"Azacitidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
| Descriptor ID |
D001374
|
| MeSH Number(s) |
D02.145.150 D03.383.742.680.245.217 D13.570.685.245.217 D13.570.800.286.300
|
| Concept/Terms |
Azacitidine- Azacitidine
- 5-Azacytidine
- 5 Azacytidine
- Azacytidine
|
Below are MeSH descriptors whose meaning is more general than "Azacitidine".
Below are MeSH descriptors whose meaning is more specific than "Azacitidine".
This graph shows the total number of publications written about "Azacitidine" by people in this website by year, and whether "Azacitidine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 1 | 2 |
| 1997 | 3 | 1 | 4 |
| 1999 | 2 | 1 | 3 |
| 2000 | 0 | 1 | 1 |
| 2001 | 4 | 0 | 4 |
| 2002 | 4 | 0 | 4 |
| 2003 | 8 | 2 | 10 |
| 2004 | 7 | 1 | 8 |
| 2005 | 10 | 6 | 16 |
| 2006 | 9 | 4 | 13 |
| 2007 | 12 | 5 | 17 |
| 2008 | 9 | 7 | 16 |
| 2009 | 9 | 8 | 17 |
| 2010 | 15 | 4 | 19 |
| 2011 | 9 | 6 | 15 |
| 2012 | 10 | 5 | 15 |
| 2013 | 10 | 8 | 18 |
| 2014 | 6 | 8 | 14 |
| 2015 | 11 | 9 | 20 |
| 2016 | 4 | 7 | 11 |
| 2017 | 6 | 10 | 16 |
| 2018 | 5 | 10 | 15 |
| 2019 | 6 | 1 | 7 |
| 2020 | 4 | 3 | 7 |
| 2021 | 10 | 10 | 20 |
| 2022 | 9 | 14 | 23 |
| 2023 | 5 | 11 | 16 |
| 2024 | 8 | 7 | 15 |
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Below are the most recent publications written about "Azacitidine" by people in Profiles.
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Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer. Clin Cancer Res. 2024 Nov 15; 30(22):5166-5179.
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Oral decitabine-cedazuridine in acute myeloid leukaemia. Br J Haematol. 2024 Nov; 205(5):1674-1676.
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Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses. Nat Cancer. 2024 Oct; 5(10):1515-1533.
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Phase 1 dose escalation study of the MDM2 inhibitor milademetan as monotherapy and in combination with azacitidine in patients with myeloid malignancies. Cancer Med. 2024 Jul; 13(14):e70028.
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Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy. Oncotarget. 2024 Jun 03; 15:361-373.
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Phase 1 study of azacitidine in combination with quizartinib in patients with FLT3 or CBL mutated MDS and MDS/MPN. Leuk Res. 2024 Jul; 142:107518.
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Guadecitabine vs TC in relapsed/refractory AML after intensive chemotherapy: a randomized phase 3 ASTRAL-2 trial. Blood Adv. 2024 04 23; 8(8):2020-2029.
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Reduced dose azacitidine plus venetoclax as maintenance therapy in acute myeloid leukaemia following intensive or low-intensity induction: a single-centre, single-arm, phase 2 trial. Lancet Haematol. 2024 Apr; 11(4):e287-e298.
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Pracinostat combined with azacitidine in newly diagnosed adult acute myeloid leukemia (AML) patients unfit for standard induction chemotherapy: PRIMULA phase III study. Leuk Res. 2024 05; 140:107480.
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Paired single-B-cell transcriptomics and receptor sequencing reveal activation states and clonal signatures that characterize B cells in acute myeloid leukemia. J Immunother Cancer. 2024 Feb 28; 12(2).