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KEITH CHAN

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressCedars-Sinai Medical Center , 8700 Bever
Los Angeles, CA 90058
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    Other Positions
    TitleAdjunct Associate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Urology
    DivisionUrology


    Collapse Research 
    Collapse research activities and funding
    R01CA255609     (CHAN, KEITH SYSON)Aug 1, 2021 - Jul 31, 2026
    NIH
    Targeting tumor repopulation and the immune microenvironment to overcome chemoresistance
    Role: Principal Investigator
    R01CA175397     (CHAN, KEITH SYSON)Sep 30, 2013 - Apr 30, 2026
    NIH
    Distinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting Approaches
    Role: Principal Investigator
    R00CA129640     (CHAN, KEITH SYSON)Aug 15, 2007 - Aug 31, 2012
    NIH
    Identification and characterization of bladder cancer stem cells
    Role: Principal Investigator
    K99CA129640     (CHAN, KEITH SYSON)Aug 15, 2007 - Aug 31, 2009
    NIH
    Identification and characterization of bladder cancer stem cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Riveros C, Ranganathan S, Haque W, Huang E, Xu J, Kulkarni GS, Geng M, Anis M, Muhammad T, Chan KS, Farach A, Teh BS, Miles BJ, Klaassen Z, Sonpavde GP, Wallis CJD, Satkunasivam R. Comparative real-world survival outcomes of muscle-invasive bladder cancer treated with bladder-only vs. whole-pelvis concurrent chemoradiation. Can Urol Assoc J. 2024 Feb; 18(2):17-24. PMID: 37931278; PMCID: PMC10841558.
      Citations:    
    2. Heiser CN, Simmons AJ, Revetta F, McKinley ET, Ramirez-Solano MA, Wang J, Kaur H, Shao J, Ayers GD, Wang Y, Glass SE, Tasneem N, Chen Z, Qin Y, Kim W, Rolong A, Chen B, Vega PN, Drewes JL, Markham NO, Saleh N, Nikolos F, Vandekar S, Jones AL, Washington MK, Roland JT, Chan KS, Sch?rpf T, Sears CL, Liu Q, Shrubsole MJ, Coffey RJ, Lau KS. Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors. Cell. 2023 12 07; 186(25):5620-5637.e16. PMID: 38065082; PMCID: PMC10756562.
      Citations: 1     Fields:    Translation:Humans
    3. Piras R, Ko EY, Barrett C, De Simone M, Lin X, Broz MT, Tessaro FHG, Castillo-Martin M, Cordon-Cardo C, Goodridge HS, Di Vizio D, Batish M, Lawrenson K, Chen YG, Chan KS, Guarnerio J. circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. Nat Commun. 2022 11 25; 13(1):7243. PMID: 36433954; PMCID: PMC9700836.
      Citations: 2     Fields:    Translation:Humans
    4. You S, Kim M, Hoi XP, Lee YC, Wang L, Spetzler D, Abraham J, Magee D, Jain P, Galsky MD, Chan KS, Theodorescu D. Discoidin Domain Receptor-Driven Gene Signatures as Markers of Patient Response to Anti-PD-L1 Immune Checkpoint Therapy. J Natl Cancer Inst. 2022 10 06; 114(10):1380-1391. PMID: 35918812; PMCID: PMC9552307.
      Citations:    
    5. Lee YC, Lam HM, Rosser C, Theodorescu D, Parks WC, Chan KS. The dynamic roles of the bladder tumour microenvironment. Nat Rev Urol. 2022 09; 19(9):515-533. PMID: 35764795; PMCID: PMC10112172.
      Citations:    Fields:    
    6. You S, Kim M, Widen S, Yu A, Galvan GC, Choi-Kuaea Y, Eyzaguirre EJ, McConkey DJ, Choi W, Theodorescu D, Chan KS, Shan Y, Tyler DS, De Hoedt AM, Freedland SJ, Williams SB, Dyrskj?t L. Characterizing molecular subtypes of high-risk non-muscle-invasive bladder cancer in African American patients. Urol Oncol. 2022 09; 40(9):410.e19-410.e27. PMID: 35618577; PMCID: PMC9741768.
      Citations:    Fields:    
    7. Tyner JW, Haderk F, Kumaraswamy A, Baughn LB, Van Ness B, Liu S, Marathe H, Alumkal JJ, Bivona TG, Chan KS, Druker BJ, Hutson AD, Nelson PS, Sawyers CL, Willey CD. Understanding Drug Sensitivity and Tackling Resistance in Cancer. Cancer Res. 2022 04 15; 82(8):1448-1460. PMID: 35195258; PMCID: PMC9018544.
      Citations:    
    8. Girardi DM, Niglio SA, Mortazavi A, Nadal R, Lara P, Pal SK, Saraiya B, Cordes L, Ley L, Ortiz OS, Cadena J, Diaz C, Bagheri H, Redd B, Steinberg SM, Costello R, Chan KS, Lee MJ, Lee S, Yu Y, Gurram S, Chalfin HJ, Valera V, Figg WD, Merino M, Toubaji A, Streicher H, Wright JJ, Sharon E, Parnes HL, Ning YM, Bottaro DP, Cao L, Trepel JB, Apolo AB. Cabozantinib plus Nivolumab Phase I Expansion Study in Patients with Metastatic Urothelial Carcinoma Refractory to Immune Checkpoint Inhibitor Therapy. Clin Cancer Res. 2022 04 01; 28(7):1353-1362. PMID: 35031545; PMCID: PMC9365339.
      Citations:    Fields:    Translation:Humans
    9. Nikolos F, Hayashi K, Hoi XP, Alonzo ME, Mo Q, Kasabyan A, Furuya H, Trepel J, Di Vizio D, Guarnerio J, Theodorescu D, Rosser C, Apolo A, Galsky M, Chan KS. Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors. Nat Commun. 2022 03 28; 13(1):1487. PMID: 35347124; PMCID: PMC8960844.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Ho SR, Lee YC, Ittmann MM, Lin FT, Chan KS, Lin WC. RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis. Cancer Lett. 2021 11 01; 520:344-360. PMID: 34400221; PMCID: PMC9420248.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Gouin KH, Ing N, Plummer JT, Rosser CJ, Ben Cheikh B, Oh C, Chen SS, Chan KS, Furuya H, Tourtellotte WG, Knott SRV, Theodorescu D. An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer. Nat Commun. 2021 08 12; 12(1):4906. PMID: 34385456; PMCID: PMC8361097.
      Citations: 7     Fields:    Translation:HumansCells
    12. Hayashi K, Nikolos F, Chan KS. Inhibitory DAMPs in immunogenic cell death and its clinical implications. Cell Stress. 2021 Mar 22; 5(4):52-54. PMID: 33821233; PMCID: PMC8012883.
      Citations: 2     
    13. Mo Q, Li R, Adeegbe DO, Peng G, Chan KS. Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy. Commun Biol. 2020 12 17; 3(1):784. PMID: 33335285; PMCID: PMC7746703.
      Citations: 9     Translation:Humans
    14. Robertson AG, Seiler R, Hoadley KA, Al-Ahmadie H, Choi W, Eriksson P, Mo Q, Kardos J, Zlotta A, Dinney CP, Bellmunt J, Powles T, Chan KS, Kim WY, McConkey DJ, Black PC, Lerner SP, Real FX, Aine M, Czerniak B, Gibb EA, Kim J, Kwiatkowski DJ, Lebret T, Siefker-Radtke AA, Sirab N, Taber A, Weinstein JN, Kamoun A, de Reyni?s A, Allory Y, Sj?dahl G, Groeneveld CS, Castro MAA, Fontugne J, Hartmann A, Malats N, Dyrskj?t L, H?glund M, Radvanyi F, Bernard-Pierrot I, Liedberg F. Reply To Kenneth B. Yatai, Mark J. Dunning, Dennis Wang. Consensus Genomic Subtypes of Muscle-invasive Bladder Cancer: A Step in the Right Direction but Still a Long Way To Go. Eur Urol 2020;77:434-5. Eur Urol. 2020 04; 77(4):436-438. PMID: 32037144.
      Citations:    Fields:    Translation:Humans
    15. Furuya H, Hayashi K, Shimizu Y, Kim N, Tsukikawa Y, Chen R, Sun Y, Chan OTM, Pagano I, Peres R, Hokutan K, Chan KS, Rosser CJ, Igari F. Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model. J Transl Med. 2020 02 05; 18(1):57. PMID: 32024545; PMCID: PMC7003426.
      Citations: 3     Fields:    Translation:Animals
    16. Furuya H, Chan OTM, Hokutan K, Tsukikawa Y, Chee K, Kozai L, Chan KS, Dai Y, Wong RS, Rosser CJ. Prognostic Significance of Lymphocyte Infiltration and a Stromal Immunostaining of a Bladder Cancer Associated Diagnostic Panel in Urothelial Carcinoma. Diagnostics (Basel). 2019 Dec 28; 10(1). PMID: 31905599; PMCID: PMC7168167.
      Citations: 4     
    17. Robertson AG, Seiler R, Hoadley KA, Al-Ahmadie H, Choi W, Eriksson P, Mo Q, Kardos J, Zlotta A, Dinney CP, Bellmunt J, Powles T, Chan KS, Kim WY, McConkey DJ, Black PC, Lerner SP, Real FX, Bladder Cancer Molecular Taxonomy Group, Kamoun A, de Reyni?s A, Allory Y, Sj?dahl G, Groeneveld CS, Castro MAA, Fontugne J, Hartmann A, Malats N, Dyrskj?t L, H?glund M, Radvanyi F. A Consensus Molecular Classification of Muscle-invasive Bladder Cancer. Eur Urol. 2020 04; 77(4):420-433. PMID: 31563503; PMCID: PMC7690647.
      Citations: 217     Fields:    Translation:Humans
    18. Lee YC, Kurtova AV, Xiao J, Nikolos F, Hayashi K, Tramel Z, Jain A, Chen F, Chokshi M, Lee C, Bao G, Zhang X, Shen J, Mo Q, Jung SY, Rowley D, Chan KS. Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung. Nat Commun. 2019 05 13; 10(1):2131. PMID: 31086186; PMCID: PMC6513865.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    19. Mo Q, Nikolos F, Chen F, Tramel Z, Lee YC, Hayashi K, Xiao J, Shen J, Chan KS. Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas. J Natl Cancer Inst. 2018 05 01; 110(5):448-459. PMID: 29342309; PMCID: PMC6279371.
      Citations: 50     Fields:    Translation:HumansCells
    20. Mo Q, Shen R, Guo C, Vannucci M, Chan KS, Hilsenbeck SG. A fully Bayesian latent variable model for integrative clustering analysis of multi-type omics data. Biostatistics. 2018 01 01; 19(1):71-86. PMID: 28541380; PMCID: PMC6455926.
      Citations: 47     Fields:    Translation:Humans
    21. Rodriguez-Brenes IA, Kurtova AV, Lin C, Lee YC, Xiao J, Mims M, Chan KS, Wodarz D. Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy. Cancer Res. 2017 05 01; 77(9):2231-2241. PMID: 28235762; PMCID: PMC5487257.
      Citations: 4     Fields:    Translation:HumansCells
    22. Brooks M, Mo Q, Krasnow R, Ho PL, Lee YC, Xiao J, Kurtova A, Lerner S, Godoy G, Jian W, Castro P, Chen F, Rowley D, Ittmann M, Chan KS. Positive association of collagen type I with non-muscle invasive bladder cancer progression. Oncotarget. 2016 Dec 13; 7(50):82609-82619. PMID: 27655672; PMCID: PMC5347718.
      Citations: 22     Fields:    Translation:HumansCells
    23. Lerner SP, McConkey DJ, Hoadley KA, Chan KS, Kim WY, Radvanyi F, H?glund M, Real FX. Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting. Bladder Cancer. 2016 Jan 07; 2(1):37-47. PMID: 27376123; PMCID: PMC4927916.
      Citations: 79     
    24. Chan KS. Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation. Clin Cancer Res. 2016 Feb 15; 22(4):802-6. PMID: 26671994; PMCID: PMC4915779.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    25. Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, Chen F, Roh TT, Lay E, Ho PL, Chan KS. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature. 2015 Jan 08; 517(7533):209-13. PMID: 25470039; PMCID: PMC4465385.
      Citations: 253     Fields:    Translation:HumansAnimalsCells
    26. Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR. RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16389-94. PMID: 25313057; PMCID: PMC4246299.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    27. Ho PL, Kurtova A, Chan KS. Normal and neoplastic urothelial stem cells: getting to the root of the problem. Nat Rev Urol. 2012 Oct; 9(10):583-94. PMID: 22890301; PMCID: PMC3468664.
      Citations: 85     Fields:    Translation:HumansCells
    28. Ho PL, Lay EJ, Jian W, Parra D, Chan KS. Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer. Cancer Res. 2012 Jul 01; 72(13):3135-42. PMID: 22532166; PMCID: PMC3418917.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    29. Volkmer JP, Sahoo D, Chin RK, Ho PL, Tang C, Kurtova AV, Willingham SB, Pazhanisamy SK, Contreras-Trujillo H, Storm TA, Lotan Y, Beck AH, Chung BI, Alizadeh AA, Godoy G, Lerner SP, van de Rijn M, Shortliffe LD, Weissman IL, Chan KS. Three differentiation states risk-stratify bladder cancer into distinct subtypes. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2078-83. PMID: 22308455; PMCID: PMC3277552.
      Citations: 122     Fields:    Translation:HumansCells
    30. Chan KS, Volkmer JP, Weissman I. Cancer stem cells in bladder cancer: a revisited and evolving concept. Curr Opin Urol. 2010 Sep; 20(5):393-7. PMID: 20657288; PMCID: PMC2997612.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    31. Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):14016-21. PMID: 19666525; PMCID: PMC2720852.
      Citations: 292     Fields:    Translation:HumansAnimalsCells
    32. Chan KS, Sano S, Kataoka K, Abel E, Carbajal S, Beltran L, Clifford J, Peavey M, Shen J, Digiovanni J. Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis. Oncogene. 2008 Feb 14; 27(8):1087-94. PMID: 17700521.
      Citations: 51     Fields:    Translation:AnimalsCells
    33. Kim DJ, Chan KS, Sano S, Digiovanni J. Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Mol Carcinog. 2007 Aug; 46(8):725-31. PMID: 17610223.
      Citations: 56     Fields:    Translation:HumansAnimals
    34. Sano S, Chan KS, DiGiovanni J. Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. J Dermatol Sci. 2008 Apr; 50(1):1-14. PMID: 17601706.
      Citations: 62     Fields:    Translation:HumansAnimals
    35. Sano S, Chan KS, Kira M, Kataoka K, Takagi S, Tarutani M, Itami S, Kiguchi K, Yokoi M, Sugasawa K, Mori T, Hanaoka F, Takeda J, DiGiovanni J. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res. 2005 Jul 01; 65(13):5720-9. PMID: 15994947.
      Citations: 38     Fields:    Translation:AnimalsCells
    36. Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, Itami S, Nickoloff BJ, DiGiovanni J. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med. 2005 Jan; 11(1):43-9. PMID: 15592573.
      Citations: 208     Fields:    Translation:HumansAnimalsCells
    37. Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, DiGiovanni J. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest. 2004 Sep; 114(5):720-8. PMID: 15343391; PMCID: PMC514583.
      Citations: 170     Fields:    Translation:Animals
    38. Chan KS, Carbajal S, Kiguchi K, Clifford J, Sano S, DiGiovanni J. Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis. Cancer Res. 2004 Apr 01; 64(7):2382-9. PMID: 15059889.
      Citations: 76     Fields:    Translation:AnimalsCells
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