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GARCIA-MANERO, GUILLERMO
One or more keywords matched the following items that are connected to GARCIA-MANERO, GUILLERMO
Item TypeName
Academic Article DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia.
Concept Mutation
Concept Germ-Line Mutation
Concept Point Mutation
Concept Mutation, Missense
Concept Frameshift Mutation
Academic Article BRAF kinase domain mutations are present in a subset of chronic myelomonocytic leukemia with wild-type RAS.
Academic Article Case series of patients with acute myeloid leukemia receiving hypomethylation therapy and retrospectively found to have IDH1 or IDH2 mutations.
Academic Article TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.
Academic Article Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome.
Academic Article Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate.
Academic Article A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.
Academic Article Trisomy 11 in myelodysplastic syndromes defines a unique group of disease with aggressive clinicopathologic features.
Academic Article Acute myeloid leukemia with t(9;11)(p21-22;q23): common properties of dysregulated ras pathway signaling and genomic progression characterize de novo and therapy-related cases.
Academic Article Low frequency of H3.3 mutations and upregulated DAXX expression in MDS.
Academic Article Dynamic acquisition of FLT3 or RAS alterations drive a subset of patients with lower risk MDS to secondary AML.
Academic Article Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors.
Academic Article Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy.
Academic Article Imatinib has limited therapeutic activity for hypereosinophilic syndrome patients with unknown or negative PDGFRalpha mutation status.
Academic Article Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis.
Academic Article Progress in myelodysplastic syndromes.
Academic Article Outcome of patients with FLT3-mutated acute myeloid leukemia in first relapse.
Academic Article Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia.
Academic Article Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia.
Academic Article Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes.
Academic Article Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.
Academic Article Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation.
Academic Article NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromes.
Academic Article Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation".
Academic Article Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies.
Academic Article A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome.
Academic Article Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.
Academic Article Lenalidomide plus prednisone results in durable clinical, histopathologic, and molecular responses in patients with myelofibrosis.
Academic Article Clinical effect of point mutations in myelodysplastic syndromes.
Academic Article Prognostic significance of alterations in IDH enzyme isoforms in patients with AML treated with high-dose cytarabine and idarubicin.
Academic Article SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value.
Academic Article Epigenetic therapy is associated with similar survival compared with intensive chemotherapy in older patients with newly diagnosed acute myeloid leukemia.
Academic Article Prognostic impact of RAS mutations in patients with myelodysplastic syndrome.
Academic Article The clinical importance of moderate/severe bone marrow fibrosis in patients with therapy-related myelodysplastic syndromes.
Academic Article Effect of NPM1 and FLT3 mutations on the outcomes of elderly patients with acute myeloid leukemia receiving standard chemotherapy.
Academic Article Toll-like receptor alterations in myelodysplastic syndrome.
Academic Article Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes.
Academic Article Modeling interactions between leukemia-specific chromosomal changes, somatic mutations, and gene expression patterns during progression of core-binding factor leukemias.
Academic Article Clinical and proteomic characterization of acute myeloid leukemia with mutated RAS.
Academic Article FLT3 mutations in myelodysplastic syndrome and chronic myelomonocytic leukemia.
Academic Article Discovery of imatinib-responsive FIP1L1-PDGFRA mutation during refractory acute myeloid leukemia transformation of chronic myelomonocytic leukemia.
Academic Article HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.
Academic Article Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors.
Academic Article Mutated NPM1 in patients with acute myeloid leukemia in remission and relapse.
Academic Article Lack of association of IDH1, IDH2 and DNMT3A mutations with outcome in older patients with acute myeloid leukemia treated with hypomethylating agents.
Academic Article Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations.
Academic Article A phase I/II study of the Janus kinase (JAK)1 and 2 inhibitor ruxolitinib in patients with relapsed or refractory acute myeloid leukemia.
Academic Article Phase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome.
Academic Article Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases.
Academic Article An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults.
Academic Article Clonal evolution of acute myeloid leukemia relapsed after 19 years of remission.
Academic Article TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases.
Academic Article Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML.
Academic Article TP53 overexpression is an independent adverse prognostic factor in de novo myelodysplastic syndromes with fibrosis.
Academic Article An international data set for CMML validates prognostic scoring systems and demonstrates a need for novel prognostication strategies.
Academic Article Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes.
Academic Article Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.
Academic Article Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC).
Academic Article IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression.
Academic Article Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation
Academic Article TP53 mutations in newly diagnosed acute myeloid leukemia
Academic Article IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression
Academic Article TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases
Academic Article Clinical implications of TP53 mutations in myelodysplastic syndromes treated with hypomethylating agents
Academic Article Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes
Academic Article Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS
Academic Article Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point
Academic Article Whole-arm translocation of der(5;17)(p10;q10) with concurrent TP53 mutations in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)
Academic Article Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS.
Academic Article Clinical implications of TP53 mutations in myelodysplastic syndromes treated with hypomethylating agents.
Academic Article TP53 mutations in newly diagnosed acute myeloid leukemia: Clinicomolecular characteristics, response to therapy, and outcomes.
Academic Article Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation.
Academic Article Whole-arm translocation of der(5;17)(p10;q10) with concurrent TP53 mutations in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): A unique molecular-cytogenetic subgroup.
Academic Article Clinical use of ruxolitinib in an academic medical center in unselected patients with myeloproliferative neoplasms not on clinical study.
Academic Article Activity of the oral mitogen-activated protein kinase kinase inhibitor trametinib in RAS-mutant relapsed or refractory myeloid malignancies.
Academic Article ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition.
Academic Article Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults.
Academic Article Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study.
Academic Article Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.
Academic Article Factors associated with risk of central nervous system relapse in patients with non-core binding factor acute myeloid leukemia.
Academic Article TP53 mutation does not confer a poor outcome in adult patients with acute lymphoblastic leukemia who are treated with frontline hyper-CVAD-based regimens.
Academic Article Bone marrow pathologic abnormalities in familial platelet disorder with propensity for myeloid malignancy and germline RUNX1 mutation.
Academic Article Vosaroxin in combination with decitabine in newly diagnosed older patients with acute myeloid leukemia or high-risk myelodysplastic syndrome.
Academic Article More than 1 TP53 abnormality is a dominant characteristic of pure erythroid leukemia.
Academic Article Characterization of TP53 mutations in low-grade myelodysplastic syndromes and myelodysplastic syndromes with a non-complex karyotype.
Academic Article Chronic myelomonocytic leukemia masquerading as cutaneous indeterminate dendritic cell tumor: Expanding the spectrum of skin lesions in chronic myelomonocytic leukemia.
Academic Article Characteristics and outcome of chronic myeloid leukemia patients with E255K/V BCR-ABL kinase domain mutations.
Academic Article Chronic Myelomonocytic Leukemia With Fibrosis Is a Distinct Disease Subset With Myeloproliferative Features and Frequent JAK2 p.V617F Mutations.
Academic Article Improving the detection of patients with inherited predispositions to hematologic malignancies using next-generation sequencing-based leukemia prognostication panels.
Academic Article Clinical implications of cancer gene mutations in patients with chronic lymphocytic leukemia treated with lenalidomide.
Academic Article Impact of the number of mutations in survival and response outcomes to hypomethylating agents in patients with myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms.
Academic Article Outcomes with lower intensity therapy in TP53-mutated acute myeloid leukemia.
Academic Article Association of bone marrow fibrosis with inferior survival outcomes in chronic myelomonocytic leukemia.
Academic Article Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia.
Academic Article Clinical Outcomes With Ring Sideroblasts and SF3B1 Mutations in Myelodysplastic Syndromes: MDS Clinical Research Consortium Analysis.
Academic Article Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes.
Academic Article Sorafenib Combined with 5-azacytidine in Older Patients with Untreated FLT3-ITD Mutated Acute Myeloid Leukemia.
Academic Article Validation of the 2017 European LeukemiaNet classification for acute myeloid leukemia with NPM1 and FLT3-internal tandem duplication genotypes.
Academic Article Late relapse in acute myeloid leukemia (AML): clonal evolution or therapy-related leukemia?
Academic Article Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.
Academic Article PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Academic Article Phase II Trial of MEK Inhibitor Binimetinib (MEK162) in RAS-mutant Acute Myeloid Leukemia.
Academic Article TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.
Academic Article Novel EZH2 mutation in a patient with secondary B-cell acute lymphocytic leukemia after deletion 5q myelodysplastic syndrome treated with lenalidomide: A case report.
Academic Article Clonal hematopoiesis of indeterminate potential-associated mutations and risk of comorbidities in patients with myelodysplastic syndrome.
Academic Article Janus kinase 2 variants associated with the transformation of myeloproliferative neoplasms into acute myeloid leukemia.
Academic Article NPM1 mutations define a specific subgroup of MDS and MDS/MPN patients with favorable outcomes with intensive chemotherapy.
Academic Article Mutational landscape of myelodysplastic/myeloproliferative neoplasm-unclassifiable.
Academic Article DDX41 mutations in myeloid neoplasms are associated with male gender, TP53 mutations and high-risk disease.
Concept Loss of Function Mutation
Concept Mutation Rate
Academic Article Prognostic significance of baseline FLT3-ITD mutant allele level in acute myeloid leukemia treated with intensive chemotherapy with/without sorafenib.
Academic Article Sorafenib plus intensive chemotherapy improves survival in patients with newly diagnosed, FLT3-internal tandem duplication mutation-positive acute myeloid leukemia.
Academic Article Successful lenalidomide treatment in high risk myelodysplastic syndrome with germline DDX41 mutation.
Academic Article Philadelphia chromosome-positive acute lymphoblastic leukemia at first relapse in the era of tyrosine kinase inhibitors.
Academic Article Impact of the variant allele frequency of ASXL1, DNMT3A, JAK2, TET2, TP53, and NPM1 on the outcomes of patients with newly diagnosed acute myeloid leukemia.
Academic Article Genomic context and TP53 allele frequency define clinical outcomes in TP53-mutated myelodysplastic syndromes.
Academic Article Outcomes of acute myeloid leukemia with myelodysplasia related changes depend on diagnostic criteria and therapy.
Academic Article Clinico-pathologic characteristics and outcomes of the World Health Organization (WHO) provisional entity de novo acute myeloid leukemia with mutated RUNX1.
Academic Article SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS.
Academic Article Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL.
Academic Article The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia.
Academic Article Clonal evolution and treatment outcomes in hematopoietic neoplasms arising in patients with germline RUNX1 mutations.
Academic Article Germline DNMT3A mutation in familial acute myeloid leukaemia.
Academic Article Outcomes with sequential FLT3-inhibitor-based therapies in patients with AML.
Academic Article Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.
Academic Article Clinical characteristics and outcomes in patients with acute myeloid leukemia with concurrent FLT3-ITD and IDH mutations.
Academic Article Clinical outcomes and influence of mutation clonal dominance in oligomonocytic and classical chronic myelomonocytic leukemia.
Academic Article Real-world diagnostic testing patterns for assessment of ring sideroblasts and SF3B1 mutations in patients with newly diagnosed lower-risk myelodysplastic syndromes.
Academic Article Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes.
Academic Article Acute myeloid leukemia: current progress and future directions.
Academic Article Outcome of T-cell acute lymphoblastic leukemia/lymphoma: Focus on near-ETP phenotype and differential impact of nelarabine.
Academic Article Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis.
Academic Article Patterns of Resistance Differ in Patients with Acute Myeloid Leukemia Treated with Type I versus Type II FLT3 inhibitors.
Academic Article Clinical, genomic, and transcriptomic differences between myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) and myelodysplastic syndrome with ring sideroblasts (MDS-RS).
Academic Article A phase I/II study of the combination of quizartinib with azacitidine or low-dose cytarabine for the treatment of patients with acute myeloid leukemia and myelodysplastic syndrome.
Academic Article Impact of splicing mutations in acute myeloid leukemia treated with hypomethylating agents combined with venetoclax.
Academic Article Clinicopathologic correlates and natural history of atypical chronic myeloid leukemia.
Academic Article Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia.
Academic Article Clonal dynamics and clinical implications of postremission clonal hematopoiesis in acute myeloid leukemia.
Academic Article Only SF3B1 mutation involving K700E independently predicts overall survival in myelodysplastic syndromes.
Academic Article Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms.
Academic Article Personalized Prediction Model to Risk Stratify Patients With Myelodysplastic Syndromes.
Academic Article Treatment outcomes for patients with myelodysplastic syndrome/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis.
Academic Article Myelodysplastic Syndromes: A New Decade.
Academic Article Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements.
Academic Article Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group.
Academic Article Marrow ring sideroblasts are highly predictive for TP53 mutation in MDS with excess blasts.
Academic Article Improved outcomes among newly diagnosed patients with FMS-like tyrosine kinase 3 internal tandem duplication mutated acute myeloid leukemia treated with contemporary therapy: Revisiting the European LeukemiaNet adverse risk classification.
Academic Article Luspatercept for myelodysplastic syndromes/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis.
Academic Article Prediction of survival with intensive chemotherapy in acute myeloid leukemia.
Academic Article Primary mediastinal germ cell tumor and clonally related and unique hematologic neoplasms with i(12p) and TP53 mutation: A report of two cases.
Academic Article Immunohistochemical loss of enhancer of Zeste Homolog 2 (EZH2) protein expression correlates with EZH2 alterations and portends a worse outcome in myelodysplastic syndromes.
Academic Article Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms.
Academic Article Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia.
Academic Article Impact of SF3B1 mutation in myelofibrosis.
Academic Article Targeted therapy with the mutant IDH2 inhibitor enasidenib for high-risk IDH2-mutant myelodysplastic syndrome.
Academic Article Concurrent Mutations in SF3B1 and PHF6 in Myeloid Neoplasms.
Academic Article Implications of RAS mutational status in subsets of patients with newly diagnosed acute myeloid leukemia across therapy subtypes.
Academic Article Contemporary outcomes in IDH-mutated acute myeloid leukemia: The impact of co-occurring NPM1 mutations and venetoclax-based treatment.
Academic Article TP53-Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia: Biology, Current Therapy, and Future Directions.
Academic Article Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML.
Academic Article Genomic profiling for clinical decision making in?myeloid neoplasms and acute leukemia.
Academic Article Prediction of survival with lower intensity therapy among older patients with acute myeloid leukemia.
Academic Article PHF6 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia and acute myeloid leukemia.
Academic Article Characteristics of patients with myelodysplastic neoplasm and spliceosome mutations.
Academic Article Venetoclax abrogates the prognostic impact of splicing factor gene mutations in newly diagnosed acute myeloid leukemia.
Academic Article Phenotypic subtypes of leukaemic transformation in chronic myelomonocytic leukaemia.
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