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JAMES POOL

TitleDistinguished Emeritus Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressBCM-Jewish Institute for Research
Houston, 77030
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    Other Positions
    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry and Molecular Pharmacology
    DivisionBiochemistry & Mol Pharmacology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Taylor AA, Pool JL. Clinical role of direct renin inhibition in hypertension. Am J Ther. 2012 May; 19(3):204-10. PMID: 21317620.
      Citations: 2     Fields:    Translation:Humans
    2. Perlstein TS, Henry RR, Mather KJ, Rickels MR, Abate NI, Grundy SM, Mai Y, Albu JB, Marks JB, Pool JL, Creager MA. Effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose. Clin Sci (Lond). 2012 Feb; 122(4):193-202. PMID: 21861845; PMCID: PMC4566948.
      Citations: 8     Fields:    Translation:Humans
    3. Hyman DJ, Pavlik VN, Greisinger AJ, Chan W, Bayona J, Mansyur C, Simms V, Pool J. Effect of a physician uncertainty reduction intervention on blood pressure in uncontrolled hypertensives--a cluster randomized trial. J Gen Intern Med. 2012 Apr; 27(4):413-9. PMID: 22033742; PMCID: PMC3304039.
      Citations: 16     Fields:    Translation:Humans
    4. Ferdinand KC, Pool J, Weitzman R, Purkayastha D, Townsend R. Peripheral and central blood pressure responses of combination aliskiren/hydrochlorothiazide and amlodipine monotherapy in African American patients with stage 2 hypertension: the ATLAAST trial. J Clin Hypertens (Greenwich). 2011 May; 13(5):366-75. PMID: 21545398; PMCID: PMC8108786.
      Citations: 12     Fields:    Translation:Humans
    5. Pavlik VN, Greisinger AJ, Pool J, Haidet P, Hyman DJ. Does reducing physician uncertainty improve hypertension control?: rationale and methods. Circ Cardiovasc Qual Outcomes. 2009 May; 2(3):257-63. PMID: 20031846; PMCID: PMC2780342.
      Citations: 9     Fields:    Translation:Humans
    6. Pool JL, Glazer R, Crikelair N, Levy D. The role of baseline blood pressure in guiding treatment choice: a secondary analysis of the use of valsartan/hydrochlorothiazide as initial therapy in hypertensive adults in a randomized, double-blind, placebo-controlled trial. Clin Drug Investig. 2009; 29(12):791-802. PMID: 19888785.
      Citations:    Fields:    Translation:Humans
    7. Pool JL. Direct renin inhibition: focus on aliskiren. J Manag Care Pharm. 2007 Oct; 13(8 Suppl B):21-33. PMID: 17970614; PMCID: PMC10438282.
      Citations: 10     Fields:    Translation:HumansAnimals
    8. Pool JL, Schmieder RE, Azizi M, Aldigier JC, Januszewicz A, Zidek W, Chiang Y, Satlin A. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens. 2007 Jan; 20(1):11-20. PMID: 17198906.
      Citations: 58     Fields:    Translation:Humans
    9. Pool JL, Glazer R, Weinberger M, Alvarado R, Huang J, Graff A. Comparison of valsartan/hydrochlorothiazide combination therapy at doses up to 320/25 mg versus monotherapy: a double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults. Clin Ther. 2007 Jan; 29(1):61-73. PMID: 17379047.
      Citations: 24     Fields:    Translation:Humans
    10. Taylor AA, Pool JL. Clinical pharmacology of antihypertensive therapy. Semin Nephrol. 2005 Jul; 25(4):215-26. PMID: 16202694.
      Citations: 1     Fields:    Translation:Humans
    11. Pool JL. Is it time to move to multidrug combinations? Am J Hypertens. 2003 Nov; 16(11 Pt 2):36S-40S. PMID: 14625159.
      Citations: 8     Fields:    Translation:Humans
    12. Kloner RA, Weinberger M, Pool JL, Chrysant SG, Prasad R, Harris SM, Zyczynski TM, Leidy NK, Michelson EL, Comparison of Candesartan and Amlodipine for Safety, Tolerability and Efficacy (CASTLE) Study Invest. Comparative effects of candesartan cilexetil and amlodipine in patients with mild systemic hypertension. Comparison of Candesartan and Amlodipine for Safety, Tolerability and Efficacy (CASTLE) Study Investigators. Am J Cardiol. 2001 Mar 15; 87(6):727-31. PMID: 11249891.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    13. Pool JL, Kirby RS. Clinical significance of alpha1-adrenoceptor selectivity in the management of benign prostatic hyperplasia. Int Urol Nephrol. 2001; 33(3):407-12. PMID: 12230262.
      Citations: 2     Fields:    Translation:Humans
    14. Kirby RS, Pool JL. Interpretation of the ALLHAT interim analysis and implications for the treatment of patients with BPH. Prostate Cancer Prostatic Dis. 2000 Nov; 3(3):152-156. PMID: 12497091.
      Citations:    Fields:    
    15. Pool JL. The role of angiotensin II in hypertension and end-organ damage. Int J Clin Pract Suppl. 2000 Aug; (111):4-8. PMID: 15977400.
      Citations: 2     Fields:    Translation:HumansAnimals
    16. Taylor AA, Shepherd AM, Polvino W, Mangoo-Karim R, Ballard K, Sunthornyothin S, Luther RR, Pool JL. Prolonged fenoldopam infusions in patients with mild to moderate hypertension: pharmacodynamic and pharmacokinetic effects. Am J Hypertens. 1999 Sep; 12(9 Pt 1):906-14. PMID: 10509549.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    17. Taylor AA, Mangoo-Karim R, Ballard KD, Luther RR, Pool JL. Sustained hemodynamic effects of the selective dopamine-1 agonist, fenoldopam, during 48-hour infusions in hypertensive patients: a dose-tolerability study. J Clin Pharmacol. 1999 May; 39(5):471-9. PMID: 10234594.
      Citations: 1     Fields:    Translation:Humans
    18. Pool JL, Glazer R, Chiang YT, Gatlin M. Dose-response efficacy of valsartan, a new angiotensin II receptor blocker. J Hum Hypertens. 1999 Apr; 13(4):275-81. PMID: 10333347.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    19. Pool J, Oparil S, Hedner T, Glazer R, Oddou-Stock P, Hester A. Dose-responsive antihypertensive efficacy of valsartan, a new angiotensin II-receptor blocker. Clin Ther. 1998 Nov-Dec; 20(6):1106-14. PMID: 9916605.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    20. Pool JL, Guthrie RM, Littlejohn TW, Raskin P, Shephard AM, Weber MA, Weir MR, Wilson TW, Wright J, Kassler-Taub KB, Reeves RA. Dose-related antihypertensive effects of irbesartan in patients with mild-to-moderate hypertension. Am J Hypertens. 1998 Apr; 11(4 Pt 1):462-70. PMID: 9607385.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    21. Pool JL, Svetkey L, Gradman AH, Larochelle P, de Champlain J, Smith WB, Lacourci?re Y. A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial of four doses of tasosartan in patients with essential hypertension. Tasosartan Investigator's Group. Am J Hypertens. 1998 Apr; 11(4 Pt 1):454-61. PMID: 9607384.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    22. Kirby RS, Pool JL. Alpha adrenoceptor blockade in the treatment of benign prostatic hyperplasia: past, present and future. Br J Urol. 1997 Oct; 80(4):521-32. PMID: 9352686.
      Citations: 10     Fields:    Translation:Humans
    23. Pool JL, Cushman WC, Saini RK, Nwachuku CE, Battikha JP. Use of the factorial design and quadratic response surface models to evaluate the fosinopril and hydrochlorothiazide combination therapy in hypertension. Am J Hypertens. 1997 Jan; 10(1):117-23. PMID: 9008256.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    24. Pool JL. Doxazosin: a new approach to hypertension and benign prostatic hyperplasia. Br J Clin Pract. 1996 Apr-May; 50(3):154-63. PMID: 8733335.
      Citations: 1     Fields:    Translation:Humans
    25. Lenz ML, Pool JL, Laddu AR, Varghese A, Johnston W, Taylor AA. Combined terazosin and verapamil therapy in essential hypertension. Hemodynamic and pharmacokinetic interactions. Am J Hypertens. 1995 Feb; 8(2):133-45. PMID: 7755941.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    26. Bradford RH, Shear CL, Chremos AN, Dujovne CA, Franklin FA, Grillo RB, Higgins J, Langendorfer A, Nash DT, Pool JL, et al. Expanded Clinical Evaluation of Lovastatin (EXCEL) study results: two-year efficacy and safety follow-up. Am J Cardiol. 1994 Oct 01; 74(7):667-73. PMID: 7942524.
      Citations: 25     Fields:    Translation:HumansCTClinical Trials
    27. Pool JL. Effects of doxazosin on coronary heart disease risk factors in the hypertensive patient. Br J Clin Pract Suppl. 1994 May; 74:8-12. PMID: 8049119.
      Citations: 2     Fields:    Translation:Humans
    28. Pool JL. Role of the sympathetic nervous system in hypertension and benign prostatic hyperplasia. Br J Clin Pract Suppl. 1994 May; 74:13-7. PMID: 7519436.
      Citations: 2     Fields:    Translation:Humans
    29. Black HR, Chrysant SG, Curry CL, Frishman WH, Grimm RH, Lasseter KC, Okun R, Pool JL, Raizada V, Vlachakis ND, et al. Antihypertensive and metabolic effects of concomitant administration of terazosin and methyclothiazide for the treatment of essential hypertension. J Clin Pharmacol. 1992 Apr; 32(4):351-9. PMID: 1349028.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    30. Pool JL, Shear CL, Downton M, Schnaper H, Stinnett S, Dujovne C, Bradford RH, Chremos AN. Lovastatin and coadministered antihypertensive/cardiovascular agents. Hypertension. 1992 Mar; 19(3):242-8. PMID: 1347757.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    31. Pool JL. Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials. Am Heart J. 1991 Sep; 122(3 Pt 2):926-31. PMID: 1678924.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    32. Dujovne CA, Chremos AN, Pool JL, Schnaper H, Bradford RH, Shear CL, Higgins J, Downton M, Franklin FA, Nash DT, et al. Expanded clinical evaluation of lovastatin (EXCEL) study results: IV. Additional perspectives on the tolerability of lovastatin. Am J Med. 1991 Jul 31; 91(1B):25S-30S. PMID: 1831006.
      Citations: 20     Fields:    Translation:HumansCTClinical Trials
    33. Bradford RH, Shear CL, Chremos AN, Franklin FA, Nash DT, Hurley DP, Dujovne CA, Pool JL, Schnaper H, Hesney M, et al. Expanded clinical evaluation of lovastatin (EXCEL) study results: III. Efficacy in modifying lipoproteins and implications for managing patients with moderate hypercholesterolemia. Am J Med. 1991 Jul 31; 91(1B):18S-24S. PMID: 1867232.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    34. Weir MR, Josselson J, Ekelund LG, Korc M, Pool JL, Stein GH, Wolbach RA, Champion D. Nicardipine as antihypertensive monotherapy: positive effects on quality of life. J Hum Hypertens. 1991 Jun; 5(3):205-13. PMID: 1920344.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    35. Pool JL. Effects of doxazosin on serum lipids: a review of the clinical data and molecular basis for altered lipid metabolism. Am Heart J. 1991 Jan; 121(1 Pt 2):251-9; discussion 259-60. PMID: 1824647.
      Citations: 5     Fields:    Translation:Humans
    36. Pool JL. Antihypertensive effect of fosinopril, a new angiotensin converting enzyme inhibitor: findings of the Fosinopril Study Group II. Clin Ther. 1990 Nov-Dec; 12(6):520-33. PMID: 2149674.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    37. Pool JL, Lenz ML, Taylor AA. Alpha 1-adrenoreceptor blockade and the molecular basis of lipid metabolism alterations. J Hum Hypertens. 1990 Oct; 4 Suppl 3:23-33. PMID: 1979819.
      Citations: 2     Fields:    Translation:HumansCells
    38. Bradford RH, Shear CL, Chremos AN, Dujovne C, Franklin FA, Hesney M, Higgins J, Pool JL, Schnaper H, Langend?rfer A, et al. Expanded clinical evaluation of lovastatin (EXCEL) study: design and patient characteristics of a double-blind, placebo-controlled study in patients with moderate hypercholesterolemia. Am J Cardiol. 1990 Sep 18; 66(8):44B-55B. PMID: 2206036.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    39. Pool JL, Taylor AA, Nelson EB. Review of the effects of doxazosin, a new selective alpha 1-adrenergic inhibitor, on lipoproteins in patients with essential hypertension. Am J Med. 1989 Aug 16; 87(2A):57S-61S. PMID: 2569825.
      Citations: 3     Fields:    Translation:Humans
    40. Taylor AA, Davies AO, Mares A, Raschko J, Pool JL, Nelson EB, Mitchell JR. Spectrum of dysautonomia in mitral valvular prolapse. Am J Med. 1989 Mar; 86(3):267-74. PMID: 2919608.
      Citations: 5     Fields:    Translation:Humans
    41. Crawford ES, Coselli JS, Safi HJ, Martin TD, Pool JL. The impact of renal fusion and ectopia on aortic surgery. J Vasc Surg. 1988 Oct; 8(4):375-83. PMID: 3172375.
      Citations: 17     Fields:    Translation:Humans
    42. Pool JL, Nelson EB, Taylor AA. Clinical experience and rationale for angiotensin-converting enzyme inhibition with lisinopril as the initial treatment for hypertension in older patients. Am J Med. 1988 Sep 23; 85(3B):19-24. PMID: 2844082.
      Citations: 2     Fields:    Translation:Humans
    43. Cubeddu LX, Pool JL, Bloomfield R, Klotman PE, Pickering BI, Wombolt DG, Nelson EB, Halperin A. Effect of doxazosin monotherapy on blood pressure and plasma lipids in patients with essential hypertension. Am J Hypertens. 1988 Apr; 1(2):158-67. PMID: 2969740.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    44. Goldfarb R, Pool JL, Wheeler T. Isolated renal artery dissection secondary to medial degeneration. J Urol. 1988 Feb; 139(2):346-7. PMID: 3339739.
      Citations:    Fields:    Translation:Humans
    45. Pool JL, Nelson EB, Taylor AA, Mitchell JR. Terazosin (Hytrin): cumulative experience of clinical trials in the USA for the treatment of mild to moderate essential hypertension. Br J Clin Pract Suppl. 1987 Dec; 54:9-14. PMID: 2905162.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    46. Simpson RK, Pool JL, Grossman RG, Rose JE, Taylor AA. Neurosurgical management of carotid sinus hypersensitivity. Report of three cases. J Neurosurg. 1987 Nov; 67(5):757-9. PMID: 3668646.
      Citations:    Fields:    Translation:Humans
    47. Schmedtje JF, Sax S, Pool JL, Goldfarb RA, Nelson EB. Localization of ectopic pheochromocytomas by magnetic resonance imaging. Am J Med. 1987 Oct; 83(4):770-2. PMID: 3674064.
      Citations: 7     Fields:    Translation:Humans
    48. Pool JL. Plasma lipid lowering effects of doxazosin, a new selective alpha1 adrenergic inhibitor for systemic hypertension. Am J Cardiol. 1987 May 29; 59(14):46G-50G. PMID: 2884853.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    49. Davies AO, Mares A, Pool JL, Taylor AA. Mitral valve prolapse with symptoms of beta-adrenergic hypersensitivity. Beta 2-adrenergic receptor supercoupling with desensitization on isoproterenol exposure. Am J Med. 1987 Feb; 82(2):193-201. PMID: 3028141.
      Citations: 7     Fields:    Translation:HumansCells
    50. Pool JL, Gennari J, Goldstein R, Kochar MS, Lewin AJ, Maxwell MH, McChesney JA, Mehta J, Nash DT, Nelson EB, et al. Controlled multicenter study of the antihypertensive effects of lisinopril, hydrochlorothiazide, and lisinopril plus hydrochlorothiazide in the treatment of 394 patients with mild to moderate essential hypertension. J Cardiovasc Pharmacol. 1987; 9 Suppl 3:S36-42. PMID: 2442550.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    51. Nelson EB, Pool JL, Taylor AA. Antihypertensive activity of isradipine in humans: a new dihydropyridine calcium channel antagonist. Clin Pharmacol Ther. 1986 Dec; 40(6):694-7. PMID: 2946507.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    52. Nelson EB, Pool JL, Taylor AA. Pharmacology of angiotensin converting enzyme inhibitors. A review. Am J Med. 1986 Oct 31; 81(4C):13-8. PMID: 3022580.
      Citations: 3     Fields:    Translation:HumansCells
    53. Taylor AA, Fennell WH, Ruud CO, Pool JL, Nelson EB, Ginos JZ, Mitchell JR. Propylbutyldopamine. Mechanism of blood pressure lowering in hypertensive patients. Hypertension. 1984 Mar-Apr; 6(2 Pt 2):I40-5. PMID: 6373598.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    54. Taburet AM, Taylor AA, Mitchell JR, Rollins DE, Pool JL. Plasma concentrations of propranolol and 4-hydroxypropranolol in man measured by high pressure liquid chromatography. Life Sci. 1979 Jan 15; 24(3):209-17. PMID: 423699.
      Citations: 4     Fields:    Translation:HumansCells
    55. Taylor AA, Pool JL, Lake CR, Ziegler MG, Rosen RA, Rollins DE, Mitchell JR. Plasma norepinephrine concentrations: no differences among normal volunteers and low, high or normal renin hypertensive patients. Life Sci. 1978 May 01; 22(17):1499-510. PMID: 672409.
      Citations: 2     Fields:    Translation:Humans
    56. Mitchell JR, Taylor AA, Pool JL, Lake CR, Rollins DE, Bartter FC. Renin-aldosterone profiling in hypertension. Ann Intern Med. 1977 Nov; 87(5):596-312. PMID: 335942.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
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