Dr. Joanna Yi is a member of Texas Children's Cancer Center's Developmental Therapeutics and Leukemia Teams. Her translational research focuses on the pre-clinical identification and development of new, targeted small molecules for the treatment of childhood cancers with the purpose of evaluating them in early phase clinical trials. She is especially interested in epigenetic drugs and combining them with other active agents.
Dr. Yi wants to discover new, less toxic, targeted drugs by combining the translational drug discovery techniques of the Center for Drug Discovery at Baylor College of Medicine, with the clinical developmental therapeutics program of Texas Children’s Cancer and Hematology Centers. In the laboratory, Dr. Yi is working with TCH and BCM investigators in the cancer center to identify and characterize small molecules with clinical promise in challenging pediatric cancers. She also is developing tests of “on-target” effect of these compounds to be used in clinical trials and evaluating the targeted small molecules in combination with other active agents to identify the best combinations to move forwards to clinical trials. Her lab is also studying the transcriptional control of pediatric leukemias to find new, druggable targets.