Cleavage And Polyadenylation Specificity Factor
"Cleavage And Polyadenylation Specificity Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An RNA-binding protein that recognizes the AAUAAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
| Descriptor ID |
D039223
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| MeSH Number(s) |
D12.776.157.725.124.240 D12.776.664.962.444.240
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cleavage And Polyadenylation Specificity Factor".
Below are MeSH descriptors whose meaning is more specific than "Cleavage And Polyadenylation Specificity Factor".
This graph shows the total number of publications written about "Cleavage And Polyadenylation Specificity Factor" by people in this website by year, and whether "Cleavage And Polyadenylation Specificity Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Cleavage And Polyadenylation Specificity Factor" by people in Profiles.
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NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1. J Neurooncol. 2023 Jul; 163(3):623-634.
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ABL kinases regulate the stabilization of HIF-1a and MYC through?CPSF1. Proc Natl Acad Sci U S A. 2023 04 18; 120(16):e2210418120.
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Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1. Genome Biol. 2021 06 03; 22(1):171.
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Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation. Elife. 2020 04 22; 9.
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Two cases of 16q12.1q21 deletions and refinement of the critical region. Eur J Med Genet. 2020 Jun; 63(6):103878.
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Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation. J Clin Invest. 2019 05 01; 129(5):1984-1999.
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Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 11; 172(1-2):106-120.e21.
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NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation. Elife. 2015 Aug 27; 4.