G-Protein-Coupled Receptor Kinase 5
"G-Protein-Coupled Receptor Kinase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions.
| Descriptor ID |
D054774
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.364.775 D12.644.360.293.875 D12.776.476.293.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "G-Protein-Coupled Receptor Kinase 5".
Below are MeSH descriptors whose meaning is more specific than "G-Protein-Coupled Receptor Kinase 5".
This graph shows the total number of publications written about "G-Protein-Coupled Receptor Kinase 5" by people in this website by year, and whether "G-Protein-Coupled Receptor Kinase 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "G-Protein-Coupled Receptor Kinase 5" by people in Profiles.
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Occupancy of human EPCR by protein C induces ?-arrestin-2 biased PAR1 signaling by both APC and thrombin. Blood. 2016 10 06; 128(14):1884-1893.
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Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients. Pharmacogenet Genomics. 2011 Jan; 21(1):42-9.
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Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation. Mol Pharmacol. 2010 Mar; 77(3):405-15.
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem. 2006 Jan 13; 281(2):1261-73.
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Endosome sorting of beta 2-adrenoceptors is GRK5 independent. Br J Pharmacol. 2004 Jan; 141(2):277-84.
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Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. FASEB J. 1999 Apr; 13(6):715-25.