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ARIANEXYS AQUINO LOPEZ

TitleInstructor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
ORCID ORCID Icon0000-0001-5515-6510 Additional info
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    Collapse Biography 
    Collapse education and training
    Baylor College of Medicine, Houston, TX06/2024Pediatric Hematology Oncology
    Baylor College of Medicine, Houston, TX06/2021Pediatrics
    UT Health MD Anderson Cancer Center, Houston, TXPhD12/2017Clinical & Translational Sciences
    University of Puerto Rico Medical Sciences Campus, San Juan, PRMD06/2018Doctor of Medicine
    University of Puerto Rico Rio Piedras Campus, San Juan, PRBS05/2010Chemistry

    Collapse Research 
    Collapse research activities and funding
    Career Development Award 1460652     (Arianexys Aquino Lopez)Jul 1, 2025 - Jun 30, 2028
    St. Baldrick's Foundation
    Virus Specific T cells and Oncolytic Adenovirus Combination as Osteosarcoma Immunotherapy
    Role Description: Osteosarcoma is a bone cancer that affects children and adolescents. Unfortunately, its treatment has remained the same since the 1980's, and once the cancer spreads to other organs, less than 40% of the patients survive despite treatment. Dr. Aquino Lopez and colleagues will use the immune system to eliminate tumor cells. During an illness with a virus, immune cells called virus specific T cells (VSTs) eliminate infected cells by recognizing "viral signals". Dr. Aquino Lopez will use an artificial virus combination called CAdVEC to modify cancer cells and make them look like they are infected with a virus. Doing so, will trigger immune cells to eliminate the cancer cells.
    Role: PI
    Outsmarting Osteosarcoma YI Award     (Arianexys Aquino Lopez)Jul 1, 2024 - Sep 30, 2025
    MIB Agents Osteosarcoma Alliance
    Repurposing Virus Specific T cells as Immune Therapy for Osteosarcoma
    Role Description: Osteosarcoma is a bone cancer that generally affects children and adolescents. Chemotherapy for osteosarcoma has remained the same since the 1980’s, with no improvement in survival. Furthermore, when cancer spreads to the lungs (metastatic disease), it is difficult to treat. Only between 10% to 40% of patients with lung spread survive for 5 years. Current therapies for metastatic osteosarcoma include drugs and surgery, but these often fail. To develop a better approach, I will redirect the patients’ own immune system to treat the tumor like a curable virus infection rather than a resistant cancer. When we get sick with a virus, cells from our immune system, called virus specific T cells (VSTs), eliminate unhealthy cells infected by virus. The way the immune system finds the unhealthy cells is by recognizing “viral signals” on the surface of the infected cells. I propose using a virus combination called CAdVEC to modify cancer cells and make them show these “viral signals”. This will trigger the immune cells in our body to attack and eliminate the cancer cells.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ?zcan AI, Aquino L?pez A, Wolff AN, Ma A, Shaw AR, Suzuki M, Brenner MK, McKenna MK. Mesenchymal stromal cells protect combined oncolytic and helper-dependent adenoviruses from humoral immunity. Mol Ther Methods Clin Dev. 2024 Sep 12; 32(3):101279. PMID: 38993326; PMCID: PMC11238183.
      Citations:    
    2. L?pez AA, Cohen CT, Small A, Lam FW, Bachim AN. Traumatic intracranial hemorrhage in pediatrics: Implications of factor XIII deficiency and consumptive coagulopathy in abusive head trauma evaluation. Child Abuse Negl. 2024 03; 149:106651. PMID: 38325162.
      Citations:    Fields:    Translation:Humans
    3. Aquino-L?pez A, Wang LL, Flores RJ. Treatment of secondary osteosarcoma in a pediatric Hodgkin lymphoma survivor: Overcoming toxicity challenges. Pediatr Blood Cancer. 2021 12; 68(12):e29269. PMID: 34383364.
      Citations:    Fields:    Translation:Humans
    4. Ray AK, Somanchi SS, Dastgheyb N, Aquino-Lopez A, Cobanoglu ZE, Geier B, Lee DA. Expression of carcinoma, apoptosis, and cell-death-related genes are determinants for sensitivity of pediatric cancer cell lines to lysis by natural killer cells. Pediatr Blood Cancer. 2019 10; 66(10):e27783. PMID: 31304677.
      Citations:    
    5. Aquino-L?pez A, Senyukov VV, Vlasic Z, Kleinerman ES, Lee DA. Interferon Gamma Induces Changes in Natural Killer (NK) Cell Ligand Expression and Alters NK Cell-Mediated Lysis of Pediatric Cancer Cell Lines. Front Immunol. 2017; 8:391. PMID: 28428785; PMCID: PMC5382194.
      Citations: 15     Fields:    
    6. Foltz JA, Somanchi SS, Yang Y, Aquino-Lopez A, Bishop EE, Lee DA. NCR1 Expression Identifies Canine Natural Killer Cell Subsets with Phenotypic Similarity to Human Natural Killer Cells. Front Immunol. 2016; 7:521. PMID: 27933061; PMCID: PMC5120128.
      Citations:    
    7. Kannan GS, Aquino-Lopez A, Lee DA. Natural killer cells in malignant hematology: A primer for the non-immunologist. Blood Rev. 2017 03; 31(2):1-10. PMID: 27665023.
      Citations:    
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