"ADAM10 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.
| Descriptor ID |
D000072197
|
| MeSH Number(s) |
D08.811.277.656.675.374.102.250 D09.400.430.500.250 D12.776.395.033.250
|
| Concept/Terms |
ADAM10 Protein- ADAM10 Protein
- CD156w Antigen
- Antigen, CD156w
- CD156c Antigen
- Antigen, CD156c
- Disintegrin and Metalloproteinase Domain-Containing Protein 10
- Disintegrin and Metalloproteinase Domain Containing Protein 10
- ADAM-10 Protein
- ADAM 10 Protein
|
Below are MeSH descriptors whose meaning is more general than "ADAM10 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAM10 Protein".
This graph shows the total number of publications written about "ADAM10 Protein" by people in this website by year, and whether "ADAM10 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
| 2020 | 0 | 3 | 3 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "ADAM10 Protein" by people in Profiles.
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ADAM10 Evens Out the Double-Edged Sword of Radiotherapy in Pancreatic Cancer. Cancer Res. 2021 06 15; 81(12):3158-3159.
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The N-glycome regulates the endothelial-to-hematopoietic transition. Science. 2020 12 04; 370(6521):1186-1191.
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miR-18a Inhibits BMP4 and HIF-1a Normalizing Brain Arteriovenous Malformations. Circ Res. 2020 10 09; 127(9):e210-e231.
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Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding. Sci Immunol. 2020 07 17; 5(49).
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Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho. PLoS One. 2020; 15(1):e0226382.
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MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. Cell Death Differ. 2019 10; 26(10):1863-1879.
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Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. Cell Mol Gastroenterol Hepatol. 2019; 7(3):533-554.
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A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. J Alzheimers Dis. 2017; 56(3):1037-1054.
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Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. Clin Immunol. 2016 08; 169:58-68.
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Adam10 mediates the choice between principal cells and intercalated cells in the kidney. J Am Soc Nephrol. 2015 Jan; 26(1):149-59.