| Item Type | Name |
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Concept
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Enzymes
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Concept
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DNA Repair Enzymes
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Concept
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Ubiquitin-Conjugating Enzymes
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Concept
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DNA Restriction Enzymes
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Academic Article
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Enzyme motifs in antibodies.
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Academic Article
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Molecular recognition in DNA-binding proteins and enzymes.
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Academic Article
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Glubodies: randomized libraries of glutathione transferase enzymes.
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Academic Article
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Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway.
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Academic Article
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Structural implications of BER enzymes: dragons dancing--the structural biology of DNA base excision repair.
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Academic Article
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DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes.
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Academic Article
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The rad50 signature motif: essential to ATP binding and biological function.
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Academic Article
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Structural and functional analysis of Mre11-3.
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Academic Article
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Structure and function of the double-strand break repair machinery.
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Academic Article
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A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks.
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Academic Article
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Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
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Academic Article
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Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography.
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Academic Article
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Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.
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Academic Article
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Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette.
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Academic Article
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The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.
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Academic Article
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DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.
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Academic Article
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SUMO-targeted ubiquitin ligases in genome stability.
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Academic Article
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Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
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Academic Article
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Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Molecular mimicry of SUMO promotes DNA repair.
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Academic Article
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Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
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Academic Article
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Substrate recognition and catalysis by flap endonucleases and related enzymes.
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Academic Article
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Structural dynamics in DNA damage signaling and repair.
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Academic Article
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XLF regulates filament architecture of the XRCC4?ligase IV complex.
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Academic Article
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Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.
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Academic Article
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XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase.
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Academic Article
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XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair.
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Academic Article
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DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
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Academic Article
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Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions.
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Academic Article
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DNA charge transport as a first step in coordinating the detection of lesions by repair proteins.
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Academic Article
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XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.
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Academic Article
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Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
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Academic Article
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DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.
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Academic Article
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ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
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Academic Article
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Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.
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Academic Article
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Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.
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Academic Article
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The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.
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Academic Article
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Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.
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Academic Article
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RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
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Academic Article
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Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.
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Academic Article
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Robust Production, Crystallization, Structure Determination, and Analysis of [Fe-S] Proteins: Uncovering Control of Electron Shuttling and Gating in the Respiratory Metabolism of Molybdopterin Guanine Dinucleotide Enzymes.
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Academic Article
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Dissection of DNA double-strand-break repair using novel single-molecule forceps.
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Academic Article
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The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
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Academic Article
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X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology.
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Academic Article
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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2.
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