Nonsense Mediated mRNA Decay
"Nonsense Mediated mRNA Decay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.
| Descriptor ID |
D059365
|
| MeSH Number(s) |
G02.111.760.112 G02.111.780.500 G03.839.112 G05.308.700.112
|
| Concept/Terms |
Nonsense Mediated mRNA Decay- Nonsense Mediated mRNA Decay
- Nonsense-Mediated mRNA Decay
- Decay, Nonsense-Mediated mRNA
- mRNA Decay, Nonsense-Mediated
|
Below are MeSH descriptors whose meaning is more general than "Nonsense Mediated mRNA Decay".
Below are MeSH descriptors whose meaning is more specific than "Nonsense Mediated mRNA Decay".
This graph shows the total number of publications written about "Nonsense Mediated mRNA Decay" by people in this website by year, and whether "Nonsense Mediated mRNA Decay" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 2 | 0 | 2 |
| 2021 | 3 | 0 | 3 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 3 | 0 | 3 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nonsense Mediated mRNA Decay" by people in Profiles.
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Inherited TBX4 frameshifting variants predicted to escape nonsense mediated decay in two families with variable phenotypes, including lethal lung developmental disorders. Hum Genomics. 2026 04 30; 20(1).
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Suppnonsense-mediated decay-linked mutations in SARS-CoV-2 and their association with COVID-19 disease severity. BMC Infect Dis. 2025 Sep 16; 25(1):1108.
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A novel homozygous frameshift mutation likely causing nonsense-mediated mRNA decay in an Algerian kindred with CD19 complex deficiency. Front Immunol. 2025; 16:1634146.
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Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay. Cell Genom. 2025 Jul 09; 5(7):100882.
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MicroRNA-mediated regulation of nonsense-mediated mRNA decay factors: Insights into microRNA prediction tools and profiling techniques. Biochim Biophys Acta Gene Regul Mech. 2024 06; 1867(2):195022.
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aenmd: annotating escape from nonsense-mediated decay for transcripts with protein-truncating variants. Bioinformatics. 2023 09 02; 39(9).
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Expanding the phenotypic and allelic spectrum of SMG8: Clinical observations reveal overlap with SMG9-associated disease trait. Am J Med Genet A. 2022 02; 188(2):648-657.
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Selection for or against escape from nonsense mediated decay is a novel signature for the detection of cancer genes. Cancer Genet. 2021 11; 258-259:80-84.
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UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction. Cell Rep. 2021 03 30; 34(13):108925.
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Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response. Neuron. 2019 11 20; 104(4):665-679.e8.