"2-Acetylaminofluorene" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Descriptor ID |
D015073
|
| MeSH Number(s) |
D02.065.064.150 D02.241.081.018.110.080 D02.455.426.559.847.389.050 D04.615.389.050
|
| Concept/Terms |
2-Acetylaminofluorene- 2-Acetylaminofluorene
- 2 Acetylaminofluorene
- 2-Acetamidofluorene
- 2 Acetamidofluorene
- 2-Fluorenylacetamide
- 2 Fluorenylacetamide
- N-2-Fluorenylacetamide
- N 2 Fluorenylacetamide
- N-Acetyl-2-Aminofluorene
- N Acetyl 2 Aminofluorene
- AAF, Aminofluorene
- Aminofluorene AAF
- 2-AAF
- Fluoren-2-ylacetamide
- Fluoren 2 ylacetamide
|
Below are MeSH descriptors whose meaning is more general than "2-Acetylaminofluorene".
Below are MeSH descriptors whose meaning is more specific than "2-Acetylaminofluorene".
This graph shows the total number of publications written about "2-Acetylaminofluorene" by people in this website by year, and whether "2-Acetylaminofluorene" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "2-Acetylaminofluorene" by people in Profiles.
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Bone marrow progenitors are not the source of expanding oval cells in injured liver. Stem Cells. 2004; 22(6):1049-61.
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Estimation of k for the poly-k test with application to animal carcinogenicity studies. Stat Med. 2003 Aug 30; 22(16):2619-36.
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Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene. 2002 Mar 27; 21(13):1945-54.
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2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway. J Biol Chem. 2001 Jan 05; 276(1):413-20.
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Biochemical basis of selenomethionine-mediated inhibition during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat. Eur J Cancer Prev. 1996 Dec; 5(6):455-63.
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Inhibitory effect of beta-carotene on chronic 2-acetylaminofluorene induced hepatocarcinogenesis in rat: reflection in hepatic drug metabolism. Carcinogenesis. 1994 May; 15(5):1055-60.
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Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Mol Carcinog. 1993; 8(2):67-73.
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Localization of DNA repair synthesis by human cell extracts to a short region at the site of a lesion. J Biol Chem. 1989 Dec 25; 264(36):21788-92.
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A comparison between different types of covalent DNA modifications (I-compounds, persistent carcinogen adducts and 5-methylcytosine) in regenerating rat liver. Carcinogenesis. 1988 Oct; 9(10):1843-8.
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Molecular aspects of mutagenesis. Mutagenesis. 1986 Nov; 1(6):399-405.