| Item Type | Name |
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Academic Article
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Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells.
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Academic Article
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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Academic Article
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Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin.
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Academic Article
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SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.
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Academic Article
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Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.
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Concept
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Down-Regulation
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Concept
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Gene Expression Regulation, Enzymologic
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Concept
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Gene Expression Regulation, Neoplastic
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Concept
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Up-Regulation
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Concept
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Gene Expression Regulation
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Academic Article
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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
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Academic Article
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Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer.
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Academic Article
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RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.
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Academic Article
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Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.
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Academic Article
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Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells.
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Academic Article
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TRIM24 links a non-canonical histone signature to breast cancer.
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Academic Article
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A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer.
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Academic Article
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Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-?-dependent cancer metastasis.
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Academic Article
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miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion.
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Academic Article
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Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties.
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Academic Article
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Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer.
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Academic Article
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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.
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Academic Article
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Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.
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Academic Article
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lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
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Academic Article
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Strategies to target HER2/neu overexpression for cancer therapy.
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Academic Article
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Dysregulation of cellular signaling by HER2/neu in breast cancer.
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Academic Article
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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
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Academic Article
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Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
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Academic Article
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Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis.
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Academic Article
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Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition.
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Academic Article
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Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
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Academic Article
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GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
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Academic Article
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A new fork for clinical application: targeting forkhead transcription factors in cancer.
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Academic Article
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Oxygen sensor boosts growth factor signaling.
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Academic Article
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In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.
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Academic Article
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Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke.
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Academic Article
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miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression.
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Academic Article
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Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.
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Academic Article
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Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis.
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Academic Article
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Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway.
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Academic Article
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A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells.
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Academic Article
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Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
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Academic Article
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Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
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Academic Article
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Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.
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Academic Article
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Co-regulation of B-Myb expression by E2F1 and EGF receptor.
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Academic Article
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ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.
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Academic Article
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Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.
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Academic Article
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The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.
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Academic Article
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Physiological regulation of Akt activity and stability.
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Academic Article
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Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.
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Academic Article
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CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.
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Academic Article
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The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells.
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Academic Article
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On mammary gland growth factors: roles in normal development and in cancer.
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Academic Article
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Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells.
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Academic Article
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Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma.
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Academic Article
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MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.
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Academic Article
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Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model.
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Academic Article
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Chemo-signal therapy, an emerging new approach to modify drug resistance in breast cancer.
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Academic Article
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Prostate-specific antitumor activity by probasin promoter-directed p202 expression.
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Academic Article
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STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis.
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Academic Article
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Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer.
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Academic Article
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Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
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Academic Article
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Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer.
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Academic Article
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Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
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Academic Article
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Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
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Academic Article
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A new mutational AKTivation in the PI3K pathway.
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Academic Article
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Regulation of breast cancer metastasis by atypical chemokine receptors.
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Academic Article
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Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.
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Academic Article
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14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.
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Academic Article
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Downregulation of microRNA miR-520h by E1A contributes to anticancer activity.
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Academic Article
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Regulation of tumor angiogenesis by EZH2.
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Academic Article
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EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-?-catenin signaling.
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Academic Article
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EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling.
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Academic Article
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IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression.
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Academic Article
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The crosstalk of mTOR/S6K1 and Hedgehog pathways.
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Academic Article
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Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
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Academic Article
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Dysregulation of microRNAs in cancer.
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Academic Article
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Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
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Academic Article
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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
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Academic Article
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Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosis.
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Academic Article
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Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.
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Academic Article
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P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.
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Academic Article
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Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
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Academic Article
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Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity.
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Academic Article
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p53 acetylation is crucial for its transcription-independent proapoptotic functions.
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Academic Article
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ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.
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Academic Article
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ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
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Academic Article
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p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.
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Academic Article
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Deciphering the role of forkhead transcription factors in cancer therapy.
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Academic Article
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Epithelial-mesenchymal transition induced by TNF-a requires NF-?B-mediated transcriptional upregulation of Twist1.
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Academic Article
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KrasG12D-induced IKK2/?/NF-?B activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.
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Academic Article
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Beyond NF-?B activation: nuclear functions of I?B kinase a.
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Academic Article
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KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.
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Academic Article
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Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells.
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Academic Article
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TNFalpha induces HIF-1alpha expression through activation of IKKbeta.
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Academic Article
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The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
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Academic Article
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Complex regulation of the adenovirus e2 promoter by the viral oncoproteins e1a and e7 and tumor-suppressor rb.
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Academic Article
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Regulation of her2/neu gene-expression (review).
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Academic Article
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Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer.
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Academic Article
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IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation.
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Academic Article
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Regulation and Role of EZH2 in Cancer.
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Academic Article
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Signaling-mediated regulation of MicroRNA processing.
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Academic Article
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The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer.
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Academic Article
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The ZNF304-integrin axis protects against anoikis in cancer.
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Academic Article
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miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.
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Academic Article
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Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
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Academic Article
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The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells.
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Academic Article
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Erythropoietin Stimulates Tumor Growth via EphB4.
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Academic Article
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FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer.
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Academic Article
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JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis.
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Academic Article
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A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.
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Academic Article
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Altered Expression and Splicing of ESRP1 in Malignant Melanoma Correlates with Epithelial-Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity.
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Academic Article
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Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma.
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Academic Article
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Regulation of therapeutic resistance in cancers by receptor tyrosine kinases
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Academic Article
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Regulation and role of EZH2 in cancer
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Academic Article
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P27kip1 down-regulation is associated with trastuzumab resistance in breast cancer cells (Cancer Research (June 1, 2004) 64 (3981-3986))
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Academic Article
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Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression
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Academic Article
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Regulation of HER2/neu gene expression
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Academic Article
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Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer
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Academic Article
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Complex regulation of the adenovirus E2 promoter by the viral oncoproteins E1A and E7 and tumor suppressor Rb
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Academic Article
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TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation.
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Academic Article
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Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.
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Academic Article
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Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.
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Academic Article
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The LINK-A lncRNA activates normoxic HIF1a signalling in triple-negative breast cancer.
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Academic Article
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Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells.
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Academic Article
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Upregulation of lactate dehydrogenase a by 14-3-3? leads to increased glycolysis critical for breast cancer initiation and progression.
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Academic Article
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A Positive TGF-?/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer.
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Academic Article
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Regulation of therapeutic resistance in cancers by receptor tyrosine kinases.
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Academic Article
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GSK3? inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.
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Academic Article
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ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.
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Academic Article
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JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression.
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Academic Article
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Metastasis regulation by PPARD expression in cancer cells.
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Academic Article
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POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells.
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Academic Article
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The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.
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Academic Article
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PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.
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Academic Article
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EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.
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Academic Article
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Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing.
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Academic Article
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Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.
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Academic Article
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Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer.
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Academic Article
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Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
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Academic Article
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BAP1 links metabolic regulation of ferroptosis to tumour suppression.
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Academic Article
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Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression.
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Academic Article
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Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.
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Academic Article
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STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.
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Academic Article
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PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression.
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Academic Article
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EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma.
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Academic Article
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MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.
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Academic Article
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Assessing metastatic potential of breast cancer cells based on EGFR dynamics.
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Academic Article
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Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
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Academic Article
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Mechanisms Controlling PD-L1 Expression in Cancer.
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Academic Article
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SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway.
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Academic Article
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Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma.
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Academic Article
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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
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Academic Article
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Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma.
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Academic Article
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PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
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Academic Article
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Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy.
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Academic Article
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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade.
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Academic Article
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PKCd-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs.
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Academic Article
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Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral Particles.
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Academic Article
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AMBRA1 Promotes TGF? Signaling via Nonproteolytic Polyubiquitylation of Smad4.
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Academic Article
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Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance.
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Academic Article
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Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies.
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Academic Article
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ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer.
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Academic Article
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GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism.
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Academic Article
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Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion.
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Academic Article
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Epigenetic regulation of asymmetric cell division by the LIBR-BRD4 axis.
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Academic Article
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BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers.
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