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JOANNA STEPHANIE YI

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Oncology
AddressOne Baylor Plaza
Houston TX 77030
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    Collapse awards and honors
    2008 - 2008Norma K. C. Ramsey Award of Excellence for the Most Outstanding Resident in Pediatric Heme/Onc/BMT, University of Minnesota Pediatrics Department
    2010 - 2010Susan Vincent Outstanding Resident Teaching Award, University of Minnesota Pediatrics Department
    2012 - 2017Loan Repayment Program, NIH
    2014 - 2014Abstract Achievement Award, American Society of Hematology

    Collapse Overview 
    Collapse overview
    Dr. Joanna Yi is a member of Texas Children's Cancer Center's Developmental Therapeutics Program, Leukemia, and Neuroblastoma Teams. Her translational research focuses on the pre-clinical identification and development of new, targeted small molecules for the treatment of childhood cancers with the purpose of evaluating them in clinical trials. She is especially interested in epigenetic drugs and combining them with other active agents.

    Dr. Yi wants to discover new, less toxic, targeted drugs by combining the translational drug discovery techniques of the Center for Drug Discovery at Baylor College of Medicine, with the clinical developmental therapeutics program of Texas Children’s Cancer and Hematology Centers. In the laboratory, Dr. Yi is working with investigators in the cancer center to identify and characterize small molecules with clinical promise in challenging pediatric cancers. She also is developing tests of “on-target” effect of these compounds to be used in clinical trials and evaluating the targeted small molecules in combination with other active agents to identify the best combinations to move forwards to clinical trials.

    Collapse keywords
    drug discovery
    early phase clinical trials
    chromatin
    epigenetic
    targeted small molecules
    Pediatric oncology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bieerkehazhi S, Chen Z, Zhao Y, Yu Y, Zhang H, Vasudevan SA, Woodfield SE, Tao L, Yi JS, Muscal JA, Pang JC, Guan S, Zhang H, Nuchtern JG, Li H, Li H, Yang J. Novel Src/Abl tyrosine kinase inhibitor bosutinib suppresses neuroblastoma growth via inhibiting Src/Abl signaling. Oncotarget. 2017 Jan 03; 8(1):1469-1480. PMID: 27903968.
      View in: PubMed
    2. Lu J, Guan S, Zhao Y, Yu Y, Wang Y, Shi Y, Mao X, Yang KL, Sun W, Xu X, Yi JS, Yang T, Yang J, Nuchtern JG. Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma. Oncotarget. 2016 Dec 13; 7(50):82757-82769. PMID: 27764791.
      View in: PubMed
    3. Yi JS, Kamihara J, Kesselheim JC, Davies K, van Hoff J, Silverman LB, Mullen EA. Synchronous occurrence of acute lymphoblastic leukemia and wilms tumor in two patients: underlying etiology and combined treatment plan. Pediatr Blood Cancer. 2016 Nov 15. PMID: 27862952.
      View in: PubMed
    4. Chen Z, Wang Z, Pang JC, Yu Y, Bieerkehazhi S, Lu J, Hu T, Zhao Y, Xu X, Zhang H, Yi JS, Liu S, Yang J. Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep. 2016; 6:29090. PMID: 27378523; PMCID: PMC4932496.
    5. Green AL, Yi J, Bezler N, Pikman Y, Tubman VN, Obeng EA, O'Neil T, Mersereau R, Morrissey L, Billett AL. A Prospective Cohort Quality Improvement Study to Reduce the Time to Antibiotics for New Fever in Neutropenic Pediatric Oncology Inpatients. Pediatr Blood Cancer. 2016 Jan; 63(1):112-7. PMID: 26292080.
      View in: PubMed
    6. Yi JS, Federation AJ, Qi J, Dhe-Paganon S, Hadler M, Xu X, St Pierre R, Varca AC, Wu L, Marineau JJ, Smith WB, Souza A, Chory EJ, Armstrong SA, Bradner JE. Structure-guided DOT1L probe optimization by label-free ligand displacement. ACS Chem Biol. 2015 Mar 20; 10(3):667-74. PMID: 25397901.
      View in: PubMed
    7. Fritch Lilla SA, Yi JS, Hall BA, Moertel CL. A novel APC gene mutation associated with a severe phenotype in a patient with Turcot syndrome. J Pediatr Hematol Oncol. 2014 Apr; 36(3):e177-9. PMID: 24309598.
      View in: PubMed
    8. Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun. 2012; 3:1288. PMID: 23250418.
      View in: PubMed
    9. Yi JS, Moertel CL, Baker KS. Homozygous alpha-thalassemia treated with intrauterine transfusions and unrelated donor hematopoietic cell transplantation. J Pediatr. 2009 May; 154(5):766-8. PMID: 19364562.
      View in: PubMed
    10. Serra A, Brozoski D, Simeon T, Yi J, Bastasic J, Franciosi R, Jacobs ER, Forster HV. Serotonin and serotonin receptor expression in the aorta of carotid intact and denervated newborns. Respir Physiol Neurobiol. 2002 Sep 4; 132(3):253-64. PMID: 12208084.
      View in: PubMed
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