Header Logo

NANCY WEBB

TitleClinical Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Ophthalmology
AddressOne Baylor Plaza
Houston, TX 77030
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R13HL147519     (WEBB, NANCY R)May 1, 2019 - Apr 30, 2020
    NIH/NHLBI
    Vascular Discovery: From Genes to Medicine Scientific Sessions 2019
    Role: Principal Investigator
    R13HL142278     (WEBB, NANCY R)Mar 1, 2018 - Feb 28, 2019
    NIH/NHLBI
    ATVB/PVD Scientific Sessions 2018
    Role: Principal Investigator
    R01HL134731     (WEBB, NANCY R)Jan 1, 2017 - Dec 31, 2020
    NIH/NHLBI
    Serum Amyloid A, Inflammasome Activation, and Abdominal Aortic Aneurysms
    Role: Principal Investigator
    I01CX000773     (WEBB, NANCY R)Jan 1, 2014 - Dec 31, 2017
    VA
    HDL Remodeling in Metabolic Syndrome
    Role: Principal Investigator
    R01DK082419     (WEBB, NANCY R)Aug 1, 2009 - Jul 31, 2014
    NIH/NIDDK
    Group X sPLA2: Regulator of Lipolysis and Glucose Homeostasis
    Role: Principal Investigator
    R01HL071098     (WEBB, NANCY R)Apr 1, 2003 - Sep 30, 2008
    NIH/NHLBI
    Group V Secretory Phospholipase A2 in Atherosclerosis
    Role: Principal Investigator
    T32DK007778     (WEBB, NANCY R)Aug 15, 2000 - Jul 31, 2020
    NIH/NIDDK
    Pharmacology and Nutritional Sciences: Multidisciplinary Approaches for Metabolic Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shridas P, Ji A, Trumbauer AC, Noffsinger VP, Meredith LW, de Beer FC, Mullick AE, Webb NR, Karounos DG, Tannock LR. Antisense oligonucleotide targeting hepatic Serum Amyloid A limits the progression of angiotensin II-induced abdominal aortic aneurysm formation. Atherosclerosis. 2024 04; 391:117492. PMID: 38461759; PMCID: PMC11006562.
      Citations:    
    2. Ji A, Trumbauer AC, Noffsinger VP, Meredith LW, Dong B, Wang Q, Guo L, Li X, De Beer FC, Webb NR, Tannock LR, Starr ME, Waters CM, Shridas P. Deficiency of Acute-Phase Serum Amyloid A Exacerbates Sepsis-Induced Mortality and Lung Injury in Mice. Int J Mol Sci. 2023 Dec 15; 24(24). PMID: 38139330; PMCID: PMC10744229.
      Citations:    
    3. Ji A, Trumbauer AC, Noffsinger VP, de Beer FC, Webb NR, Tannock LR, Shridas P. Serum amyloid A augments the atherogenic effects of cholesteryl ester transfer protein. J Lipid Res. 2023 05; 64(5):100365. PMID: 37004910; PMCID: PMC10165456.
      Citations:    
    4. Ji A, Trumbauer AC, Noffsinger VP, Jeon H, Patrick AC, De Beer FC, Webb NR, Tannock LR, Shridas P. Serum Amyloid A is not obligatory for high-fat, high-sucrose, cholesterol-fed diet-induced obesity and its metabolic and inflammatory complications. PLoS One. 2022; 17(4):e0266688. PMID: 35436297; PMCID: PMC9015120.
      Citations:    
    5. Shridas P, Ji A, Trumbauer AC, Noffsinger VP, Leung SW, Dugan AJ, Thatcher SE, Cassis LA, de Beer FC, Webb NR, Tannock LR. Adipocyte-Derived Serum Amyloid A Promotes Angiotensin II-Induced Abdominal Aortic Aneurysms in Obese C57BL/6J Mice. Arterioscler Thromb Vasc Biol. 2022 05; 42(5):632-643. PMID: 35344382; PMCID: PMC9050948.
      Citations:    Fields:    Translation:AnimalsCells
    6. Webb NR. Correction to: High-Density Lipoproteins and Serum Amyloid A (SAA). Curr Atheroscler Rep. 2022 Jan; 24(1):73. PMID: 35132572; PMCID: PMC9172640.
      Citations:    
    7. Nordness MJ, Baxter BT, Matsumura J, Terrin M, Zhang K, Ye F, Webb NR, Dalman RL, Curci JA. The effect of diabetes on abdominal aortic aneurysm growth over 2?years. J Vasc Surg. 2022 04; 75(4):1211-1222.e1. PMID: 34695550; PMCID: PMC8940607.
      Citations:    
    8. Webb NR. High-Density Lipoproteins and Serum Amyloid A (SAA). Curr Atheroscler Rep. 2021 01 15; 23(2):7. PMID: 33447953; PMCID: PMC7808882.
      Citations:    
    9. Shen YH, LeMaire SA, Webb NR, Cassis LA, Daugherty A, Lu HS. Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections. Arterioscler Thromb Vasc Biol. 2020 04; 40(4):e78-e86. PMID: 32208998; PMCID: PMC7122036.
      Citations: 5     Fields:    Translation:HumansCells
    10. Shen YH, LeMaire SA, Webb NR, Cassis LA, Daugherty A, Lu HS. Aortic Aneurysms and Dissections Series. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):e37-e46. PMID: 32101472; PMCID: PMC7233726.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    11. Barnett JV, Beckman JA, Bonaca MP, Carnethon MR, Cassis LA, Creager MA, Daugherty A, Feinberg MW, Freiberg MS, Goodney PP, Greenland P, Leeuwenburgh C, LeMaire SA, McDermott MM, Sabatine MS, Shen YH, Wasserman DH, Webb NR, Wells QS. American Heart Association Vascular Disease Strategically Focused Research Network. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):e47-e54. PMID: 31969016; PMCID: PMC7047580.
      Citations:    Fields:    Translation:HumansAnimals
    12. Ji A, Wang X, Noffsinger VP, Jennings D, de Beer MC, de Beer FC, Tannock LR, Webb NR. Serum amyloid A is not incorporated into HDL during HDL biogenesis. J Lipid Res. 2020 03; 61(3):328-337. PMID: 31915139; PMCID: PMC7053844.
      Citations:    
    13. Lee JW, Stone ML, Porrett PM, Thomas SK, Komar CA, Li JH, Delman D, Graham K, Gladney WL, Hua X, Black TA, Chien AL, Majmundar KS, Thompson JC, Yee SS, O'Hara MH, Aggarwal C, Xin D, Shaked A, Gao M, Liu D, Borad MJ, Ramanathan RK, Carpenter EL, Ji A, de Beer MC, de Beer FC, Webb NR, Beatty GL. Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature. 2019 03; 567(7747):249-252. PMID: 30842658; PMCID: PMC6430113.
      Citations:    
    14. Wilson PG, Thompson JC, Shridas P, McNamara PJ, de Beer MC, de Beer FC, Webb NR, Tannock LR. Serum Amyloid A Is an Exchangeable Apolipoprotein. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1890-1900. PMID: 29976766; PMCID: PMC6202200.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    15. Shridas P, De Beer MC, Webb NR. High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation. J Biol Chem. 2018 08 24; 293(34):13257-13269. PMID: 29976759; PMCID: PMC6109913.
      Citations:    
    16. Tannock LR, De Beer MC, Ji A, Shridas P, Noffsinger VP, den Hartigh L, Chait A, De Beer FC, Webb NR. Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein. J Lipid Res. 2018 02; 59(2):339-347. PMID: 29247043; PMCID: PMC5794427.
      Citations:    
    17. Thompson JC, Wilson PG, Shridas P, Ji A, de Beer M, de Beer FC, Webb NR, Tannock LR. Serum amyloid A3 is pro-atherogenic. Atherosclerosis. 2018 01; 268:32-35. PMID: 29175652; PMCID: PMC5839639.
      Citations:    
    18. Shridas P, Noffsinger VP, Trumbauer AC, Webb NR. The dual role of group V secretory phospholipase A2 in pancreatic ?-cells. Endocrine. 2017 Oct; 58(1):47-58. PMID: 28825176; PMCID: PMC5693688.
      Citations:    
    19. Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen ME, Jeammet L, Payré C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R, B?ttcher R, Payr? C, Lambeau G. Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. Cell Stem Cell. 2016 07 07; 19(1):38-51. PMID: 27292189.
      Citations:    
    20. Kim MH, de Beer MC, Wroblewski JM, Charnigo RJ, Ji A, Webb NR, de Beer FC, van der Westhuyzen DR. Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice. J Lipid Res. 2016 06; 57(6):969-79. PMID: 27018443; PMCID: PMC4878182.
      Citations:    
    21. Rosenson RS, Brewer HB, Ansell BJ, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR, Chapman MJ, Kontush A. Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat Rev Cardiol. 2016 Jan; 13(1):48-60. PMID: 26323267; PMCID: PMC6245940.
      Citations:    
    22. Webb NR, De Beer MC, Wroblewski JM, Ji A, Bailey W, Shridas P, Charnigo RJ, Noffsinger VP, Witta J, Howatt DA, Balakrishnan A, Rateri DL, Daugherty A, De Beer FC. Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1156-65. PMID: 25745063; PMCID: PMC4823018.
      Citations: 26     Fields:    Translation:AnimalsCells
    23. Layne JD, Shridas P, Webb NR. Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis. J Biol Chem. 2015 Mar 20; 290(12):7851-60. PMID: 25623068; PMCID: PMC4367284.
      Citations:    
    24. Thompson JC, Jayne C, Thompson J, Wilson PG, Yoder MH, Webb N, Tannock LR. A brief elevation of serum amyloid A is sufficient to increase atherosclerosis. J Lipid Res. 2015 Feb; 56(2):286-93. PMID: 25429103; PMCID: PMC4306683.
      Citations:    
    25. Shridas P, Zahoor L, Forrest KJ, Layne JD, Webb NR. Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism. J Biol Chem. 2014 Oct 03; 289(40):27410-7. PMID: 25122761; PMCID: PMC4183781.
      Citations:    
    26. Ji A, Wroblewski JM, Webb NR, van der Westhuyzen DR. Impact of phospholipid transfer protein on nascent high-density lipoprotein formation and remodeling. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1910-6. PMID: 25060793; PMCID: PMC4141034.
      Citations: 10     Fields:    Translation:AnimalsCells
    27. De Beer MC, Wroblewski JM, Noffsinger VP, Rateri DL, Howatt DA, Balakrishnan A, Ji A, Shridas P, Thompson JC, van der Westhuyzen DR, Tannock LR, Daugherty A, Webb NR, De Beer FC. Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2014 Feb; 34(2):255-61. PMID: 24265416; PMCID: PMC3951741.
      Citations: 33     Fields:    Translation:AnimalsCells
    28. Rosenson RS, Brewer HB, Ansell B, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR. Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges. Circulation. 2013 Sep 10; 128(11):1256-67. PMID: 24019446.
      Citations:    
    29. de Beer MC, Wroblewski JM, Noffsinger VP, Ji A, Meyer JM, van der Westhuyzen DR, de Beer FC, Webb NR. The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A. J Lipids. 2013; 2013:283486. PMID: 23431457; PMCID: PMC3572687.
      Citations:    
    30. Boyanovsky BB, Bailey W, Dixon L, Shridas P, Webb NR. Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice. Am J Pathol. 2012 Sep; 181(3):1088-98. PMID: 22813854; PMCID: PMC3432434.
      Citations: 7     Fields:    Translation:Animals
    31. Ji A, Wroblewski JM, Cai L, de Beer MC, Webb NR, van der Westhuyzen DR, Ji A, Wroblewski JM, Cai L, de Beer MC, Webb NR, van der Westhuyzen DR. Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI. J Lipid Res. 2012 Mar; 53(3):446-455. PMID: 22190590; PMCID: PMC3276468.
      Citations:    
    32. Wroblewski JM, Jahangiri A, Ji A, de Beer FC, van der Westhuyzen DR, Webb NR, Wroblewski JM, Jahangiri A, Ji A, de Beer FC, van der Westhuyzen DR, Webb NR. Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase. J Lipid Res. 2011 Dec; 52(12):2255-2261. PMID: 21957202; PMCID: PMC3220292.
      Citations:    
    33. Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR. Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):2014-21. PMID: 20844270; PMCID: PMC2958102.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    34. Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR. Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Atherosclerosis. 2011 Jan; 214(1):58-64. PMID: 20833395; PMCID: PMC3005558.
      Citations: 20     Fields:    Translation:HumansAnimals
    35. Li X, Shridas P, Forrest K, Bailey W, Webb NR. Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models. FASEB J. 2010 Nov; 24(11):4313-24. PMID: 20585029; PMCID: PMC2974424.
      Citations:    
    36. Shridas P, Bailey WM, Boyanovsky BB, Oslund RC, Gelb MH, Webb NR. Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands. J Biol Chem. 2010 Jun 25; 285(26):20031-9. PMID: 20421306; PMCID: PMC2888415.
      Citations:    
    37. de Beer MC, Webb NR, Whitaker NL, Wroblewski JM, Jahangiri A, van der Westhuyzen DR, de Beer FC. SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL. Arterioscler Thromb Vasc Biol. 2009 Sep; 29(9):1298-303. PMID: 19304574; PMCID: PMC2754709.
      Citations: 4     Fields:    Translation:AnimalsCells
    38. Boyanovsky B, Zack M, Forrest K, Webb NR. The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo. Arterioscler Thromb Vasc Biol. 2009 Apr; 29(4):532-8. PMID: 19164803; PMCID: PMC2782483.
      Citations: 17     Fields:    Translation:AnimalsCells
    39. Jahangiri A, de Beer MC, Noffsinger V, Tannock LR, Ramaiah C, Webb NR, van der Westhuyzen DR, de Beer FC. HDL remodeling during the acute phase response. Arterioscler Thromb Vasc Biol. 2009 Feb; 29(2):261-7. PMID: 19008529; PMCID: PMC2760005.
      Citations: 61     Fields:    Translation:HumansCells
    40. Wilson PG, Thompson JC, Webb NR, de Beer FC, King VL, Tannock LR. Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner. Am J Pathol. 2008 Dec; 173(6):1902-10. PMID: 18974302; PMCID: PMC2626400.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    41. Boyanovsky BB, Webb NR. Biology of secretory phospholipase A2. Cardiovasc Drugs Ther. 2009 Feb; 23(1):61-72. PMID: 18853244; PMCID: PMC7101564.
      Citations:    
    42. Sun B, Boyanovsky BB, Connelly MA, Shridas P, van der Westhuyzen DR, Webb NR. Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI. J Lipid Res. 2007 Dec; 48(12):2560-70. PMID: 17876058.
      Citations:    
    43. van der Westhuyzen DR, de Beer FC, Webb NR. HDL cholesterol transport during inflammation. Curr Opin Lipidol. 2007 Apr; 18(2):147-51. PMID: 17353662.
      Citations:    
    44. Bostrom MA, Boyanovsky BB, Jordan CT, Wadsworth MP, Taatjes DJ, de Beer FC, Webb NR. Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice. Arterioscler Thromb Vasc Biol. 2007 Mar; 27(3):600-6. PMID: 17204667.
      Citations: 49     Fields:    Translation:Animals
    45. de Beer FC, Webb NR. Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant. Arterioscler Thromb Vasc Biol. 2006 Jul; 26(7):1421-2. PMID: 16794232.
      Citations: 3     Fields:    Translation:HumansAnimals
    46. Sun B, Eckhardt ER, Shetty S, van der Westhuyzen DR, Webb NR. Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts. J Lipid Res. 2006 Aug; 47(8):1700-13. PMID: 16705213.
      Citations:    
    47. de Beer MC, van der Westhuyzen DR, Whitaker NL, Webb NR, de Beer FC. SR-BI-mediated selective lipid uptake segregates apoA-I and apoA-II catabolism. J Lipid Res. 2005 Oct; 46(10):2143-50. PMID: 16061955.
      Citations:    
    48. Boyanovsky BB, van der Westhuyzen DR, Webb NR. Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. J Biol Chem. 2005 Sep 23; 280(38):32746-52. PMID: 16040605.
      Citations:    
    49. Daugherty A, Webb NR, Rateri DL, King VL. Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis. J Lipid Res. 2005 Sep; 46(9):1812-22. PMID: 15995168.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    50. Wooton-Kee CR, Boyanovsky BB, Nasser MS, de Villiers WJ, Webb NR. Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. Arterioscler Thromb Vasc Biol. 2004 Apr; 24(4):762-7. PMID: 14962950.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    51. Webb NR, Bostrom MA, Szilvassy SJ, van der Westhuyzen DR, Daugherty A, de Beer FC. Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2003 Feb 01; 23(2):263-8. PMID: 12588769.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    52. Webb NR, de Beer MC, Yu J, Kindy MS, Daugherty A, van der Westhuyzen DR, de Beer FC. Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice. J Lipid Res. 2002 Sep; 43(9):1421-8. PMID: 12235173.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    WEBB's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (281)
    Explore
    _
    Co-Authors (2)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _