"Angiopoietin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.
| Descriptor ID |
D042683
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| MeSH Number(s) |
D12.644.276.100.100.100 D12.776.467.100.100.100 D23.529.100.100.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Angiopoietin-1".
Below are MeSH descriptors whose meaning is more specific than "Angiopoietin-1".
This graph shows the total number of publications written about "Angiopoietin-1" by people in this website by year, and whether "Angiopoietin-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Angiopoietin-1" by people in Profiles.
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Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1. Crit Care. 2023 06 26; 27(1):250.
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Associations of Angiopoietins With Heart Failure Incidence and Severity. J Card Fail. 2021 07; 27(7):786-795.
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Endothelial Hypoxia-Inducible Factor-2a Is Required for the Maintenance of Airway Microvasculature. Circulation. 2019 01 22; 139(4):502-517.
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PDGFRa+ Cells in Embryonic Stem Cell Cultures Represent the In?Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors. Stem Cell Reports. 2017 02 14; 8(2):318-333.
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Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis. PLoS One. 2016; 11(7):e0158908.
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p53-independent ibrutinib responses in an E?-TCL1 mouse model demonstrates efficacy in high-risk CLL. Blood Cancer J. 2016 06 10; 6:e434.
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Antiangiogenic therapy in oncology: current status and future directions. Lancet. 2016 Jul 30; 388(10043):518-29.
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Angiopoietin-1 improves endothelial progenitor cell-dependent neovascularization in diabetic wounds. Surgery. 2015 Sep; 158(3):846-56.
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Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial. Lancet Oncol. 2014 Jul; 15(8):799-808.
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Linking transgene expression of engineered mesenchymal stem cells and angiopoietin-1-induced differentiation to target cancer angiogenesis. Ann Surg. 2011 Mar; 253(3):566-71.