Connection | Profiles RNS

Search Result Details

Back to Search Results

This page shows the details of why an item matched the keywords from your search.

Search Results

LOZANO, GUILLERMINA

One or more keywords matched the following items that are connected to LOZANO, GUILLERMINA

Item Type	Name
Academic Article	Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure.
Academic Article	Developmental control of transcription of the CAT reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice.
Academic Article	Mammary tumor modifiers in BALB/cJ mice heterozygous for p53.
Academic Article	A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
Academic Article	Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
Academic Article	MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis.
Academic Article	Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.
Academic Article	20 years studying p53 functions in genetically engineered mice.
Academic Article	p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation.
Academic Article	Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.
Academic Article	p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.
Academic Article	The cenpB gene is not essential in mice.
Academic Article	An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.
Academic Article	Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.
Concept	Mammary Tumor Virus, Mouse
Concept	Mice, Inbred MRL lpr
Concept	Mice, Knockout
Concept	Mice, Inbred BALB C
Concept	Mice, Inbred C3H
Concept	Mice, Nude
Concept	Mice, SCID
Concept	Mice, Inbred Strains
Concept	Mice
Concept	Mice, Inbred DBA
Concept	Mice, Mutant Strains
Concept	Mice, Inbred C57BL
Concept	Mice, Transgenic
Academic Article	Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice.
Academic Article	Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.
Academic Article	SV40 T antigen abrogates p53-mediated transcriptional activity.
Academic Article	Bcl-2 inhibits p53 nuclear import following DNA damage.
Academic Article	The loss of mdm2 induces p53-mediated apoptosis.
Academic Article	Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Academic Article	Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
Academic Article	Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
Academic Article	Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.
Academic Article	Crippling p53 activities via knock-in mutations in mouse models.
Academic Article	The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.
Academic Article	p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.
Academic Article	Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Academic Article	Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation.
Academic Article	Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner.
Academic Article	Transcriptional mechanisms controlling types I and III collagen genes.
Academic Article	Serotonin 5-HT1C receptors are expressed at high density on choroid plexus tumors from transgenic mice.
Academic Article	The tumor suppressor p53 regulates its own transcription.
Academic Article	PML, a growth suppressor disrupted in acute promyelocytic leukemia.
Academic Article	The organization and expression of the mdm2 gene.
Academic Article	mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts.
Academic Article	Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment.
Academic Article	Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
Academic Article	Overproduction of MDM2 in vivo disrupts S phase independent of E2F1.
Academic Article	Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
Academic Article	Organization, expression, and localization of the murine mdmx gene and pseudogene.
Academic Article	An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2.
Academic Article	Disrupting TP53 in mouse models of human cancers.
Academic Article	Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice.
Academic Article	A novel genetic modifier of p53, mop1, results in embryonic lethality.
Academic Article	p53 mutation heterogeneity in cancer.
Academic Article	p21 delays tumor onset by preservation of chromosomal stability.
Academic Article	A genetic mouse model for metastatic lung cancer with gender differences in survival.
Academic Article	Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.
Academic Article	The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival.
Academic Article	EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.
Academic Article	Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities.
Academic Article	Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice.
Academic Article	E2F3 is a mediator of DNA damage-induced apoptosis.
Academic Article	You can win by losing: p53 mutations in rhabdomyosarcomas.
Academic Article	Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.
Academic Article	Multiple stress signals activate mutant p53 in vivo.
Academic Article	The mutant p53 mouse as a pre-clinical model.
Academic Article	DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-?-driven epithelial-mesenchymal transition.
Academic Article	The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.
Academic Article	USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.
Academic Article	Tissue-specific expression of p53 in transgenic mice is regulated by intron sequences.
Academic Article	Analysis of p53 mutants for transcriptional activity.
Academic Article	Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene.
Academic Article	The expression of viral and cellular genes in papillomas of the choroid plexus induced in transgenic mice.
Academic Article	Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53.
Academic Article	Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality.
Academic Article	Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes.
Academic Article	Mouse models dissect the role of p53 in cancer and development.
Academic Article	The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53.
Academic Article	Germ cell expression of an isolated human endogenous retroviral long terminal repeat of the HERV-K/HTDV family in transgenic mice.
Academic Article	p53-independent functions of the p19(ARF) tumor suppressor.
Academic Article	Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
Academic Article	Conditional allele of mdm2 which encodes a p53 inhibitor.
Academic Article	p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells.
Academic Article	The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells.
Academic Article	Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.
Academic Article	Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Academic Article	Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
Academic Article	Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
Academic Article	Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.
Academic Article	Distinct roles of Mdm2 and Mdm4 in red cell production.
Academic Article	The oncogenic roles of p53 mutants in mouse models.
Academic Article	Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos.
Academic Article	New mouse models of cancer: single-cell knockouts.
Academic Article	Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence.
Academic Article	Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.
Academic Article	Mtbp haploinsufficiency in mice increases tumor metastasis.
Academic Article	The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Academic Article	Mdm2 and Mdm4 loss regulates distinct p53 activities.
Academic Article	p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
Academic Article	A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis.
Academic Article	Mouse models of p53 functions.
Academic Article	Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4.
Academic Article	A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Academic Article	Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
Academic Article	Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-? (TGF-?).
Academic Article	Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop.
Academic Article	The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.
Academic Article	Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis.
Academic Article	Mutant p53 prolongs NF-?B activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
Academic Article	An intron binding protein is required for transformation ability of p53.
Academic Article	Cyclin E restores p53 activity in contact-inhibited cells.
Academic Article	The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo.
Academic Article	Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice.
Academic Article	High metastatic potential in mice inheriting a targeted p53 missense mutation.
Academic Article	Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.
Academic Article	RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties.
Academic Article	The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development.
Academic Article	Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation.
Academic Article	The ups and downs of p53 regulation in hematopoietic stem cells.
Academic Article	ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63.
Academic Article	The Mdm network and its regulation of p53 activities: a rheostat of cancer risk.
Academic Article	Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells.
Academic Article	Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice.
Academic Article	Mutation of phosphoserine 389 affects p53 function in vivo.
Academic Article	14-3-3 sigma positively regulates p53 and suppresses tumor growth.
Academic Article	What have animal models taught us about the p53 pathway?
Academic Article	Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Academic Article	p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
Academic Article	Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair.
Academic Article	Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Academic Article	Tissue-specific and age-dependent effects of global Mdm2 loss.
Academic Article	Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors.
Academic Article	Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity.
Academic Article	Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Academic Article	TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.
Academic Article	Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma.
Academic Article	Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.
Academic Article	p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.
Academic Article	MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Academic Article	Distinct downstream targets manifest p53-dependent pathologies in mice
Academic Article	Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
Academic Article	Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice
Academic Article	Manipulating the p53 gene in the mouse
Academic Article	Developing genetically engineered mouse models to study tumor suppression.
Academic Article	Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.
Academic Article	Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice.
Academic Article	Distinct downstream targets manifest p53-dependent pathologies in mice.
Academic Article	Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo.
Academic Article	Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End.
Academic Article	The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.
Academic Article	Tumorigenesis promotes Mdm4-S overexpression.
Academic Article	Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.
Academic Article	Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.
Academic Article	Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.
Academic Article	Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration.
Academic Article	A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53.
Academic Article	Daxx Functions Are p53-Independent In Vivo.
Academic Article	Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.
Academic Article	Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.
Academic Article	One step at a time.
Academic Article	CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo.
Academic Article	Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination.
Concept	Mice, 129 Strain
Academic Article	Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity.
Academic Article	Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress.
Academic Article	Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.
Academic Article	p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo.
Academic Article	The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model.
Academic Article	MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.
Academic Article	Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis.
Academic Article	Wnt/?-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells.
Academic Article	Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.
Academic Article	Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo.
Academic Article	Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo.
Academic Article	EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.
Academic Article	Is loss of p53 a driver of ductal carcinoma in situ progression?
Academic Article	p53 Activation Paradoxically Causes Liver Cancer.
Academic Article	Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss.
Academic Article	Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas.
Academic Article	Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling.
Academic Article	Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program.
Academic Article	Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants.
Academic Article	Triple-negative breast tumors are dependent on mutant p53 for growth and survival.
Academic Article	The histone chaperone function of Daxx is dispensable for embryonic development.
Academic Article	p53R245W Mutation Fuels Cancer Initiation and Metastases in NASH-driven Liver Tumorigenesis.
Academic Article	Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo.

Search Criteria

Mice