"Fluorodeoxyuridylate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine.
| Descriptor ID |
D005468
|
| MeSH Number(s) |
D03.383.742.686.850.210.200 D13.695.201.200.270 D13.695.740.850.210.200
|
| Concept/Terms |
Fluorodeoxyuridylate- Fluorodeoxyuridylate
- 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate
- 5 Fluoro 2' Deoxyuridine 5' Monophosphate
- FdUMP
|
Below are MeSH descriptors whose meaning is more general than "Fluorodeoxyuridylate".
Below are MeSH descriptors whose meaning is more specific than "Fluorodeoxyuridylate".
This graph shows the total number of publications written about "Fluorodeoxyuridylate" by people in this website by year, and whether "Fluorodeoxyuridylate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fluorodeoxyuridylate" by people in Profiles.
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The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies. Mol Ther. 2004 Nov; 10(5):916-28.
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[Changes of the number of FdUMP binding sites of thymidylate synthase and folate pools in human colorectal carcinomas following the administration of tegafur and uracil: preliminary report]. Nihon Geka Gakkai Zasshi. 1993 Feb; 94(2):193.
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Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate. J Biol Chem. 1990 Nov 05; 265(31):19163-9.
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Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation. Biochem Pharmacol. 1989 Sep 15; 38(18):2985-93.
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Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil. Cancer Res. 1988 Oct 15; 48(20):5894-900.
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Tumor cell responses to inhibition of thymidylate synthase. Adv Exp Med Biol. 1988; 244:71-83.