RNA, Small Interfering

"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Descriptor ID	D034741
MeSH Number(s)	D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
Concept/Terms	RNA, Small Interfering RNA, Small Interfering Interfering RNA, Small Short Interfering RNA Interfering RNA, Short RNA, Short Interfering Small Interfering RNA siRNA Piwi-Interacting RNA Piwi-Interacting RNA Piwi Interacting RNA RNA, Piwi-Interacting RNA, Piwi Interacting piRNA Short Hairpin RNA Short Hairpin RNA Hairpin RNA, Short RNA, Short Hairpin Small Hairpin RNA Hairpin RNA, Small RNA, Small Hairpin shRNA Repeat-Associated siRNA Repeat-Associated siRNA Repeat Associated siRNA siRNA, Repeat-Associated siRNA, Repeat Associated Scan RNA Scan RNA scnRNA Small Scan RNA RNA, Small Scan Scan RNA, Small RNA, Scan Trans-Acting siRNA Trans-Acting siRNA Trans Acting siRNA tasiRNA siRNA, Trans-Acting siRNA, Trans Acting

Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Antisense Elements (Genetics) [D13.150]
RNA, Antisense [D13.150.650]
RNA, Small Interfering [D13.150.650.700]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Antisense [D13.444.735.150]
RNA, Small Interfering [D13.444.735.150.700]
RNA, Untranslated [D13.444.735.790]
RNA, Small Untranslated [D13.444.735.790.552]
RNA, Small Interfering [D13.444.735.790.552.875]

Below are MeSH descriptors whose meaning is related to "RNA, Small Interfering".

Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.

Bar chart showing 1171 publications over 21 distinct years, with a maximum of 113 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	2	3
2003	4	16	20
2004	2	39	41
2005	8	69	77
2006	6	59	65
2007	3	73	76
2008	11	86	97
2009	9	78	87
2010	12	101	113
2011	12	78	90
2012	6	82	88
2013	6	75	81
2014	9	65	74
2015	6	59	65
2016	6	45	51
2017	7	31	38
2018	6	39	45
2019	4	25	29
2020	1	14	15
2021	4	9	13
2022	0	3	3

Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.

Wei J, Song R, Sabbagh A, Marisetty A, Shukla N, Fang D, Najem H, Ott M, Long J, Zhai L, Lesniak MS, James CD, Platanias L, Curran M, Heimberger AB. Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system. Oncoimmunology. 2022; 11(1):2062827.

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Kodali S, Li M, Budai MM, Chen M, Wang J. Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy. J Immunol. 2022 03 01; 208(5):1085-1098.

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Kara G, Calin GA, Ozpolat B. RNAi-based therapeutics and tumor targeted delivery in cancer. Adv Drug Deliv Rev. 2022 03; 182:114113.

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Sas DJ, Magen D, Hayes W, Shasha-Lavsky H, Michael M, Schulte I, Sellier-Leclerc AL, Lu J, Seddighzadeh A, Habtemariam B, McGregor TL, Fujita KP, Frishberg Y. Phase 3 trial of lumasiran for primary hyperoxaluria type 1: A new RNAi therapeutic in infants and young children. Genet Med. 2022 03; 24(3):654-662.

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Shaikh A, Neeli PK, Singuru G, Panangipalli S, Banerjee R, Maddi SR, Thennati R, Bathula SR, Kotamraju S. A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent. Chem Commun (Camb). 2021 Nov 19; 57(92):12329-12332.

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Fekadu S, Kanehiro Y, Kartika AV, Hamada K, Sakurai N, Mizote T, Akada J, Yamaoka Y, Iizasa H, Yoshiyama H. Gastric epithelial attachment of Helicobacter pylori induces EphA2 and NMHC-IIA receptors for Epstein-Barr virus. Cancer Sci. 2021 Nov; 112(11):4799-4811.

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Marom R, Burrage LC, Venditti R, Clément A, Blanco-Sánchez B, Jain M, Scott DA, Rosenfeld JA, Sutton VR, Shinawi M, Mirzaa G, DeVile C, Roberts R, Calder AD, Allgrove J, Grafe I, Lanza DG, Li X, Joeng KS, Lee YC, Song IW, Sliepka JM, Batkovskyte D, Washington M, Dawson BC, Jin Z, Jiang MM, Chen S, Chen Y, Tran AA, Emrick LT, Murdock DR, Hanchard NA, Zapata GE, Mehta NR, Weis MA, Scott AA, Tremp BA, Phillips JB, Wegner J, Taylor-Miller T, Gibbs RA, Muzny DM, Jhangiani SN, Hicks J, Stottmann RW, Dickinson ME, Seavitt JR, Heaney JD, Eyre DR, Westerfield M, De Matteis MA, Lee B. COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay. Am J Hum Genet. 2021 09 02; 108(9):1710-1724.

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Popli P, Shukla V, Kaushal JB, Kumar R, Gupta K, Dwivedi A. Peroxiredoxin 6 Plays Essential Role in Mediating Fertilization and Early Embryonic Development in Rabbit Oviduct. Reprod Sci. 2022 05; 29(5):1560-1576.

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Santiago-Sánchez GS, Noriega-Rivera R, Hernández-O'Farrill E, Valiyeva F, Quiñones-Diaz B, Villodre ES, Debeb BG, Rosado-Albacarys A, Vivas-Mejía PE. Targeting Lipocalin-2 in Inflammatory Breast Cancer Cells with Small Interference RNA and Small Molecule Inhibitors. Int J Mol Sci. 2021 Aug 10; 22(16).

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Goodman LD, Cope H, Nil Z, Ravenscroft TA, Charng WL, Lu S, Tien AC, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, van Binsbergen E, Kirmse B, Robinette B, Cogné B, Isidor B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Si Y, Begtrup A, Moulton MJ, Dutta D, Kanca O, Wangler MF, Yamamoto S, Bellen HJ, Tan QK. TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. Am J Hum Genet. 2021 09 02; 108(9):1669-1691.

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