"Succinate-CoA Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (EC 6.2.1.5) or GTP to GDP (EC 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and ITP instead of GTP.EC 6.2.1.-.
| Descriptor ID |
D013389
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| MeSH Number(s) |
D08.811.464.267.500.600
|
| Concept/Terms |
Succinate-CoA Ligases- Succinate-CoA Ligases
- Ligases, Succinate-CoA
- Succinate CoA Ligases
- Succinyl Coenzyme A Synthetases
- Succinic Thiokinases
- Thiokinases, Succinic
- Succinyl CoA Synthetases
- CoA Synthetases, Succinyl
- Synthetases, Succinyl CoA
|
Below are MeSH descriptors whose meaning is more general than "Succinate-CoA Ligases".
Below are MeSH descriptors whose meaning is more specific than "Succinate-CoA Ligases".
This graph shows the total number of publications written about "Succinate-CoA Ligases" by people in this website by year, and whether "Succinate-CoA Ligases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Succinate-CoA Ligases" by people in Profiles.
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Succinyl-CoA synthetase (SUCLA2) deficiency in two siblings with impaired activity of other mitochondrial oxidative enzymes in skeletal muscle without mitochondrial DNA depletion. Mol Genet Metab. 2017 03; 120(3):213-222.
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Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant. Mol Genet Metab. 2016 09; 119(1-2):68-74.
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Next generation sequencing of patients with mut methylmalonic aciduria: Validation of somatic cell studies and identification of 16 novel mutations. Mol Genet Metab. 2016 08; 118(4):264-71.
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Added value of next generation gene panel analysis for patients with elevated methylmalonic acid and no clinical diagnosis following functional studies of vitamin B12 metabolism. Mol Genet Metab. 2016 Mar; 117(3):363-8.
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Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Dis Model Mech. 2014 Feb; 7(2):271-80.
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Fatal infantile lactic acidosis and a novel homozygous mutation in the SUCLG1 gene: a mitochondrial DNA depletion disorder. Mol Genet Metab. 2011 Feb; 102(2):149-52.