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TAINER, JOHN
One or more keywords matched the following items that are connected to TAINER, JOHN
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Concept Poly(ADP-ribose) Polymerases
Academic Article Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex.
Academic Article The ARTT motif and a unified structural understanding of substrate recognition in ADP-ribosylating bacterial toxins and eukaryotic ADP-ribosyltransferases.
Academic Article Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.
Academic Article Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
Academic Article Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.
Academic Article An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.
Academic Article What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.
Concept Poly(ADP-ribose) Polymerase Inhibitors
Concept Poly ADP Ribosylation
Concept Poly-ADP-Ribose Binding Proteins
Academic Article Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Academic Article Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
Academic Article A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
Academic Article Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus.
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