"Apolipoprotein E2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D053329
|
| MeSH Number(s) |
D10.532.091.500.249 D12.776.070.400.500.249 D12.776.521.120.500.249
|
| Concept/Terms |
Apolipoprotein E2- Apolipoprotein E2
- APOE-epsilon2
- APOE epsilon2
- ApoE2
- APOE-epsilon 2
- APOE epsilon 2
- Apo E-2
- Apo E 2
- Apo E2
- Apolipoprotein E-epsilon2
- Apolipoprotein E epsilon2
- Apolipoprotein E-2
- Apolipoprotein E 2
|
Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E2".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E2".
This graph shows the total number of publications written about "Apolipoprotein E2" by people in this website by year, and whether "Apolipoprotein E2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apolipoprotein E2" by people in Profiles.
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Advanced photon counting CT imaging pipeline for cardiac phenotyping of apolipoprotein E mouse models. PLoS One. 2023; 18(10):e0291733.
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Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. JAMA Neurol. 2022 07 01; 79(7):652-663.
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Harnessing the paradoxical phenotypes of APOE ?2 and APOE ?4 to identify genetic modifiers in Alzheimer's disease. Alzheimers Dement. 2021 05; 17(5):831-846.
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Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020 02 03; 11(1):667.
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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017 Nov 07; 26(5):719-737.e6.
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Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec; 9(6):511-520.
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APOE e variants increase risk of warfarin-related intracerebral hemorrhage. Neurology. 2014 Sep 23; 83(13):1139-46.
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Validation of association of the apolipoprotein E e2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants. J Thorac Cardiovasc Surg. 2014 Dec; 148(6):2560-6.
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Risk factors for intracerebral hemorrhage differ according to hemorrhage location. Neurology. 2012 Dec 04; 79(23):2275-82.
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Effects of apolipoprotein E genotype on blood cholesterol in adolescent girls. Am J Prev Med. 2009 Jul; 37(1 Suppl):S78-85.