"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D008247
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| MeSH Number(s) |
A11.284.430.214.190.875.190.550
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in this website by year, and whether "Lysosomes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 2 | 1 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 3 | 4 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 3 | 5 |
| 2010 | 2 | 2 | 4 |
| 2011 | 4 | 2 | 6 |
| 2012 | 3 | 2 | 5 |
| 2013 | 5 | 6 | 11 |
| 2014 | 8 | 8 | 16 |
| 2015 | 7 | 2 | 9 |
| 2016 | 9 | 9 | 18 |
| 2017 | 7 | 3 | 10 |
| 2018 | 5 | 11 | 16 |
| 2019 | 10 | 4 | 14 |
| 2020 | 5 | 5 | 10 |
| 2021 | 1 | 7 | 8 |
| 2022 | 4 | 5 | 9 |
| 2023 | 4 | 9 | 13 |
| 2024 | 3 | 3 | 6 |
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Below are the most recent publications written about "Lysosomes" by people in Profiles.
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Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis. JCI Insight. 2024 Dec 19; 10(3).
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Investigating p.Ala1035Val in NPC1: New Cellular Models for Niemann-Pick Type C Disease. Int J Mol Sci. 2024 Nov 13; 25(22).
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Assessment of genes involved in lysosomal diseases using the ClinGen clinical validity framework. Mol Genet Metab. 2024 Nov; 143(3):108593.
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USF2 and TFEB compete in regulating lysosomal and autophagy genes. Nat Commun. 2024 Sep 27; 15(1):8334.
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Developing a scoring system for gene curation prioritization in lysosomal diseases. Mol Genet Metab. 2024 Sep-Oct; 143(1-2):108572.
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Dominantly acting variants in?ATP6V1C1?and?ATP6V1B2 cause a multisystem phenotypic spectrum by altering lysosomal and/or autophagosome function. HGG Adv. 2024 Oct 10; 5(4):100349.
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Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. Cell Death Dis. 2024 01 22; 15(1):80.
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TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nat Neurosci. 2024 Jan; 27(1):48-62.
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Inducible tricolor reporter mouse for parallel imaging of lysosomes, mitochondria, and microtubules. J Cell Biol. 2024 01 01; 223(1).
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TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression. EMBO J. 2023 11 02; 42(21):e113928.