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DEPINHO, RONALD A
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Academic Article Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs.
Academic Article Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.
Academic Article Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Academic Article Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.
Academic Article Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice.
Academic Article Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.
Academic Article Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.
Academic Article Transcription factor FoxO1 is essential for enamel biomineralization.
Academic Article Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
Academic Article PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas.
Academic Article Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
Academic Article SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.
Academic Article Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.
Academic Article Passenger deletions generate therapeutic vulnerabilities in cancer.
Academic Article mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Academic Article Proinvasion metastasis drivers in early-stage melanoma are oncogenes.
Concept Mammary Tumor Virus, Mouse
Concept Mice, Inbred mdx
Concept Mice, Inbred CBA
Concept Mice, Knockout
Concept Mice, Inbred NOD
Concept Mice, Inbred BALB C
Concept Mice, Obese
Concept Mice, Nude
Concept Mice, SCID
Concept Mice, Congenic
Concept Mice, Inbred Strains
Concept Mice
Concept Mice, Inbred DBA
Concept Mice, Mutant Strains
Concept Mice, Inbred ICR
Concept Mice, Inbred C57BL
Concept Mice, Transgenic
Academic Article Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice.
Academic Article Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer.
Academic Article Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver.
Academic Article IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis.
Academic Article Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53.
Academic Article Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
Academic Article Expression and activity of L-Myc in normal mouse development.
Academic Article Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.
Academic Article Essential role of mouse telomerase in highly proliferative organs.
Academic Article A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.
Academic Article p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.
Academic Article A critical role for telomeres in suppressing and facilitating carcinogenesis.
Academic Article Flipping the oncogene switch: illumination of tumor maintenance and regression.
Academic Article The age of cancer.
Academic Article DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.
Academic Article Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
Academic Article Modeling prostate cancer in the mouse.
Academic Article Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Academic Article Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.
Academic Article Constitutive telomerase expression promotes mammary carcinomas in aging mice.
Academic Article Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
Academic Article Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Academic Article Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells.
Academic Article The age of cancer: telomeres, checkpoints, and longevity.
Academic Article The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Academic Article The LKB1 tumor suppressor negatively regulates mTOR signaling.
Academic Article Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
Academic Article Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production.
Academic Article The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.
Academic Article Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.
Academic Article HDAC2 negatively regulates memory formation and synaptic plasticity.
Academic Article Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.
Academic Article Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.
Academic Article Somatic p16(INK4a) loss accelerates melanomagenesis.
Academic Article Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.
Academic Article FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.
Academic Article IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.
Academic Article Telomere dysfunction induces metabolic and mitochondrial compromise.
Academic Article Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
Academic Article Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2.
Academic Article Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia.
Academic Article Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle.
Academic Article Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection.
Academic Article Instability of immunoglobulin genes in S107 cell line.
Academic Article IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.
Academic Article Structure and expression of the murine L-myc gene.
Academic Article p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
Academic Article Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer.
Academic Article Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection.
Academic Article Mouse models for the study of telomerase.
Academic Article Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Academic Article p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.
Academic Article The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
Academic Article Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.
Academic Article Essential role for Max in early embryonic growth and development.
Academic Article Overexpression of Mad transcription factor inhibits proliferation of cultured human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals.
Academic Article Animal models of melanoma: recent advances and future prospects.
Academic Article The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.
Academic Article DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Academic Article Hepatocyte transplantation improves survival in mice with liver toxicity induced by hepatic overexpression of Mad1 transcription factor.
Academic Article Tetracycline-inducible system for photoreceptor-specific gene expression.
Academic Article Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility.
Academic Article Telomere dysfunction alters the chemotherapeutic profile of transformed cells.
Academic Article Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
Academic Article Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame.
Academic Article p16(INK4a) and p53 deficiency cooperate in tumorigenesis.
Academic Article Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression.
Academic Article Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation.
Academic Article Genetic determinants of malignancy in a mouse model for oligodendroglioma.
Academic Article Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a.
Academic Article Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.
Academic Article LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.
Academic Article mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.
Academic Article Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
Academic Article Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination.
Academic Article Molecular diversity of astrocytes with implications for neurological disorders.
Academic Article Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
Academic Article Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
Academic Article Cancer: crime and punishment.
Academic Article Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.
Academic Article Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
Academic Article Characterization of melanocyte-specific inducible Cre recombinase transgenic mice.
Academic Article Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Academic Article Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation.
Academic Article Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16.
Academic Article A mouse to human search for plasma proteome changes associated with pancreatic tumor development.
Academic Article Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.
Academic Article Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.
Academic Article Codependent activators direct myoblast-specific MyoD transcription.
Academic Article Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.
Academic Article Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.
Academic Article Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice.
Academic Article FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.
Academic Article Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.
Academic Article Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.
Academic Article PI3 kinase signals BCR-dependent mature B cell survival.
Academic Article FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice.
Academic Article FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Academic Article FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.
Academic Article Mig-6 controls EGFR trafficking and suppresses gliomagenesis.
Academic Article Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells.
Academic Article Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis.
Academic Article Towards patient-based cancer therapeutics.
Academic Article Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.
Academic Article The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.
Academic Article A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis.
Academic Article FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.
Academic Article Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Academic Article AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Academic Article Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases.
Academic Article Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Academic Article Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators.
Academic Article Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction.
Academic Article Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1.
Academic Article Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.
Academic Article Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma.
Academic Article PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Academic Article PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis.
Academic Article Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Academic Article Structural and functional analysis of the mouse mdr1b gene promoter.
Academic Article myc family oncogenes in the development of normal and neoplastic cells.
Academic Article The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression.
Academic Article Differential regulation of the N-myc gene in transfected cells and transgenic mice.
Academic Article Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice.
Academic Article Myc family genes: a dispersed multi-gene family.
Academic Article Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells.
Academic Article Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene.
Academic Article Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.
Academic Article Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution.
Academic Article Role of the INK4a locus in tumor suppression and cell mortality.
Academic Article Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.
Academic Article The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Academic Article Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.
Academic Article Repression by the Mad(Mxi1)-Sin3 complex.
Academic Article Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors.
Academic Article Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.
Academic Article Longevity, stress response, and cancer in aging telomerase-deficient mice.
Academic Article Telomere-dependent senescence.
Academic Article Essential role for oncogenic Ras in tumour maintenance.
Academic Article Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells.
Academic Article Gene-target recognition among members of the myc superfamily and implications for oncogenesis.
Academic Article Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice.
Academic Article Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.
Academic Article N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
Academic Article Mice without telomerase: what can they teach us about human cancer?
Academic Article Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
Academic Article Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Academic Article Telomere dysfunction triggers developmentally regulated germ cell apoptosis.
Academic Article Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.
Academic Article Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.
Academic Article p16(Ink4a) in melanocyte senescence and differentiation.
Academic Article Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.
Academic Article Telomerase extracurricular activities.
Academic Article The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.
Academic Article Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.
Academic Article Conquering the complexity of p53.
Academic Article Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
Academic Article Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF.
Academic Article Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development.
Academic Article mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
Academic Article Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
Academic Article Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.
Academic Article The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Academic Article Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Academic Article Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.
Academic Article Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression.
Academic Article Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53.
Academic Article Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.
Academic Article DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.
Academic Article FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription.
Academic Article FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Academic Article FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Academic Article Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.
Academic Article The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.
Academic Article Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Academic Article ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.
Academic Article Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.
Academic Article Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
Academic Article LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Academic Article Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.
Academic Article A mouse plasma peptide atlas as a resource for disease proteomics.
Academic Article Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.
Academic Article Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.
Academic Article Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.
Academic Article mTORC1 signaling governs hematopoietic stem cell quiescence.
Academic Article The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.
Academic Article Foxo1 integrates insulin signaling with mitochondrial function in the liver.
Academic Article Telomeres and telomerase in cancer.
Academic Article FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
Academic Article Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.
Academic Article SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Academic Article Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene.
Academic Article PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-?B-cytokine network.
Academic Article FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.
Academic Article The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism.
Academic Article Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6.
Academic Article From the Cover: Neutralization of terminal differentiation in gliomagenesis.
Academic Article Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Academic Article Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4.
Academic Article Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.
Academic Article Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
Academic Article Voltage-activated K+ channels and membrane depolarization regulate accumulation of the cyclin-dependent kinase inhibitors p27(Kip1) and p21(CIP1) in glial progenitor cells.
Academic Article Dual inactivation of RB and p53 pathways in RAS-induced melanomas.
Academic Article STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.
Academic Article Take care of your chromosomes lest cancer take care of you.
Academic Article Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus.
Academic Article Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
Academic Article Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes.
Academic Article Genetics and biology of pancreatic ductal adenocarcinoma.
Academic Article Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy.
Academic Article The mighty mouse: genetically engineered mouse models in cancer drug development.
Academic Article Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Academic Article Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.
Academic Article Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.
Academic Article Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway.
Academic Article p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
Academic Article Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.
Academic Article Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas.
Academic Article Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.
Academic Article Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells.
Academic Article Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
Academic Article Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice.
Academic Article IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.
Academic Article STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.
Academic Article FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.
Academic Article Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma.
Academic Article mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.
Academic Article An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3.
Academic Article Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo.
Academic Article A biochemical and biological analysis of Myc superfamily interactions.
Academic Article A bumper crop of cancer genes.
Academic Article Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery.
Academic Article Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.
Academic Article The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.
Academic Article Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations.
Academic Article PCAF modulates PTEN activity.
Academic Article Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.
Academic Article Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.
Academic Article A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
Academic Article Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.
Academic Article Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation.
Academic Article FOXO1 in the ventromedial hypothalamus regulates energy balance.
Academic Article Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.
Academic Article FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin.
Academic Article Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis.
Academic Article Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy.
Academic Article Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer.
Academic Article Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.
Academic Article Telomere dysfunction suppresses multiple endocrine neoplasia in mice.
Academic Article Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy.
Academic Article FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization.
Academic Article Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome.
Academic Article MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas.
Academic Article Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression.
Academic Article In?Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.
Academic Article Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma.
Academic Article FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice (Journal of Clinical Investigation (2010) 120, 1 (357-368) (DOI
Academic Article Telomere dysfunction suppresses multiple endocrine Neoplasia in mice
Academic Article Mouse model for regulation of telomerase
Academic Article PRKCI promotes immune suppression in ovarian cancer.
Academic Article Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.
Academic Article Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.
Academic Article Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.
Academic Article Oncogenic Kras drives invasion and maintains metastases in colorectal cancer.
Academic Article Effective combinatorial immunotherapy for castration-resistant prostate cancer.
Academic Article Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion.
Academic Article PAF promotes stemness and radioresistance of glioma stem cells.
Academic Article Opposing roles of TGF? and BMP signaling in prostate cancer development.
Academic Article FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.
Academic Article STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers.
Academic Article An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
Academic Article Genetics and biology of prostate cancer.
Academic Article FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase.
Academic Article Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.
Academic Article SUMOylation of ROR-?t inhibits IL-17 expression and inflammation via HDAC2.
Academic Article An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer.
Academic Article Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.
Academic Article KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Concept Mice, 129 Strain
Academic Article Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma.
Academic Article USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.
Academic Article Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment.
Academic Article Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment.
Academic Article Programmable base editing of mutated TERT promoter inhibits brain tumour growth.
Academic Article The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation.
Academic Article Effective combinatorial immunotherapy for penile squamous cell carcinoma.
Academic Article Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer.
Academic Article Telomere dysfunction activates YAP1 to drive tissue inflammation.
Academic Article An enolase inhibitor for the targeted treatment of ENO1-deleted cancers.
Academic Article FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
Academic Article Single-cell RNA sequencing in pancreatic cancer.
Academic Article Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Academic Article USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer.
Academic Article Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer.
Academic Article Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models.
Academic Article Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer.
Academic Article ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer.
Academic Article HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing a2d-1 Expression and Associated NMDA Receptor Activity.
Academic Article Histone demethylase KDM5D upregulation drives sex differences in colon cancer.
Academic Article Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T?cells.
Academic Article Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer.
Academic Article Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression.
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