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JOHN TAINER

TitleProfessor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Moiani D, Tainer JA. A goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions. Front Mol Biosci. 2024; 11:1442267. PMID: 39669672; PMCID: PMC11635304.
      Citations:    
    2. Provasek VE, Bacolla A, Rangaswamy S, Mitra J, Kodavati M, Yusuf IO, Malojirao VH, Vasquez V, Britz GW, Li GM, Xu Z, Mitra S, Garruto RM, Tainer JA, Hegde ML, Provasek VE, Bacolla A, Rangaswamy S, Mitra J, Kodavati M, Yusuf IO, Malojirao VH, Vasquez V, Britz GW, Li GM, Xu Z, Mitra S, Garruto RM, Tainer JA, Hegde ML, Provasek VE, Hegde ML. RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability. bioRxiv. 2024 Nov 08. PMID: 38798341; PMCID: PMC11118483.
      Citations:    
    3. Yu J, Yan C, Paul T, Brewer L, Tsutakawa SE, Tsai CL, Hamdan SM, Tainer JA, Ivanov I. Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair. Nat Commun. 2024 Oct 01; 15(1):8511. PMID: 39353945; PMCID: PMC11445577.
      Citations:    Fields:    Translation:HumansCells
    4. De-Paula RB, Bacolla A, Syed A, Tainer JA. Enriched G4 forming repeats in the human genome are associated with robust well-coordinated transcription and reduced cancer transcriptome variation. J Biol Chem. 2024 Nov; 300(11):107822. PMID: 39341500; PMCID: PMC11532954.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Longo MA, Ahmed SM, Chen Y, Tsai CL, Namjoshi S, Wang X, Perera RL, Arvai A, Lee M, Kong LR, Engl W, Shyuan W, Zhao ZW, Venkitaraman AR, Tainer JA, Schlacher K. BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability. bioRxiv. 2024 Sep 22. PMID: 39345573; PMCID: PMC11429943.
      Citations:    
    6. Pradhan S, Bush K, Zhang N, Pandita RK, Tsai CL, Smith C, Pandlebury DF, Gaikwad S, Leonard F, Nie L, Tao A, Russell W, Yuan S, Choudhary S, Ramos KS, Elferink C, Wairkar YP, Tainer JA, Thompson LM, Pandita TK, Sarkar PS. Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons. bioRxiv. 2024 Sep 20. PMID: 39345557; PMCID: PMC11429940.
      Citations:    
    7. Chinnam NB, Thapar R, Arvai AS, Sarker AH, Soll JM, Paul T, Syed A, Rosenberg DJ, Hammel M, Bacolla A, Katsonis P, Asthana A, Tsai MS, Ivanov I, Lichtarge O, Silverman RH, Mosammaparast N, Tsutakawa SE, Tainer JA. ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J Biol Chem. 2024 Jun; 300(6):107368. PMID: 38750793; PMCID: PMC11214414.
      Citations: 1     Fields:    Translation:HumansCells
    8. Das C, Bhattacharya A, Adhikari S, Mondal A, Mondal P, Adhikary S, Roy S, Ramos K, Yadav KK, Tainer JA, Pandita TK. A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance. Oncogene. 2024 Jun; 43(23):1727-1741. PMID: 38719949; PMCID: PMC11161412.
      Citations: 4     Fields:    Translation:Humans
    9. Brosey CA, Link TM, Shen R, Moiani D, Burnett K, Hura GL, Jones DE, Tainer JA. Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nat Chem Biol. 2024 Sep; 20(9):1199-1209. PMID: 38671223; PMCID: PMC11358040.
      Citations: 1     Fields:    Translation:HumansCells
    10. Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC, Tainer JA, Jiang W, Kim BYS. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nat Biomed Eng. 2024 May; 8(5):593-610. PMID: 38641710; PMCID: PMC11162332.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Fu J, Ling J, Li CF, Tsai CL, Yin W, Hou J, Chen P, Cao Y, Kang Y, Sun Y, Xia X, Jiang Z, Furukawa K, Lu Y, Wu M, Huang Q, Yao J, Hawke DH, Pan BF, Zhao J, Huang J, Wang H, Bahassi EIM, Stambrook PJ, Huang P, Fleming JB, Maitra A, Tainer JA, Hung MC, Lin C, Chiao PJ. Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nat Commun. 2024 Apr 11; 15(1):3149. PMID: 38605037; PMCID: PMC11009390.
      Citations: 1     Fields:    Translation:HumansAnimals
    12. Filandr F, Sarpe V, Raval S, Crowder DA, Khan MF, Douglas P, Coales S, Viner R, Syed A, Tainer JA, Lees-Miller SP, Schriemer DC. Author Correction: Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology. Nat Commun. 2024 Apr 02; 15(1):2836. PMID: 38565885; PMCID: PMC10987663.
      Citations:    Fields:    
    13. Filandr F, Sarpe V, Raval S, Crowder DA, Khan MF, Douglas P, Coales S, Viner R, Syed A, Tainer JA, Lees-Miller SP, Schriemer DC. Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology. Nat Commun. 2024 Mar 11; 15(1):2200. PMID: 38467655; PMCID: PMC10928179.
      Citations: 2     Fields:    Translation:Animals
    14. Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nat Commun. 2024 Mar 08; 15(1):2132. PMID: 38459011; PMCID: PMC10923831.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    15. Woltz R, Schweibenz B, Tsutakawa SE, Zhao C, Ma L, Shurina B, Hura GL, John R, Vorobiev S, Swapna G, Solotchi M, Tainer JA, Krug RM, Patel SS, Montelione GT. The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral response. bioRxiv. 2024 Jan 24. PMID: 38328244; PMCID: PMC10849492.
      Citations:    
    16. Syed A, Filandr F, Patterson-Fortin J, Bacolla A, Ravindranathan R, Zhou J, McDonald DT, Albuhluli ME, Verway-Cohen A, Newman JA, Tsai MS, Jones DE, Schriemer DC, D'Andrea AD, Tainer JA. Novobiocin blocks nucleic acid binding to Pol? and inhibits stimulation of its ATPase activity. Nucleic Acids Res. 2023 Oct 13; 51(18):9920-9937. PMID: 37665033; PMCID: PMC10570058.
      Citations: 2     Fields:    Translation:HumansCells
    17. Swift ML, Zhou R, Syed A, Moreau LA, Tomasik B, Tainer JA, Konstantinopoulos PA, D'Andrea AD, He YJ, Chowdhury D. Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs. Nat Struct Mol Biol. 2023 10; 30(10):1456-1467. PMID: 37696958; PMCID: PMC10686051.
      Citations: 2     Fields:    Translation:Cells
    18. Longo MA, Roy S, Chen Y, Tomaszowski KH, Arvai AS, Pepper JT, Boisvert RA, Kunnimalaiyaan S, Keshvani C, Schild D, Bacolla A, Williams GJ, Tainer JA, Schlacher K. RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nat Commun. 2023 07 24; 14(1):4445. PMID: 37488098; PMCID: PMC10366140.
      Citations: 4     Fields:    Translation:HumansCells
    19. Townley BA, Buerer L, Tsao N, Bacolla A, Mansoori F, Rusanov T, Clark N, Goodarzi N, Schmidt N, Srivatsan SN, Sun H, Sample RA, Brickner JR, McDonald D, Tsai MS, Walter MJ, Wozniak DF, Holehouse AS, Pena V, Tainer JA, Fairbrother WG, Mosammaparast N. A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy. Mol Cell. 2023 07 06; 83(13):2258-2275.e11. PMID: 37369199; PMCID: PMC10483886.
      Citations: 1     Fields:    Translation:AnimalsCells
    20. Yu J, Yan C, Dodd T, Tsai CL, Tainer JA, Tsutakawa SE, Ivanov I. Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases. Nat Commun. 2023 05 13; 14(1):2758. PMID: 37179334; PMCID: PMC10183003.
      Citations: 1     Fields:    Translation:Cells
    21. LeBleu VS, Dai J, Tsutakawa S, MacDonald BA, Alge JL, Sund M, Xie L, Sugimoto H, Tainer J, Zon LI, Kalluri R. Identification of unique a4 chain structure and conserved antiangiogenic activity of a3NC1 type IV collagen in zebrafish. Dev Dyn. 2023 07; 252(7):1046-1060. PMID: 37002899; PMCID: PMC10524752.
      Citations:    Fields:    Translation:HumansAnimalsCells
    22. Zhou R, Swift ML, Syed A, Huang K, Moreau L, Tainer JA, Konstantinopoulos PA, D? Andrea AD, He YJ, Chowdhury D. Dynamics of the DYNLL1/MRE11 complex regulates DNA end resection and recruitment of the Shieldin complex to DSBs. bioRxiv. 2023 Mar 27. PMID: 37034578; PMCID: PMC10081242.
      Citations:    
    23. Das C, Adhikari S, Bhattacharya A, Chakraborty S, Mondal P, Yadav SS, Adhikary S, Hunt CR, Yadav KK, Pandita S, Roy S, Tainer JA, Ahmed Z, Pandita TK. Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer. Cancer Res. 2023 03 02; 83(5):657-666. PMID: 36661847; PMCID: PMC11285093.
      Citations:    Fields:    Translation:HumansCells
    24. Bralic A, Tehseen M, Sobhy MA, Tsai CL, Alhudhali L, Yi G, Yu J, Yan C, Ivanov I, Tsutakawa SE, Tainer JA, Hamdan SM. A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair. Nucleic Acids Res. 2023 02 22; 51(3):1019-1033. PMID: 36477609; PMCID: PMC9943652.
      Citations: 1     Fields:    Translation:Cells
    25. Tainer JA. Preface. Methods Enzymol. 2023; 678:xv-xix. PMID: 36641219.
      Citations:    Fields:    
    26. Brosey CA, Shen R, Moiani D, Jones DE, Burnett K, Hura GL, Tainer JA. Applying HT-SAXS to chemical ligand screening. Methods Enzymol. 2023; 678:331-350. PMID: 36641213; PMCID: PMC11239221.
      Citations:    Fields:    Translation:Cells
    27. Fan C, Chen K, Wang Y, Ball EV, Stenson PD, Mort M, Bacolla A, Kehrer-Sawatzki H, Tainer JA, Cooper DN, Zhao H. Profiling human pathogenic repeat expansion regions by synergistic and multi-level impacts on molecular connections. Hum Genet. 2023 Feb; 142(2):245-274. PMID: 36344696; PMCID: PMC10290229.
      Citations:    Fields:    Translation:HumansCells
    28. Chinnam NB, Syed A, Hura GL, Hammel M, Tainer JA, Tsutakawa SE. Combining small angle X-ray scattering (SAXS) with protein structure predictions to characterize conformations in solution. Methods Enzymol. 2023; 678:351-376. PMID: 36641214; PMCID: PMC10132260.
      Citations:    Fields:    Translation:Cells
    29. Kim M, Kim HS, D'Souza A, Gallagher K, Jeong E, Topolska-W?s A, Ogorodnik Le Meur K, Tsai CL, Tsai MS, Kee M, Tainer JA, Yeo JE, Chazin WJ, Sch?rer OD. Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2207408119. PMID: 35969784; PMCID: PMC9407234.
      Citations:    
    30. Yuan X, Duan Y, Xiao Y, Sun K, Qi Y, Zhang Y, Ahmed Z, Moiani D, Yao J, Li H, Zhang L, Yuzhalin AE, Li P, Zhang C, Badu-Nkansah A, Saito Y, Liu X, Kuo WL, Ying H, Sun SC, Chang JC, Tainer JA, Yu D. Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1. Cancer Discov. 2022 07 06; 12(7):1742-1759. PMID: 35420681; PMCID: PMC9262841.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Qi M, Stenson PD, Ball EV, Tainer JA, Bacolla A, Kehrer-Sawatzki H, Cooper DN, Zhao H. Distinct sequence features underlie microdeletions and gross deletions in the human genome. Hum Mutat. 2022 03; 43(3):328-346. PMID: 34918412; PMCID: PMC9069542.
      Citations:    Fields:    Translation:HumansCells
    32. Berroyer A, Bacolla A, Tainer JA, Kim N. Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability. Microb Cell. 2022 Mar 07; 9(3):52-68. PMID: 35291312; PMCID: PMC8890623.
      Citations:    
    33. Bacolla A, Tainer JA. Robust Computational Approaches to Defining Insights on the Interface of DNA Repair with Replication and Transcription in Cancer. Methods Mol Biol. 2022; 2444:1-13. PMID: 35290628; PMCID: PMC9377048.
      Citations:    Fields:    Translation:HumansCells
    34. Chinnam NB, Syed A, Burnett KH, Hura GL, Tainer JA, Tsutakawa SE. Universally Accessible Structural Data on Macromolecular Conformation, Assembly, and Dynamics by Small Angle X-Ray Scattering for DNA Repair Insights. Methods Mol Biol. 2022; 2444:43-68. PMID: 35290631; PMCID: PMC9020468.
      Citations:    Fields:    Translation:Cells
    35. Rosenberg DJ, Syed A, Tainer JA, Hura GL. Monitoring Nuclease Activity by X-Ray Scattering Interferometry Using Gold Nanoparticle-Conjugated DNA. Methods Mol Biol. 2022; 2444:183-205. PMID: 35290639; PMCID: PMC9512051.
      Citations: 1     Fields:    Translation:Cells
    36. Tainer JA. Preface. Methods Enzymol. 2022; 677:xv-xix. PMID: 36410964.
      Citations:    Fields:    
    37. Ye Z, Shi Y, Lees-Miller SP, Tainer JA. Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy. Front Immunol. 2021; 12:797880. PMID: 34970273; PMCID: PMC8712645.
      Citations: 3     Fields:    Translation:HumansAnimals
    38. Tsutakawa SE, Bacolla A, Katsonis P, Bralic A, Hamdan SM, Lichtarge O, Tainer JA, Tsai CL. Decoding Cancer Variants of Unknown Significance for Helicase-Nuclease-RPA Complexes Orchestrating DNA Repair During Transcription and Replication. Front Mol Biosci. 2021; 8:791792. PMID: 34966786; PMCID: PMC8710748.
      Citations:    
    39. Twayana S, Bacolla A, Barreto-Galvez A, De-Paula RB, Drosopoulos WC, Kosiyatrakul ST, Bouhassira EE, Tainer JA, Madireddy A, Schildkraut CL. Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites. Proc Natl Acad Sci U S A. 2021 11 30; 118(48). PMID: 34815340; PMCID: PMC8640788.
      Citations: 2     Fields:    Translation:HumansCells
    40. Mondal A, Bhattacharya A, Singh V, Pandita S, Bacolla A, Pandita RK, Tainer JA, Ramos KS, Pandita TK, Das C. Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics. Mol Cell Biol. 2022 01 20; 42(1):e0048321. PMID: 34748401; PMCID: PMC8773053.
      Citations:    Fields:    Translation:HumansCells
    41. Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun H, Bacolla A, Zhang L, Lukinovic V, Soll JM, Townley BA, Casanova AG, Tainer JA, He C, Vindigni A, Reynoird N, Mosammaparast N. Aberrant RNA methylation triggers recruitment of an alkylation repair complex. Mol Cell. 2021 10 21; 81(20):4228-4242.e8. PMID: 34686315; PMCID: PMC8931856.
      Citations: 2     Fields:    Translation:HumansCells
    42. Alexander LT, Lepore R, Kryshtafovych A, Adamopoulos A, Alahuhta M, Arvin AM, Bomble YJ, Chiarini V, Chinnam NB, Chiu W, Fidelis K, Grinter R, Gupta GD, Hayes CS, Heidebrecht T, Ilari A, Joachimiak A, Kim Y, Linares R, Lovering AL, Lunin VV, Michalska K, Moult J, Mukherjee PK, Nutt WS, Oliver SL, Perrakis A, Stols L, Tainer JA, Topf M, Tsutakawa SE, Valdivia-Delgado M, Schwede T, B?ttcher B, Breyton C, Hartmann MD, Lupas AN, Makbul C. Target highlights in CASP14: Analysis of models by structure providers. Proteins. 2021 12; 89(12):1647-1672. PMID: 34561912; PMCID: PMC8616854.
      Citations: 2     Fields:    Translation:Cells
    43. Moiani D, Link TM, Brosey CA, Katsonis P, Lichtarge O, Kim Y, Joachimiak A, Ma Z, Kim IK, Ahmed Z, Jones DE, Tsutakawa SE, Tainer JA. An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol. 2021; 661:407-431. PMID: 34776222; PMCID: PMC8474023.
      Citations: 2     Fields:    Translation:HumansCells
    44. Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021 Aug; 7(32). PMID: 34348893; PMCID: PMC8336959.
      Citations: 5     Fields:    
    45. Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, Chazin WJ, Tsutakawa SE, Russell P, Schlacher K, Pandita TK, Tainer JA. EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart. Mol Cell. 2021 07 15; 81(14):2989-3006.e9. PMID: 34197737; PMCID: PMC8720176.
      Citations: 8     Fields:    Translation:HumansCells
    46. Rashid I, Hammel M, Tsai MS, Tainer JA, Tomkinson AE, Sverzhinsky A, Pascal JM. Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. J Biol Chem. 2021 Aug; 297(2):100921. PMID: 34181949; PMCID: PMC8318918.
      Citations:    Fields:    Translation:HumansCells
    47. Banday S, Pandita RK, Mushtaq A, Bacolla A, Mir US, Singh DK, Jan S, Bhat KP, Hunt CR, Rao G, Charaka VK, Tainer JA, Pandita TK, Altaf M. Autism-Associated Vigilin Depletion Impairs DNA Damage Repair. Mol Cell Biol. 2021 06 23; 41(7):e0008221. PMID: 33941620; PMCID: PMC8224237.
      Citations: 3     Fields:    Translation:HumansCells
    48. Zhou J, Gelot C, Pantelidou C, Li A, Davis RE, Kochupurakkal B, Syed A, Shapiro GI, Tainer JA, Blagg BSJ, Ceccaldi R, D'Andrea AD, Y?cel H, F?rkkil? A. A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nat Cancer. 2021 06; 2(6):598-610. PMID: 34179826; PMCID: PMC8224818.
      Citations: 33     Translation:Humans
    49. Hammel M, Tainer JA. X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. Protein Sci. 2021 09; 30(9):1735-1756. PMID: 34056803; PMCID: PMC8376411.
      Citations: 7     Fields:    Translation:HumansCells
    50. Guo HF, Bota-Rabassedas N, Terajima M, Leticia Rodriguez B, Gibbons DL, Chen Y, Banerjee P, Tsai CL, Tan X, Liu X, Yu J, Tokmina-Roszyk M, Stawikowska R, Fields GB, Miller MD, Wang X, Lee J, Dalby KN, Creighton CJ, Phillips GN, Tainer JA, Yamauchi M, Kurie JM. A collagen glucosyltransferase drives lung adenocarcinoma progression in mice. Commun Biol. 2021 04 19; 4(1):482. PMID: 33875777; PMCID: PMC8055892.
      Citations: 2     Translation:Animals
    51. Zhang X, Blundell T, Tainer JA. The renaissance in biophysics and molecular biology enabled by the interface of DNA repair and replication with cancer. Prog Biophys Mol Biol. 2021 08; 163:1-4. PMID: 33798567; PMCID: PMC11314391.
      Citations:    Fields:    Translation:HumansCells
    52. Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL. An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. Prog Biophys Mol Biol. 2021 08; 163:143-159. PMID: 33675849; PMCID: PMC8722130.
      Citations: 6     Fields:    Translation:HumansCells
    53. Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186. PMID: 33636189; PMCID: PMC7901392.
      Citations: 16     Fields:    Translation:HumansCells
    54. Thapar R, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Tainer JA, Wang JL, Strick TR. Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids Res. 2021 01 25; 49(2):1199-1200. PMID: 33337499; PMCID: PMC7826246.
      Citations: 5     Fields:    
    55. Bacolla A, Sengupta S, Ye Z, Yang C, Mitra J, De-Paula RB, Hegde ML, Ahmed Z, Mort M, Cooper DN, Mitra S, Tainer JA. Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. Nucleic Acids Res. 2021 01 11; 49(1):221-243. PMID: 33300026; PMCID: PMC7797072.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    56. Hammel M, Rashid I, Pourfarjam Y, Tsai MS, Ellenberger T, Kim IK, Tainer JA, Tomkinson AE, Sverzhinsky A, Pascal JM. An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIa within a flexible DNA repair complex. Nucleic Acids Res. 2021 01 11; 49(1):306-321. PMID: 33330937; PMCID: PMC7797052.
      Citations: 8     Fields:    Translation:HumansCells
    57. Walker RG, Kattamuri C, Goebel EJ, Zhang F, Hammel M, Tainer JA, Linhardt RJ, Thompson TB. Heparin-mediated dimerization of follistatin. Exp Biol Med (Maywood). 2021 02; 246(4):467-482. PMID: 33197333; PMCID: PMC7885052.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    58. Thapar R, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Tainer JA, Wang JL, Hammel M, Strick TR. Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids Res. 2020 11 04; 48(19):10953-10972. PMID: 33045735; PMCID: PMC7641761.
      Citations: 19     Fields:    Translation:HumansCells
    59. Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol. 2020 Nov; 22(11):1396. PMID: 33033376.
      Citations: 4     Fields:    
    60. Wilson DM, Deacon AM, Duncton MAJ, Pellicena P, Georgiadis MM, Yeh AP, Arvai AS, Moiani D, Tainer JA, Das D. Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog Biophys Mol Biol. 2021 08; 163:130-142. PMID: 33115610; PMCID: PMC8666131.
      Citations: 8     Fields:    Translation:Cells
    61. Lees-Miller JP, Cobban A, Katsonis P, Bacolla A, Tsutakawa SE, Hammel M, Meek K, Anderson DW, Lichtarge O, Tainer JA, Lees-Miller SP. Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Prog Biophys Mol Biol. 2021 08; 163:87-108. PMID: 33035590; PMCID: PMC8021618.
      Citations: 18     Fields:    Translation:HumansCells
    62. Hammel M, Rosenberg DJ, Bierma J, Hura GL, Thapar R, Lees-Miller SP, Tainer JA. Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. Prog Biophys Mol Biol. 2021 08; 163:74-86. PMID: 32966823; PMCID: PMC8896507.
      Citations: 7     Fields:    Translation:Cells
    63. Tsutakawa SE, Tsai CL, Yan C, Bralic A, Chazin WJ, Hamdan SM, Ivanov I, Tainer JA, Sch?rer OD. Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair. DNA Repair (Amst). 2020 12; 96:102972. PMID: 33007515; PMCID: PMC7669588.
      Citations: 13     Fields:    Translation:HumansCells
    64. Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol. 2020 10; 22(10):1264-1275. PMID: 32929201; PMCID: PMC7653546.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    65. Singh M, Bacolla A, Chaudhary S, Hunt CR, Pandita S, Chauhan R, Gupta A, Tainer JA, Pandita TK. Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development. Mol Cell Biol. 2020 08 28; 40(18). PMID: 32661120; PMCID: PMC7459263.
      Citations: 6     Fields:    Translation:HumansCells
    66. Eckelmann BJ, Bacolla A, Wang H, Ye Z, Guerrero EN, Hegde ML, Tainer JA, Mitra S, Jiang W, El-Zein R, Tomkinson AE. XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells. NAR Cancer. 2020 Sep; 2(3):zcaa013. PMID: 32776008; PMCID: PMC7397735.
      Citations: 24     
    67. Tsutakawa SE, Sarker AH, Ng C, Arvai AS, Shin DS, Shih B, Jiang S, Thwin AC, Tsai MS, Willcox A, Her MZ, Trego KS, Raetz AG, Rosenberg D, Bacolla A, Hammel M, Griffith JD, Cooper PK, Tainer JA. Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14127-14138. PMID: 32522879; PMCID: PMC7321962.
      Citations: 20     Fields:    Translation:HumansCells
    68. Seo SH, Bacolla A, Yoo D, Koo YJ, Cho SI, Kim MJ, Seong MW, Kim HJ, Kim JM, Tainer JA, Park SS, Kim JY, Jeon B. Replication-Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease. Mov Disord. 2020 05; 35(5):868-876. PMID: 32039503; PMCID: PMC7359376.
      Citations: 6     Fields:    Translation:Humans
    69. Tsai CL, Tripp P, Sivabalasarma S, Zhang C, Rodriguez-Franco M, Wipfler RL, Chaudhury P, Banerjee A, Beeby M, Whitaker RJ, Tainer JA, Albers SV. The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility. Nat Microbiol. 2020 01; 5(1):216-225. PMID: 31844299; PMCID: PMC6952060.
      Citations: 9     Fields:    Translation:Cells
    70. Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 12 11; 10(1):5654. PMID: 31827085; PMCID: PMC6906431.
      Citations: 39     Fields:    Translation:HumansCells
    71. Zhang H, Chen Z, Ye Y, Ye Z, Cao D, Xiong Y, Srivastava M, Feng X, Tang M, Wang C, Tainer JA, Chen J. SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Nucleic Acids Res. 2019 11 04; 47(19):10181-10201. PMID: 31495888; PMCID: PMC6821277.
      Citations: 13     Fields:    Translation:HumansCells
    72. Hura GL, Hodge CD, Rosenberg D, Guzenko D, Duarte JM, Monastyrskyy B, Grudinin S, Kryshtafovych A, Tainer JA, Fidelis K, Tsutakawa SE. Small angle X-ray scattering-assisted protein structure prediction in CASP13 and emergence of solution structure differences. Proteins. 2019 12; 87(12):1298-1314. PMID: 31589784; PMCID: PMC6851496.
      Citations: 7     Fields:    Translation:Cells
    73. Bacolla A, Tainer JA. DNA damage response mechanisms and structures fundamental to cancer research progress. Prog Biophys Mol Biol. 2019 10; 147:1-3. PMID: 31470026; PMCID: PMC7380103.
      Citations:    Fields:    Translation:Humans
    74. Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFB, Glover JNM. Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis. Structure. 2019 10 01; 27(10):1485-1496.e4. PMID: 31402222; PMCID: PMC6827562.
      Citations: 7     Fields:    Translation:HumansCells
    75. Brosey CA, Tainer JA. Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology. Curr Opin Struct Biol. 2019 10; 58:197-213. PMID: 31204190; PMCID: PMC6778498.
      Citations: 38     Fields:    Translation:Cells
    76. Yan C, Dodd T, He Y, Tainer JA, Tsutakawa SE, Ivanov I. Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. Nat Struct Mol Biol. 2019 06; 26(6):397-406. PMID: 31110295; PMCID: PMC6642811.
      Citations: 29     Fields:    Translation:HumansCells
    77. Bacolla A, Ye Z, Ahmed Z, Tainer JA. Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction. Prog Biophys Mol Biol. 2019 10; 147:47-61. PMID: 30880007; PMCID: PMC6745008.
      Citations: 18     Fields:    Translation:HumansCells
    78. Appel MJ, Meier KK, Lafrance-Vanasse J, Lim H, Tsai CL, Hedman B, Hodgson KO, Tainer JA, Solomon EI, Bertozzi CR. Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5370-5375. PMID: 30824597; PMCID: PMC6431200.
      Citations: 7     Fields:    Translation:Cells
    79. Syed A, Tainer JA. Charge Transport Communication through DNA by Protein Fe-S Clusters: How Far Is Not Too Far? ACS Cent Sci. 2019 Jan 23; 5(1):7-9. PMID: 30693320; PMCID: PMC6346388.
      Citations: 1     
    80. Tang HYH, Shin DS, Hura GL, Yang Y, Hu X, Lightstone FC, McGee MD, Padgett HS, Yannone SM, Tainer JA. Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase. Biochemistry. 2018 12 04; 57(48):6688-6700. PMID: 30376300; PMCID: PMC6642699.
      Citations: 1     Fields:    Translation:Cells
    81. Thapar R, Bacolla A, Oyeniran C, Brickner JR, Chinnam NB, Mosammaparast N, Tainer JA. RNA Modifications: Reversal Mechanisms and Cancer. Biochemistry. 2019 02 05; 58(5):312-329. PMID: 30346748.
      Citations: 19     Fields:    Translation:HumansCells
    82. Guo HF, Tsai CL, Terajima M, Tan X, Banerjee P, Miller MD, Liu X, Yu J, Byemerwa J, Alvarado S, Kaoud TS, Dalby KN, Bota-Rabassedas N, Chen Y, Yamauchi M, Tainer JA, Phillips GN, Kurie JM. Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding. Nat Commun. 2018 07 10; 9(1):2719. PMID: 29988035; PMCID: PMC6039523.
      Citations:    Fields:    
    83. Wu Q, Ochi T, Liang S, Tsutakawa SE, Lees-Miller SP, Tainer JA, Blundell TL, Wang JL, Duboc C, Nadal M, Strick TR. Dissection of DNA double-strand-break repair using novel single-molecule forceps. Nat Struct Mol Biol. 2018 06; 25(6):482-487. PMID: 29786079; PMCID: PMC5990469.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    84. Syed A, Tainer JA. The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair. Annu Rev Biochem. 2018 06 20; 87:263-294. PMID: 29709199; PMCID: PMC6076887.
      Citations: 139     Fields:    Translation:HumansCells
    85. Moiani D, Brosey CA, Arvai AS, Syed A, Petricci E, Tainer JA, Ronato DA, Masson JY. Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. Methods Enzymol. 2018; 601:205-241. PMID: 29523233; PMCID: PMC6070142.
      Citations: 16     Fields:    Translation:HumansCells
    86. Ogorzalek TL, Hura GL, Belsom A, Burnett KH, Kryshtafovych A, Tainer JA, Rappsilber J, Tsutakawa SE, Fidelis K. Small angle X-ray scattering and cross-linking for data assisted protein structure prediction in CASP 12 with prospects for improved accuracy. Proteins. 2018 03; 86 Suppl 1:202-214. PMID: 29314274; PMCID: PMC6003418.
      Citations: 13     Fields:    Translation:HumansCells
    87. Guo HF, Tsai CL, Terajima M, Tan X, Banerjee P, Miller MD, Liu X, Yu J, Byemerwa J, Alvarado S, Kaoud TS, Dalby KN, Bota-Rabassedas N, Chen Y, Yamauchi M, Tainer JA, Phillips GN, Kurie JM. Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding. Nat Commun. 2018 02 06; 9(1):512. PMID: 29410444; PMCID: PMC5802723.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    88. Tsai CL, Tainer JA. Robust Production, Crystallization, Structure Determination, and Analysis of [Fe-S] Proteins: Uncovering Control of Electron Shuttling and Gating in the Respiratory Metabolism of Molybdopterin Guanine Dinucleotide Enzymes. Methods Enzymol. 2018; 599:157-196. PMID: 29746239; PMCID: PMC6049808.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    89. Hura GL, Tainer JA. Coiled coils unspring protein origami. Nat Biotechnol. 2017 11 09; 35(11):1044-1045. PMID: 29121029; PMCID: PMC6002763.
      Citations:    Fields:    Translation:Cells
    90. Trewhella J, Duff AP, Guss JM, Hendrickson WA, Hura GL, Jacques DA, Kirby NM, Kwan AH, Pollack L, Ryan TM, Sali A, Schneidman-Duhovny D, Schwede T, Svergun DI, Sugiyama M, Tainer JA, Westbrook J, Whitten AE, Durand D, Gabel F, P?rez J, Vachette P. 2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update. Acta Crystallogr D Struct Biol. 2017 Sep 01; 73(Pt 9):710-728. PMID: 28876235; PMCID: PMC5586245.
      Citations: 87     Translation:HumansAnimalsCells
    91. Tsutakawa SE, Thompson MJ, Arvai AS, Neil AJ, Shaw SJ, Algasaier SI, Kim JC, Finger LD, Jardine E, Gotham VJB, Sarker AH, Her MZ, Rashid F, Hamdan SM, Mirkin SM, Grasby JA, Tainer JA. Corrigendum: Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun. 2017; 8:16145. PMID: 31305777; PMCID: PMC5603723.
      Citations:    Fields:    
    92. Tainer JA. Uncovering the secrets of protein interactions with the DNA enforcing genomic stability. Prog Biophys Mol Biol. 2017 08; 127:89-92. PMID: 28709479.
      Citations:    Fields:    Translation:Cells
    93. Tsutakawa SE, Thompson MJ, Arvai AS, Neil AJ, Shaw SJ, Algasaier SI, Kim JC, Finger LD, Jardine E, Gotham VJB, Sarker AH, Her MZ, Rashid F, Hamdan SM, Mirkin SM, Grasby JA, Tainer JA. Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun. 2017 06 27; 8:15855. PMID: 28653660; PMCID: PMC5490271.
      Citations: 42     Fields:    Translation:HumansCells
    94. Aceytuno RD, Piett CG, Havali-Shahriari Z, Edwards RA, Rey M, Ye R, Javed F, Fang S, Mani R, Weinfeld M, Hammel M, Tainer JA, Schriemer DC, Lees-Miller SP, Glover JNM. Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex. Nucleic Acids Res. 2017 Jun 02; 45(10):6238-6251. PMID: 28453785; PMCID: PMC5449630.
      Citations: 20     Fields:    Translation:HumansCells
    95. Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA. What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses. Methods Enzymol. 2017; 592:417-455. PMID: 28668129; PMCID: PMC5549440.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    96. Gradia SD, Ishida JP, Tsai MS, Jeans C, Tainer JA, Fuss JO. MacroBac: New Technologies for Robust and Efficient Large-Scale Production of Recombinant Multiprotein Complexes. Methods Enzymol. 2017; 592:1-26. PMID: 28668116; PMCID: PMC6028233.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    97. Dutta A, Eckelmann B, Adhikari S, Ahmed KM, Sengupta S, Pandey A, Hegde PM, Tsai MS, Tainer JA, Weinfeld M, Hegde ML, Mitra S. Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex. Nucleic Acids Res. 2017 03 17; 45(5):2585-2599. PMID: 27994036; PMCID: PMC5389627.
      Citations: 42     Fields:    Translation:HumansCells
    98. Rashid F, Harris PD, Zaher MS, Sobhy MA, Joudeh LI, Yan C, Piwonski H, Tsutakawa SE, Ivanov I, Tainer JA, Habuchi S, Hamdan SM. Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1. Elife. 2017 02 23; 6. PMID: 28230529; PMCID: PMC5358979.
      Citations: 20     Fields:    Translation:HumansCells
    99. Wallen JR, Zhang H, Weis C, Cui W, Foster BM, Ho CMW, Hammel M, Tainer JA, Gross ML, Ellenberger T. Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome. Structure. 2017 01 03; 25(1):157-166. PMID: 28052235; PMCID: PMC5267931.
      Citations: 11     Fields:    Translation:Cells
    100. Tang HYH, Tainer JA, Hura GL. High Resolution Distance Distributions Determined by X-Ray and Neutron Scattering. Adv Exp Med Biol. 2017; 1009:167-181. PMID: 29218559.
      Citations: 3     Fields:    Translation:HumansCells
    101. Lai YT, Hura GL, Dyer KN, Tang HY, Tainer JA, Yeates TO. Designing and defining dynamic protein cage nanoassemblies in solution. Sci Adv. 2016 12; 2(12):e1501855. PMID: 27990489; PMCID: PMC5156514.
      Citations: 16     Fields:    
    102. Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA. An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex. J Biol Chem. 2016 12 30; 291(53):26987-27006. PMID: 27875301; PMCID: PMC5207133.
      Citations: 33     Fields:    Translation:HumansCells
    103. Brosey CA, Ho C, Long WZ, Singh S, Burnett K, Hura GL, Nix JC, Bowman GR, Ellenberger T, Tainer JA. Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. Structure. 2016 12 06; 24(12):2067-2079. PMID: 27818101; PMCID: PMC5143173.
      Citations: 20     Fields:    Translation:HumansCells
    104. Tsai CL, Tainer JA. The ATPase Motor Turns for Type IV Pilus Assembly. Structure. 2016 11 01; 24(11):1857-1859. PMID: 27806257.
      Citations: 5     Fields:    Translation:Cells
    105. Stingele J, Bellelli R, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A, Tainer JA, Skehel JM, Boulton SJ, Alte F, Kj?r S, Groll M. Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN. Mol Cell. 2016 11 17; 64(4):688-703. PMID: 27871365; PMCID: PMC5128726.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    106. Susa AC, Xia Z, Tang HYH, Tainer JA, Williams ER. Charging of Proteins in Native Mass Spectrometry. J Am Soc Mass Spectrom. 2017 02; 28(2):332-340. PMID: 27734326; PMCID: PMC5283922.
      Citations: 15     Fields:    
    107. Hammel M, Amlanjyoti D, Reyes FE, Chen JH, Parpana R, Tang HY, Larabell CA, Tainer JA, Adhya S. HU multimerization shift controls nucleoid compaction. Sci Adv. 2016 07; 2(7):e1600650. PMID: 27482541; PMCID: PMC4966879.
      Citations: 37     Fields:    Translation:Cells
    108. Lees-Miller SP, Beattie TL, Tainer JA. Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer. Nat Struct Mol Biol. 2016 06 07; 23(6):509-10. PMID: 27273637; PMCID: PMC5549438.
      Citations: 8     Fields:    Translation:HumansCells
    109. Schneidman-Duhovny D, Hammel M, Tainer JA, Sali A. FoXS, FoXSDock and MultiFoXS: Single-state and multi-state structural modeling of proteins and their complexes based on SAXS profiles. Nucleic Acids Res. 2016 Jul 08; 44(W1):W424-9. PMID: 27151198; PMCID: PMC4987932.
      Citations: 173     Fields:    Translation:Cells
    110. Bacolla A, Tainer JA, Vasquez KM, Cooper DN. Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences. Nucleic Acids Res. 2016 07 08; 44(12):5673-88. PMID: 27084947; PMCID: PMC4937311.
      Citations: 67     Fields:    Translation:HumansCells
    111. Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. 2016 Apr 01; 35(7):791. PMID: 27037288; PMCID: PMC4818762.
      Citations: 2     Fields:    
    112. Youngblut MD, Tsai CL, Clark IC, Carlson HK, Maglaqui AP, Gau-Pan PS, Redford SA, Wong A, Tainer JA, Coates JD. Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues. J Biol Chem. 2016 Apr 22; 291(17):9190-202. PMID: 26940877; PMCID: PMC4861485.
      Citations: 17     Fields:    Translation:Cells
    113. Hodge CD, Ismail IH, Edwards RA, Hura GL, Xiao AT, Tainer JA, Hendzel MJ, Glover JN. RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment. J Biol Chem. 2016 Apr 29; 291(18):9396-410. PMID: 26903517; PMCID: PMC4850281.
      Citations: 18     Fields:    Translation:AnimalsCells
    114. Brunette TJ, Parmeggiani F, Huang PS, Bhabha G, Ekiert DC, Tsutakawa SE, Hura GL, Tainer JA, Baker D. Exploring the repeat protein universe through computational protein design. Nature. 2015 Dec 24; 528(7583):580-4. PMID: 26675729; PMCID: PMC4845728.
      Citations: 83     Fields:    Translation:Cells
    115. Chaudhury P, Neiner T, D'Imprima E, Reindl S, Ghosh A, Arvai AS, Mills DJ, van der Does C, Tainer JA, Vonck J, Albers SV, Banerjee A. The nucleotide-dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor. Mol Microbiol. 2016 Feb; 99(4):674-85. PMID: 26508112; PMCID: PMC5019145.
      Citations: 26     Fields:    Translation:Cells
    116. Shin DS, Tainer JA. Molecular biology: DNA repair without flipping out. Nature. 2015 Nov 12; 527(7577):168-9. PMID: 26524524.
      Citations: 2     Fields:    Translation:Cells
    117. Pratt AJ, DiDonato M, Shin DS, Cabelli DE, Bruns CK, Belzer CA, Gorringe AR, Langford PR, Tabatabai LB, Kroll JS, Tainer JA, Getzoff ED. Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus. J Bacteriol. 2015 Dec; 197(24):3834-47. PMID: 26459556; PMCID: PMC4652047.
      Citations: 8     Fields:    Translation:AnimalsCells
    118. He W, Scharadin TM, Saldana M, Gellner C, Hoang-Phou S, Takanishi C, Hura GL, Tainer JA, Carraway KL, Henderson PT, Coleman MA. Cell-free expression of functional receptor tyrosine kinases. Sci Rep. 2015 Aug 14; 5:12896. PMID: 26274523; PMCID: PMC4929682.
      Citations: 17     Fields:    Translation:Cells
    119. Tsai CL, Williams GJ, Perry JJ, Tainer JA. An AAA+ ATPase Clamshell Targets Transposition. Cell. 2015 Aug 13; 162(4):701-3. PMID: 26276624; PMCID: PMC5550827.
      Citations:    Fields:    Translation:Cells
    120. Kukshal V, Kim IK, Hura GL, Tomkinson AE, Tainer JA, Ellenberger T. Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining. Nucleic Acids Res. 2015 Aug 18; 43(14):7021-31. PMID: 26130724; PMCID: PMC4538836.
      Citations: 11     Fields:    Translation:HumansCells
    121. Tsutakawa SE, Tainer JA. Bending Forks and Wagging Dogs--It's about the DNA 3' Tail. Mol Cell. 2015 Jun 18; 58(6):972-3. PMID: 26091346; PMCID: PMC5356400.
      Citations: 1     Fields:    Translation:HumansCells
    122. Rambo RP, Tainer JA. Modeling macromolecular motions by x-ray-scattering-constrained molecular dynamics. Biophys J. 2015 May 19; 108(10):2421-2423. PMID: 25992719; PMCID: PMC4457040.
      Citations: 2     Fields:    Translation:Cells
    123. Banerjee A, Tsai CL, Chaudhury P, Tripp P, Arvai AS, Ishida JP, Tainer JA, Albers SV. FlaF Is a ?-Sandwich Protein that Anchors the Archaellum in the Archaeal Cell Envelope by Binding the S-Layer Protein. Structure. 2015 May 05; 23(5):863-872. PMID: 25865246; PMCID: PMC4425475.
      Citations: 32     Fields:    Translation:Cells
    124. Tsutakawa SE, Yan C, Xu X, Weinacht CP, Freudenthal BD, Yang K, Zhuang Z, Washington MT, Tainer JA, Ivanov I. Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response. Structure. 2015 Apr 07; 23(4):724-733. PMID: 25773143; PMCID: PMC4394044.
      Citations: 29     Fields:    Translation:AnimalsCells
    125. Tainer JA. Dynamic structures in DNA damage responses & cancer. Prog Biophys Mol Biol. 2015 Mar; 117(2-3):129-133. PMID: 25934179; PMCID: PMC5080980.
      Citations: 1     Fields:    Translation:HumansCells
    126. Fuss JO, Tsai CL, Ishida JP, Tainer JA. Emerging critical roles of Fe-S clusters in DNA replication and repair. Biochim Biophys Acta. 2015 Jun; 1853(6):1253-71. PMID: 25655665; PMCID: PMC4576882.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    127. Lafrance-Vanasse J, Williams GJ, Tainer JA. Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair. Prog Biophys Mol Biol. 2015 Mar; 117(2-3):182-193. PMID: 25576492; PMCID: PMC4417436.
      Citations: 53     Fields:    Translation:HumansCells
    128. Tsai CL, Burkinshaw BJ, Strynadka NC, Tainer JA. The Salmonella type III secretion system virulence effector forms a new hexameric chaperone assembly for export of effector/chaperone complexes. J Bacteriol. 2015 Feb 15; 197(4):672-5. PMID: 25488302; PMCID: PMC4334186.
      Citations: 5     Fields:    Translation:Cells
    129. Lai YT, Reading E, Hura GL, Tsai KL, Laganowsky A, Asturias FJ, Tainer JA, Robinson CV, Yeates TO. Structure of a designed protein cage that self-assembles into a highly porous cube. Nat Chem. 2014 Dec; 6(12):1065-71. PMID: 25411884; PMCID: PMC4239666.
      Citations: 75     Fields:    
    130. Pratt AJ, Shin DS, Merz GE, Rambo RP, Lancaster WA, Dyer KN, Borbat PP, Poole FL, Adams MW, Freed JH, Crane BR, Tainer JA, Getzoff ED. Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4568-76. PMID: 25316790; PMCID: PMC4217430.
      Citations: 26     Fields:    Translation:Humans
    131. Holton JM, Classen S, Frankel KA, Tainer JA. The R-factor gap in macromolecular crystallography: an untapped potential for insights on accurate structures. FEBS J. 2014 Sep; 281(18):4046-60. PMID: 25040949; PMCID: PMC4282448.
      Citations: 36     Fields:    Translation:Cells
    132. Tsai CL, Shi Y, Tainer JA. How substrate specificity is imposed on a histone demethylase--lessons from KDM2A. Genes Dev. 2014 Aug 15; 28(16):1735-8. PMID: 25128493; PMCID: PMC4197959.
      Citations: 4     Fields:    Translation:Animals
    133. McTernan PM, Chandrayan SK, Wu CH, Vaccaro BJ, Lancaster WA, Yang Q, Fu D, Hura GL, Tainer JA, Adams MW. Intact functional fourteen-subunit respiratory membrane-bound [NiFe]-hydrogenase complex of the hyperthermophilic archaeon Pyrococcus furiosus. J Biol Chem. 2014 Jul 11; 289(28):19364-72. PMID: 24860091; PMCID: PMC4094048.
      Citations: 21     Fields:    Translation:Cells
    134. Mason AC, Rambo RP, Greer B, Pritchett M, Tainer JA, Cortez D, Eichman BF. A structure-specific nucleic acid-binding domain conserved among DNA repair proteins. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7618-23. PMID: 24821763; PMCID: PMC4040553.
      Citations: 17     Fields:    Translation:AnimalsCells
    135. Tsutakawa SE, Lafrance-Vanasse J, Tainer JA. The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once. DNA Repair (Amst). 2014 Jul; 19:95-107. PMID: 24754999; PMCID: PMC4051888.
      Citations: 51     Fields:    Translation:HumansCells
    136. Groocock LM, Nie M, Prudden J, Moiani D, Wang T, Cheltsov A, Rambo RP, Arvai AS, Hitomi C, Tainer JA, Luger K, Perry JJ, Lazzerini-Denchi E, Boddy MN. RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. EMBO Rep. 2014 May; 15(5):601-8. PMID: 24714598; PMCID: PMC4210088.
      Citations: 28     Fields:    Translation:AnimalsCells
    137. Seeger F, Quintyn R, Tanimoto A, Williams GJ, Tainer JA, Wysocki VH, Garcin ED. Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity. Biochemistry. 2014 Apr 08; 53(13):2153-65. PMID: 24669844; PMCID: PMC3985721.
      Citations: 22     Fields:    Translation:HumansCells
    138. Williams GJ, Hammel M, Radhakrishnan SK, Ramsden D, Lees-Miller SP, Tainer JA. Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. DNA Repair (Amst). 2014 May; 17:110-20. PMID: 24656613; PMCID: PMC4102006.
      Citations: 57     Fields:    Translation:HumansCells
    139. Shin DS, Pratt AJ, Tainer JA. Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins. Archaea. 2014; 2014:206735. PMID: 24701133; PMCID: PMC3950489.
      Citations: 6     Fields:    Translation:AnimalsCells
    140. Roset R, Inagaki A, Hohl M, Brenet F, Lafrance-Vanasse J, Lange J, Scandura JM, Tainer JA, Keeney S, Petrini JH. The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev. 2014 Mar 01; 28(5):451-62. PMID: 24532689; PMCID: PMC3950343.
      Citations: 24     Fields:    Translation:AnimalsCells
    141. Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. 2014 Mar 03; 33(5):482-500. PMID: 24493214; PMCID: PMC3989629.
      Citations: 87     Fields:    Translation:Cells
    142. Reyes FE, Schwartz CR, Tainer JA, Rambo RP. Methods for using new conceptual tools and parameters to assess RNA structure by small-angle X-ray scattering. Methods Enzymol. 2014; 549:235-63. PMID: 25432752.
      Citations: 16     Fields:    Translation:Cells
    143. Dyer KN, Hammel M, Rambo RP, Tsutakawa SE, Rodic I, Classen S, Tainer JA, Hura GL. High-throughput SAXS for the characterization of biomolecules in solution: a practical approach. Methods Mol Biol. 2014; 1091:245-58. PMID: 24203338; PMCID: PMC4057279.
      Citations: 92     Fields:    Translation:Cells
    144. Tsai CL, Tainer JA. Probing DNA by 2-OG-dependent dioxygenase. Cell. 2013 Dec 19; 155(7):1448-50. PMID: 24360270; PMCID: PMC3916139.
      Citations: 2     Fields:    Translation:Humans
    145. Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Ismail A, Neale MJ, Bristow RG, Jeggo PA, Tainer JA, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismalaj E, Petricci E, Masson JY, Wyman C. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 09; 53(1):7-18. PMID: 24316220; PMCID: PMC3909494.
      Citations: 280     Fields:    Translation:HumansCells
    146. Webb BM, Dong GQ, Schneidman-Duhovny D, Fan H, Kim SJ, Khuri N, Spill YG, Weinkam P, Hammel M, Tainer JA, Nilges M, Sali A, Pieper U. ModBase, a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res. 2014 Jan; 42(Database issue):D336-46. PMID: 24271400; PMCID: PMC3965011.
      Citations: 110     Fields:    Translation:HumansCells
    147. Crown KN, Savytskyy OP, Malik SB, Logsdon J, Williams RS, Tainer JA, Zolan ME. A mutation in the FHA domain of Coprinus cinereus Nbs1 Leads to Spo11-independent meiotic recombination and chromosome segregation. G3 (Bethesda). 2013 Nov 06; 3(11):1927-43. PMID: 24062528; PMCID: PMC3815056.
      Citations: 8     Fields:    Translation:AnimalsCells
    148. Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P. Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res. 2014 Jan; 42(2):906-17. PMID: 24150939; PMCID: PMC3902922.
      Citations: 29     Fields:    Translation:AnimalsCells
    149. Hura GL, Tsai CL, Claridge SA, Mendillo ML, Smith JM, Williams GJ, Mastroianni AJ, Alivisatos AP, Putnam CD, Kolodner RD, Tainer JA. DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17308-13. PMID: 24101514; PMCID: PMC3808630.
      Citations: 35     Fields:    Translation:Cells
    150. Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X. Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):14918-23. PMID: 23980170; PMCID: PMC3773798.
      Citations: 75     Fields:    Translation:HumansCells
    151. Schneidman-Duhovny D, Hammel M, Tainer JA, Sali A. Accurate SAXS profile computation and its assessment by contrast variation experiments. Biophys J. 2013 Aug 20; 105(4):962-74. PMID: 23972848; PMCID: PMC3752106.
      Citations: 224     Fields:    Translation:Cells
    152. Trewhella J, Hendrickson WA, Kleywegt GJ, Sali A, Sato M, Schwede T, Svergun DI, Tainer JA, Westbrook J, Berman HM. Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB. Structure. 2013 Jun 04; 21(6):875-81. PMID: 23747111.
      Citations: 41     Fields:    Translation:Cells
    153. Hura GL, Budworth H, Dyer KN, Rambo RP, Hammel M, McMurray CT, Tainer JA. Comprehensive macromolecular conformations mapped by quantitative SAXS analyses. Nat Methods. 2013 Jun; 10(6):453-4. PMID: 23624664; PMCID: PMC3728378.
      Citations: 68     Fields:    Translation:Cells
    154. Rambo RP, Tainer JA. Accurate assessment of mass, models and resolution by small-angle scattering. Nature. 2013 Apr 25; 496(7446):477-81. PMID: 23619693; PMCID: PMC3714217.
      Citations: 350     Fields:    Translation:Cells
    155. Hegde ML, Tsutakawa SE, Hegde PM, Holthauzen LM, Li J, Oezguen N, Hilser VJ, Tainer JA, Mitra S. The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions. J Mol Biol. 2013 Jul 10; 425(13):2359-71. PMID: 23542007; PMCID: PMC3779128.
      Citations: 26     Fields:    Translation:Cells
    156. Rambo RP, Tainer JA. Super-resolution in solution X-ray scattering and its applications to structural systems biology. Annu Rev Biophys. 2013; 42:415-41. PMID: 23495971.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    157. Reindl S, Ghosh A, Williams GJ, Lassak K, Neiner T, Henche AL, Albers SV, Tainer JA. Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics. Mol Cell. 2013 Mar 28; 49(6):1069-82. PMID: 23416110; PMCID: PMC3615136.
      Citations: 46     Fields:    Translation:Cells
    158. Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP. XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. Biochem Cell Biol. 2013 Feb; 91(1):31-41. PMID: 23442139; PMCID: PMC3725335.
      Citations: 56     Fields:    Translation:HumansCells
    159. Perry JJ, Tainer JA. Developing advanced X-ray scattering methods combined with crystallography and computation. Methods. 2013 Mar; 59(3):363-71. PMID: 23376408; PMCID: PMC3684416.
      Citations: 7     Fields:    Translation:Cells
    160. Tsutakawa SE, Shin DS, Mol CD, Izumi T, Arvai AS, Mantha AK, Szczesny B, Ivanov IN, Hosfield DJ, Maiti B, Pique ME, Frankel KA, Hitomi K, Cunningham RP, Mitra S, Tainer JA. Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. J Biol Chem. 2013 Mar 22; 288(12):8445-8455. PMID: 23355472; PMCID: PMC3605660.
      Citations: 43     Fields:    Translation:HumansCells
    161. Classen S, Hura GL, Holton JM, Rambo RP, Rodic I, McGuire PJ, Dyer K, Hammel M, Meigs G, Frankel KA, Tainer JA. Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source. J Appl Crystallogr. 2013 Feb 01; 46(Pt 1):1-13. PMID: 23396808; PMCID: PMC3547225.
      Citations: 113     
    162. Brosey CA, Yan C, Tsutakawa SE, Heller WT, Rambo RP, Tainer JA, Ivanov I, Chazin WJ. A new structural framework for integrating replication protein A into DNA processing machinery. Nucleic Acids Res. 2013 Feb 01; 41(4):2313-27. PMID: 23303776; PMCID: PMC3575853.
      Citations: 57     Fields:    Translation:Cells
    163. Nilsen L, Korvald H, Huffman J, McMurray CT, Alseth I, Tainer JA, Dalhus B, Forstr?m RJ, Bj?r?s M. Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2. Structure. 2013 Jan 08; 21(1):154-166. PMID: 23245849; PMCID: PMC3545110.
      Citations: 5     Fields:    Translation:AnimalsCells
    164. Wilkinson OJ, Latypov V, Tubbs JL, Millington CL, Morita R, Blackburn H, Marriott A, McGown G, Thorncroft M, Watson AJ, Connolly BA, Grasby JA, Masui R, Hunter CA, Tainer JA, Margison GP, Williams DM. Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-p interactions. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18755-60. PMID: 23112169; PMCID: PMC3503161.
      Citations: 9     Fields:    Translation:AnimalsCells
    165. Shi K, Kurahashi K, Gao R, Tsutakawa SE, Tainer JA, Pommier Y, Aihara H. Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2. Nat Struct Mol Biol. 2012 Dec; 19(12):1372-7. PMID: 23104058; PMCID: PMC3515695.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    166. Limbo O, Moiani D, Kertokalio A, Wyman C, Tainer JA, Russell P. Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair. Nucleic Acids Res. 2012 Dec; 40(22):11435-49. PMID: 23080121; PMCID: PMC3526295.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    167. Lee KC, Padget K, Curtis H, Cowell IG, Moiani D, Sondka Z, Morris NJ, Jackson GH, Cockell SJ, Tainer JA, Austin CA. MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biol Open. 2012 Sep 15; 1(9):863-73. PMID: 23213480; PMCID: PMC3507232.
      Citations: 35     Fields:    
    168. Omanakuttan A, Nambiar J, Harris RM, Bose C, Pandurangan N, Varghese RK, Kumar GB, Tainer JA, Banerji A, Perry JJ, Nair BG. Anacardic acid inhibits the catalytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9. Mol Pharmacol. 2012 Oct; 82(4):614-22. PMID: 22745359; PMCID: PMC3463216.
      Citations: 17     Fields:    Translation:AnimalsCells
    169. Latypov VF, Tubbs JL, Watson AJ, Marriott AS, McGown G, Thorncroft M, Wilkinson OJ, Senthong P, Butt A, Arvai AS, Millington CL, Povey AC, Williams DM, Santibanez-Koref MF, Tainer JA, Margison GP. Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Mol Cell. 2012 Jul 13; 47(1):50-60. PMID: 22658721; PMCID: PMC3398191.
      Citations: 17     Fields:    Translation:AnimalsCells
    170. Kim IK, Kiefer JR, Ho CM, Stegeman RA, Classen S, Tainer JA, Ellenberger T. Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element. Nat Struct Mol Biol. 2012 May 20; 19(6):653-6. PMID: 22609859; PMCID: PMC3381899.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    171. Yan C, Xu X, Tsutakawa SE, Tsai MS, Tainer JA, Cooper PK, Nogales E, Ivanov I, Querol-Aud? J. Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8528-33. PMID: 22586102; PMCID: PMC3365210.
      Citations: 31     Fields:    Translation:HumansCells
    172. Christie JM, Hitomi K, Arvai AS, Hartfield KA, Mettlen M, Pratt AJ, Tainer JA, Getzoff ED. Structural tuning of the fluorescent protein iLOV for improved photostability. J Biol Chem. 2012 Jun 22; 287(26):22295-304. PMID: 22573334; PMCID: PMC3381190.
      Citations: 49     Fields:    Translation:AnimalsCells
    173. Roberts VA, Pique ME, Hsu S, Li S, Slupphaug G, Rambo RP, Jamison JW, Liu T, Lee JH, Tainer JA, Ten Eyck LF, Woods VL. Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Res. 2012 Jul; 40(13):6070-81. PMID: 22492624; PMCID: PMC3401472.
      Citations: 21     Fields:    Translation:Cells
    174. Ruigrok VJ, van Duijn E, Barendregt A, Dyer K, Tainer JA, Stoltenburg R, Strehlitz B, Levisson M, Smidt H, van der Oost J. Kinetic and stoichiometric characterisation of streptavidin-binding aptamers. Chembiochem. 2012 Apr 16; 13(6):829-36. PMID: 22416028.
      Citations: 6     Fields:    Translation:Cells
    175. Yamagata A, Milgotina E, Scanlon K, Craig L, Tainer JA, Donnenberg MS. Structure of an essential type IV pilus biogenesis protein provides insights into pilus and type II secretion systems. J Mol Biol. 2012 May 25; 419(1-2):110-24. PMID: 22387466; PMCID: PMC3338861.
      Citations: 18     Fields:    Translation:Cells
    176. Patel N, Atack JM, Finger LD, Exell JC, Thompson P, Tsutakawa S, Tainer JA, Williams DM, Grasby JA. Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends. Nucleic Acids Res. 2012 May; 40(10):4507-19. PMID: 22319208; PMCID: PMC3378889.
      Citations: 33     Fields:    Translation:HumansCells
    177. Sontz PA, Mui TP, Fuss JO, Tainer JA, Barton JK. DNA charge transport as a first step in coordinating the detection of lesions by repair proteins. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):1856-61. PMID: 22308447; PMCID: PMC3277573.
      Citations: 50     Fields:    Translation:Cells
    178. Tsutakawa SE, Tainer JA. Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily. Mech Ageing Dev. 2012 Apr; 133(4):195-202. PMID: 22244820; PMCID: PMC3345168.
      Citations: 13     Fields:    Translation:HumansCells
    179. Finger LD, Atack JM, Tsutakawa S, Classen S, Tainer J, Grasby J, Shen B. The wonders of flap endonucleases: structure, function, mechanism and regulation. Subcell Biochem. 2012; 62:301-26. PMID: 22918592; PMCID: PMC3728657.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    180. Hitomi K, Arvai AS, Yamamoto J, Hitomi C, Teranishi M, Hirouchi T, Yamamoto K, Iwai S, Tainer JA, Hidema J, Getzoff ED. Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants. J Biol Chem. 2012 Apr 06; 287(15):12060-9. PMID: 22170053; PMCID: PMC3320952.
      Citations: 16     Fields:    Translation:AnimalsCells
    181. Yannone SM, Hartung S, Menon AL, Adams MW, Tainer JA. Metals in biology: defining metalloproteomes. Curr Opin Biotechnol. 2012 Feb; 23(1):89-95. PMID: 22138493; PMCID: PMC3273585.
      Citations: 23     Fields:    Translation:HumansCells
    182. Grasby JA, Finger LD, Tsutakawa SE, Atack JM, Tainer JA. Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases. Trends Biochem Sci. 2012 Feb; 37(2):74-84. PMID: 22118811; PMCID: PMC3341984.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    183. Hartung S, Arvai AS, Wood T, Kolappan S, Shin DS, Craig L, Tainer JA. Ultrahigh resolution and full-length pilin structures with insights for filament assembly, pathogenic functions, and vaccine potential. J Biol Chem. 2011 Dec 23; 286(51):44254-44265. PMID: 22027840; PMCID: PMC3243539.
      Citations: 39     Fields:    Translation:Cells
    184. Tsutakawa SE, Van Wynsberghe AW, Freudenthal BD, Weinacht CP, Gakhar L, Washington MT, Zhuang Z, Tainer JA, Ivanov I. Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17672-7. PMID: 22006297; PMCID: PMC3203759.
      Citations: 37     Fields:    Translation:HumansCells
    185. Mui TP, Fuss JO, Ishida JP, Tainer JA, Barton JK. ATP-stimulated, DNA-mediated redox signaling by XPD, a DNA repair and transcription helicase. J Am Chem Soc. 2011 Oct 19; 133(41):16378-81. PMID: 21939244; PMCID: PMC3234108.
      Citations: 35     Fields:    Translation:Cells
    186. Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, Pique ME, Fang S, Mahaney BL, Weinfeld M, Schriemer DC, Lees-Miller SP, Tainer JA. XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair. J Biol Chem. 2011 Sep 16; 286(37):32638-50. PMID: 21775435; PMCID: PMC3173232.
      Citations: 95     Fields:    Translation:HumansCells
    187. Tomlinson CG, Syson K, Atack JM, Sayers JR, Swanson L, Tainer JA, Williams NH, Grasby JA, Sengerov? B. Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions. J Biol Chem. 2011 Sep 02; 286(35):30878-30887. PMID: 21734257; PMCID: PMC3162448.
      Citations: 10     Fields:    Translation:Cells
    188. Ghosh A, Hartung S, van der Does C, Tainer JA, Albers SV. Archaeal flagellar ATPase motor shows ATP-dependent hexameric assembly and activity stimulation by specific lipid binding. Biochem J. 2011 Jul 01; 437(1):43-52. PMID: 21506936; PMCID: PMC3213642.
      Citations: 33     Fields:    Translation:Cells
    189. Trego KS, Chernikova SB, Davalos AR, Perry JJ, Finger LD, Ng C, Tsai MS, Yannone SM, Tainer JA, Campisi J, Cooper PK. The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle. 2011 Jun 15; 10(12):1998-2007. PMID: 21558802; PMCID: PMC3154418.
      Citations: 28     Fields:    Translation:HumansCells
    190. Tubbs JL, Tainer JA. P53 conformational switching for selectivity may reveal a general solution for specific DNA binding. EMBO J. 2011 Jun 01; 30(11):2099-100. PMID: 21629273; PMCID: PMC3117650.
      Citations: 1     Fields:    Translation:HumansCells
    191. Fuss JO, Tainer JA. XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase. DNA Repair (Amst). 2011 Jul 15; 10(7):697-713. PMID: 21571596; PMCID: PMC3234290.
      Citations: 79     Fields:    Translation:HumansCells
    192. Kazantsev AV, Rambo RP, Karimpour S, Santalucia J, Tainer JA, Pace NR. Solution structure of RNase P RNA. RNA. 2011 Jun; 17(6):1159-71. PMID: 21531920; PMCID: PMC3096047.
      Citations: 20     Fields:    Translation:Cells
    193. Rambo RP, Tainer JA. Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law. Biopolymers. 2011 Aug; 95(8):559-71. PMID: 21509745; PMCID: PMC3103662.
      Citations: 245     Fields:    Translation:Cells
    194. Tsutakawa SE, Classen S, Chapados BR, Arvai AS, Finger LD, Guenther G, Tomlinson CG, Thompson P, Sarker AH, Shen B, Cooper PK, Grasby JA, Tainer JA. Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily. Cell. 2011 Apr 15; 145(2):198-211. PMID: 21496641; PMCID: PMC3086263.
      Citations: 150     Fields:    Translation:HumansCells
    195. Perry JJ, Tainer JA. All stressed out without ATM kinase. Sci Signal. 2011 Apr 05; 4(167):pe18. PMID: 21467296; PMCID: PMC3308628.
      Citations: 8     Fields:    Translation:HumansCells
    196. Prudden J, Perry JJ, Nie M, Vashisht AA, Arvai AS, Hitomi C, Guenther G, Wohlschlegel JA, Tainer JA, Boddy MN. DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes. Mol Cell Biol. 2011 Jun; 31(11):2299-310. PMID: 21444718; PMCID: PMC3133251.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    197. Williams GJ, Williams RS, Williams JS, Moncalian G, Arvai AS, Limbo O, Guenther G, SilDas S, Hammel M, Russell P, Tainer JA. ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair. Nat Struct Mol Biol. 2011 Apr; 18(4):423-31. PMID: 21441914; PMCID: PMC3118400.
      Citations: 104     Fields:    Translation:Cells
    198. Heideker J, Prudden J, Perry JJ, Tainer JA, Boddy MN. SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability. PLoS Genet. 2011 Mar; 7(3):e1001320. PMID: 21408210; PMCID: PMC3048374.
      Citations: 33     Fields:    Translation:AnimalsCells
    199. Lancaster WA, Praissman JL, Poole FL, Cvetkovic A, Menon AL, Scott JW, Jenney FE, Thorgersen MP, Kalisiak E, Apon JV, Trauger SA, Siuzdak G, Tainer JA, Adams MW. A computational framework for proteome-wide pursuit and prediction of metalloproteins using ICP-MS and MS/MS data. BMC Bioinformatics. 2011 Feb 28; 12:64. PMID: 21356119; PMCID: PMC3058030.
      Citations: 9     Fields:    Translation:Cells
    200. Arthur DC, Edwards RA, Tsutakawa S, Tainer JA, Frost LS, Glover JN. Mapping interactions between the RNA chaperone FinO and its RNA targets. Nucleic Acids Res. 2011 May; 39(10):4450-63. PMID: 21278162; PMCID: PMC3105414.
      Citations: 22     Fields:    Translation:Cells
    201. Wellhauser L, Luna-Chavez C, D'Antonio C, Tainer J, Bear CE. ATP induces conformational changes in the carboxyl-terminal region of ClC-5. J Biol Chem. 2011 Feb 25; 286(8):6733-41. PMID: 21173145; PMCID: PMC3057859.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    202. Lintner NG, Frankel KA, Tsutakawa SE, Alsbury DL, Young MJ, Tainer JA, Lawrence CM, Copi? V. The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system. J Mol Biol. 2011 Jan 28; 405(4):939-55. PMID: 21093452; PMCID: PMC4507800.
      Citations: 44     Fields:    Translation:Cells
    203. Rambo RP, Williams GJ, Tainer JA. Achieving fidelity in homologous recombination despite extreme complexity: informed decisions by molecular profiling. Mol Cell. 2010 Nov 12; 40(3):347-8. PMID: 21070960; PMCID: PMC3003302.
      Citations: 2     Fields:    
    204. Hammel M, Yu Y, Fang S, Lees-Miller SP, Tainer JA. XLF regulates filament architecture of the XRCC4?ligase IV complex. Structure. 2010 Nov 10; 18(11):1431-42. PMID: 21070942; PMCID: PMC3008546.
      Citations: 77     Fields:    Translation:HumansCells
    205. Dobbs TA, Tainer JA, Lees-Miller SP. A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair (Amst). 2010 Dec 10; 9(12):1307-14. PMID: 21030321; PMCID: PMC3045832.
      Citations: 111     Fields:    Translation:Cells
    206. Williams GJ, Lees-Miller SP, Tainer JA. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst). 2010 Dec 10; 9(12):1299-306. PMID: 21035407; PMCID: PMC3008338.
      Citations: 120     Fields:    Translation:Cells
    207. Kashiwagi S, Kuraoka I, Fujiwara Y, Hitomi K, Cheng QJ, Fuss JO, Shin DS, Masutani C, Tainer JA, Hanaoka F, Iwai S. Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana. J Nucleic Acids. 2010 Sep 20; 2010. PMID: 20936172; PMCID: PMC2945680.
      Citations: 7     
    208. Classen S, Rodic I, Holton J, Hura GL, Hammel M, Tainer JA. Software for the high-throughput collection of SAXS data using an enhanced Blu-Ice/DCS control system. J Synchrotron Radiat. 2010 Nov; 17(6):774-81. PMID: 20975223; PMCID: PMC2964114.
      Citations: 23     Fields:    
    209. Cotner-Gohara E, Kim IK, Hammel M, Tainer JA, Tomkinson AE, Ellenberger T. Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states. Biochemistry. 2010 Jul 27; 49(29):6165-76. PMID: 20518483; PMCID: PMC2922849.
      Citations: 60     Fields:    Translation:HumansCells
    210. Rosenfeld RJ, Bonaventura J, Szymczyna BR, MacCoss MJ, Arvai AS, Yates JR, Tainer JA, Getzoff ED. Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation. J Biol Chem. 2010 Oct 08; 285(41):31581-9. PMID: 20659888; PMCID: PMC2951232.
      Citations: 14     Fields:    Translation:AnimalsCells
    211. Cvetkovic A, Menon AL, Thorgersen MP, Scott JW, Poole FL, Jenney FE, Lancaster WA, Praissman JL, Shanmukh S, Vaccaro BJ, Trauger SA, Kalisiak E, Apon JV, Siuzdak G, Yannone SM, Tainer JA, Adams MW. Microbial metalloproteomes are largely uncharacterized. Nature. 2010 Aug 05; 466(7307):779-82. PMID: 20639861.
      Citations: 129     Fields:    Translation:Cells
    212. Rahal EA, Henricksen LA, Li Y, Williams RS, Tainer JA, Dixon K. ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. Cell Cycle. 2010 Jul 15; 9(14):2866-77. PMID: 20647759; PMCID: PMC3040963.
      Citations: 39     Fields:    Translation:HumansCells
    213. Tainer JA, McCammon JA, Ivanov I. Recognition of the ring-opened state of proliferating cell nuclear antigen by replication factor C promotes eukaryotic clamp-loading. J Am Chem Soc. 2010 Jun 02; 132(21):7372-8. PMID: 20455582; PMCID: PMC2876781.
      Citations: 28     Fields:    Translation:AnimalsCells
    214. Perry JJ, Asaithamby A, Barnebey A, Kiamanesch F, Chen DJ, Han S, Tainer JA, Yannone SM. Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. J Biol Chem. 2010 Aug 13; 285(33):25699-707. PMID: 20516064; PMCID: PMC2919133.
      Citations: 15     Fields:    Translation:HumansCells
    215. Lim MS, Ng D, Zong Z, Arvai AS, Taylor RK, Tainer JA, Craig L. Vibrio cholerae El Tor TcpA crystal structure and mechanism for pilus-mediated microcolony formation. Mol Microbiol. 2010 Aug; 77(3):755-70. PMID: 20545841; PMCID: PMC2939829.
      Citations: 22     Fields:    Translation:Cells
    216. Tubbs JL, Tainer JA. Alkyltransferase-like proteins: molecular switches between DNA repair pathways. Cell Mol Life Sci. 2010 Nov; 67(22):3749-62. PMID: 20502938; PMCID: PMC3088651.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    217. Perry JJ, Cotner-Gohara E, Ellenberger T, Tainer JA. Structural dynamics in DNA damage signaling and repair. Curr Opin Struct Biol. 2010 Jun; 20(3):283-94. PMID: 20439160; PMCID: PMC2916978.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    218. Pretto DI, Tsutakawa S, Brosey CA, Castillo A, Chagot ME, Smith JA, Tainer JA, Chazin WJ. Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering. Biochemistry. 2010 Apr 06; 49(13):2880-9. PMID: 20184389; PMCID: PMC2847624.
      Citations: 24     Fields:    Translation:HumansCells
    219. Tomlinson CG, Atack JM, Chapados B, Tainer JA, Grasby JA. Substrate recognition and catalysis by flap endonucleases and related enzymes. Biochem Soc Trans. 2010 Apr; 38(2):433-7. PMID: 20298197.
      Citations: 25     Fields:    Translation:HumansCells
    220. Aramini JM, Tubbs JL, Kanugula S, Rossi P, Ertekin A, Maglaqui M, Hamilton K, Ciccosanti CT, Jiang M, Xiao R, Soong TT, Rost B, Acton TB, Everett JK, Pegg AE, Tainer JA, Montelione GT. Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein. J Biol Chem. 2010 Apr 30; 285(18):13736-41. PMID: 20212037; PMCID: PMC2859536.
      Citations: 13     Fields:    Translation:HumansCells
    221. Das D, Moiani D, Axelrod HL, Miller MD, McMullan D, Jin KK, Abdubek P, Astakhova T, Burra P, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, Ernst D, Feuerhelm J, Grant JC, Grzechnik A, Grzechnik SK, Han GW, Jaroszewski L, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Marciano D, Morse AT, Nigoghossian E, Okach L, Paulsen J, Reyes R, Rife CL, Sefcovic N, Tien HJ, Trame CB, van den Bedem H, Weekes D, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Tainer JA, Wilson IA, Elsliger MA. Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair. J Mol Biol. 2010 Apr 02; 397(3):647-63. PMID: 20122942; PMCID: PMC2839085.
      Citations: 26     Fields:    Translation:Cells
    222. Rambo RP, Tainer JA. Improving small-angle X-ray scattering data for structural analyses of the RNA world. RNA. 2010 Mar; 16(3):638-46. PMID: 20106957; PMCID: PMC2822928.
      Citations: 47     Fields:    Translation:Cells
    223. Rambo RP, Tainer JA. Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering. Curr Opin Struct Biol. 2010 Feb; 20(1):128-37. PMID: 20097063; PMCID: PMC2829847.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    224. Williams JS, Williams RS, Dovey CL, Guenther G, Tainer JA, Russell P. gammaH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J. 2010 Mar 17; 29(6):1136-48. PMID: 20094029; PMCID: PMC2845269.
      Citations: 54     Fields:    Translation:AnimalsCells
    225. Perry JJ, Shin DS, Tainer JA. Amyotrophic lateral sclerosis. Adv Exp Med Biol. 2010; 685:9-20. PMID: 20687491.
      Citations: 14     Fields:    Translation:HumansAnimals
    226. Fang Q, Kanugula S, Tubbs JL, Tainer JA, Pegg AE. Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases. J Biol Chem. 2010 Mar 12; 285(11):8185-95. PMID: 20026607; PMCID: PMC2832970.
      Citations: 11     Fields:    Translation:HumansCells
    227. Perry JJ, Shin DS, Getzoff ED, Tainer JA. The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta. 2010 Feb; 1804(2):245-62. PMID: 19914407; PMCID: PMC3098211.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    228. Aleshin AE, Gramatikova S, Hura GL, Bobkov A, Strongin AY, Stec B, Tainer JA, Liddington RC, Smith JW. Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case. Structure. 2009 Nov 11; 17(11):1465-75. PMID: 19913481; PMCID: PMC3615642.
      Citations: 15     Fields:    Translation:Cells
    229. Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, Phipps BM, Rambo RP, Hura GL, Pelikan M, So S, Abolfath RM, Chen DJ, Lees-Miller SP, Tainer JA. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem. 2010 Jan 08; 285(2):1414-23. PMID: 19893054; PMCID: PMC2801267.
      Citations: 114     Fields:    Translation:HumansCells
    230. Williams RS, Dodson GE, Limbo O, Yamada Y, Williams JS, Guenther G, Classen S, Glover JN, Iwasaki H, Russell P, Tainer JA. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell. 2009 Oct 02; 139(1):87-99. PMID: 19804755; PMCID: PMC2762657.
      Citations: 183     Fields:    Translation:HumansAnimalsCells
    231. Bernstein NK, Hammel M, Mani RS, Weinfeld M, Pelikan M, Tainer JA, Glover JN. Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase. Nucleic Acids Res. 2009 Oct; 37(18):6161-73. PMID: 19671525; PMCID: PMC2764422.
      Citations: 28     Fields:    Translation:AnimalsCells
    232. Hura GL, Menon AL, Hammel M, Rambo RP, Poole FL, Tsutakawa SE, Jenney FE, Classen S, Frankel KA, Hopkins RC, Yang SJ, Scott JW, Dillard BD, Adams MW, Tainer JA. Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS). Nat Methods. 2009 Aug; 6(8):606-12. PMID: 19620974; PMCID: PMC3094553.
      Citations: 315     Fields:    Translation:Cells
    233. Tubbs JL, Latypov V, Kanugula S, Butt A, Melikishvili M, Kraehenbuehl R, Fleck O, Marriott A, Watson AJ, Verbeek B, McGown G, Thorncroft M, Santibanez-Koref MF, Millington C, Arvai AS, Kroeger MD, Peterson LA, Williams DM, Fried MG, Margison GP, Pegg AE, Tainer JA. Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature. 2009 Jun 11; 459(7248):808-13. PMID: 19516334; PMCID: PMC2729916.
      Citations: 73     Fields:    Translation:HumansCells
    234. Perry JJ, Harris RM, Moiani D, Olson AJ, Tainer JA. p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses. J Mol Biol. 2009 Aug 07; 391(1):1-11. PMID: 19501598; PMCID: PMC2724755.
      Citations: 18     Fields:    Translation:HumansCells
    235. Perry JJ, Hitomi K, Tainer JA. Flexibility promotes fidelity. Structure. 2009 May 13; 17(5):633-4. PMID: 19446518.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    236. Perry JJ, Hearn AS, Cabelli DE, Nick HS, Tainer JA, Silverman DN. Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. Biochemistry. 2009 Apr 21; 48(15):3417-24. PMID: 19265433; PMCID: PMC2756076.
      Citations: 23     Fields:    Translation:HumansCells
    237. Prudden J, Perry JJ, Arvai AS, Tainer JA, Boddy MN. Molecular mimicry of SUMO promotes DNA repair. Nat Struct Mol Biol. 2009 May; 16(5):509-16. PMID: 19363481; PMCID: PMC2711901.
      Citations: 33     Fields:    Translation:AnimalsCells
    238. Hitomi K, DiTacchio L, Arvai AS, Yamamoto J, Kim ST, Todo T, Tainer JA, Iwai S, Panda S, Getzoff ED. Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):6962-7. PMID: 19359474; PMCID: PMC2678464.
      Citations: 49     Fields:    Translation:AnimalsCells
    239. Min X, Akella R, He H, Humphreys JM, Tsutakawa SE, Lee SJ, Tainer JA, Cobb MH, Goldsmith EJ. The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure. 2009 Jan 14; 17(1):96-104. PMID: 19141286; PMCID: PMC3689539.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    240. Arvai AS, Rosnes I, Backe PH, Alseth I, Gao H, Cao W, Tainer JA, Dalhus B, Olsen ?E, Bj?r?s M. Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair. Nat Struct Mol Biol. 2009 Feb; 16(2):138-43. PMID: 19136958; PMCID: PMC3560532.
      Citations: 50     Fields:    Translation:Cells
    241. Williams RS, Williams GJ, Tainer JA. A charged performance by gp17 in viral packaging. Cell. 2008 Dec 26; 135(7):1169-71. PMID: 19109888.
      Citations: 1     Fields:    Translation:Cells
    242. Shin DS, Didonato M, Barondeau DP, Hura GL, Hitomi C, Berglund JA, Getzoff ED, Cary SC, Tainer JA. Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis. J Mol Biol. 2009 Feb 06; 385(5):1534-55. PMID: 19063897; PMCID: PMC2669833.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    243. Acharya SN, Many AM, Schroeder AP, Kennedy FM, Savytskyy OP, Grubb JT, Vincent JA, Friedle EA, Celerin M, Maillet DS, Palmerini HJ, Greischar MA, Moncalian G, Williams RS, Tainer JA, Zolan ME. Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination. Genetics. 2008 Dec; 180(4):1889-907. PMID: 18940790; PMCID: PMC2600930.
      Citations: 12     Fields:    Translation:AnimalsCells
    244. Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov; 4(11):700-7. PMID: 18849972; PMCID: PMC2868503.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    245. Edwards RA, Lee MS, Tsutakawa SE, Williams RS, Nazeer I, Kleiman FE, Tainer JA, Glover JN. The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50. Biochemistry. 2008 Nov 04; 47(44):11446-56. PMID: 18842000; PMCID: PMC2654182.
      Citations: 17     Fields:    Translation:HumansCells
    246. Williams RS, Moncalian G, Williams JS, Yamada Y, Limbo O, Shin DS, Groocock LM, Cahill D, Hitomi C, Guenther G, Moiani D, Carney JP, Russell P, Tainer JA. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell. 2008 Oct 03; 135(1):97-109. PMID: 18854158; PMCID: PMC2681233.
      Citations: 273     Fields:    Translation:AnimalsCells
    247. Fang Q, Noronha AM, Murphy SP, Wilds CJ, Tubbs JL, Tainer JA, Chowdhury G, Guengerich FP, Pegg AE. Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 2008 Oct 14; 47(41):10892-903. PMID: 18803403; PMCID: PMC2632579.
      Citations: 15     Fields:    Translation:HumansCells
    248. Syson K, Tomlinson C, Chapados BR, Sayers JR, Tainer JA, Williams NH, Grasby JA. Three metal ions participate in the reaction catalyzed by T5 flap endonuclease. J Biol Chem. 2008 Oct 17; 283(42):28741-6. PMID: 18697748; PMCID: PMC2568906.
      Citations: 27     Fields:    Translation:Cells
    249. Pebernard S, Perry JJ, Tainer JA, Boddy MN. Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. Mol Biol Cell. 2008 Oct; 19(10):4099-109. PMID: 18667531; PMCID: PMC2555936.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    250. Fan L, Fuss JO, Cheng QJ, Arvai AS, Hammel M, Roberts VA, Cooper PK, Tainer JA. XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. Cell. 2008 May 30; 133(5):789-800. PMID: 18510924; PMCID: PMC3055247.
      Citations: 203     Fields:    Translation:Cells
    251. Chrencik JE, Brooun A, Zhang H, Mathews II, Hura GL, Foster SA, Perry JJ, Streiff M, Ramage P, Widmer H, Bokoch GM, Tainer JA, Weckbecker G, Kuhn P. Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J Mol Biol. 2008 Jul 25; 380(5):828-43. PMID: 18589439; PMCID: PMC2620086.
      Citations: 32     Fields:    Translation:HumansCells
    252. Garcin ED, Hosfield DJ, Desai SA, Haas BJ, Cunningham RP, Tainer JA, Bj?ras M. DNA apurinic-apyrimidinic site binding and excision by endonuclease IV. Nat Struct Mol Biol. 2008 May; 15(5):515-22. PMID: 18408731.
      Citations: 50     Fields:    Translation:Cells
    253. Perry JJ, Tainer JA, Boddy MN. A SIM-ultaneous role for SUMO and ubiquitin. Trends Biochem Sci. 2008 May; 33(5):201-8. PMID: 18403209.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    254. Prudden J, Pebernard S, Raffa G, Slavin DA, Perry JJ, Tainer JA, McGowan CH, Boddy MN. SUMO-targeted ubiquitin ligases in genome stability. EMBO J. 2007 Sep 19; 26(18):4089-101. PMID: 17762865; PMCID: PMC2230673.
      Citations: 183     Fields:    Translation:HumansAnimalsCells
    255. Roberts BR, Tainer JA, Getzoff ED, Malencik DA, Anderson SR, Bomben VC, Meyers KR, Karplus PA, Beckman JS. Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS. J Mol Biol. 2007 Nov 02; 373(4):877-90. PMID: 17888947; PMCID: PMC2175016.
      Citations: 54     Fields:    Translation:HumansCells
    256. Williams RS, Williams JS, Tainer JA. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem Cell Biol. 2007 Aug; 85(4):509-20. PMID: 17713585.
      Citations: 204     Fields:    Translation:HumansCells
    257. Putnam CD, Hammel M, Hura GL, Tainer JA. X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution. Q Rev Biophys. 2007 Aug; 40(3):191-285. PMID: 18078545.
      Citations: 481     Fields:    Translation:Cells
    258. Tubbs JL, Pegg AE, Tainer JA. DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair (Amst). 2007 Aug 01; 6(8):1100-15. PMID: 17485252; PMCID: PMC1993358.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    259. Williams R, Osborne S, Syson K, Ault S, Kilgour A, Chapados BR, Tainer JA, Sayers JR, Grasby JA, Sengerov? B. Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease. J Mol Biol. 2007 Aug 03; 371(1):34-48. PMID: 17559871; PMCID: PMC1993357.
      Citations: 16     Fields:    Translation:Cells
    260. Williams RS, Tainer JA. Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette. Mol Cell. 2007 Mar 23; 25(6):789-91. PMID: 17386254.
      Citations: 2     Fields:    Translation:HumansCells
    261. Barondeau DP, Kassmann CJ, Tainer JA, Getzoff ED. The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis. J Am Chem Soc. 2007 Mar 21; 129(11):3118-26. PMID: 17326633.
      Citations: 17     Fields:    Translation:Cells
    262. Vijayakumar S, Chapados BR, Schmidt KH, Kolodner RD, Tainer JA, Tomkinson AE. The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase. Nucleic Acids Res. 2007; 35(5):1624-37. PMID: 17308348; PMCID: PMC1865074.
      Citations: 40     Fields:    Translation:Cells
    263. Yamagata A, Tainer JA. Hexameric structures of the archaeal secretion ATPase GspE and implications for a universal secretion mechanism. EMBO J. 2007 Feb 07; 26(3):878-90. PMID: 17255937; PMCID: PMC1794398.
      Citations: 56     Fields:    Translation:Cells
    264. Ivanov I, Tainer JA, McCammon JA. Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1465-70. PMID: 17242363; PMCID: PMC1780068.
      Citations: 35     Fields:    Translation:Cells
    265. Hitomi K, Iwai S, Tainer JA. The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. DNA Repair (Amst). 2007 Apr 01; 6(4):410-28. PMID: 17208522.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    266. Perry JJ, Fan L, Tainer JA. Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. Neuroscience. 2007 Apr 14; 145(4):1280-99. PMID: 17174478; PMCID: PMC1904427.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    267. Ivanov I, Chapados BR, McCammon JA, Tainer JA. Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications. Nucleic Acids Res. 2006; 34(20):6023-33. PMID: 17071716; PMCID: PMC1635319.
      Citations: 43     Fields:    Translation:Cells
    268. Tsutakawa SE, Hura GL, Frankel KA, Cooper PK, Tainer JA. Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography. J Struct Biol. 2007 May; 158(2):214-23. PMID: 17182256.
      Citations: 32     Fields:    Translation:Cells
    269. Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell. 2006 Oct 20; 24(2):279-91. PMID: 17052461.
      Citations: 87     Fields:    Translation:Cells
    270. Craig L, Volkmann N, Arvai AS, Pique ME, Yeager M, Egelman EH, Tainer JA. Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions. Mol Cell. 2006 Sep 01; 23(5):651-62. PMID: 16949362.
      Citations: 206     Fields:    Translation:HumansCells
    271. Sundheim O, Sousa MM, Talstad V, Aas PA, Krokan HE, Tainer JA, Slupphaug G, V?gb? CB, Bj?r?s M, Drabl?s F. Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J. 2006 Jul 26; 25(14):3389-97. PMID: 16858410; PMCID: PMC1523172.
      Citations: 81     Fields:    Translation:HumansCells
    272. Perry JJ, Yannone SM, Holden LG, Hitomi C, Asaithamby A, Han S, Cooper PK, Chen DJ, Tainer JA. WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol. 2006 May; 13(5):414-22. PMID: 16622405.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    273. Barondeau DP, Kassmann CJ, Tainer JA, Getzoff ED. Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation. J Am Chem Soc. 2006 Apr 12; 128(14):4685-93. PMID: 16594705.
      Citations: 24     Fields:    Translation:Cells
    274. Fan L, Arvai AS, Cooper PK, Iwai S, Hanaoka F, Tainer JA. Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. Mol Cell. 2006 Apr 07; 22(1):27-37. PMID: 16600867.
      Citations: 72     Fields:    Translation:Cells
    275. Doi Y, Katafuchi A, Fujiwara Y, Hitomi K, Tainer JA, Ide H, Iwai S. Synthesis and characterization of oligonucleotides containing 2'-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction. Nucleic Acids Res. 2006; 34(5):1540-51. PMID: 16547199; PMCID: PMC1409675.
      Citations: 8     Fields:    Translation:Cells
    276. Fan L, Kim S, Farr CL, Schaefer KT, Randolph KM, Tainer JA, Kaguni LS. A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase. J Mol Biol. 2006 May 19; 358(5):1229-43. PMID: 16574152; PMCID: PMC4703138.
      Citations: 34     Fields:    Translation:HumansCells
    277. Barondeau DP, Tainer JA, Getzoff ED. Structural evidence for an enolate intermediate in GFP fluorophore biosynthesis. J Am Chem Soc. 2006 Mar 15; 128(10):3166-8. PMID: 16522096.
      Citations: 11     Fields:    Translation:Cells
    278. Wood TI, Barondeau DP, Hitomi C, Kassmann CJ, Tainer JA, Getzoff ED. Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis. Biochemistry. 2005 Dec 13; 44(49):16211-20. PMID: 16331981.
      Citations: 26     Fields:    Translation:Cells
    279. Ayala P, Wilbur JS, Wetzler LM, Tainer JA, Snyder A, So M. The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells. Cell Microbiol. 2005 Dec; 7(12):1736-48. PMID: 16309460.
      Citations: 12     Fields:    Translation:HumansCells
    280. Sarker AH, Tsutakawa SE, Kostek S, Ng C, Shin DS, Peris M, Campeau E, Tainer JA, Nogales E, Cooper PK. Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome. Mol Cell. 2005 Oct 28; 20(2):187-98. PMID: 16246722.
      Citations: 101     Fields:    Translation:HumansCells
    281. Putnam CD, Tainer JA. Protein mimicry of DNA and pathway regulation. DNA Repair (Amst). 2005 Dec 08; 4(12):1410-20. PMID: 16226493.
      Citations: 41     Fields:    Translation:AnimalsCells
    282. Williams RS, Tainer JA. A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks. Mol Cell. 2005 Sep 16; 19(6):724-6. PMID: 16168369.
      Citations: 15     Fields:    Translation:HumansCells
    283. Arvai A, Bello P, Gondeau C, Hopfner KP, Neyroz P, Heitz F, Tainer J, Divita G, Simeoni F. Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. Biochemistry. 2005 Sep 13; 44(36):11997-2008. PMID: 16142897.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    284. Ayala I, Perry JJ, Szczepanski J, Tainer JA, Vala MT, Nick HS, Silverman DN. Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine. Biophys J. 2005 Dec; 89(6):4171-9. PMID: 16150974; PMCID: PMC1366982.
      Citations: 8     Fields:    Translation:HumansCells
    285. Huffman JL, Sundheim O, Tainer JA. DNA base damage recognition and removal: new twists and grooves. Mutat Res. 2005 Sep 04; 577(1-2):55-76. PMID: 15941573.
      Citations: 107     Fields:    Translation:Cells
    286. Tubbs JL, Tainer JA, Getzoff ED. Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation. Biochemistry. 2005 Jul 26; 44(29):9833-40. PMID: 16026155.
      Citations: 19     Fields:    Translation:AnimalsCells
    287. Crowther LJ, Yamagata A, Craig L, Tainer JA, Donnenberg MS. The ATPase activity of BfpD is greatly enhanced by zinc and allosteric interactions with other Bfp proteins. J Biol Chem. 2005 Jul 01; 280(26):24839-48. PMID: 15866879; PMCID: PMC1224739.
      Citations: 12     Fields:    Translation:Cells
    288. Barondeau DP, Kassmann CJ, Tainer JA, Getzoff ED. Understanding GFP chromophore biosynthesis: controlling backbone cyclization and modifying post-translational chemistry. Biochemistry. 2005 Feb 15; 44(6):1960-70. PMID: 15697221.
      Citations: 20     Fields:    Translation:AnimalsCells
    289. Doi Y, Hitomi K, Tainer JA, Iwai S. Synthesis of oligonucleotides containing 2'-fluorinated thymidine glycol as mechanism-based inhibitors of endonuclease III. Nucleic Acids Symp Ser (Oxf). 2005; (49):195-6. PMID: 17150700.
      Citations:    Fields:    
    290. Manuel RC, Hitomi K, Arvai AS, House PG, Kurtz AJ, Dodson ML, McCullough AK, Tainer JA, Lloyd RS. Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase. J Biol Chem. 2004 Nov 05; 279(45):46930-9. PMID: 15326180.
      Citations: 21     Fields:    Translation:Cells
    291. Shin DS, Chahwan C, Huffman JL, Tainer JA. Structure and function of the double-strand break repair machinery. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):863-73. PMID: 15279771.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    292. Barondeau DP, Kassmann CJ, Bruns CK, Tainer JA, Getzoff ED. Nickel superoxide dismutase structure and mechanism. Biochemistry. 2004 Jun 29; 43(25):8038-47. PMID: 15209499.
      Citations: 92     Fields:    Translation:Cells
    293. Daniels DS, Woo TT, Luu KX, Noll DM, Clarke ND, Pegg AE, Tainer JA. DNA binding and nucleotide flipping by the human DNA repair protein AGT. Nat Struct Mol Biol. 2004 Aug; 11(8):714-20. PMID: 15221026.
      Citations: 128     Fields:    Translation:HumansCells
    294. Garcin ED, Bruns CM, Lloyd SJ, Hosfield DJ, Tiso M, Gachhui R, Stuehr DJ, Tainer JA, Getzoff ED. Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. J Biol Chem. 2004 Sep 03; 279(36):37918-27. PMID: 15208315.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    295. de Jager M, Trujillo KM, Sung P, Hopfner KP, Carney JP, Tainer JA, Connelly JC, Leach DR, Kanaar R, Wyman C. Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex. J Mol Biol. 2004 Jun 11; 339(4):937-49. PMID: 15165861.
      Citations: 32     Fields:    Translation:HumansCells
    296. Greenleaf WB, Perry JJ, Hearn AS, Cabelli DE, Lepock JR, Stroupe ME, Tainer JA, Nick HS, Silverman DN. Role of hydrogen bonding in the active site of human manganese superoxide dismutase. Biochemistry. 2004 Jun 08; 43(22):7038-45. PMID: 15170341.
      Citations: 16     Fields:    Translation:HumansCells
    297. Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P, Millichip I, Nicholls DJ, Rosenfeld RJ, St-Gallay SA, Tainer J, Tinker AC, Wallace AV. 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J Med Chem. 2004 Jun 03; 47(12):3320-3. PMID: 15163211.
      Citations: 12     Fields:    Translation:Animals
    298. Craig L, Pique ME, Tainer JA. Type IV pilus structure and bacterial pathogenicity. Nat Rev Microbiol. 2004 May; 2(5):363-78. PMID: 15100690.
      Citations: 348     Fields:    Translation:Cells
    299. Arthur LM, Gustausson K, Hopfner KP, Carson CT, Stracker TH, Karcher A, Felton D, Weitzman MD, Tainer J, Carney JP. Structural and functional analysis of Mre11-3. Nucleic Acids Res. 2004; 32(6):1886-93. PMID: 15047855; PMCID: PMC390353.
      Citations: 31     Fields:    Translation:HumansCells
    300. Qiu J, Liu R, Chapados BR, Sherman M, Tainer JA, Shen B. Interaction interface of human flap endonuclease-1 with its DNA substrates. J Biol Chem. 2004 Jun 04; 279(23):24394-402. PMID: 15037610.
      Citations: 12     Fields:    Translation:HumansCells
    301. Moncalian G, Lengsfeld B, Bhaskara V, Hopfner KP, Karcher A, Alden E, Tainer JA, Paull TT. The rad50 signature motif: essential to ATP binding and biological function. J Mol Biol. 2004 Jan 23; 335(4):937-51. PMID: 14698290.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    302. Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA. Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell. 2004 Jan 09; 116(1):39-50. PMID: 14718165.
      Citations: 153     Fields:    Translation:AnimalsCells
    303. Hearn AS, Fan L, Lepock JR, Luba JP, Greenleaf WB, Cabelli DE, Tainer JA, Nick HS, Silverman DN. Amino acid substitution at the dimeric interface of human manganese superoxide dismutase. J Biol Chem. 2004 Feb 13; 279(7):5861-6. PMID: 14638684.
      Citations: 12     Fields:    Translation:HumansCells
    304. Barondeau DP, Putnam CD, Kassmann CJ, Tainer JA, Getzoff ED. Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12111-6. PMID: 14523232; PMCID: PMC218721.
      Citations: 62     Fields:    Translation:Cells
    305. DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RM, Kassmann CJ, Lo TP, Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA. ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. J Mol Biol. 2003 Sep 19; 332(3):601-15. PMID: 12963370.
      Citations: 81     Fields:    Translation:HumansCells
    306. Shin DS, Pellegrini L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK, Hitomi C, Arvai AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA. Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO J. 2003 Sep 01; 22(17):4566-76. PMID: 12941707; PMCID: PMC202371.
      Citations: 126     Fields:    Translation:HumansCells
    307. Huffman JL, Li H, White RH, Tainer JA. Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii. J Mol Biol. 2003 Aug 22; 331(4):885-96. PMID: 12909016.
      Citations: 9     Fields:    Translation:Cells
    308. McMurray CT, Tainer JA. Cancer, cadmium and genome integrity. Nat Genet. 2003 Jul; 34(3):239-41. PMID: 12833042.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    309. Wang M, Howell JM, Libbey JE, Tainer JA, Fujinami RS. Manganese superoxide dismutase induction during measles virus infection. J Med Virol. 2003 Jul; 70(3):470-4. PMID: 12767013.
      Citations: 5     Fields:    Translation:HumansCells
    310. Craig L, Taylor RK, Pique ME, Adair BD, Arvai AS, Singh M, Lloyd SJ, Shin DS, Getzoff ED, Yeager M, Forest KT, Tainer JA. Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin. Mol Cell. 2003 May; 11(5):1139-50. PMID: 12769840.
      Citations: 142     Fields:    Translation:Cells
    311. Hopfner KP, Tainer JA. Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures. Curr Opin Struct Biol. 2003 Apr; 13(2):249-55. PMID: 12727520.
      Citations: 99     Fields:    Translation:Cells
    312. Cardoso RM, Daniels DS, Bruns CM, Tainer JA. Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum. Proteins. 2003 Apr 01; 51(1):137-46. PMID: 12596270.
      Citations: 10     Fields:    Translation:AnimalsCells
    313. Hearn AS, Stroupe ME, Cabelli DE, Ramilo CA, Luba JP, Tainer JA, Nick HS, Silverman DN. Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel. Biochemistry. 2003 Mar 18; 42(10):2781-9. PMID: 12627943.
      Citations: 25     Fields:    Translation:HumansCells
    314. Aoyagi M, Arvai AS, Tainer JA, Getzoff ED. Structural basis for endothelial nitric oxide synthase binding to calmodulin. EMBO J. 2003 Feb 17; 22(4):766-75. PMID: 12574113; PMCID: PMC145438.
      Citations: 65     Fields:    Translation:AnimalsCells
    315. Brudler R, Hitomi K, Daiyasu H, Toh H, Kucho K, Ishiura M, Kanehisa M, Roberts VA, Todo T, Tainer JA, Getzoff ED. Identification of a new cryptochrome class. Structure, function, and evolution. Mol Cell. 2003 Jan; 11(1):59-67. PMID: 12535521.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    316. Rosenfeld RJ, Garcin ED, Panda K, Andersson G, Aberg A, Wallace AV, Morris GM, Olson AJ, Stuehr DJ, Tainer JA, Getzoff ED. Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. Biochemistry. 2002 Nov 26; 41(47):13915-25. PMID: 12437348.
      Citations: 21     Fields:    Translation:HumansCells
    317. Cardoso RM, Thayer MM, DiDonato M, Lo TP, Bruns CK, Getzoff ED, Tainer JA. Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase. J Mol Biol. 2002 Nov 22; 324(2):247-56. PMID: 12441104.
      Citations: 27     Fields:    Translation:Humans
    318. Abdalla AM, Bruns CM, Tainer JA, Mannervik B, Stenberg G. Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein. Protein Eng. 2002 Oct; 15(10):827-34. PMID: 12468717.
      Citations: 11     Fields:    Translation:HumansCells
    319. Hopfner KP, Craig L, Moncalian G, Zinkel RA, Usui T, Owen BA, Karcher A, Henderson B, Bodmer JL, McMurray CT, Carney JP, Petrini JH, Tainer JA. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature. 2002 Aug 01; 418(6897):562-6. PMID: 12152085.
      Citations: 233     Fields:    Translation:HumansAnimalsCells
    320. Morris MC, Gondeau C, Tainer JA, Divita G. Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk. J Biol Chem. 2002 Jun 28; 277(26):23847-53. PMID: 11959850.
      Citations: 20     Fields:    Translation:Cells
    321. Barondeau DP, Kassmann CJ, Tainer JA, Getzoff ED. Structural chemistry of a green fluorescent protein Zn biosensor. J Am Chem Soc. 2002 Apr 10; 124(14):3522-4. PMID: 11929238.
      Citations: 35     Fields:    Translation:Cells
    322. Hopfner KP, Putnam CD, Tainer JA. DNA double-strand break repair from head to tail. Curr Opin Struct Biol. 2002 Feb; 12(1):115-22. PMID: 11839498.
      Citations: 54     Fields:    Translation:Cells
    323. Han S, Tainer JA. The ARTT motif and a unified structural understanding of substrate recognition in ADP-ribosylating bacterial toxins and eukaryotic ADP-ribosyltransferases. Int J Med Microbiol. 2002 Feb; 291(6-7):523-9. PMID: 11890553.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    324. Mol CD, Arvai AS, Begley TJ, Cunningham RP, Tainer JA. Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases. J Mol Biol. 2002 Jan 18; 315(3):373-84. PMID: 11786018.
      Citations: 26     Fields:    Translation:Cells
    325. Castagnetto JM, Hennessy SW, Roberts VA, Getzoff ED, Tainer JA, Pique ME. MDB: the Metalloprotein Database and Browser at The Scripps Research Institute. Nucleic Acids Res. 2002 Jan 01; 30(1):379-82. PMID: 11752342; PMCID: PMC99158.
      Citations: 67     Fields:    Translation:AnimalsCells
    326. Adak S, Bilwes AM, Panda K, Hosfield D, Aulak KS, McDonald JF, Tainer JA, Getzoff ED, Crane BR, Stuehr DJ. Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):107-12. PMID: 11756668; PMCID: PMC117522.
      Citations: 37     Fields:    Translation:AnimalsCells
    327. Aoyagi M, Arvai AS, Ghosh S, Stuehr DJ, Tainer JA, Getzoff ED. Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. Biochemistry. 2001 Oct 30; 40(43):12826-32. PMID: 11669619.
      Citations: 5     Fields:    Translation:AnimalsCells
    328. Hearn AS, Stroupe ME, Cabelli DE, Lepock JR, Tainer JA, Nick HS, Silverman DN. Kinetic analysis of product inhibition in human manganese superoxide dismutase. Biochemistry. 2001 Oct 09; 40(40):12051-8. PMID: 11580280.
      Citations: 22     Fields:    Translation:HumansCells
    329. Putnam CD, Clancy SB, Tsuruta H, Gonzalez S, Wetmur JG, Tainer JA. Structure and mechanism of the RuvB Holliday junction branch migration motor. J Mol Biol. 2001 Aug 10; 311(2):297-310. PMID: 11478862.
      Citations: 61     Fields:    Translation:Cells
    330. Chung JH, Suh MJ, Park YI, Tainer JA, Han YS. Repair activities of 8-oxoguanine DNA glycosylase from Archaeoglobus fulgidus, a hyperthermophilic archaeon. Mutat Res. 2001 Jul 12; 486(2):99-111. PMID: 11425515.
      Citations: 10     Fields:    Translation:Cells
    331. Hopfner KP, Karcher A, Craig L, Woo TT, Carney JP, Tainer JA. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell. 2001 May 18; 105(4):473-85. PMID: 11371344.
      Citations: 227     Fields:    Translation:HumansCells
    332. Ayala BP, Vasquez B, Clary S, Tainer JA, Rodland K, So M. The pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease. Cell Microbiol. 2001 Apr; 3(4):265-75. PMID: 11298650.
      Citations: 23     Fields:    Translation:HumansCells
    333. Chapados BR, Chai Q, Hosfield DJ, Qiu J, Shen B, Tainer JA. Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication. J Mol Biol. 2001 Mar 23; 307(2):541-56. PMID: 11254381.
      Citations: 28     Fields:    Translation:Cells
    334. Han S, Arvai AS, Clancy SB, Tainer JA. Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis. J Mol Biol. 2001 Jan 05; 305(1):95-107. PMID: 11114250.
      Citations: 49     Fields:    Translation:Cells
    335. Tainer JA. Structural implications of BER enzymes: dragons dancing--the structural biology of DNA base excision repair. Prog Nucleic Acid Res Mol Biol. 2001; 68:299-304. PMID: 11554306.
      Citations: 1     Fields:    
    336. Hosfield DJ, Daniels DS, Mol CD, Putnam CD, Parikh SS, Tainer JA. DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes. Prog Nucleic Acid Res Mol Biol. 2001; 68:315-47. PMID: 11554309.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    337. Hopfner KP, Tainer JA. DNA mismatch repair: the hands of a genome guardian. Structure. 2000 Dec 15; 8(12):R237-41. PMID: 11188699.
      Citations: 10     Fields:    Translation:Cells
    338. Hopfner KP, Karcher A, Shin D, Fairley C, Tainer JA, Carney JP. Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine. J Bacteriol. 2000 Nov; 182(21):6036-41. PMID: 11029422; PMCID: PMC94736.
      Citations: 59     Fields:    Translation:Cells
    339. Tainer JA, Friedberg EC. Dancing with the elephants: envisioning the structural biology of DNA repair pathways. Mutat Res. 2000 Aug 30; 460(3-4):139-41. PMID: 10946224.
      Citations: 1     Fields:    Translation:Cells
    340. Daniels DS, Tainer JA. Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase. Mutat Res. 2000 Aug 30; 460(3-4):151-63. PMID: 10946226.
      Citations: 26     Fields:    Translation:HumansCells
    341. Parikh SS, Putnam CD, Tainer JA. Lessons learned from structural results on uracil-DNA glycosylase. Mutat Res. 2000 Aug 30; 460(3-4):183-99. PMID: 10946228.
      Citations: 50     Fields:    Translation:HumansCells
    342. Mol CD, Hosfield DJ, Tainer JA. Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means. Mutat Res. 2000 Aug 30; 460(3-4):211-29. PMID: 10946230.
      Citations: 102     Fields:    Translation:HumansCells
    343. Bourne Y, Watson MH, Arvai AS, Bernstein SL, Reed SI, Tainer JA. Crystal structure and mutational analysis of the Saccharomyces cerevisiae cell cycle regulatory protein Cks1: implications for domain swapping, anion binding and protein interactions. Structure. 2000 Aug 15; 8(8):841-50. PMID: 10997903.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    344. Hopfner KP, Karcher A, Shin DS, Craig L, Arthur LM, Carney JP, Tainer JA. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell. 2000 Jun 23; 101(7):789-800. PMID: 10892749.
      Citations: 365     Fields:    Translation:Cells
    345. Stroupe ME, Lepock JR, Cabelli DE, Tainer JA, Nick HS, Silverman DN, L?v?que VJ. Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis. Biochemistry. 2000 Jun 20; 39(24):7131-7. PMID: 10852710.
      Citations: 19     Fields:    Translation:HumansCells
    346. Parikh SS, Walcher G, Jones GD, Slupphaug G, Krokan HE, Blackburn GM, Tainer JA. Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5083-8. PMID: 10805771; PMCID: PMC25785.
      Citations: 99     Fields:    Translation:HumansCells
    347. Crane BR, Arvai AS, Ghosh S, Getzoff ED, Stuehr DJ, Tainer JA. Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins. Biochemistry. 2000 Apr 25; 39(16):4608-21. PMID: 10769116.
      Citations: 22     Fields:    Translation:AnimalsCells
    348. Daniels DS, Mol CD, Arvai AS, Kanugula S, Pegg AE, Tainer JA. Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding. EMBO J. 2000 Apr 03; 19(7):1719-30. PMID: 10747039; PMCID: PMC310240.
      Citations: 76     Fields:    Translation:HumansCells
    349. Putnam CD, Arvai AS, Bourne Y, Tainer JA. Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. J Mol Biol. 2000 Feb 11; 296(1):295-309. PMID: 10656833.
      Citations: 96     Fields:    Translation:HumansCells
    350. Mol CD, Izumi T, Mitra S, Tainer JA. DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]. Nature. 2000 Jan 27; 403(6768):451-6. PMID: 10667800.
      Citations: 315     Fields:    Translation:HumansCells
    351. Putnam CD, Tainer JA. The food of sweet and bitter fancy. Nat Struct Biol. 2000 Jan; 7(1):17-8. PMID: 10625418.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    352. Hopfner KP, Parikh SS, Tainer JA. Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair. Cold Spring Harb Symp Quant Biol. 2000; 65:113-26. PMID: 12760026.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    353. Ghosh DK, Crane BR, Ghosh S, Wolan D, Gachhui R, Crooks C, Presta A, Tainer JA, Getzoff ED, Stuehr DJ. Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. EMBO J. 1999 Nov 15; 18(22):6260-70. PMID: 10562538; PMCID: PMC1171689.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    354. Crane BR, Rosenfeld RJ, Arvai AS, Ghosh DK, Ghosh S, Tainer JA, Stuehr DJ, Getzoff ED. N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization. EMBO J. 1999 Nov 15; 18(22):6271-81. PMID: 10562539; PMCID: PMC1171690.
      Citations: 25     Fields:    Translation:AnimalsCells
    355. Han S, Craig JA, Putnam CD, Carozzi NB, Tainer JA. Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex. Nat Struct Biol. 1999 Oct; 6(10):932-6. PMID: 10504727.
      Citations: 80     Fields:    Translation:Cells
    356. Ramilo CA, Leveque V, Guan Y, Lepock JR, Tainer JA, Nick HS, Silverman DN. Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase. J Biol Chem. 1999 Sep 24; 274(39):27711-6. PMID: 10488113.
      Citations: 16     Fields:    Translation:HumansCells
    357. Adak S, Crooks C, Wang Q, Crane BR, Tainer JA, Getzoff ED, Stuehr DJ. Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition. J Biol Chem. 1999 Sep 17; 274(38):26907-11. PMID: 10480900.
      Citations: 21     Fields:    Translation:Cells
    358. Cabelli DE, Guan Y, Leveque V, Hearn AS, Tainer JA, Nick HS, Silverman DN. Role of tryptophan 161 in catalysis by human manganese superoxide dismutase. Biochemistry. 1999 Sep 07; 38(36):11686-92. PMID: 10512624.
      Citations: 15     Fields:    Translation:HumansCells
    359. Ghosh S, Wolan D, Adak S, Crane BR, Kwon NS, Tainer JA, Getzoff ED, Stuehr DJ. Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase. J Biol Chem. 1999 Aug 20; 274(34):24100-12. PMID: 10446182.
      Citations: 8     Fields:    Translation:Cells
    360. Hosfield DJ, Guan Y, Haas BJ, Cunningham RP, Tainer JA. Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis. Cell. 1999 Aug 06; 98(3):397-408. PMID: 10458614.
      Citations: 97     Fields:    Translation:AnimalsCells
    361. Pellequer JL, Chen Sw, Roberts VA, Tainer JA, Getzoff ED. Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding. J Mol Recognit. 1999 Jul-Aug; 12(4):267-75. PMID: 10440998.
      Citations: 9     Fields:    Translation:HumansCells
    362. Bruns CM, Hubatsch I, Mannervik B, Tainer JA, Ridderstr?m M. Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. J Mol Biol. 1999 May 07; 288(3):427-39. PMID: 10329152.
      Citations: 57     Fields:    Translation:HumansCells
    363. Haas BJ, Sandigursky M, Tainer JA, Franklin WA, Cunningham RP. Purification and characterization of Thermotoga maritima endonuclease IV, a thermostable apurinic/apyrimidinic endonuclease and 3'-repair diesterase. J Bacteriol. 1999 May; 181(9):2834-9. PMID: 10217775; PMCID: PMC93726.
      Citations: 12     Fields:    Translation:Cells
    364. Shroyer MJ, Bennett SE, Putnam CD, Tainer JA, Mosbaugh DW. Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis. Biochemistry. 1999 Apr 13; 38(15):4834-45. PMID: 10200172.
      Citations: 10     Fields:    Translation:Cells
    365. Putnam CD, Shroyer MJ, Lundquist AJ, Mol CD, Arvai AS, Mosbaugh DW, Tainer JA. Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J Mol Biol. 1999 Mar 26; 287(2):331-46. PMID: 10080896.
      Citations: 51     Fields:    Translation:Cells
    366. Parikh SS, Mol CD, Hosfield DJ, Tainer JA. Envisioning the molecular choreography of DNA base excision repair. Curr Opin Struct Biol. 1999 Feb; 9(1):37-47. PMID: 10047578.
      Citations: 39     Fields:    Translation:HumansCells
    367. Forest KT, Dunham SA, Koomey M, Tainer JA. Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology. Mol Microbiol. 1999 Feb; 31(3):743-52. PMID: 10048019.
      Citations: 35     Fields:    Translation:Cells
    368. Mol CD, Parikh SS, Putnam CD, Lo TP, Tainer JA. DNA repair mechanisms for the recognition and removal of damaged DNA bases. Annu Rev Biophys Biomol Struct. 1999; 28:101-28. PMID: 10410797.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    369. Guan Y, Manuel RC, Arvai AS, Parikh SS, Mol CD, Miller JH, Lloyd S, Tainer JA. MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nat Struct Biol. 1998 Dec; 5(12):1058-64. PMID: 9846876.
      Citations: 115     Fields:    Translation:Cells
    370. Hosfield DJ, Frank G, Weng Y, Tainer JA, Shen B. Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1. J Biol Chem. 1998 Oct 16; 273(42):27154-61. PMID: 9765234.
      Citations: 25     Fields:    Translation:HumansCells
    371. Hosfield DJ, Mol CD, Shen B, Tainer JA. Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Cell. 1998 Oct 02; 95(1):135-46. PMID: 9778254.
      Citations: 107     Fields:    Translation:Cells
    372. Schnecke V, Swanson CA, Getzoff ED, Tainer JA, Kuhn LA. Screening a peptidyl database for potential ligands to proteins with side-chain flexibility. Proteins. 1998 Oct 01; 33(1):74-87. PMID: 9741846.
      Citations: 38     Fields:    Translation:Cells
    373. Parikh SS, Mol CD, Slupphaug G, Bharati S, Krokan HE, Tainer JA. Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO J. 1998 Sep 01; 17(17):5214-26. PMID: 9724657; PMCID: PMC1170849.
      Citations: 153     Fields:    Translation:HumansCells
    374. Coombs GS, Bergstrom RC, Pellequer JL, Baker SI, Navre M, Smith MM, Tainer JA, Madison EL, Corey DR. Substrate specificity of prostate-specific antigen (PSA). Chem Biol. 1998 Sep; 5(9):475-88. PMID: 9751643.
      Citations: 22     Fields:    Translation:HumansCells
    375. Shen B, Qiu J, Hosfield D, Tainer JA. Flap endonuclease homologs in archaebacteria exist as independent proteins. Trends Biochem Sci. 1998 May; 23(5):171-3. PMID: 9612080.
      Citations: 13     Fields:    Translation:Cells
    376. Tong W, Burdi D, Riggs-Gelasco P, Chen S, Edmondson D, Huynh BH, Stubbe J, Han S, Arvai A, Tainer J. Characterization of Y122F R2 of Escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and X-ray crystallography. Biochemistry. 1998 Apr 28; 37(17):5840-8. PMID: 9558317.
      Citations: 4     Fields:    Translation:Cells
    377. Guan Y, Hickey MJ, Borgstahl GE, Hallewell RA, Lepock JR, O'Connor D, Hsieh Y, Nick HS, Silverman DN, Tainer JA. Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34. Biochemistry. 1998 Apr 07; 37(14):4722-30. PMID: 9537987.
      Citations: 36     Fields:    Translation:HumansCells
    378. Hsieh Y, Guan Y, Tu C, Bratt PJ, Angerhofer A, Lepock JR, Hickey MJ, Tainer JA, Nick HS, Silverman DN. Probing the active site of human manganese superoxide dismutase: the role of glutamine 143. Biochemistry. 1998 Apr 07; 37(14):4731-9. PMID: 9537988.
      Citations: 23     Fields:    Translation:HumansCells
    379. Crane BR, Arvai AS, Ghosh DK, Wu C, Getzoff ED, Stuehr DJ, Tainer JA. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science. 1998 Mar 27; 279(5359):2121-6. PMID: 9516116.
      Citations: 168     Fields:    Translation:AnimalsCells
    380. Forest K, Tainer J, Nassif X, Marceau M, B?retti JL. Consequences of the loss of O-linked glycosylation of meningococcal type IV pilin on piliation and pilus-mediated adhesion. Mol Microbiol. 1998 Feb; 27(4):705-15. PMID: 9515697.
      Citations: 49     Fields:    Translation:HumansCells
    381. Parikh SS, Mol CD, Tainer JA. Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway. Structure. 1997 Dec 15; 5(12):1543-50. PMID: 9438868.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    382. Gorman MA, Morera S, Rothwell DG, de La Fortelle E, Mol CD, Tainer JA, Hickson ID, Freemont PS. The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites. EMBO J. 1997 Nov 03; 16(21):6548-58. PMID: 9351835; PMCID: PMC1170259.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    383. Crane BR, Arvai AS, Gachhui R, Wu C, Ghosh DK, Getzoff ED, Stuehr DJ, Tainer JA. The structure of nitric oxide synthase oxygenase domain and inhibitor complexes. Science. 1997 Oct 17; 278(5337):425-31. PMID: 9334294.
      Citations: 58     Fields:    Translation:Cells
    384. Fisher CL, Cabelli DE, Hallewell RA, Beroza P, Lo TP, Getzoff ED, Tainer JA. Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase. Proteins. 1997 Sep; 29(1):103-12. PMID: 9294870.
      Citations: 14     Fields:    Translation:HumansCells
    385. Forest KT, Tainer JA. Type-4 pilus-structure: outside to inside and top to bottom--a minireview. Gene. 1997 Jun 11; 192(1):165-9. PMID: 9224887.
      Citations: 25     Fields:    Translation:Cells
    386. Boissinot M, Karnas S, Lepock JR, Cabelli DE, Tainer JA, Getzoff ED, Hallewell RA. Function of the Greek key connection analysed using circular permutants of superoxide dismutase. EMBO J. 1997 May 01; 16(9):2171-8. PMID: 9171332; PMCID: PMC1169819.
      Citations: 9     Fields:    Translation:HumansCells
    387. Zu JS, Deng HX, Lo TP, Mitsumoto H, Ahmed MS, Hung WY, Cai ZJ, Tainer JA, Siddique T. Exon 5 encoded domain is not required for the toxic function of mutant SOD1 but essential for the dismutase activity: identification and characterization of two new SOD1 mutations associated with familial amyotrophic lateral sclerosis. Neurogenetics. 1997 May; 1(1):65-71. PMID: 10735277.
      Citations: 12     Fields:    Translation:HumansCells
    388. Roberts VA, Nachman RJ, Coast GM, Hariharan M, Chung JS, Holman GM, Williams H, Tainer JA. Consensus chemistry and beta-turn conformation of the active core of the insect kinin neuropeptide family. Chem Biol. 1997 Feb; 4(2):105-17. PMID: 9190285.
      Citations:    Fields:    Translation:AnimalsCells
    389. Bourne Y, Redford SM, Steinman HM, Lepock JR, Tainer JA, Getzoff ED. Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12774-9. PMID: 8917495; PMCID: PMC23996.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    390. Slupphaug G, Mol CD, Kavli B, Arvai AS, Krokan HE, Tainer JA. A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature. 1996 Nov 07; 384(6604):87-92. PMID: 8900285.
      Citations: 185     Fields:    Translation:HumansCells
    391. Mol CD, Harris JM, McIntosh EM, Tainer JA. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. Structure. 1996 Sep 15; 4(9):1077-92. PMID: 8805593.
      Citations: 60     Fields:    Translation:HumansCells
    392. Watson MH, Bourne Y, Arvai AS, Hickey MJ, Santiago A, Bernstein SL, Tainer JA, Reed SI. A mutation in the human cyclin-dependent kinase interacting protein, CksHs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly. J Mol Biol. 1996 Sep 06; 261(5):646-57. PMID: 8800213.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    393. Kavli B, Slupphaug G, Mol CD, Arvai AS, Peterson SB, Tainer JA, Krokan HE. Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO J. 1996 Jul 01; 15(13):3442-7. PMID: 8670846; PMCID: PMC451908.
      Citations: 73     Fields:    Translation:HumansCells
    394. Napolitano EW, Villar HO, Kauvar LM, Higgins DL, Roberts D, Mandac J, Lee SK, Engqvist-Goldstein A, Bukar R, Calio BL, Tainer JA, J?ck HM. Glubodies: randomized libraries of glutathione transferase enzymes. Chem Biol. 1996 May; 3(5):359-67. PMID: 8807865.
      Citations:    Fields:    Translation:HumansCells
    395. Borgstahl GE, Parge HE, Hickey MJ, Johnson MJ, Boissinot M, Hallewell RA, Lepock JR, Cabelli DE, Tainer JA. Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface. Biochemistry. 1996 Apr 09; 35(14):4287-97. PMID: 8605177.
      Citations: 40     Fields:    Translation:HumansCells
    396. Bourne Y, Watson MH, Hickey MJ, Holmes W, Rocque W, Reed SI, Tainer JA. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell. 1996 Mar 22; 84(6):863-74. PMID: 8601310.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    397. Ogihara NL, Parge HE, Hart PJ, Weiss MS, Goto JJ, Crane BR, Tsang J, Slater K, Roe JA, Valentine JS, Eisenberg D, Tainer JA. Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase. Biochemistry. 1996 Feb 20; 35(7):2316-21. PMID: 8652572.
      Citations: 22     Fields:    Translation:AnimalsCells
    398. Forest KT, Bernstein SL, Getzoff ED, So M, Tribbick G, Geysen HM, Deal CD, Tainer JA. Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies. Infect Immun. 1996 Feb; 64(2):644-52. PMID: 8550220; PMCID: PMC173814.
      Citations: 24     Fields:    Translation:AnimalsCells
    399. Kuhn LA, Swanson CA, Pique ME, Tainer JA, Getzoff ED. Atomic and residue hydrophilicity in the context of folded protein structures. Proteins. 1995 Dec; 23(4):536-47. PMID: 8749849.
      Citations: 27     Fields:    Translation:Cells
    400. Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA. Structure of the fibre-forming protein pilin at 2.6 A resolution. Nature. 1995 Nov 02; 378(6552):32-8. PMID: 7477282.
      Citations: 174     Fields:    Translation:Cells
    401. Bourne Y, Arvai AS, Bernstein SL, Watson MH, Reed SI, Endicott JE, Noble ME, Johnson LN, Tainer JA. Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10232-6. PMID: 7479758; PMCID: PMC40770.
      Citations: 20     Fields:    Translation:AnimalsCells
    402. Phillips JP, Tainer JA, Getzoff ED, Boulianne GL, Kirby K, Hilliker AJ. Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8574-8. PMID: 7567977; PMCID: PMC41008.
      Citations: 46     Fields:    Translation:AnimalsCells
    403. Mol CD, Arvai AS, Sanderson RJ, Slupphaug G, Kavli B, Krokan HE, Mosbaugh DW, Tainer JA. Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. Cell. 1995 Sep 08; 82(5):701-8. PMID: 7671300.
      Citations: 105     Fields:    Translation:HumansCells
    404. Pond L, Kuhn LA, Teyton L, Schutze MP, Tainer JA, Jackson MR, Peterson PA. A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway. J Biol Chem. 1995 Aug 25; 270(34):19989-97. PMID: 7650016.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    405. Thayer MM, Ahern H, Xing D, Cunningham RP, Tainer JA. Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. EMBO J. 1995 Aug 15; 14(16):4108-20. PMID: 7664751; PMCID: PMC394490.
      Citations: 165     Fields:    Translation:Cells
    406. Barzilay G, Mol CD, Robson CN, Walker LJ, Cunningham RP, Tainer JA, Hickson ID. Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1. Nat Struct Biol. 1995 Jul; 2(7):561-8. PMID: 7664124.
      Citations: 45     Fields:    Translation:HumansCells
    407. Arvai AS, Bourne Y, Hickey MJ, Tainer JA. Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. J Mol Biol. 1995 Jun 23; 249(5):835-42. PMID: 7791211.
      Citations: 24     Fields:    Translation:HumansCells
    408. Beckman G, Deng HX, Iqbal Z, Tainer JA, Siddique T, Sj?lander A. The D90A mutation results in a polymorphism of Cu,Zn superoxide dismutase that is prevalent in northern Sweden and Finland. Hum Mol Genet. 1995 Jun; 4(6):1105-8. PMID: 7655469.
      Citations: 3     Fields:    Translation:HumansCells
    409. Deng HX, Tainer JA, Mitsumoto H, Ohnishi A, He X, Hung WY, Zhao Y, Juneja T, Hentati A, Siddique T. Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis. Hum Mol Genet. 1995 Jun; 4(6):1113-6. PMID: 7655471.
      Citations: 5     Fields:    Translation:HumansCells
    410. McTigue MA, Bernstein SL, Williams DR, Tainer JA. Purification and crystallization of a schistosomal glutathione S-transferase. Proteins. 1995 May; 22(1):55-7. PMID: 7675787.
      Citations: 2     Fields:    Translation:AnimalsCells
    411. Mol CD, Arvai AS, Slupphaug G, Kavli B, Alseth I, Krokan HE, Tainer JA. Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis. Cell. 1995 Mar 24; 80(6):869-78. PMID: 7697717.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    412. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Nature. 1995 Mar 23; 374(6520):381-6. PMID: 7885481.
      Citations: 118     Fields:    Translation:HumansCells
    413. McTigue MA, Williams DR, Tainer JA. Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel. J Mol Biol. 1995 Feb 10; 246(1):21-7. PMID: 7853399.
      Citations: 77     Fields:    Translation:AnimalsCells
    414. Tainer JA, Thayer MM, Cunningham RP. DNA repair proteins. Curr Opin Struct Biol. 1995 Feb; 5(1):20-6. PMID: 7773744.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    415. Arvai AS, Bourne Y, Williams D, Reed SI, Tainer JA. Crystallization and preliminary crystallographic study of human CksHs1: a cell cycle regulatory protein. Proteins. 1995 Jan; 21(1):70-3. PMID: 7716171.
      Citations: 4     Fields:    Translation:HumansCells
    416. Friedman AR, Roberts VA, Tainer JA. Predicting molecular interactions and inducible complementarity: fragment docking of Fab-peptide complexes. Proteins. 1994 Sep; 20(1):15-24. PMID: 7529922.
      Citations: 12     Fields:    Translation:Cells
    417. Tainer J, Russell P. Enzyme structure. Cracking tyrosine phosphatases. Nature. 1994 Aug 18; 370(6490):506-7. PMID: 8052305.
      Citations: 3     Fields:    Translation:Cells
    418. Cunningham RP, Ahern H, Xing D, Thayer MM, Tainer JA. Structure and function of Escherichia coli endonuclease III. Ann N Y Acad Sci. 1994 Jul 29; 726:215-22. PMID: 8092678.
      Citations: 7     Fields:    Translation:Cells
    419. Kuo CF, Mol CD, Thayer MM, Cunningham RP, Tainer JA. Structure and function of the DNA repair enzyme exonuclease III from E. coli. Ann N Y Acad Sci. 1994 Jul 29; 726:223-34; discussion 234-5. PMID: 8092679.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    420. Fisher CL, Cabelli DE, Tainer JA, Hallewell RA, Getzoff ED. The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis. Proteins. 1994 May; 19(1):24-34. PMID: 8066083.
      Citations: 41     Fields:    Translation:HumansCells
    421. Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA. Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. Science. 1993 Oct 15; 262(5132):387-95. PMID: 8211159.
      Citations: 27     Fields:    Translation:HumansCells
    422. Chang CP, Lazar CS, Walsh BJ, Komuro M, Collawn JF, Kuhn LA, Tainer JA, Trowbridge IS, Farquhar MG, Rosenfeld MG, et al. Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors. J Biol Chem. 1993 Sep 15; 268(26):19312-20. PMID: 8396132.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    423. Deng HX, Hentati A, Tainer JA, Iqbal Z, Cayabyab A, Hung WY, Getzoff ED, Hu P, Herzfeldt B, Roos RP, et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science. 1993 Aug 20; 261(5124):1047-51. PMID: 8351519.
      Citations: 349     Fields:    Translation:HumansCells
    424. Tainer JA, Cunningham RP. Molecular recognition in DNA-binding proteins and enzymes. Curr Opin Biotechnol. 1993 Aug; 4(4):474-83. PMID: 7763979.
      Citations: 2     Fields:    Translation:Cells
    425. Boissinot M, Kuhn LA, Lee P, Fisher CL, Wang Y, Hallewell RA, Tainer JA. Rational design and expression of a heparin-targeted human superoxide dismutase. Biochem Biophys Res Commun. 1993 Jan 15; 190(1):250-6. PMID: 8422249.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    426. Kuo CF, McRee DE, Cunningham RP, Tainer JA. Purification, crystallization and space group determination of DNA repair enzyme exonuclease III from E. coli. J Mol Biol. 1993 Jan 05; 229(1):239-42. PMID: 8421304.
      Citations: 2     Fields:    Translation:Cells
    427. Kuhn LA, Siani MA, Pique ME, Fisher CL, Getzoff ED, Tainer JA. The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures. J Mol Biol. 1992 Nov 05; 228(1):13-22. PMID: 1447777.
      Citations: 38     Fields:    Translation:Cells
    428. Kuo CF, McRee DE, Fisher CL, O'Handley SF, Cunningham RP, Tainer JA. Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III. Science. 1992 Oct 16; 258(5081):434-40. PMID: 1411536.
      Citations: 84     Fields:    Translation:Cells
    429. Borgstahl GE, Parge HE, Hickey MJ, Beyer WF, Hallewell RA, Tainer JA. The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. Cell. 1992 Oct 02; 71(1):107-18. PMID: 1394426.
      Citations: 113     Fields:    Translation:HumansCells
    430. Kuo CF, McRee DE, Cunningham RP, Tainer JA. Crystallization and crystallographic characterization of the iron-sulfur-containing DNA-repair enzyme endonuclease III from Escherichia coli. J Mol Biol. 1992 Sep 05; 227(1):347-51. PMID: 1522598.
      Citations: 9     Fields:    Translation:Cells
    431. Tainer JA, Roberts VA, Getzoff ED. Protein metal-binding sites. Curr Opin Biotechnol. 1992 Aug; 3(4):378-87. PMID: 1368439.
      Citations: 24     Fields:    Translation:Cells
    432. Parge HE, Hallewell RA, Tainer JA. Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):6109-13. PMID: 1463506; PMCID: PMC49447.
      Citations: 83     Fields:    Translation:HumansCells
    433. Alexander H, Alexander S, Getzoff ED, Tainer JA, Geysen HM, Lerner RA. Altering the antigenicity of proteins. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3352-6. PMID: 1373498; PMCID: PMC48865.
      Citations: 7     Fields:    Translation:Cells
    434. Hallewell RA, Imlay KC, Lee P, Fong NM, Gallegos C, Getzoff ED, Tainer JA, Cabelli DE, Tekamp-Olson P, Mullenbach GT, et al. Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines. Biochem Biophys Res Commun. 1991 Nov 27; 181(1):474-80. PMID: 1958215.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    435. Collawn JF, Kuhn LA, Liu LF, Tainer JA, Trowbridge IS. Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor. EMBO J. 1991 Nov; 10(11):3247-53. PMID: 1655415; PMCID: PMC453049.
      Citations: 29     Fields:    Translation:HumansCells
    436. Tainer JA, Roberts VA, Getzoff ED. Metal-binding sites in proteins. Curr Opin Biotechnol. 1991 Aug; 2(4):582-91. PMID: 1367679.
      Citations: 39     Fields:    Translation:Cells
    437. Roberts VA, Freeman HC, Olson AJ, Tainer JA, Getzoff ED. Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c. J Biol Chem. 1991 Jul 15; 266(20):13431-41. PMID: 1649191.
      Citations: 19     Fields:    Translation:AnimalsCells
    438. Nachman RJ, Roberts VA, Dyson HJ, Holman GM, Tainer JA. Active conformation of an insect neuropeptide family. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4518-22. PMID: 2034692; PMCID: PMC51692.
      Citations: 8     Fields:    Translation:AnimalsCells
    439. Alexander H, Alexander S, Heffron F, Fieser TM, Hay BN, Getzoff ED, Tainer JA, Lerner RA. Synthesis and characterization of a recombinant myohemerythrin protein encoded by a synthetic gene. Gene. 1991 Mar 15; 99(2):151-6. PMID: 1708739.
      Citations: 1     Fields:    Translation:AnimalsCells
    440. Tainer JA, Deal CD, Geysen HM, Roberts VA, Getzoff ED. Defining antibody-antigen recognition: towards engineered antibodies and epitopes. Int Rev Immunol. 1991; 7(2):165-88. PMID: 1721650.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    441. Roberts VA, Fisher CL, Redford SM, McRee DE, Parge HE, Getzoff ED, Tainer JA. Mechanism and atomic structure of superoxide dismutase. Free Radic Res Commun. 1991; 12-13 Pt 1:269-78. PMID: 1649094.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    442. Fisher CL, Hallewell RA, Roberts VA, Tainer JA, Getzoff ED. Probing the structural basis for enzyme-substrate recognition in Cu,Zn superoxide dismutase. Free Radic Res Commun. 1991; 12-13 Pt 1:287-96. PMID: 1649096.
      Citations: 2     Fields:    Translation:AnimalsCells
    443. Tainer JA, Roberts VA. Enzyme motifs in antibodies. Nature. 1990 Dec 13; 348(6302):589. PMID: 2123525.
      Citations: 1     Fields:    Translation:Cells
    444. Collawn JF, Stangel M, Kuhn LA, Esekogwu V, Jing SQ, Trowbridge IS, Tainer JA. Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis. Cell. 1990 Nov 30; 63(5):1061-72. PMID: 2257624.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    445. Kuhn LA, Griffin JH, Fisher CL, Greengard JS, Bouma BN, Tainer JA, Espa?a F. Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8506-10. PMID: 2172989; PMCID: PMC54985.
      Citations: 16     Fields:    Translation:HumansCells
    446. Fisher CL, Tainer JA, Pique ME, Getzoff ED. Visualization of molecular flexibility and its effects on electrostatic recognition. J Mol Graph. 1990 Sep; 8(3):125-32, 145. PMID: 2279008.
      Citations: 1     Fields:    
    447. Roberts VA, Iverson BL, Iverson SA, Benkovic SJ, Lerner RA, Getzoff ED, Tainer JA. Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6654-8. PMID: 2395868; PMCID: PMC54595.
      Citations: 20     Fields:    Translation:Cells
    448. McRee DE, Redford SM, Getzoff ED, Lepock JR, Hallewell RA, Tainer JA. Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine. J Biol Chem. 1990 Aug 25; 265(24):14234-41. PMID: 2387847.
      Citations: 26     Fields:    Translation:AnimalsCells
    449. Iverson BL, Iverson SA, Roberts VA, Getzoff ED, Tainer JA, Benkovic SJ, Lerner RA. Metalloantibodies. Science. 1990 Aug 10; 249(4969):659-62. PMID: 2116666.
      Citations: 17     Fields:    Translation:Cells
    450. Redford SM, McRee DE, Getzoff ED, Steinman HM, Tainer JA. Crystallographic characterization of a Cu,Zn superoxide dismutase from Photobacterium leiognathi. J Mol Biol. 1990 Apr 05; 212(3):449-51. PMID: 2325128.
      Citations: 4     Fields:    Translation:Cells
    451. Parge HE, Bernstein SL, Deal CD, McRee DE, Christensen D, Capozza MA, Kays BW, Fieser TM, Draper D, So M, Getzoff ED, Tainer JA. Biochemical purification and crystallographic characterization of the fiber-forming protein pilin from Neisseria gonorrhoeae. J Biol Chem. 1990 Feb 05; 265(4):2278-85. PMID: 1967608.
      Citations: 15     Fields:    Translation:Cells
    452. McRee DE, Tainer JA, Meyer TE, Van Beeumen J, Cusanovich MA, Getzoff ED. Crystallographic structure of a photoreceptor protein at 2.4 A resolution. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6533-7. PMID: 2771940; PMCID: PMC297878.
      Citations: 20     Fields:    Translation:Cells
    453. Hallewell RA, Laria I, Tabrizi A, Carlin G, Getzoff ED, Tainer JA, Cousens LS, Mullenbach GT. Genetically engineered polymers of human CuZn superoxide dismutase. Biochemistry and serum half-lives. J Biol Chem. 1989 Mar 25; 264(9):5260-8. PMID: 2647749.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    454. Getzoff ED, Tainer JA, Stempien MM, Bell GI, Hallewell RA. Evolution of CuZn superoxide dismutase and the Greek key beta-barrel structural motif. Proteins. 1989; 5(4):322-36. PMID: 2798409.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    455. Mullenbach GT, Tabrizi A, Irvine BD, Bell GI, Tainer JA, Hallewell RA. Selenocysteine's mechanism of incorporation and evolution revealed in cDNAs of three glutathione peroxidases. Protein Eng. 1988 Sep; 2(3):239-46. PMID: 2976939.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    456. Getzoff ED, Parge HE, McRee DE, Tainer JA. Understanding the structure and antigenicity of gonococcal pili. Rev Infect Dis. 1988 Jul-Aug; 10 Suppl 2:S296-9. PMID: 2903537.
      Citations: 1     Fields:    Translation:Cells
    457. Tainer JA, Hallewell RA, Roberts VA, Parge HE, Getzoff ED. Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase. Basic Life Sci. 1988; 49:635-40. PMID: 3250519.
      Citations: 1     Fields:    Translation:AnimalsCells
    458. Getzoff ED, Tainer JA, Lerner RA, Geysen HM. The chemistry and mechanism of antibody binding to protein antigens. Adv Immunol. 1988; 43:1-98. PMID: 3055852.
      Citations: 51     Fields:    Translation:Cells
    459. Fieser TM, Tainer JA, Geysen HM, Houghten RA, Lerner RA. Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8568-72. PMID: 2446325; PMCID: PMC299586.
      Citations: 49     Fields:    Translation:Cells
    460. Geysen HM, Tainer JA, Rodda SJ, Mason TJ, Alexander H, Getzoff ED, Lerner RA. Chemistry of antibody binding to a protein. Science. 1987 Mar 06; 235(4793):1184-90. PMID: 3823878.
      Citations: 53     Fields:    
    461. Getzoff ED, Geysen HM, Rodda SJ, Alexander H, Tainer JA, Lerner RA. Mechanisms of antibody binding to a protein. Science. 1987 Mar 06; 235(4793):1191-6. PMID: 3823879.
      Citations: 38     Fields:    Translation:AnimalsCells
    462. Parge HE, McRee DE, Capozza MA, Bernstein SL, Getzoff ED, Tainer JA. Three dimensional structure of bacterial pili. Antonie Van Leeuwenhoek. 1987; 53(6):447-53. PMID: 2897188.
      Citations: 4     Fields:    Translation:Cells
    463. Parge HE, Getzoff ED, Scandella CS, Hallewell RA, Tainer JA. Crystallographic characterization of recombinant human CuZn superoxide dismutase. J Biol Chem. 1986 Dec 05; 261(34):16215-8. PMID: 3782115.
      Citations: 12     Fields:    Translation:Humans
    464. Hazzard JT, Cusanovich MA, Tainer JA, Getzoff ED, Tollin G. Kinetic studies of reduction of a 1:1 cytochrome c-flavodoxin complex by free flavin semiquinones and rubredoxin. Biochemistry. 1986 Jun 03; 25(11):3318-28. PMID: 3015203.
      Citations: 3     Fields:    Translation:Cells
    465. Getzoff ED, Tainer JA, Olson AJ. Recognition and interactions controlling the assemblies of beta barrel domains. Biophys J. 1986 Jan; 49(1):191-206. PMID: 3955170; PMCID: PMC1329621.
      Citations: 10     Fields:    Translation:Cells
    466. Wilson IA, Haft DH, Getzoff ED, Tainer JA, Lerner RA, Brenner S. Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5255-9. PMID: 2410917; PMCID: PMC390546.
      Citations: 62     Fields:    Translation:AnimalsCells
    467. So M, Billyard E, Deal C, Getzoff E, Hagblom P, Meyer TF, Segal E, Tainer J. Gonococcal pilus: genetics and structure. Curr Top Microbiol Immunol. 1985; 118:13-28. PMID: 2414068.
      Citations: 5     Fields:    Translation:Cells
    468. Tainer JA, Getzoff ED, Paterson Y, Olson AJ, Lerner RA. The atomic mobility component of protein antigenicity. Annu Rev Immunol. 1985; 3:501-35. PMID: 2415142.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    469. Tainer JA, Getzoff ED, Alexander H, Houghten RA, Olson AJ, Lerner RA, Hendrickson WA. The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature. 1984 Nov 8-14; 312(5990):127-34. PMID: 6209578.
      Citations: 99     Fields:    Translation:AnimalsCells
    470. Tainer JA, Getzoff ED, Richardson JS, Richardson DC. Structure and mechanism of copper, zinc superoxide dismutase. Nature. 1983 Nov 17-23; 306(5940):284-7. PMID: 6316150.
      Citations: 150     Fields:    Translation:Cells
    471. Getzoff ED, Tainer JA, Weiner PK, Kollman PA, Richardson JS, Richardson DC. Electrostatic recognition between superoxide and copper, zinc superoxide dismutase. Nature. 1983 Nov 17-23; 306(5940):287-90. PMID: 6646211.
      Citations: 100     Fields:    Translation:Cells
    472. Turner SR, Tainer JA. Non-chemokinetic neutrophil attractants derived from arachidonic acid. Cell Biol Int Rep. 1983 Oct; 7(10):843-8. PMID: 6416688.
      Citations:    Fields:    Translation:Humans
    473. Tainer JA, Getzoff ED, Beem KM, Richardson JS, Richardson DC. Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase. J Mol Biol. 1982 Sep 15; 160(2):181-217. PMID: 7175933.
      Citations: 150     Fields:    Translation:Cells
    474. Richardson JS, Tainer JA, Richardson DC. An illustrated museum of protein structures. Biophys J. 1980 Oct; 32(1):211-3. PMID: 19431356; PMCID: PMC1327281.
      Citations: 1     Fields:    
    475. Lynn WS, Kylstra JA, Sahu SC, Tainer J, Shelburne J, Pratt PC, Gutknecht WF, Shaw R, Ingram P. Investigations of black bronchoalveolar human lavage fluid. Chest. 1977 Oct; 72(4):483-8. PMID: 908217.
      Citations: 6     Fields:    Translation:HumansCells
    476. Tainer JA, Turner SR, Lynn WS. New aspects of chemotaxis. Specific target-cell attraction by lipid and lipoprotein fractions of Escherichia coli chemotactic factor. Am J Pathol. 1975 Nov; 81(2):401-10. PMID: 1103633; PMCID: PMC2032212.
      Citations: 20     Fields:    Translation:Cells
    477. Turner SR, Tainer JA, Lynn WS. Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets. Nature. 1975 Oct 23; 257(5528):680-1. PMID: 810723.
      Citations: 78     Fields:    Translation:HumansCells
    478. MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biology Open. 1:863-873.
    479. Crystallographic structures of metalloenzymes for dna repair. Protein Engineering, Design and Selection. 6:39.
    480. Perchlorate reductase is distinguished by active site aromatic gate residues. Journal of Biological Chemistry. 291:9190-9202.
    481. RNF8 E3 ubiquitin ligase stimulates Ubc13 E2 conjugating activity that is essential for DNA double strand break signaling and BRCA1 tumor suppressor recruitment. Journal of Biological Chemistry. 291:9396-9410.
    482. Inhibition of neutrophil migration by metal ions is a function of ion reduction potential. Federation Proceedings. 43.
    483. Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer. Nature Structural and Molecular Biology. 23:509-510.
    484. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 89:11106.
    485. Summary of 'superoxide dismutase (SOD) and free radicals in amyotrophic lateral sclerosis and neurodegeneration' conference. Neurology. 45:1779-1780.
    486. Theories about oxygen toxicity [5] (multiple letters). Chemical and Engineering News. 62.
    487. Science, citation, and funding [1]. Science. 251:1408.
    488. MICROBIOLOGY 1975. 202-205.
    489. Modeling macromolecular motions by x-ray-scattering-constrained molecular dynamics. Biophysical Journal. 108:2421-2423.
    490. Kinetic and structural characterization of human manganese superoxide dismutase containing 3-fluorotyrosines. Journal of Molecular Structure. 790:168-173.
    491. The crystal structure of inducible nitric oxide synthase oxygenase domain dimer with L-arginine and tetrahydrobiopterin. Chemtracts. 12:557-564.
    492. Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. Structure. 24:2067-2079.
    493. The nucleotide-dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor. Molecular Microbiology. 99:674-685.
    494. Erratum. EMBO Journal. 22:1234.
    495. Cell-free expression of functional receptor tyrosine kinases. Scientific Reports. 5.
    496. Erratum. EMBO Journal. 35:791.
    497. High-throughput SAXS for the characterization of biomolecules in solution. 245-258.
    498. Erratum. Journal of Biological Chemistry. 284:21100.
    499. Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair. Progress in Biophysics and Molecular Biology. 117:182-193.
    500. The crystal structure of inducible nitric oxide synthase oxygenase domain dimer with L-arginine and tetrahydrobiopterin. Chemtracts. 13:859-866.
    501. Colour illustration. Journal of Molecular Graphics. 8:145-152.
    502. Structural, functional, and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from Neisseria meningitidis and Brucella abortus. Journal of Bacteriology. 197:3834-3847.
    503. Erratum. Nature Structural and Molecular Biology. 19:364.
    504. Erratum DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. [Molecular Cell 53, 9, (2014) 7-18]. Molecular Cell. 53:361.
    505. Structure and design, prediction and evolution. Current Opinion in Biotechnology. 9:335-337.
    506. The total chemical synthesis of L- and D-superoxide dismutnse. Protein Engineering. 10:23.
    507. Amino acid hydrophobicity in the context of folded proteins. Protein Engineering, Design and Selection. 6:129.
    508. Exploring the repeat protein universe through computational protein design. Nature. 528:580-584.
    509. Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences. Nucleic Acids Research. 44:5673-5688.
    510. The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50 (Biochemistry (2008), 47, 44 (11446-11456)). Biochemistry. 48:4008.
    511. Erratum. Nature. 404:525.
    512. Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN. Molecular Cell. 64:688-703.
    513. Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome. Structure. 25:157-166.
    514. An intrinsically disordered APLF links Ku, DNA-PKcs, and XRCC4-DNA ligase IV in an extended flexible non-homologous end joining complex. Journal of Biological Chemistry. 291:26987-27006.
    515. Erratum. Nature Structural and Molecular Biology. 18:1084.
    516. Serum albumin perturbs chemotaxis dose-inhibition profiles for 3 nonsteroidal antiinflammatory drugs. Federation Proceedings. 43.
    517. ELECTROSTATIC FORCES BETWEEN LIGANDS AND MACROMOLECULES. 538.
    518. FlaF is a β-sandwich protein that anchors the archaellum in the archaeal cell envelope by binding the S-layer protein. Structure. 23:863-872.
    519. The ATPase Motor Turns for Type IV Pilus Assembly. Structure. 24:1857-1859.
    520. Dynamic structures in DNA damage responses & cancer. Progress in Biophysics and Molecular Biology. 117:129-133.
    521. Implementation and performance of SIBYLS. Journal of Applied Crystallography. 46:1-13.
    522. Erratum. Journal of Molecular Biology. 334:175.
    523. Mobility and evolutionary variability factors in protein antigenicity. Nature. 317:90.
    524. Charging of Proteins in Native Mass Spectrometry. Journal of the American Society for Mass Spectrometry. 28:332-340.
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