"Receptor, EphA2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An Eph family receptor found abundantly in tissues of epithelial origin. It is expressed in a diverse array of tissues during embryonic development, suggesting that it may play a role in embryogenesis. In adult tissues high levels of the receptor are expressed in the LUNG; SKIN; SMALL INTESTINE and OVARY.
| Descriptor ID |
D036104
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.850.100 D12.776.543.750.630.500.100
|
| Concept/Terms |
Receptor, EphA2- Receptor, EphA2
- Epithelial Cell Kinase Protein
- EphA2 Receptor
- EphA2-Tyrosine Kinase
- EphA2 Tyrosine Kinase
- EphA2 Receptor Tyrosine Kinase
- EphA2 Protein
- Mammary-Derived Tyrosine Kinase 2
- Mammary Derived Tyrosine Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "Receptor, EphA2".
Below are MeSH descriptors whose meaning is more specific than "Receptor, EphA2".
This graph shows the total number of publications written about "Receptor, EphA2" by people in this website by year, and whether "Receptor, EphA2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptor, EphA2" by people in Profiles.
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Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology. Proc Natl Acad Sci U S A. 2024 May 07; 121(19):e2322934121.
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Gastric epithelial attachment of Helicobacter pylori induces EphA2 and NMHC-IIA receptors for Epstein-Barr virus. Cancer Sci. 2021 Nov; 112(11):4799-4811.
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Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas. J Immunother Cancer. 2021 05; 9(5).
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Phosphorylation of PLC?1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer. Mol Cancer Res. 2020 11; 18(11):1735-1743.
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Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma. Neuro Oncol. 2018 03 27; 20(4):506-518.
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The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. Sci Signal. 2017 Dec 05; 10(508).
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The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer. Cancer Res. 2016 04 01; 76(7):1825-36.
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miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene. Carcinogenesis. 2015 Sep; 36(9):1051-60.
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Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype. Cancer Discov. 2015 Mar; 5(3):264-73.
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Cross-talk between EphA2 and BRaf/CRaf is a key determinant of response to Dasatinib. Clin Cancer Res. 2014 Apr 01; 20(7):1846-55.