Asparaginase

"Asparaginase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.

Descriptor ID	D001215
MeSH Number(s)	D08.811.277.087.116
Concept/Terms	Asparaginase Asparaginase Asparagine Deaminase Deaminase, Asparagine Colaspase Asparaginase II Erwinase Erwinase Paronal Paronal Crasnitin Crasnitin Kidrolase Kidrolase Leunase Elspar Elspar Asparaginase medac Asparaginase medac medac, Asparaginase

Below are MeSH descriptors whose meaning is more general than "Asparaginase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Amidohydrolases [D08.811.277.087]
Asparaginase [D08.811.277.087.116]

Below are MeSH descriptors whose meaning is related to "Asparaginase".

Below are MeSH descriptors whose meaning is more specific than "Asparaginase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Asparaginase" by people in this website by year, and whether "Asparaginase" was a major or minor topic of these publications.

Bar chart showing 60 publications over 23 distinct years, with a maximum of 7 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1992	0	1	1
1993	2	2	4
1995	0	2	2
1996	0	1	1
1998	0	1	1
1999	0	1	1
2002	0	1	1
2005	1	0	1
2006	1	0	1
2008	1	2	3
2009	1	3	4
2010	1	1	2
2011	1	1	2
2013	1	1	2
2014	5	2	7
2015	2	2	4
2016	1	1	2
2017	2	2	4
2018	1	2	3
2019	1	3	4
2020	1	3	4
2021	2	3	5
2022	0	1	1

Below are the most recent publications written about "Asparaginase" by people in Profiles.

Olayinka L, Poventud-Fuentes I, Rahman Ansari S, Garnett E, Devaraj S. True hyponatremia in the setting of pegasparagase-induced hypertriglyceridemia: A case report. Clin Chim Acta. 2022 Jun 01; 531:68-70.

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Butler M, van Ingen Schenau DS, Yu J, Jenni S, Dobay MP, Hagelaar R, Vervoort BMT, Tee TM, Hoff FW, Meijerink JP, Kornblau SM, Bornhauser B, Bourquin JP, Kuiper RP, van der Meer LT, van Leeuwen FN. BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway. Blood. 2021 12 09; 138(23):2383-2395.

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Koo G, Anvari S, Friedman DL, Zarnegar-Lumley S, Szafron V, Kahwash BM, Onasch KM, Hall L, Phillips EJ, Stone CA. mRNA COVID-19 vaccine safety in patients with previous immediate hypersensitivity to pegaspargase. J Allergy Clin Immunol Pract. 2022 01; 10(1):322-325.

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Gibson A, Hernandez C, Tejada FNH, Kawedia J, Rytting M, Cuglievan B. Asparaginase-Associated Pancreatitis in Pediatric Patients with Acute Lymphoblastic Leukemia: Current Perspectives. Paediatr Drugs. 2021 Sep; 23(5):457-463.

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Maese L, Rizzari C, Coleman R, Power A, van der Sluis I, Rau RE. Can recombinant technology address asparaginase Erwinia chrysanthemi shortages? Pediatr Blood Cancer. 2021 10; 68(10):e29169.

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Morita K, Jain N, Kantarjian H, Takahashi K, Fang H, Konopleva M, El Hussein S, Wang F, Short NJ, Maiti A, Sasaki K, Garcia-Manero G, Konoplev S, Ravandi F, Khoury JD, Jabbour E. Outcome of T-cell acute lymphoblastic leukemia/lymphoma: Focus on near-ETP phenotype and differential impact of nelarabine. Am J Hematol. 2021 05 01; 96(5):589-598.

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Koller PB, Zhang H, Kantarjian H, Jabbour E, Pierce S, Gocho Y, Roberts KG, Yang W, Mullighan CG, Yang J, Konopleva M, Jain N. GATA3 rs3824662A allele in B-cell acute lymphoblastic leukemia in adults, adolescents and young adults: association with CRLF2 rearrangement and poor prognosis. Am J Hematol. 2021 03 01; 96(3):E71-E74.

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Dunsmore KP, Winter SS, Devidas M, Wood BL, Esiashvili N, Chen Z, Eisenberg N, Briegel N, Hayashi RJ, Gastier-Foster JM, Carroll AJ, Heerema NA, Asselin BL, Rabin KR, Zweidler-Mckay PA, Raetz EA, Loh ML, Schultz KR, Winick NJ, Carroll WL, Hunger SP. Children's Oncology Group AALL0434: A Phase III Randomized Clinical Trial Testing Nelarabine in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia. J Clin Oncol. 2020 10 01; 38(28):3282-3293.

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Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM. Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children's Oncology Group AALL0434. J Clin Oncol. 2020 09 10; 38(26):3062-3070.

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Grimes AC, Chen Y, Bansal H, Aguilar C, Perez Prado L, Quezada G, Estrada J, Tomlinson GE. Genetic markers for treatment-related pancreatitis in a cohort of Hispanic children with acute lymphoblastic leukemia. Support Care Cancer. 2021 Feb; 29(2):725-731.

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