ATP Binding Cassette Transporter 1
"ATP Binding Cassette Transporter 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of large integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. It is implicated in TANGIER DISEASE characterized by accumulation of cholesteryl ester in various tissues.
| Descriptor ID |
D064286
|
| MeSH Number(s) |
D12.776.157.530.100.190.500 D12.776.395.550.020.381.500 D12.776.543.550.192.381.500 D12.776.543.585.100.190.500
|
| Concept/Terms |
ATP Binding Cassette Transporter 1- ATP Binding Cassette Transporter 1
- ATP-Binding Cassette Sub-Family A Member 1
- ATP Binding Cassette Sub Family A Member 1
- CERP Protein
- Protein, CERP
- ABCA1 Protein
- Protein, ABCA1
- Cholesterol-Efflux Regulatory Protein
- Cholesterol Efflux Regulatory Protein
- Protein, Cholesterol-Efflux Regulatory
- Regulatory Protein, Cholesterol-Efflux
|
Below are MeSH descriptors whose meaning is more general than "ATP Binding Cassette Transporter 1".
Below are MeSH descriptors whose meaning is more specific than "ATP Binding Cassette Transporter 1".
This graph shows the total number of publications written about "ATP Binding Cassette Transporter 1" by people in this website by year, and whether "ATP Binding Cassette Transporter 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 2 | 3 |
| 2019 | 0 | 2 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "ATP Binding Cassette Transporter 1" by people in Profiles.
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Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease. Nat Genet. 2022 12; 54(12):1786-1794.
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Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis. Mol Ther. 2020 01 08; 28(1):202-216.
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Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell Stem Cell. 2019 02 07; 24(2):299-308.e6.
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Is RCT (Reverse Cholesterol Transport) Ready for an RCT (Randomized Controlled Trial)? J Am Coll Cardiol. 2018 12 25; 72(25):3270-3273.
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Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux. Oncogene. 2019 03; 38(12):2135-2150.
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Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans. Arterioscler Thromb Vasc Biol. 2018 07; 38(7):1440-1453.
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MiR-33a Decreases High-Density Lipoprotein-Induced Radiation Sensitivity in?Breast Cancer. Int J Radiat Oncol Biol Phys. 2016 06 01; 95(2):791-9.
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Impact of phospholipid transfer protein on nascent high-density lipoprotein formation and remodeling. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1910-6.
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The WWOX gene modulates high-density lipoprotein and lipid metabolism. Circ Cardiovasc Genet. 2014 Aug; 7(4):491-504.
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The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1. J Pharmacol Exp Ther. 2013 Sep; 346(3):381-92.