Nonsense Mediated mRNA Decay
"Nonsense Mediated mRNA Decay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.
| Descriptor ID |
D059365
|
| MeSH Number(s) |
G02.111.760.112 G02.111.780.500 G03.839.112 G05.308.700.112
|
| Concept/Terms |
Nonsense Mediated mRNA Decay- Nonsense Mediated mRNA Decay
- Nonsense-Mediated mRNA Decay
- Decay, Nonsense-Mediated mRNA
- mRNA Decay, Nonsense-Mediated
|
Below are MeSH descriptors whose meaning is more general than "Nonsense Mediated mRNA Decay".
Below are MeSH descriptors whose meaning is more specific than "Nonsense Mediated mRNA Decay".
This graph shows the total number of publications written about "Nonsense Mediated mRNA Decay" by people in this website by year, and whether "Nonsense Mediated mRNA Decay" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 2 | 0 | 2 |
| 2015 | 2 | 1 | 3 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 3 | 0 | 3 |
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Below are the most recent publications written about "Nonsense Mediated mRNA Decay" by people in Profiles.
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Expanding the phenotypic and allelic spectrum of SMG8: Clinical observations reveal overlap with SMG9-associated disease trait. Am J Med Genet A. 2022 02; 188(2):648-657.
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Selection for or against escape from nonsense mediated decay is a novel signature for the detection of cancer genes. Cancer Genet. 2021 11; 258-259:80-84.
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Inhibition of nonsense-mediated decay rescues p53?/? isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers. J Biol Chem. 2021 11; 297(5):101163.
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UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction. Cell Rep. 2021 03 30; 34(13):108925.
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De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. Am J Hum Genet. 2020 04 02; 106(4):549-558.
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Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response. Neuron. 2019 11 20; 104(4):665-679.e8.
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Identifying Genes Whose Mutant Transcripts Cause Dominant Disease Traits by Potential Gain-of-Function Alleles. Am J Hum Genet. 2018 08 02; 103(2):171-187.
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Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome. Am J Hum Genet. 2018 06 07; 102(6):1126-1142.
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HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition. Nat Commun. 2018 01 30; 9(1):431.
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p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells. J Biol Chem. 2017 09 15; 292(37):15266-15276.