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RONALD PARCHEM

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


    Collapse Research 
    Collapse research activities and funding
    R01HD098131     (PARCHEM, RONALD J)Mar 10, 2020 - Feb 28, 2025
    NIH
    MicroRNA regulation of neural tube closure
    Role: Principal Investigator
    R01HD099252     (PARCHEM, RONALD J)Aug 1, 2019 - May 31, 2025
    NIH
    MicroRNA regulation of neural crest differentiation
    Role: Principal Investigator
    F32HD070572     (PARCHEM, RONALD J)Sep 30, 2012 - Sep 29, 2014
    NIH
    P0044380 Parchem - Role of Small RNA's in Development
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ye J, Boileau RM, Parchem RJ, Judson-Torres RL, Blelloch R. The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells. bioRxiv. 2024 Sep 03. PMID: 39282363; PMCID: PMC11398367.
      Citations:    
    2. Reyes JM, Tovy A, Zhang L, Bortoletto AS, Rosas C, Chen CW, Waldvogel SM, Guzman AG, Aguilar R, Gupta S, Liu L, Buckley MT, Patel KR, Marcogliese AN, Li Y, Curry CV, Rando TA, Brunet A, Parchem RJ, Rau RE, Goodell MA. Erratum: Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation. iScience. 2024 Jul 19; 27(7):110313. PMID: 39027369; PMCID: PMC11255835.
      Citations:    
    3. Reyes JM, Tovy A, Zhang L, Bortoletto AS, Rosas C, Chen CW, Waldvogel SM, Guzman AG, Aguilar R, Gupta S, Liu L, Buckley MT, Patel KR, Marcogliese AN, Li Y, Curry CV, Rando T, Brunet A, Parchem RJ, Rau RE, Goodell MA, Rando TA. Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation. iScience. 2024 Mar 15; 27(3):109122. PMID: 38414863; PMCID: PMC10897855.
      Citations: 2     
    4. Cermakova K, Tao L, Dejmek M, Sala M, Montierth MD, Chan YS, Patel I, Chambers C, Loeza Cabrera M, Hoffman D, Parchem RJ, Wang W, Nencka R, Barbieri E, Hodges HC. Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF. Nucleic Acids Res. 2024 Jan 11; 52(1):4-21. PMID: 37993417; PMCID: PMC10783513.
      Citations:    Fields:    
    5. Bortoletto AS, Parchem RJ. A pancreatic player in dementia: pathological role for islet amyloid polypeptide accumulation in the brain. Neural Regen Res. 2023 Oct; 18(10):2141-2146. PMID: 37056121; PMCID: PMC10328265.
      Citations:    
    6. Keuls RA, Finnell RH, Parchem RJ. Maternal metabolism influences neural tube closure. Trends Endocrinol Metab. 2023 09; 34(9):539-553. PMID: 37468429; PMCID: PMC10529122.
      Citations: 2     Fields:    Translation:Humans
    7. Bortoletto AS, Parchem RJ. KRAS Hijacks the miRNA Regulatory Pathway in Cancer. Cancer Res. 2023 05 15; 83(10):1563-1572. PMID: 36946612; PMCID: PMC10183808.
      Citations: 3     Fields:    Translation:Humans
    8. Yang ZZ, Parchem RJ. The role of noncoding RNAs in pancreatic birth defects. Birth Defects Res. 2023 11 15; 115(19):1785-1808. PMID: 37066622; PMCID: PMC10579456.
      Citations:    Fields:    
    9. Keuls RA, Oh YS, Patel I, Parchem RJ. Post-transcriptional regulation in cranial neural crest cells expands developmental potential. Proc Natl Acad Sci U S A. 2023 02 07; 120(6):e2212578120. PMID: 36724256; PMCID: PMC9963983.
      Citations: 1     Fields:    Translation:Cells
    10. Bortoletto AS, Graham WV, Trout G, Bonito-Oliva A, Kazmi MA, Gong J, Weyburne E, Houser BL, Sakmar TP, Parchem RJ. Human Islet Amyloid Polypeptide (hIAPP) Protofibril-Specific Antibodies for Detection and Treatment of Type 2 Diabetes. Adv Sci (Weinh). 2022 12; 9(34):e2202342. PMID: 36257905; PMCID: PMC9731688.
      Citations: 2     Fields:    
    11. Gonz?lez Corona C, Parchem RJ. Maternal diabetes negatively impacts fetal health. Open Biol. 2022 09; 12(9):220135. PMID: 36128718; PMCID: PMC9490340.
      Citations:    
    12. Patel I, Parchem RJ. Regulation of Oct4 in stem cells and neural crest cells. Birth Defects Res. 2022 10 01; 114(16):983-1002. PMID: 35365980; PMCID: PMC9525453.
      Citations:    Fields:    
    13. Tao L, Moreno-Smith M, Milazzo G, Drolet NA, Hernandez BE, Oh YS, Patel I, Kim JJ, Zorman B, Patel T, Kamal AHM, Zhao Y, Hicks J, Vasudevan SA, Putluri N, Coarfa C, Sumazin P, Perini G, Parchem RJ, Uribe RA, Barbieri E, Ibarra-Garc?a-Padilla R. CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming. Adv Sci (Weinh). 2021 10; 8(19):e2005047. PMID: 34365742; PMCID: PMC8498874.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    14. Keuls RA, Parchem RJ. Single-Cell Multiomic Approaches Reveal Diverse Labeling of the Nervous System by Common Cre-Drivers. Front Cell Neurosci. 2021; 15:648570. PMID: 33935652; PMCID: PMC8079645.
      Citations: 1     
    15. Keuls RA, Kojima K, Lozzi B, Steele JW, Chen Q, Gross SS, Finnell RH, Parchem RJ. MiR-302 Regulates Glycolysis to Control Cell-Cycle during Neural Tube Closure. Int J Mol Sci. 2020 Oct 13; 21(20). PMID: 33066028; PMCID: PMC7589003.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Keuls RA, Parchem R. Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos. J Vis Exp. 2020 10 09; (164). PMID: 33104065.
      Citations:    Fields:    Translation:Animals
    17. Bonito-Oliva A, Schedin-Weiss S, Younesi SS, Tiiman A, Adura C, Paknejad N, Brendel M, Romin Y, Parchem RJ, Graff C, Vukojevic V, Tjernberg LO, Terenius L, Winblad B, Sakmar TP, Graham WV. Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen. J Cell Mol Med. 2019 03; 23(3):2103-2114. PMID: 30663210; PMCID: PMC6378190.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    18. Krishnakumar R, Chen AF, Pantovich MG, Danial M, Parchem RJ, Labosky PA, Blelloch R. FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity. Cell Stem Cell. 2018 Aug 02; 23(2):306-307. PMID: 30075131.
      Citations: 1     Fields:    
    19. Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. Stem Cells. 2016 07; 34(7):1985-91. PMID: 27066911; PMCID: PMC5145290.
      Citations: 12     Fields:    Translation:HumansCells
    20. Krishnakumar R, Chen AF, Pantovich MG, Danial M, Parchem RJ, Labosky PA, Blelloch R. FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity. Cell Stem Cell. 2016 Jan 07; 18(1):104-17. PMID: 26748757; PMCID: PMC4775235.
      Citations: 40     Fields:    Translation:AnimalsCells
    21. Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein JL, Schneider RA, Blelloch R. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep. 2015 Aug 04; 12(5):760-73. PMID: 26212322; PMCID: PMC4741278.
      Citations: 44     Fields:    Translation:AnimalsCells
    22. Parchem RJ, Ye J, Judson RL, LaRussa MF, Krishnakumar R, Blelloch A, Oldham MC, Blelloch R. Two miRNA clusters reveal alternative paths in late-stage reprogramming. Cell Stem Cell. 2014 May 01; 14(5):617-31. PMID: 24630794; PMCID: PMC4305531.
      Citations: 48     Fields:    Translation:Animals
    23. Judson RL, Greve TS, Parchem RJ, Blelloch R. MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat Struct Mol Biol. 2013 Oct; 20(10):1227-35. PMID: 24037508; PMCID: PMC3955211.
      Citations: 30     Fields:    Translation:AnimalsCells
    24. Hannibal RL, Price AL, Parchem RJ, Patel NH. Analysis of snail genes in the crustacean Parhyale hawaiensis: insight into snail gene family evolution. Dev Genes Evol. 2012 May; 222(3):139-51. PMID: 22466422.
      Citations: 3     Fields:    Translation:Animals
    25. Vargas-Vila MA, Hannibal RL, Parchem RJ, Liu PZ, Patel NH. A prominent requirement for single-minded and the ventral midline in patterning the dorsoventral axis of the crustacean Parhyale hawaiensis. Development. 2010 Oct; 137(20):3469-76. PMID: 20843860; PMCID: PMC2947759.
      Citations: 15     Fields:    Translation:Animals
    26. Parchem RJ, Poulin F, Stuart AB, Amemiya CT, Patel NH. BAC library for the amphipod crustacean, Parhyale hawaiensis. Genomics. 2010 May; 95(5):261-7. PMID: 20298775; PMCID: PMC5105605.
      Citations: 8     Fields:    Translation:AnimalsCells
    27. Parchem RJ, Perry MW, Patel NH. Patterns on the insect wing. Curr Opin Genet Dev. 2007 Aug; 17(4):300-8. PMID: 17627807.
      Citations: 15     Fields:    Translation:Animals
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