Multiple Endocrine Neoplasia Type 2a
"Multiple Endocrine Neoplasia Type 2a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
| Descriptor ID |
D018813
|
| MeSH Number(s) |
C04.588.322.400.505 C04.651.600.505 C04.700.630.505 C16.320.700.630.505 C19.344.400.505
|
| Concept/Terms |
Multiple Endocrine Neoplasia Type 2a- Multiple Endocrine Neoplasia Type 2a
- MEA II
- MEA IIa
- MEN 2
- MEN 2a
- MEN II
- MEN IIa
- MEN-2A Syndrome
- MEN 2A Syndrome
- MEN-2A Syndromes
- MEN2a
- Multiple Endocrine Neoplasia Type 2
- Multiple Endocrine Neoplasms Type 2a
- Neoplasia, Multiple Endocrine Type 2a
- Neoplasms, Multiple Endocrine Type 2a
- Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
- Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
- Sipple Syndrome
- Multiple Endocrine Neoplasia, Type IIa
- MEA 2a
|
Below are MeSH descriptors whose meaning is more general than "Multiple Endocrine Neoplasia Type 2a".
Below are MeSH descriptors whose meaning is more specific than "Multiple Endocrine Neoplasia Type 2a".
This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 2a" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 2a" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 2a" by people in Profiles.
-
Genetic characterization of medullary thyroid cancer in childhood survivors of the Chernobyl accident. Surgery. 2019 01; 165(1):58-63.
-
My, How Things Have Changed in Multiple Endocrine Neoplasia Type 2A! J Clin Endocrinol Metab. 2015 Jul; 100(7):2532-5.
-
Novel intra-adrenal secondary lymphoid follicle formation. Endocr Pathol. 2013 Dec; 24(4):248-9.
-
The characterization of pheochromocytoma and its impact on overall survival in multiple endocrine neoplasia type 2. J Clin Endocrinol Metab. 2013 Nov; 98(11):E1813-9.
-
Ultrasonography should not guide the timing of thyroidectomy in pediatric patients diagnosed with multiple endocrine neoplasia syndrome 2A through genetic screening. Ann Surg Oncol. 2013 Jan; 20(1):53-9.
-
Do the recent American Thyroid Association (ATA) Guidelines accurately guide the timing of prophylactic thyroidectomy in MEN2A? Surgery. 2010 Dec; 148(6):1302-9; discussion 1309-10.
-
Efficacy of 4D-CT preoperative localization in 2 patients with MEN 2A. J Surg Educ. 2008 May-Jun; 65(3):182-5.
-
Medullary thyroid cancer. Surg Oncol Clin N Am. 2006 Jul; 15(3):639-60.
-
Genetic testing in endocrinology: lessons learned from experience with multiple endocrine neoplasia type 2 (MEN2). Growth Horm IGF Res. 2004 Jun; 14 Suppl A:S150-7.
-
The role of genetics in the surgical management of familial endocrinopathy syndromes. J Am Coll Surg. 2003 Nov; 197(5):818-31.