Endothelin A Receptor Antagonists
"Endothelin A Receptor Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds and drugs that bind to and inhibit or block the activation of ENDOTHELIN A RECECPTORS.
| Descriptor ID |
D065130
|
| MeSH Number(s) |
D27.505.519.364.500
|
| Concept/Terms |
Endothelin A Receptor Antagonists- Endothelin A Receptor Antagonists
- Blockers, Endothelin A Receptor
- Endothelin Type A Receptor Antagonists
- Antagonists, Endothelin A Receptor
- Endothelin A Receptor Blockers
|
Below are MeSH descriptors whose meaning is more general than "Endothelin A Receptor Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Endothelin A Receptor Antagonists".
This graph shows the total number of publications written about "Endothelin A Receptor Antagonists" by people in this website by year, and whether "Endothelin A Receptor Antagonists" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2011 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Endothelin A Receptor Antagonists" by people in Profiles.
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Safety, efficacy, and clinical utility of macitentan in the treatment of pulmonary arterial hypertension. Drug Des Devel Ther. 2016; 10:1675-82.
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Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes. Cancer Res. 2011 Dec 01; 71(23):7259-69.
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CPU0213, a non-selective ETA/ETB receptor antagonist, improves pulmonary arteriolar remodeling of monocrotaline-induced pulmonary hypertension in rats. Clin Exp Pharmacol Physiol. 2009 Feb; 36(2):169-75.
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The endothelin receptor antagonist CPU0213 is more effective than aminoguanidine to attenuate isoproterenol-induced vascular abnormality by suppressing overexpression of NADPH oxidase [correction of oxidas], ETA, ETB, and MMP9 in the vasculature. J Cardiovasc Pharmacol. 2008 Jul; 52(1):42-8.
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Endothelin receptors, localized in sympathetic nerve terminals of the heart, modulate norepinephrine release and reperfusion arrhythmias. Basic Res Cardiol. 2007 Mar; 102(2):154-62.
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Endothelin-A receptor blockade and inhaled nitric oxide in a porcine model of meconium aspiration syndrome. Pediatr Res. 2004 Sep; 56(3):353-8.