Phosphodiesterase 4 Inhibitors
"Phosphodiesterase 4 Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that specifically inhibit PHOSPHODIESTERASE 4.
| Descriptor ID |
D058988
|
| MeSH Number(s) |
D27.505.519.389.735.374
|
| Concept/Terms |
Phosphodiesterase 4 Inhibitors- Phosphodiesterase 4 Inhibitors
- Inhibitors, Phosphodiesterase 4
- PDE4 Inhibitors
- Inhibitors, PDE4
- Phosphodiesterase Type 4 Inhibitors
- PDE-4 Inhibitors
- Inhibitors, PDE-4
- PDE 4 Inhibitors
|
Below are MeSH descriptors whose meaning is more general than "Phosphodiesterase 4 Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Phosphodiesterase 4 Inhibitors".
This graph shows the total number of publications written about "Phosphodiesterase 4 Inhibitors" by people in this website by year, and whether "Phosphodiesterase 4 Inhibitors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phosphodiesterase 4 Inhibitors" by people in Profiles.
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Selective inhibition of long isoforms of phosphodiesterase 4D mitigates liver fibrosis in mouse models. J Clin Invest. 2026 Jan 02; 136(1).
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Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis. PLoS One. 2021; 16(6):e0253269.
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Phosphodiesterase 4 inhibitors. J Am Acad Dermatol. 2018 03; 78(3 Suppl 1):S43-S52.
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The Analgesic Effect of Rolipram, a Phosphodiesterase 4 Inhibitor, on Chemotherapy-Induced Neuropathic Pain in Rats. Anesth Analg. 2015 Sep; 121(3):822-828.
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Pooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD. Respir Med. 2014 Feb; 108(2):366-75.
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Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure. Kidney Int. 2012 May; 81(9):856-64.
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The COPD Pipeline XII. COPD. 2011 Oct; 8(5):387-91.