"Fibrillin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fibrillin (FBN1) that functions as a structural support protein for MICROFIBRILS. It also regulates the maturation of OSTEOBLASTS by controlling the availability and concentration of TGF-BETA and BONE MORPHOGENETIC PROTEINS. Mutations in the FBN1 gene are associated with MARFAN SYNDROME.
| Descriptor ID |
D000071838
|
| MeSH Number(s) |
D09.400.430.875.500 D12.776.395.341.500 D12.776.860.300.400.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Fibrillin-1".
Below are MeSH descriptors whose meaning is more specific than "Fibrillin-1".
This graph shows the total number of publications written about "Fibrillin-1" by people in this website by year, and whether "Fibrillin-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 4 | 4 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibrillin-1" by people in Profiles.
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Asprosin promotes feeding through SK channel-dependent activation of AgRP neurons. Sci Adv. 2023 02 22; 9(8):eabq6718.
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Overexpression and ELISA-based detection of asprosin in cultured cells and mice. STAR Protoc. 2022 12 16; 3(4):101762.
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A clinical scoring system for early onset (neonatal) Marfan syndrome. Genet Med. 2022 07; 24(7):1503-1511.
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Protein tyrosine phosphatase receptor d serves as the orexigenic asprosin receptor. Cell Metab. 2022 04 05; 34(4):549-563.e8.
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Molecular characterization and investigation of the role of genetic variation in phenotypic variability and response to treatment in a large pediatric Marfan syndrome cohort. Genet Med. 2022 05; 24(5):1045-1053.
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Marfan syndrome. Nat Rev Dis Primers. 2021 09 02; 7(1):64.
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Asprosin-neutralizing antibodies as a treatment for metabolic syndrome. Elife. 2021 04 27; 10.
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Ciprofloxacin accelerates aortic enlargement and promotes dissection and rupture in Marfan mice. J Thorac Cardiovasc Surg. 2022 03; 163(3):e215-e226.
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Energy Regulation Mechanism and Therapeutic Potential of Asprosin. Diabetes. 2020 04; 69(4):559-566.
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Genetic and molecular mechanism for distinct clinical phenotypes conveyed by allelic truncating mutations implicated in FBN1. Mol Genet Genomic Med. 2020 01; 8(1):e1023.