Eukaryotic Initiation Factor-4A
"Eukaryotic Initiation Factor-4A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of eukaryotic initiation factor 4F that as an RNA helicase involved in unwinding the secondary structure of the 5' UNTRANSLATED REGION of MRNA. The unwinding facilitates the binding of the 40S ribosomal subunit.
| Descriptor ID |
D039601
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| MeSH Number(s) |
D08.811.913.696.445.735.720.500 D12.776.835.725.868.500.500
|
| Concept/Terms |
Eukaryotic Initiation Factor-4A- Eukaryotic Initiation Factor-4A
- Eukaryotic Initiation Factor 4A
- Initiation Factor-4A, Eukaryotic
- EIF-4A
- Eukaryotic Peptide Initiation Factor-4A
- Eukaryotic Peptide Initiation Factor 4A
- Peptide Initiation Factor EIF-4A
- Peptide Initiation Factor EIF 4A
- Eukaryotic Initiation Factor EIF-4A
- Eukaryotic Initiation Factor EIF 4A
Eukaryotic Initiation Factor-4A2- Eukaryotic Initiation Factor-4A2
- Eukaryotic Initiation Factor 4A2
- Factor-4A2, Eukaryotic Initiation
- Initiation Factor-4A2, Eukaryotic
- EIF-4A2
Eukaryotic Initiation Factor-4A3- Eukaryotic Initiation Factor-4A3
- Eukaryotic Initiation Factor 4A3
- Factor-4A3, Eukaryotic Initiation
- Initiation Factor-4A3, Eukaryotic
- EIF-4A3
- EIF4AIII
- Eukaryotic Translation-Initiation Factor 4AIII
- Eukaryotic Translation Initiation Factor 4AIII
Eukaryotic Initiation Factor-4A1- Eukaryotic Initiation Factor-4A1
- Eukaryotic Initiation Factor 4A1
- Factor-4A1, Eukaryotic Initiation
- Initiation Factor-4A1, Eukaryotic
- EIF-4A1
|
Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-4A".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-4A".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-4A" by people in this website by year, and whether "Eukaryotic Initiation Factor-4A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-4A" by people in Profiles.
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Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy. Am J Hum Genet. 2023 01 05; 110(1):120-145.
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Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia. 2021 09; 35(9):2469-2481.
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Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia. Leukemia. 2019 07; 33(7):1663-1674.
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FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation. Cancer Res. 2018 08 01; 78(15):4229-4240.
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A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4118-23.