"Dithiothreitol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
| Descriptor ID |
D004229
|
| MeSH Number(s) |
D02.033.800.196 D02.886.740.224 D09.853.196
|
| Concept/Terms |
Dithiothreitol- Dithiothreitol
- Cleland's Reagent
- Clelands Reagent
- Reagent, Cleland's
- Cleland Reagent
- Reagent, Cleland
|
Below are MeSH descriptors whose meaning is more general than "Dithiothreitol".
Below are MeSH descriptors whose meaning is more specific than "Dithiothreitol".
This graph shows the total number of publications written about "Dithiothreitol" by people in this website by year, and whether "Dithiothreitol" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dithiothreitol" by people in Profiles.
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Efficient neutralization of daratumumab in pretransfusion samples using a novel recombinant monoclonal anti-idiotype antibody. Transfusion. 2022 08; 62(8):1511-1518.
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S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation. PLoS One. 2014; 9(3):e93315.
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Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects. MAbs. 2013 Jul-Aug; 5(4):608-13.
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Activation of inhibitors by sortase triggers irreversible modification of the active site. J Biol Chem. 2007 Aug 10; 282(32):23129-39.
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Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery. J Clin Invest. 2004 Jan; 113(1):65-73.
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Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis. Biochemistry. 2003 Apr 08; 42(13):3874-81.
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Reductive unfolding and oxidative refolding of a Bowman-Birk inhibitor from horsegram seeds (Dolichos biflorus): evidence for "hyperreactive" disulfide bonds and rate-limiting nature of disulfide isomerization in folding. Biochim Biophys Acta. 2002 Jun 03; 1597(2):280-91.
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Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. J Biol Chem. 2002 Mar 22; 277(12):10638-41.
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Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):107-12.
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Discrimination between native and non-native disulfides by protein-disulfide isomerase. J Biol Chem. 2001 May 11; 276(19):15747-52.