"4-Aminopyridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the POTASSIUM CHANNEL BLOCKERS with secondary effect on calcium currents which is used mainly as a research tool and to characterize channel subtypes.
| Descriptor ID |
D015761
|
| MeSH Number(s) |
D02.092.080.060 D03.383.725.050.060
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "4-Aminopyridine".
Below are MeSH descriptors whose meaning is more specific than "4-Aminopyridine".
This graph shows the total number of publications written about "4-Aminopyridine" by people in this website by year, and whether "4-Aminopyridine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 6 | 6 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "4-Aminopyridine" by people in Profiles.
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Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review. Acta Neurol Taiwan. 2023 Mar 30; 32(1):37-41.
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KCNA1 gain-of-function epileptic encephalopathy treated with 4-aminopyridine. Ann Clin Transl Neurol. 2023 04; 10(4):656-663.
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Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine. Muscle Nerve. 2016 Feb; 53(2):165-8.
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Ion channel expression in the developing enteric nervous system. PLoS One. 2015; 10(3):e0123436.
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Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition. Mol Pharmacol. 2014 Dec; 86(6):760-72.
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Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts. J Neurosci Methods. 2013 Jun 15; 216(2):142-5.
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Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. J Cell Physiol. 2012 Jul; 227(7):2907-16.
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Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit. J Biol Chem. 2009 Dec 25; 284(52):36453-36461.
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Histamine enhances voltage-gated potassium currents of ON bipolar cells in macaque retina. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):959-65.
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Rhythmic discharge induced by temperature variation and drugs in isolated sympathetic ganglia. Clin Exp Hypertens. 2008 Oct; 30(7):497-510.