Phosphoglycerate Dehydrogenase
"Phosphoglycerate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of 3-phosphoglycerate to 3-phosphohydroxypyruvate. It takes part in the L-SERINE biosynthesis pathway.
| Descriptor ID |
D050543
|
| MeSH Number(s) |
D08.811.682.047.150.650
|
| Concept/Terms |
Phosphoglycerate Dehydrogenase- Phosphoglycerate Dehydrogenase
- Dehydrogenase, Phosphoglycerate
- Phosphoglycerate Oxidoreductase
- Oxidoreductase, Phosphoglycerate
- D-3-Phosphoglycerate Dehydrogenase
- D 3 Phosphoglycerate Dehydrogenase
- Dehydrogenase, D-3-Phosphoglycerate
- 3-Phosphoglycerate Dehydrogenase
- 3 Phosphoglycerate Dehydrogenase
- Dehydrogenase, 3-Phosphoglycerate
- 3-Phosphoglycerate-NAD+ 2-Oxidoreductase
- 2-Oxidoreductase, 3-Phosphoglycerate-NAD+
- 3 Phosphoglycerate NAD+ 2 Oxidoreductase
|
Below are MeSH descriptors whose meaning is more general than "Phosphoglycerate Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Phosphoglycerate Dehydrogenase".
This graph shows the total number of publications written about "Phosphoglycerate Dehydrogenase" by people in this website by year, and whether "Phosphoglycerate Dehydrogenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phosphoglycerate Dehydrogenase" by people in Profiles.
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PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T?cell immunotherapy. Cell Metab. 2023 03 07; 35(3):517-534.e8.
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Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma. Cell Rep. 2021 01 26; 34(4):108678.
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Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. Nat Commun. 2018 12 21; 9(1):5442.
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Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomic profiling. Mol Genet Metab. 2018 03; 123(3):309-316.
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Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 2014 Dec; 4(12):1406-17.
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Binding partners for curcumin in human schwannoma cells: biologic implications. Bioorg Med Chem. 2013 Feb 15; 21(4):932-9.