Spinocerebellar Degenerations

"Spinocerebellar Degenerations" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A heterogenous group of degenerative syndromes marked by progressive cerebellar dysfunction either in isolation or combined with other neurologic manifestations. Sporadic and inherited subtypes occur. Inheritance patterns include autosomal dominant, autosomal recessive, and X-linked.

Descriptor ID	D013132
MeSH Number(s)	C10.228.140.252.700 C10.228.854.787 C10.574.500.825 C16.320.400.780
Concept/Terms	Spinocerebellar Degenerations Spinocerebellar Degenerations Degeneration, Spinocerebellar Degenerations, Spinocerebellar Spinocerebellar Diseases Spinocerebellar Disease Spinocerebellar Degeneration Spino Cerebellar Degenerations Degeneration, Spino Cerebellar Degenerations, Spino Cerebellar Spino Cerebellar Degeneration Spino-Cerebellar Degenerations Degeneration, Spino-Cerebellar Spino-Cerebellar Degeneration Cerebellar Ataxia, Early Onset Cerebellar Ataxia, Early Onset Early Onset Cerebellar Ataxia Marinesco-Sjogren Syndrome Marinesco-Sjogren Syndrome Marinesco Sjogren Syndrome Syndrome, Marinesco-Sjogren Hereditary Oligophrenic Cerebello-Lental Degeneration Hereditary Oligophrenic Cerebello Lental Degeneration Marinesco-Sjögren Syndrome Marinesco Sjögren Syndrome Syndrome, Marinesco-Sjögren Marinesco-Sjogren Syndrome-Hypergonadotrophic Hypogonadism Hypogonadism, Marinesco-Sjogren Syndrome-Hypergonadotrophic Marinesco Sjogren Syndrome Hypergonadotrophic Hypogonadism Syndrome-Hypergonadotrophic Hypogonadism, Marinesco-Sjogren Marinesco-Sjogren Syndrome-Myopathy Marinesco Sjogren Syndrome Myopathy Syndrome-Myopathy, Marinesco-Sjogren Marinesco-Sjogren-Garland Syndrome Marinesco Sjogren Garland Syndrome Syndrome, Marinesco-Sjogren-Garland Garland-Moorhouse Syndrome Garland Moorhouse Syndrome Syndrome, Garland-Moorhouse Marinesco-Garland Syndrome Marinesco Garland Syndrome Syndrome, Marinesco-Garland Cerebellar Degenerations, Primary Cerebellar Degenerations, Primary Cerebellar Degeneration, Primary Degeneration, Primary Cerebellar Degenerations, Primary Cerebellar Primary Cerebellar Degeneration Primary Cerebellar Degenerations Corticostriatal-Spinal Degeneration Corticostriatal-Spinal Degeneration Corticostriatal Spinal Degeneration Corticostriatal-Spinal Degenerations Degeneration, Corticostriatal-Spinal Degenerations, Corticostriatal-Spinal Marie Cerebellar Ataxia Marie Cerebellar Ataxia Cerebellar Ataxia, Marie Marie's Cerebellar Ataxia Cerebellar Ataxia, Marie's Ataxias, Hereditary Ataxias, Hereditary Ataxia, Hereditary Hereditary Ataxia Hereditary Ataxias Hereditary Spinocerebellar Degenerations Degeneration, Hereditary Spinocerebellar Degenerations, Hereditary Spinocerebellar Hereditary Spinocerebellar Degeneration Spinocerebellar Degeneration, Hereditary Spinocerebellar Degenerations, Hereditary Inherited Spinocerebellar Degenerations Degeneration, Inherited Spinocerebellar Degenerations, Inherited Spinocerebellar Inherited Spinocerebellar Degeneration Spinocerebellar Degeneration, Inherited Spinocerebellar Degenerations, Inherited Familial Spinocerebellar Degenerations Degeneration, Familial Spinocerebellar Degenerations, Familial Spinocerebellar Familial Spinocerebellar Degeneration Spinocerebellar Degeneration, Familial Spinocerebellar Degenerations, Familial Cerebellar Ataxia, Late Onset Cerebellar Ataxia, Late Onset Late Onset Cerebellar Ataxia

Below are MeSH descriptors whose meaning is more general than "Spinocerebellar Degenerations".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Cerebellar Diseases [C10.228.140.252]
Spinocerebellar Degenerations [C10.228.140.252.700]
Spinal Cord Diseases [C10.228.854]
Spinocerebellar Degenerations [C10.228.854.787]
Neurodegenerative Diseases [C10.574]
Heredodegenerative Disorders, Nervous System [C10.574.500]
Spinocerebellar Degenerations [C10.574.500.825]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Heredodegenerative Disorders, Nervous System [C16.320.400]
Spinocerebellar Degenerations [C16.320.400.780]

Below are MeSH descriptors whose meaning is related to "Spinocerebellar Degenerations".

Below are MeSH descriptors whose meaning is more specific than "Spinocerebellar Degenerations".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Spinocerebellar Degenerations" by people in this website by year, and whether "Spinocerebellar Degenerations" was a major or minor topic of these publications.

Bar chart showing 50 publications over 14 distinct years, with a maximum of 11 publications in 1995

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	4	1	5
1994	2	1	3
1995	10	1	11
1996	4	0	4
1997	5	1	6
1998	3	1	4
1999	4	0	4
2001	1	0	1
2002	1	2	3
2005	2	0	2
2012	1	0	1
2013	2	1	3
2018	2	0	2
2021	1	0	1

Below are the most recent publications written about "Spinocerebellar Degenerations" by people in Profiles.

Perez BA, Shorrock HK, Banez-Coronel M, Zu T, Romano LE, Laboissonniere LA, Reid T, Ikeda Y, Reddy K, Gomez CM, Bird T, Ashizawa T, Schut LJ, Brusco A, Berglund JA, Hasholt LF, Nielsen JE, Subramony SH, Ranum LP. CCG•CGG interruptions in high-penetrance SCA8 families increase RAN translation and protein toxicity. EMBO Mol Med. 2021 11 08; 13(11):e14095.

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Shashi V, Magiera MM, Klein D, Zaki M, Schoch K, Rudnik-Schöneborn S, Norman A, Lopes Abath Neto O, Dusl M, Yuan X, Bartesaghi L, De Marco P, Alfares AA, Marom R, Arold ST, Guzmán-Vega FJ, Pena LD, Smith EC, Steinlin M, Babiker MO, Mohassel P, Foley AR, Donkervoort S, Kaur R, Ghosh PS, Stanley V, Musaev D, Nava C, Mignot C, Keren B, Scala M, Tassano E, Picco P, Doneda P, Fiorillo C, Issa MY, Alassiri A, Alahmad A, Gerard A, Liu P, Yang Y, Ertl-Wagner B, Kranz PG, Wentzensen IM, Stucka R, Stong N, Allen AS, Goldstein DB, Schoser B, Rösler KM, Alfadhel M, Capra V, Chrast R, Strom TM, Kamsteeg EJ, Bönnemann CG, Gleeson JG, Martini R, Janke C, Senderek J. Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. EMBO J. 2018 12 03; 37(23).

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Ayhan F, Perez BA, Shorrock HK, Zu T, Banez-Coronel M, Reid T, Furuya H, Clark HB, Troncoso JC, Ross CA, Subramony SH, Ashizawa T, Wang ET, Yachnis AT, Ranum LP. SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. EMBO J. 2018 10 01; 37(19).

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Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5655-64.

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Subramony SH, Advincula J, Perlman S, Rosales RL, Lee LV, Ashizawa T, Waters MF. Comprehensive phenotype of the p.Arg420his allelic form of spinocerebellar ataxia type 13. Cerebellum. 2013 Dec; 12(6):932-6.

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Middlebrooks JC, Nick HS, Subramony SH, Advincula J, Rosales RL, Lee LV, Ashizawa T, Waters MF. Mutation in the kv3.3 voltage-gated potassium channel causing spinocerebellar ataxia 13 disrupts sound-localization mechanisms. PLoS One. 2013; 8(10):e76749.

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Craigen WJ, Graham BH, Wong LJ, Scaglia F, Lewis RA, Bonnen PE. Exome sequencing of a patient with suspected mitochondrial disease reveals a likely multigenic etiology. BMC Med Genet. 2013 Aug 16; 14:83.

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Waters MF, Subramony SH, Advincula J, Perlman S, Ashizawa T. Oculomotor and visual axis systems sparing in spinocerebellar ataxia type 13(R420H). Neurology. 2012 Sep 11; 79(11):1181-2.

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Zoghbi HY. SILencing misbehaving proteins. Nat Genet. 2005 Dec; 37(12):1302-3.

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Yu F, Sabeti PC, Hardenbol P, Fu Q, Fry B, Lu X, Ghose S, Vega R, Perez A, Pasternak S, Leal SM, Willis TD, Nelson DL, Belmont J, Gibbs RA. Positive selection of a pre-expansion CAG repeat of the human SCA2 gene. PLoS Genet. 2005 Sep; 1(3):e41.

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