 2017 07 01; 23(13):e123-e132.
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Risk Profile of the RET A883F Germline Mutation: An International Collaborative Study. J Clin Endocrinol Metab. 2017 06 01; 102(6):2069-2074.
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Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid. 2015 Jun; 25(6):567-610.
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Vandetanib successfully controls medullary thyroid cancer-related Cushing syndrome in an adolescent patient. J Clin Endocrinol Metab. 2014 Sep; 99(9):3055-9.
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ER/PR positive epidermotropic primary cutaneous eccrine carcinoma as a cutaneous manifestation of MEN 2B. J Am Acad Dermatol. 2013 Dec; 69(6):e310-2.
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Multiple endocrine neoplasia type 2B with a RET proto-oncogene A883F mutation displays a more indolent form of medullary thyroid carcinoma compared with a RET M918T mutation. Thyroid. 2011 Feb; 21(2):189-92.