N-Terminal Acetyltransferase A
"N-Terminal Acetyltransferase A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An N-terminal acetyltransferase subtype that consists of the Naa10p catalytic subunit and the Naa15p auxiliary subunit. The structure of this enzyme is conserved between lower and higher eukaryotes. It has specificity for N-terminal SERINE; ALANINE; THREONINE; GLYCINE; VALINE; and CYSTINE residues and acts on nascent peptide chains after the removal of the initiator METHIONINE by METHIONYL AMINOPEPTIDASES.
| Descriptor ID |
D063209
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| MeSH Number(s) |
D08.811.913.050.134.423.100
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| Concept/Terms |
N-Terminal Acetyltransferase A- N-Terminal Acetyltransferase A
- N Terminal Acetyltransferase A
- NatA N-Terminal Acetyltransferase
- N-Terminal Acetyltransferase, NatA
- NatA N Terminal Acetyltransferase
- N-Terminal Acetyltransferase Type A
- N Terminal Acetyltransferase Type A
|
Below are MeSH descriptors whose meaning is more general than "N-Terminal Acetyltransferase A".
Below are MeSH descriptors whose meaning is more specific than "N-Terminal Acetyltransferase A".
This graph shows the total number of publications written about "N-Terminal Acetyltransferase A" by people in this website by year, and whether "N-Terminal Acetyltransferase A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "N-Terminal Acetyltransferase A" by people in Profiles.
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Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. Hum Mol Genet. 2019 09 01; 28(17):2900-2919.
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A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy. Eur J Hum Genet. 2018 09; 26(9):1294-1305.
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Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies. Am J Hum Genet. 2018 05 03; 102(5):985-994.
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Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Mol Cell. 2017 Mar 02; 65(5):917-931.e6.
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Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet. 2011 Jul 15; 89(1):28-43.
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ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal. 2010 Feb 09; 3(108):ra9.
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Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. Biochem Biophys Res Commun. 2009 Nov 06; 389(1):156-61.