"Heteroduplex Analysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A method of detecting gene mutation by mixing PCR-amplified mutant and wild-type DNA followed by denaturation and reannealing. The resultant products are resolved by gel electrophoresis, with single base substitutions detectable under optimal electrophoretic conditions and gel formulations. Large base pair mismatches may also be analyzed by using electron microscopy to visualize heteroduplex regions.
| Descriptor ID |
D020180
|
| MeSH Number(s) |
E05.393.661.250
|
| Concept/Terms |
Heteroduplex Analysis- Heteroduplex Analysis
- Analyses, Heteroduplex
- Analysis, Heteroduplex
- Heteroduplex Analyses
|
Below are MeSH descriptors whose meaning is more general than "Heteroduplex Analysis".
Below are MeSH descriptors whose meaning is more specific than "Heteroduplex Analysis".
This graph shows the total number of publications written about "Heteroduplex Analysis" by people in this website by year, and whether "Heteroduplex Analysis" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
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Below are the most recent publications written about "Heteroduplex Analysis" by people in Profiles.
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Screening for mutations in a genetically heterogeneous disorder: DHPLC versus DNA sequence for mutation detection in multiple genes causing Charcot-Marie-Tooth neuropathy. Genet Med. 2001 Sep-Oct; 3(5):335-42.
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Human homologue of the murine bare patches/striated gene is not mutated in incontinentia pigmenti type 2. Am J Med Genet. 2000 Mar 20; 91(3):241-4.
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Reduction in hMSH2 mRNA levels by premature translation termination: implications for mutation screening in hereditary nonpolyposis colorectal cancer. Dig Dis Sci. 1999 Mar; 44(3):553-9.
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Human NDUFB9 gene: genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q13. Hum Hered. 1999 Mar; 49(2):75-80.
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Novel mutations in the Wiskott-Aldrich syndrome protein gene and their effects on transcriptional, translational, and clinical phenotypes. Hum Mutat. 1999; 14(1):54-66.
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Intragenic telSMN mutations: frequency, distribution, evidence of a founder effect, and modification of the spinal muscular atrophy phenotype by cenSMN copy number. Am J Hum Genet. 1998 Dec; 63(6):1712-23.