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JIANJUN SHEN

TitleProfessor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
AddressPO Box 389
Smithville TX 78957-0389
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Abba MC, Gong T, Lu Y, Lee J, Zhong Y, Lacunza E, Butti M, Takata Y, Gaddis S, Shen J, Estecio MR, Sahin AA, Aldaz CM. A Molecular Portrait of High-Grade Ductal Carcinoma In Situ. Cancer Res. 2015 Sep 15; 75(18):3980-90. PMID: 26249178.
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    2. Simper MS, Rundhaug JE, Mikulec C, Bowen R, Shen J, Lu Y, Lin K, Surh I, Fischer SM. The tumor promoting activity of the EP4 receptor for prostaglandin E2 in murine skin. Mol Oncol. 2014 Dec; 8(8):1626-39. PMID: 25034079.
      View in: PubMed
    3. Liu B, Badeaux MD, Choy G, Chandra D, Shen I, Jeter CR, Rycaj K, Lee CF, Person MD, Liu C, Chen Y, Shen J, Jung SY, Qin J, Tang DG. Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species. PLoS One. 2014; 9(3):e90615. PMID: 24598770; PMCID: PMC3944193.
    4. Xia X, Liu S, Xiao Z, Zhu F, Song NY, Zhou M, Liu B, Shen J, Nagashima K, Veenstra TD, Burkett S, Datla M, Willette-Brown J, Shen H, Hu Y. An IKK?-nucleophosmin axis utilizes inflammatory signaling to promote genome integrity. Cell Rep. 2013 Dec 12; 5(5):1243-55. PMID: 24290756; PMCID: PMC4159076.
    5. Shen J, Abel EL, Riggs PK, Repass J, Hensley SC, Schroeder LJ, Temple A, Chau A, McClellan SA, Rho O, Kiguchi K, Ward MD, Semmes OJ, Person MD, Angel JM, Digiovanni J. Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice. Carcinogenesis. 2012 Nov; 33(11):2208-19. PMID: 22782996.
      View in: PubMed
    6. Wang-Johanning F, Rycaj K, Plummer JB, Li M, Yin B, Frerich K, Garza JG, Shen J, Lin K, Yan P, Glynn SA, Dorsey TH, Hunt KK, Ambs S, Johanning GL. Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors. J Natl Cancer Inst. 2012 Feb 8; 104(3):189-210. PMID: 22247020; PMCID: PMC3274512.
    7. Blando J, Moore T, Hursting S, Jiang G, Saha A, Beltran L, Shen J, Repass J, Strom S, DiGiovanni J. Dietary energy balance modulates prostate cancer progression in Hi-Myc mice. Cancer Prev Res (Phila). 2011 Dec; 4(12):2002-14. PMID: 21952584; PMCID: PMC4171652.
    8. Benavides F, Perez C, Blando J, Contreras O, Shen J, Coussens LM, Fischer SM, Kusewitt DF, DiGiovanni J, Conti CJ. Protective role of cathepsin L in mouse skin carcinogenesis. Mol Carcinog. 2012 Apr; 51(4):352-61. PMID: 21538579.
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    9. Jeter CR, Liu B, Liu X, Chen X, Liu C, Calhoun-Davis T, Repass J, Zaehres H, Shen JJ, Tang DG. NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene. 2011 Sep 8; 30(36):3833-45. PMID: 21499299; PMCID: PMC3140601.
    10. Yan L, Della Coletta L, Powell KL, Shen J, Thames H, Aldaz CM, MacLeod MC. Activation of the canonical Wnt/?-catenin pathway in ATF3-induced mammary tumors. PLoS One. 2011; 6(1):e16515. PMID: 21304988; PMCID: PMC3031586.
    11. Short JD, Dere R, Houston KD, Cai SL, Kim J, Bergeron JM, Shen J, Liang J, Bedford MT, Mills GB, Walker CL. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog. 2010 May; 49(5):429-39. PMID: 20146253; PMCID: PMC3818129.
    12. Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4153-8. PMID: 20160076.
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    13. Shen J, Fischer SM. Molecular profiling of the epidermis: a proteomics approach. Methods Mol Biol. 2010; 585:225-52. PMID: 19908007.
      View in: PubMed
    14. Kuang X, Shen J, Wong PK, Yan M. Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm-/- mice. Biochem Biophys Res Commun. 2009 Jun 5; 383(3):368-72. PMID: 19364503.
      View in: PubMed
    15. Short JD, Houston KD, Dere R, Cai SL, Kim J, Johnson CL, Broaddus RR, Shen J, Miyamoto S, Tamanoi F, Kwiatkowski D, Mills GB, Walker CL. AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res. 2008 Aug 15; 68(16):6496-506. PMID: 18701472; PMCID: PMC3011867.
    16. Bhatia B, Multani AS, Patrawala L, Chen X, Calhoun-Davis T, Zhou J, Schroeder L, Schneider-Broussard R, Shen J, Pathak S, Chang S, Tang DG. Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT. Int J Cancer. 2008 Apr 1; 122(7):1483-95. PMID: 18059027.
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    17. Yan M, Shen J, Person MD, Kuang X, Lynn WS, Atlas D, Wong PK. Endoplasmic reticulum stress and unfolded protein response in Atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidative stress. Neoplasia. 2008 Feb; 10(2):160-7. PMID: 18283338.
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    18. Park E, Zhu F, Liu B, Xia X, Shen J, Bustos T, Fischer SM, Hu Y. Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. Cancer Res. 2007 Oct 1; 67(19):9158-68. PMID: 17909021.
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    19. Fan T, Li R, Todd NW, Qiu Q, Fang HB, Wang H, Shen J, Zhao RY, Caraway NP, Katz RL, Stass SA, Jiang F. Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target. Cancer Res. 2007 Aug 15; 67(16):7901-6. PMID: 17699796.
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    20. Chan KS, Sano S, Kataoka K, Abel E, Carbajal S, Beltran L, Clifford J, Peavey M, Shen J, Digiovanni J. Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis. Oncogene. 2008 Feb 14; 27(8):1087-94. PMID: 17700521.
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    21. Morrison AJ, Kim JA, Person MD, Highland J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman JS, Delrow J, Krogan NJ, Haber JE, Shen X. Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell. 2007 Aug 10; 130(3):499-511. PMID: 17693258.
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    22. Zhu F, Xia X, Liu B, Shen J, Hu Y, Person M, Hu Y. IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. Mol Cell. 2007 Jul 20; 27(2):214-27. PMID: 17643371.
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    23. Shen J, Riggs PK, Hensley SC, Schroeder LJ, Traner AR, Kochan KJ, Person MD, DiGiovanni J. Differential expression of multiple anti-apoptotic proteins in epidermis of IGF-1 transgenic mice as revealed by 2-dimensional gel electrophoresis/mass spectrometry analysis. Mol Carcinog. 2007 May; 46(5):331-40. PMID: 17330866.
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    24. Yan M, Kuang X, Scofield VL, Shen J, Lynn WS, Wong PK. The glucocorticoid receptor is increased in Atm-/- thymocytes and in Atm-/- thymic lymphoma cells, and its nuclear translocation counteracts c-myc expression. Steroids. 2007 May; 72(5):415-21. PMID: 17418878.
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    25. Shen J, Pavone A, Mikulec C, Hensley SC, Traner A, Chang TK, Person MD, Fischer SM. Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometry. J Proteome Res. 2007 Jan; 6(1):273-86. PMID: 17203971.
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    26. Liu B, Park E, Zhu F, Bustos T, Liu J, Shen J, Fischer SM, Hu Y. A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17202-7. PMID: 17079494.
      View in: PubMed
    27. Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol. 2006 Apr 24; 173(2):279-89. PMID: 16636147; PMCID: PMC2063818.
    28. Person MD, Shen J, Traner A, Hensley SC, Lo HH, Abbruzzese JL, Li D. Protein fragment domains identified using 2D gel electrophoresis/MALDI-TOF. J Biomol Tech. 2006 Apr; 17(2):145-56. PMID: 16741242; PMCID: PMC2291776.
    29. Shen J, Person MD, Zhu J, Abbruzzese JL, Li D. Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res. 2004 Dec 15; 64(24):9018-26. PMID: 15604267.
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    30. Soliman AS, Vulimiri SV, Kleiner HE, Shen J, Eissa S, Morad M, Taha H, Lukmanji F, Li D, Johnston DA, Lo HH, Lau S, Digiovanni J, Bondy ML. High levels of oxidative DNA damage in lymphocyte DNA of premenopausal breast cancer patients from Egypt. Int J Environ Health Res. 2004 Apr; 14(2):121-34. PMID: 15203457.
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    31. Yadav N, Lee J, Kim J, Shen J, Hu MC, Aldaz CM, Bedford MT. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6464-8. PMID: 12756295; PMCID: PMC164469.
    32. Lopes EC, Garcia M, Benavides F, Shen J, Conti CJ, Alvarez E, Hajos SE. Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype. Leuk Res. 2003 May; 27(5):413-23. PMID: 12620293.
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    33. Liu JW, Shen JJ, Tanzillo-Swarts A, Bhatia B, Maldonado CM, Person MD, Lau SS, Tang DG. Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration. Oncogene. 2003 Mar 13; 22(10):1475-85. PMID: 12629510.
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    34. Kochan KJ, Wright DA, Schroeder LJ, Shen J, Morizot DC. Genetic linkage maps of the West African clawed frog Xenopus tropicalis. Dev Dyn. 2003 Jan; 226(1):99-102. PMID: 12508229.
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    35. Yan M, Kuang X, Qiang W, Shen J, Claypool K, Lynn WS, Wong PK. Prevention of thymic lymphoma development in Atm-/- mice by dexamethasone. Cancer Res. 2002 Sep 15; 62(18):5153-7. PMID: 12234978.
      View in: PubMed
    36. Vanzulli S, Efeyan A, Benavides F, Helguero LA, Peters G, Shen J, Conti CJ, Lanari C, Molinolo A. p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas. Carcinogenesis. 2002 May; 23(5):749-58. PMID: 12016147.
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    37. Shen JJ, Chen YT. Molecular characterization of glycogen storage disease type III. Curr Mol Med. 2002 Mar; 2(2):167-75. PMID: 11949933.
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    38. Tang S, Bhatia B, Maldonado CJ, Yang P, Newman RA, Liu J, Chandra D, Traag J, Klein RD, Fischer SM, Chopra D, Shen J, Zhau HE, Chung LW, Tang DG. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. J Biol Chem. 2002 May 3; 277(18):16189-201. PMID: 11839751.
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    39. Li D, Firozi PF, Zhang W, Shen J, DiGiovanni J, Lau S, Evans D, Friess H, Hassan M, Abbruzzese JL. DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer. Mutat Res. 2002 Jan 15; 513(1-2):37-48. PMID: 11719088.
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    40. Xu H, Shen J, Walker CL, Kleymenova E. Tissue-specific expression and splicing of the rat polycystic kidney disease 1 gene. DNA Seq. 2001 Dec; 12(5-6):361-6. PMID: 11913782.
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    41. Kiguchi K, Carbajal S, Chan K, Beltrán L, Ruffino L, Shen J, Matsumoto T, Yoshimi N, DiGiovanni J. Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma. Cancer Res. 2001 Oct 1; 61(19):6971-6. PMID: 11585718.
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    42. Li D, Zhang W, Zhu J, Chang P, Sahin A, Singletary E, Bondy M, Hazra T, Mitra S, Lau SS, Shen J, DiGiovanni J. Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer. Mol Carcinog. 2001 Aug; 31(4):214-23. PMID: 11536371.
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    43. Yan M, Qiang W, Liu N, Shen J, Lynn WS, Wong PK. The ataxia-telangiectasia gene product may modulate DNA turnover and control cell fate by regulating cellular redox in lymphocytes. FASEB J. 2001 May; 15(7):1132-8. PMID: 11344081.
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    44. Shen JC, Klein RD, Wei Q, Guan Y, Contois JH, Wang TT, Chang S, Hursting SD. Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. Mol Carcinog. 2000 Oct; 29(2):92-102. PMID: 11074606.
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    45. Van Hove JL, Kahler SG, Feezor MD, Ramakrishna JP, Hart P, Treem WR, Shen JJ, Matern D, Millington DS. Acylcarnitines in plasma and blood spots of patients with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase defiency. J Inherit Metab Dis. 2000 Sep; 23(6):571-82. PMID: 11032332.
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    46. Shen JJ, Matern D, Millington DS, Hillman S, Feezor MD, Bennett MJ, Qumsiyeh M, Kahler SG, Chen YT, Van Hove JL. Acylcarnitines in fibroblasts of patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and other fatty acid oxidation disorders. J Inherit Metab Dis. 2000 Feb; 23(1):27-44. PMID: 10682306.
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    47. Shaiu WL, Kishnani PS, Shen J, Liu HM, Chen YT. Genotype-phenotype correlation in two frequent mutations and mutation update in type III glycogen storage disease. Mol Genet Metab. 2000 Jan; 69(1):16-23. PMID: 10655153.
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    48. Shen J, Liu HM, McConkie-Rosell A, Chen YT. Prenatal diagnosis of glycogen storage disease type IV using PCR-based DNA mutation analysis. Prenat Diagn. 1999 Sep; 19(9):837-9. PMID: 10521841.
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    49. Hadjigeorgiou GM, Comi GP, Bordoni A, Shen J, Chen YT, Salani S, Toscano A, Fortunato F, Lucchiari S, Bresolin N, Rodolico C, Piscaglia MG, Franceschina L, Papadimitriou A, Scarlato G. Novel donor splice site mutations of AGL gene in glycogen storage disease type IIIa. J Inherit Metab Dis. 1999 Aug; 22(6):762-3. PMID: 10472540.
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    50. Parvari R, Shen J, Hershkovitz E, Chen YT, Moses SW. Two new mutations in the 3' coding region of the glycogen debranching enzyme in a glycogen storage disease type IIIa Ashkenazi Jewish patient. J Inherit Metab Dis. 1998 Apr; 21(2):141-8. PMID: 9584265.
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    51. Shen J, Liu HM, McConkie-Rosell A, Chen YT. Prenatal diagnosis and carrier detection for glycogen storage disease type III using polymorphic DNA markers. Prenat Diagn. 1998 Jan; 18(1):61-4. PMID: 9483641.
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    52. Parvari R, Moses S, Shen J, Hershkovitz E, Lerner A, Chen YT. A single-base deletion in the 3'-coding region of glycogen-debranching enzyme is prevalent in glycogen storage disease type IIIA in a population of North African Jewish patients. Eur J Hum Genet. 1997 Sep-Oct; 5(5):266-70. PMID: 9412782.
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    53. Shen J, Bao Y, Chen YT. A nonsense mutation due to a single base insertion in the 3'-coding region of glycogen debranching enzyme gene associated with a severe phenotype in a patient with glycogen storage disease type IIIa. Hum Mutat. 1997; 9(1):37-40. PMID: 8990006.
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    54. Shen J, Liu HM, Bao Y, Chen YT. Polymorphic markers of the glycogen debranching enzyme gene allowing linkage analysis in families with glycogen storage disease type III. J Med Genet. 1997 Jan; 34(1):34-8. PMID: 9032647; PMCID: PMC1050844.
    55. Shen J, Bao Y, Liu HM, Lee P, Leonard JV, Chen YT. Mutations in exon 3 of the glycogen debranching enzyme gene are associated with glycogen storage disease type III that is differentially expressed in liver and muscle. J Clin Invest. 1996 Jul 15; 98(2):352-7. PMID: 8755644; PMCID: PMC507437.
    56. McConkie-Rosell A, Wilson C, Piccoli DA, Boyle J, DeClue T, Kishnani P, Shen JJ, Boney A, Brown B, Chen YT. Clinical and laboratory findings in four patients with the non-progressive hepatic form of type IV glycogen storage disease. J Inherit Metab Dis. 1996; 19(1):51-8. PMID: 8830177.
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    57. Weeks JR, Hardin SE, Shen J, Lee JM, Greenleaf AL. Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing. Genes Dev. 1993 Dec; 7(12A):2329-44. PMID: 8253380.
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    58. Reprogramming of the epigenome by MLL1 links early-life environmental exposures to prostate cancer risk. Molecular Endocrinology. 30:856-871.
    59. Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus. Human Molecular Genetics. 24:6932-6943.
    60. Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells. Oncotarget. 7:84093-84117.
    61. Sex-specific molecular genetic response to UVB exposure in Xiphophorus maculatus skin. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 178:76-85.
    62. Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer. Nature Communications. 7.
    63. Maternal Setdb1 Is Required for Meiotic Progression and Preimplantation Development in Mouse. PLoS Genetics. 12.
    64. LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nature Communications. 6.
    65. Erratum. Developmental Dynamics. 227:155-156.
    66. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS (Proceedings of the National Academy of Sciences (2010) 107 (4153-4158) DOI. Proceedings of the National Academy of Sciences of the United States of America. 109:8352.
    67. Obesity-associated alterations in inflammation, epigenetics, and mammary tumor growth persist in formerly obese mice. Cancer Prevention Research. 9:339-348.
    68. CSA-RRBS. 105-110.
    69. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nature Communications. 7.
    70. Defining a population of stem-like human prostate cancer cells that can generate and propagate castration-resistant prostate cancer. Clinical Cancer Research. 22:4505-4516.
    71. Erratum. Nature Communications. 7.
    72. Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells. Oncotarget. 6:23959-23986.
    73. DMBA induced mouse mammary tumors display high incidence of activating Pik3caH1047 and loss of function Pten mutations. Oncotarget. 7:64289-64299.
    74. Serum exosomal miR-4772-3p is a predictor of tumor recurrence in stage II and III colon cancer. Oncotarget. 7:76250-76260.
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